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公开(公告)号：US10344051B2
公开(公告)日：2019-07-09
申请号：US15714781
申请日：2017-09-25
Applicant: Puridify Ltd.
Inventor： Daniel Gilbert Bracewell , Robert Stevens , Oliver Hardick
IPC: C07K1/16 , B01D15/36 , B01J20/28 , B01J20/285 , B01J20/30 , C07K1/18 , C07K1/22 , B01D15/18 , B01D15/38 , B01J20/24 , B82Y30/00
Abstract: The present invention provides a chromatography medium comprising one or more electrospun polymer nanofibers which in use form a stationary phase comprising a plurality of pores through which a mobile phase can permeate and use of the same.
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公开(公告)号：US20220268745A1
公开(公告)日：2022-08-25
申请号：US17737163
申请日：2022-05-05
Applicant: Puridify Ltd.
Inventor： Michael Williams , Iwan Roberts , Oliver Hardick , Matthew Townsend , Christopher Morris , Shameer Subratty
Abstract: A chromatography system for at least one of tangential flow chromatography and lateral flow chromatography comprising: an inlet; a functionalised adsorbent chromatography medium downstream of the inlet; an outlet downstream of the adsorbent chromatography medium; and a flow guide downstream of the inlet and upstream of the adsorbent chromatography medium and configured to distribute a flow of a liquid from the inlet across a width of the adsorbent chromatography medium; wherein the flow guide comprises a pattern of channels providing flow paths from the inlet to different parts of the adsorbent chromatography medium along the width of the adsorbent chromatography medium, wherein the pattern of channels is provided so as to reduce a difference in arrival time and/or flow velocity of liquid reaching the adsorbent chromatography medium across the width of the adsorbent chromatography medium.
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公开(公告)号：US20210162370A1
公开(公告)日：2021-06-03
申请号：US17078435
申请日：2020-10-23
Applicant: Puridify Ltd.
Inventor： Oliver Hardick , Daniel Gilbert Bracewell , Stewart Dods
IPC: B01J20/26 , B01D15/38 , C07K1/18 , B01J20/285 , B01J20/24 , B01J20/30 , B01D15/36 , B01J20/28 , B01D15/32 , B01J39/05 , B01J41/13 , B01J41/07 , B01J39/19 , B01D39/14 , B01D39/16 , B01J20/287 , B01J20/288 , B01J39/26 , B01J41/20 , B29C65/02 , B29C65/00 , B32B5/02 , B32B27/08 , B32B27/12 , B32B27/32 , B32B37/06 , B32B37/10 , B32B37/18 , C07K1/16 , C07K1/20 , C07K1/22
Abstract: The present invention provides a process for preparing a functionalised polymeric chromatography medium, which process comprises (I) providing two or more non-woven sheets stacked one on top of the other, each said sheet comprising one or more polymer nanofibres, (II) simultaneously heating and pressing the stack of sheets to fuse points of contact between the nanofibres of adjacent sheets, and (III) contacting the pressed and heated product with a reagent which functionalises the product of step (II) as a chromatography medium.
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公开(公告)号：US20190255513A1
公开(公告)日：2019-08-22
申请号：US16314943
申请日：2017-07-14
Applicant: Puridify Ltd.
Inventor： Ian Scanlon
IPC: B01J20/285 , C12N7/00 , A61K48/00 , A61P35/00 , B01J20/28
Abstract: The present invention provides a process for recovering a viral product from a composition comprising said product and product-related impurities, which process comprises contacting the composition with a functionalised chromatography medium comprising one or more polymer nanofibres, wherein the viral product comprises a plurality of viruses, virus particles/virions, viral cores, membrane-stripped viruses, viral cores with outer membrane(s) removed and/or capsids removed, or proviruses, each of which contains one or more polynucleotides, and wherein the product-related impurities comprise a plurality of viruses, virus particles/virions, virus-like particles, viral cores, membrane-stripped viruses, viral cores with outer membrane(s) removed and/or capsids removed or proviruses, each of which is substantially devoid of polynucleotides.
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Patent Agency Ranking
公开(公告)号：US20180094022A1
公开(公告)日：2018-04-05
申请号：US15714781
申请日：2017-09-25
Applicant: Puridify Ltd.
Inventor： Daniel Gilbert Bracewell , Robert Stevens , Oliver Hardick
IPC: C07K1/16 , B01J20/28 , B01J20/285 , B01J20/30 , C07K1/18 , B01D15/36 , B01D15/18 , B01D15/38 , B01J20/24 , B82Y30/00 , C07K1/22
CPC classification number: C07K1/16 , B01D15/1821 , B01D15/361 , B01D15/3804 , B01J20/24 , B01J20/28007 , B01J20/28038 , B01J20/28083 , B01J20/28085 , B01J20/285 , B01J20/3007 , B82Y30/00 , C07K1/18 , C07K1/22
Abstract: The present invention provides a chromatography medium comprising one or more electrospun polymer nanofibres which in use form a stationary phase comprising a plurality of pores through which a mobile phase can permeate and use of the same.
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公开(公告)号：US20160288089A1
公开(公告)日：2016-10-06
申请号：US15091158
申请日：2016-04-05
Applicant: Puridify Ltd.
