公开(公告)号：US20180269051A1

公开(公告)日：2018-09-20

申请号：US15982451

申请日：2018-05-17

Applicant: Micromass UK Limited

Inventor： Michael Raymond Morris ,  Steven Derek Pringle ,  Keith Richardson ,  Ian Sinclair

IPC: H01J49/10 ,  H01J49/00 ,  H01J49/04 ,  G01N29/02

CPC classification number: H01J49/10 ,  G01N29/02 ,  G01N2291/011 ,  G01N2291/02818 ,  H01J49/0027 ,  H01J49/0454

Abstract: An ion source for a mass spectrometer is disclosed comprising an ultrasonic transducer which focuses ultrasonic energy onto a surface of a sample fluid without directly contacting the sample fluid.

公开(公告)号：US10079136B2

公开(公告)日：2018-09-18

申请号：US15317314

申请日：2015-06-12

Applicant: Micromass UK Limited

Inventor： Jeffery Mark Brown ,  Paul Murray ,  Keith Richardson

IPC: H01J49/40 ,  H01J49/10 ,  H01J49/00

CPC classification number: H01J49/0009 ,  H01J49/0031 ,  H01J49/0036 ,  H01J49/40

Abstract: A method of calibrating a mass spectrometer is disclosed comprising mass analyzing first ions derived from an analyte molecule, wherein the first ions have a first charge state; determining a first mass or mass to charge ratio of the first ions; mass analyzing second ions derived from the analyte molecule, wherein the second ions have a second different charge state and wherein the second ions comprise protonated or adduct variants of the first ions; determining a second mass or mass to charge ratio of the second ions; a determining a calibration correction based upon the first mass or mass to charge ratio and the second mass or mass to charge ratio.

公开(公告)号：US10043645B2

公开(公告)日：2018-08-07

申请号：US15304634

申请日：2015-04-14

Applicant: MICROMASS UK LIMITED

Inventor： Martin Raymond Green ,  Keith Richardson

IPC: H01J49/00 ,  G01N33/92 ,  G01B15/00

Abstract: A method of mass spectrometry for analyzing lipids and similar biological molecules is disclosed. The lipid molecules may be ionized to form a plurality of lipid parent ions and subjected to photon-induced fragmentation to form a plurality of fragment or product ions. The position of one or more unsaturated bonds in the lipid molecules may be determined by mass analyzing the fragment and product ions and analyzing their intensity profile.

公开(公告)号：US09812309B2

公开(公告)日：2017-11-07

申请号：US15101688

申请日：2014-12-05

Applicant: Micromass UK Limited

Inventor： John Brian Hoyes ,  Keith Richardson

IPC: H01J49/00 ,  H01J43/02 ,  G01N30/00 ,  G01T1/16 ,  H01J49/02 ,  G01T1/20 ,  G01N30/72 ,  H01J40/00 ,  H01J49/40

CPC classification number: H01J49/025 ,  G01N30/72 ,  G01T1/20 ,  H01J40/00 ,  H01J43/02 ,  H01J49/0031 ,  H01J49/401

Abstract: An ion detector system for a mass spectrometer is disclosed comprising a first device arranged and adapted to receive ions and emit or output first electrons and a microwave cavity resonator arranged and adapted to deflect the first electrons onto a first detector.

公开(公告)号：US09772304B2

公开(公告)日：2017-09-26

申请号：US15100034

申请日：2014-12-01

Applicant: Micromass UK Limited

Inventor： Martin Raymond Green ,  Keith Richardson ,  Jason Lee Wildgoose

IPC: G01N27/447 ,  H01J49/04 ,  H01J49/00 ,  G01N27/62

CPC classification number: G01N27/44717 ,  G01N27/4473 ,  G01N27/44782 ,  G01N27/44791 ,  G01N27/624 ,  H01J49/0027 ,  H01J49/0031 ,  H01J49/004 ,  H01J49/0404

Abstract: A method of mass spectrometry or ion mobility spectrometry is disclosed in which analyte ions of a desired charge state are isolated. The method comprises: separating analytes according to their electrophoretic mobility; ionizing the analytes; and mass filtering the resulting analyte ions, wherein the mass to charge ratios of the ions transmitted by a mass filter are varied as a function of the electrophoretic mobility and according to a predetermined relationship such that substantially only ions having said desired charge state are transmitted by the mass filter.

公开(公告)号：US09711337B2

公开(公告)日：2017-07-18

申请号：US14774981

申请日：2014-03-14

Applicant: Micromass UK Limited

Inventor： Martin Raymond Green ,  Keith Richardson ,  Jason Lee Wildgoose

IPC: H01J49/00 ,  H01J49/40 ,  H01J49/42

CPC classification number: H01J49/0036 ,  H01J49/0031 ,  H01J49/40 ,  H01J49/4215

Abstract: A method of mass spectrometry is disclosed comprising setting an attenuation factor of an attenuation device to a first value and then separating or filtering ions according to a first physico-chemical property and separating or filtering ions according to a second physico-chemical property and obtaining a multi-dimensional array of data. The most intense ion peak within one or more subsets of the multi-dimensional array of data is determined. If it is determined that the most intense ion peak would cause saturation of an ion detector or ion detection system then the method further comprises adjusting the attenuation factor of the attenuation device to a second value and obtaining mass spectral data wherein the adjustment of the attenuation factor substantially alters the intensity of all ions which are detected by the ion detector or ion detection system equally and irrespective of the mass to charge ratio of the ions. The intensity of the mass spectral data is then scaled based upon the degree to which the attenuation factor of the attenuation device was increased or reduced.

