公开(公告)号：US20210109076A1

公开(公告)日：2021-04-15

申请号：US17128270

申请日：2020-12-21

Applicant: DOTS Technology Corp.

Inventor： Adi Gilboa-Geffen ,  Renuka Babu Brown ,  Sarah Stidham ,  Valerie Villareal ,  Adam J. Young ,  Joshua Glenn Anthony ,  Patrick Murphy ,  John H. Kepler ,  Adam Jacobs

IPC: G01N33/02 ,  C12M1/34 ,  G01N1/08 ,  C12N15/115 ,  G01N1/14 ,  G01N1/28 ,  G01N33/53 ,  G01N33/58

Abstract: The present invention provides systems, devices, signaling polynucleotides (SPNs), detection agents and methods for detecting the presence and/or absence of one or more allergens in a sample particularly a food sample. The detection system includes a separate sampler, at least one disposable detection vessel for receiving and processing a test sample and a detection device for measuring a fluorescent signal. SPNs derived from aptamer that bind allergens are provided as detection agents. SPNs have a single open structure, and are labeled with a fluorophore. Changes in fluorescence polarization of SPNs upon the binding of allergens are measured to calculate the allergen content in a sample.

公开(公告)号：US10908139B2

公开(公告)日：2021-02-02

申请号：US16084996

申请日：2017-03-10

Applicant: DOTS Technology Corp.

Inventor： Adi Gilboa-Geffen ,  Renuka Babu Brown ,  Sarah Stidham ,  Valerie Villareal ,  Adam J. Young ,  Joshua Glenn Anthony ,  Patrick Murphy ,  John H. Kepler ,  Adam Jacobs

IPC: B01L3/00 ,  B01L1/00 ,  G01N33/02 ,  C12M1/34 ,  G01N1/08 ,  C12N15/115 ,  G01N1/14 ,  G01N1/28 ,  G01N33/53 ,  G01N33/58

Abstract: The present invention provides systems, devices, signaling polynucleotides (SPNs), detection agents and methods for detecting the presence and/or absence of one or more allergens in a sample particularly a food sample. The detection system includes a separate sampler, at least one disposable detection vessel for receiving and processing a test sample and a detection device for measuring a fluorescent signal. SPNs derived from aptamer that bind allergens are provided as detection agents. SPNs have a single open structure, and are labeled with a fluorophore. Changes in fluorescence polarization of SPNs upon the binding of allergens are measured to calculate the allergen content in a sample.

公开(公告)号：US20190079063A1

公开(公告)日：2019-03-14

申请号：US16084996

申请日：2017-03-10

Applicant: DOTS Technology Corp.

Inventor： Adi Gilboa-Geffen ,  Renuka Babu Brown ,  Sarah Stidham ,  Valerie Villareal ,  Adam J. Young ,  Joshua Glenn Anthony ,  Patrick Murphy ,  John H. Kepler ,  Adam Jacobs

IPC: G01N33/02 ,  G01N33/53 ,  G01N33/58 ,  G01N1/28

Abstract: The present invention provides systems, devices, signaling polynucleotides (SPNs), detection agents and methods for detecting the presence and/or absence of one or more allergens in a sample particularly a food sample. The detection system includes a separate sampler, at least one disposable detection vessel for receiving and processing a test sample and a detection device for measuring a fluorescent signal. SPNs derived from aptamer that bind allergens are provided as detection agents. SPNs have a single open structure, and are labeled with a fluorophore. Changes in fluorescence polarization of SPNs upon the binding of allergens are measured to calculate the allergen content in a sample.