Inventor： Oliver Hardick , Daniel Gilbert Bracewell , Stewart Dods
IPC: B01J20/26 , C07K1/22 , C07K1/20 , C07K1/16 , B01J20/28 , B01J20/287 , B01J20/288 , B01J39/18 , B01J39/04 , B01J39/26 , B01J41/04 , B01J41/12 , B01J41/20 , B01J20/30 , B01D15/36 , B01D15/38 , B29C65/02 , B29C65/00 , B32B37/06 , B32B5/02 , B32B27/32 , B32B27/08 , B32B27/12 , B32B37/10 , B32B37/18 , C07K1/18
CPC classification number: B01J20/265 , B01D15/327 , B01D15/361 , B01D15/362 , B01D15/363 , B01D15/38 , B01D15/3804 , B01D15/3809 , B01D15/3819 , B01J20/24 , B01J20/28007 , B01J20/28033 , B01J20/28038 , B01J20/28083 , B01J20/28085 , B01J20/285 , B01J20/287 , B01J20/288 , B01J20/3007 , B01J20/3085 , B01J39/05 , B01J39/19 , B01J39/26 , B01J41/07 , B01J41/13 , B01J41/20 , B01J2220/54 , B29C65/02 , B29C66/45 , B29C66/712 , B29C66/7294 , B29K2601/12 , B29K2627/18 , B29K2713/00 , B29L2009/00 , B32B5/022 , B32B27/08 , B32B27/12 , B32B27/322 , B32B37/06 , B32B37/10 , B32B37/182 , B32B2262/04 , B32B2317/18 , B32B2327/18 , C07K1/16 , C07K1/165 , C07K1/18 , C07K1/20 , C07K1/22
Abstract: The present invention provides a process for preparing a functionalised polymeric chromatography medium, which process comprises (I) providing two or more non-woven sheets stacked one on top of the other, each said sheet comprising one or more polymer nanofibres, (II) simultaneously heating and pressing the stack of sheets to fuse points of contact between the nanofibres of adjacent sheets, and (III) contacting the pressed and heated product with a reagent which functionalises the product of step (II) as a chromatography medium.
Abstract translation: 本发明提供了一种制备官能化聚合物色谱介质的方法，该方法包括（I）提供两个或更多个层叠在另一个上的非织造片材，每个所述片材同时包含一种或多种聚合物纳米纤维（II） 加热和压制叠片以熔化相邻片材的纳米纤维之间的接触点，和（III）使被加压和加热的产物与将作为色谱介质的步骤（II）的产物起作用的试剂接触。
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公开(公告)号：US20240210365A1
公开(公告)日：2024-06-27
申请号：US18408693
申请日：2024-01-10
Applicant: Puridify Ltd.
Inventor： Michael Williams , Iwan Roberts , Oliver Hardick , Matthew Townsend , Christopher Morris , Shameer Subratty
CPC classification number: G01N30/38 , G01N30/6017 , G01N2030/386
Abstract: A chromatography system for at least one of tangential flow chromatography and lateral flow chromatography comprising: an inlet; a functionalised adsorbent chromatography medium downstream of the inlet; an outlet downstream of the adsorbent chromatography medium; and a flow guide downstream of the inlet and upstream of the adsorbent chromatography medium and configured to distribute a flow of a liquid from the inlet across a width of the adsorbent chromatography medium; wherein the flow guide comprises a pattern of channels providing flow paths from the inlet to different parts of the adsorbent chromatography medium along the width of the adsorbent chromatography medium, wherein the pattern of channels is provided so as to reduce a difference in arrival time and/or flow velocity of liquid reaching the adsorbent chromatography medium across the width of the adsorbent chromatography medium.
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公开(公告)号：US11931719B2
公开(公告)日：2024-03-19
申请号：US16959373
申请日：2019-01-07
Applicant: Puridify Ltd.
Inventor： Marc Hummersone , Benjamin Wallis , Frederic Leroux , William Howard Albert Law
IPC: B01D15/32 , B01D15/36 , B01J20/26 , B01J20/285 , B01J20/32 , B01J39/05 , B01J39/07 , B01J41/05 , B01J41/07
CPC classification number: B01J20/265 , B01D15/327 , B01D15/362 , B01D15/363 , B01J20/285 , B01J20/3274 , B01J39/05 , B01J39/07 , B01J41/05 , B01J41/07 , B01J2219/00844 , B01J2219/00846
Abstract: The invention discloses a functionalised chromatography medium, comprising: i) at least one non-woven layer (10) of polymeric nano fibres (20) comprising a plurality of nanofibre-nano fibre fusion points (30); ii) a grafted polymer coating covering the polymeric nanofibres and the nanofibre-nanofibre fusion points; iii) a plurality of ligand groups covalently bound to the grafted polymer coating, wherein the ligand groups are capable of interacting with a target biomolecule.
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公开(公告)号：US11913918B2
公开(公告)日：2024-02-27
申请号：US17737163
申请日：2022-05-05
Applicant: Puridify Ltd.
Inventor： Michael Williams , Iwan Roberts , Oliver Hardick , Matthew Townsend , Christopher Morris , Shameer Subratty
CPC classification number: G01N30/38 , G01N30/6017 , G01N2030/386 , G01N30/6017 , G01N2030/386
Abstract: A chromatography system for at least one of tangential flow chromatography and lateral flow chromatography comprising: an inlet; a functionalised adsorbent chromatography medium downstream of the inlet; an outlet downstream of the adsorbent chromatography medium; and a flow guide downstream of the inlet and upstream of the adsorbent chromatography medium and configured to distribute a flow of a liquid from the inlet across a width of the adsorbent chromatography medium; wherein the flow guide comprises a pattern of channels providing flow paths from the inlet to different parts of the adsorbent chromatography medium along the width of the adsorbent chromatography medium, wherein the pattern of channels is provided so as to reduce a difference in arrival time and/or flow velocity of liquid reaching the adsorbent chromatography medium across the width of the adsorbent chromatography medium.
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