公开(公告)号：US20170018414A1

公开(公告)日：2017-01-19

申请号：US15101688

申请日：2014-12-05

Applicant: MICROMASS UK LIMITED

Inventor： John Brian Hoyes ,  Keith Richardson

IPC: H01J49/02 ,  H01J49/00 ,  H01J49/40

CPC classification number: H01J49/025 ,  G01N30/72 ,  G01T1/20 ,  H01J40/00 ,  H01J43/02 ,  H01J49/0031 ,  H01J49/401

Abstract: An ion detector system for a mass spectrometer is disclosed comprising a first device arranged and adapted to receive ions and emit or output first electrons and a microwave cavity resonator arranged and adapted to deflect the first electrons onto a first detector.

Abstract translation: 公开了一种用于质谱仪的离子检测器系统，包括布置并适于接收离子并发射或输出第一电子的第一器件和布置并适于将第一电子偏转到第一检测器上的微波空腔谐振器。

公开(公告)号：US09514924B2

公开(公告)日：2016-12-06

申请号：US14719665

申请日：2015-05-22

Applicant: Micromass UK Limited

Inventor： Michael Raymond Morris ,  Steven Derek Pringle ,  Keith Richardson

IPC: H01J49/26 ,  H01J49/16 ,  H01J49/00 ,  H01J49/02 ,  H01J49/04 ,  G01N27/62 ,  G01N29/22 ,  H01J49/24

CPC classification number: H01J49/165 ,  G01N27/622 ,  G01N29/22 ,  H01J49/0031 ,  H01J49/022 ,  H01J49/0454 ,  H01J49/24 ,  H01J49/26 ,  Y10T137/0391 ,  Y10T137/206

Abstract: An ion source for a mass spectrometer is disclosed comprising an ionization device which emits a stream of droplets and one or more ultrasonic transmitters which create one or more acoustic standing waves. The acoustic standing waves may be used to further nebulize the stream of droplets and induce internal mixing of the droplets.

公开(公告)号：US20160343556A1

公开(公告)日：2016-11-24

申请号：US15224989

申请日：2016-08-01

Applicant: Micromass UK Limited

Inventor： Martin Raymond Green ,  Jason Lee Wildgoose ,  Steven Derek Pringle ,  Keith Richardson

IPC: H01J49/00 ,  G01R29/26

CPC classification number: H01J49/0031 ,  G01R29/26 ,  H01J49/025

Abstract: A control system and method of determining a signal to noise (S/N) ratio of an ion detector system, including an ion detector, electron multiplier or photomultiplier, operates by determining an area of a noise peak, determining an area of a signal peak and determining a ratio of the area of the signal peak to the area of the noise peak. Based thereon, the signal to noise ratio can be optimised. The system has particular applicability for use in mass spectrometry.

Abstract translation: 确定离子检测器系统（包括离子检测器，电子倍增器或光电倍增管）的信噪比（S / N）比的控制系统和方法通过确定噪声峰值的面积来确定信号峰值的面积 并且确定信号峰值的面积与噪声峰值的面积的比率。 基于此，可以优化信噪比。 该系统特别适用于质谱分析。

公开(公告)号：US20160027628A1

公开(公告)日：2016-01-28

申请号：US14774820

申请日：2014-03-14

Applicant: MICROMASS UK LIMITED

Inventor： Martin Raymond Green ,  Keith Richardson

IPC: H01J49/00 ,  H01J49/02 ,  G06F17/18

CPC classification number: H01J49/0036 ,  G06F17/18 ,  H01J49/025

Abstract: A method of mass spectrometry is disclosed comprising obtaining first data at a first time and/or location and second data at a second subsequent time and/or location. A future trend or rate of change in the data is predicted from the first and second data. An attenuation factor of an attenuation device is adjusted in response to the predicted future trend or rate of change in the data so as to maintain operation of a detector or detector system within the dynamic range of the detector or detector system and/or to prevent saturation of the detector or detector system.

Abstract translation: 公开了一种质谱法，其包括在第二时间和/或位置在第一时间和/或位置获得第一数据和第二数据。 从第一和第二数据预测数据的未来趋势或变化率。 响应于预测的未来趋势或数据变化率来调整衰减装置的衰减因子，以便将检测器或检测器系统的操作保持在检测器或检测器系统的动态范围内和/或防止饱和 的检测器或检测器系统。