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公开(公告)号：US20140175685A1
公开(公告)日：2014-06-26
申请号：US14108426
申请日：2013-12-17
Applicant: Novartis AG
Inventor： Jinyu Huang , Daqing Wu , Uwe Haken , Horngyih Huang , Manivakkam J. Shankernarayanan
IPC: B29D11/00
CPC classification number: B29D11/00192
Abstract: The instant invention pertains to a method and a fluid polymerizable composition for producing contact lenses with improved lens quality and with increased product yield. The method of the invention involves adding a water soluble and/or water dispersible quaternary ammonium cationic group containing silicone surfactant into a fluid polymerizable composition including a lens-forming material in an amount sufficient to reduce an averaged mold separation force by at least about 30% in comparison with that without the water soluble and/or water dispersible quaternary ammonium cationic group containing silicone surfactant.
Abstract translation: 本发明涉及一种用于制造具有改善的镜片质量和增加的产品产率的隐形眼镜的方法和流体可聚合组合物。 本发明的方法包括将含有硅氧烷表面活性剂的水溶性和/或水分散性季铵阳离子基团加入到包含透镜形成材料的流体可聚合组合物中，其量足以将平均的模具分离力减小至少约30％ 与不含水溶性和/或水分散性季铵阳离子基团的硅氧烷表面活性剂相比。
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公开(公告)号：US10920102B2
公开(公告)日：2021-02-16
申请号：US16720932
申请日：2019-12-19
Applicant: Novartis AG
Inventor： Yongxing Qiu , Newton T. Samuel , John Dallas Pruitt , Chandana Kolluru , Arturo Norberto Medina , Lynn Cook Winterton , Daqing Wu , Xinming Qian , Jared Nelson
IPC: C09D177/06 , B29D11/00 , G02B1/18 , G02B1/04 , G02C7/04 , G02B1/10 , C08J7/04 , C08L83/04 , C08G77/388 , C08J5/00 , C09D5/16 , C09D133/02 , C09D133/14 , C09D133/26 , C09D171/02
Abstract: The invention is related to a cost-effective method for making a silicone hydrogel contact lens having a crosslinked hydrophilic coating thereon. A method of the invention involves heating a silicone hydrogel contact lens in an aqueous solution in the presence of a water-soluble, highly branched, thermally-crosslinkable hydrophilic polymeric material having positively-charged azetidinium groups, to and at a temperature from about 40° C. to about 140° C. for a period of time sufficient to covalently attach the thermally-crosslinkable hydrophilic polymeric material onto the surface of the silicone hydrogel contact lens through covalent linkages each formed between one azetidinium group and one of the reactive functional groups on and/or near the surface of the silicone hydrogel contact lens, thereby forming a crosslinked hydrophilic coating on the silicone hydrogel contact lens. Such method can be advantageously implemented directly in a sealed lens package during autoclave.
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公开(公告)号：US20180356562A1
公开(公告)日：2018-12-13
申请号：US16000930
申请日：2018-06-06
Applicant: Novartis AG
Inventor： Daqing Wu , Junhao Ge , Steve Yun Zhang , Richard Charles Breitkopf , Xinming Qian , Zach Munoz , Matthew D. Nelson , Augustine Twum Kumi , Weihong Lang , Ying Zheng , Feng Jing , Frank Chang
CPC classification number: G02B1/043 , B29D11/00134 , C08F230/08 , C08L83/04
Abstract: The present invention generally relates to inherently wettable silicone hydrogel contact lenses having relatively high oxygen permeability, relatively high equilibrium water content and relatively low elastic modulus. The present invention is also related to a method for making such inherently wettable silicone hydrogel contact lenses.
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公开(公告)号：US20180355112A1
公开(公告)日：2018-12-13
申请号：US16000933
申请日：2018-06-06
Applicant: Novartis AG
Inventor： Steve Yun Zhang , Daqing Wu , Junhao Ge , Richard Charles Breitkopf , Xinming Qian , Zach Munoz , Matthew D. Nelson , Augustine Twum Kumi , Weihong Lang , Ying Zheng , Feng Jing , Frank Chang
IPC: C08G77/442 , C08G77/20 , C08G77/388 , C08G77/392 , C08G77/14 , C08G77/12 , C08L83/10 , G02B1/04
CPC classification number: C08G77/442 , B29D11/00134 , C08G77/12 , C08G77/14 , C08G77/20 , C08G77/388 , C08G77/392 , C08G2210/00 , C08L83/10 , C08L2201/10 , G02B1/043 , G02B2207/109 , G02C7/04
Abstract: The present invention generally relates to inherently wettable silicone hydrogel contact lenses having relatively high oxygen permeability, relatively high equilibrium water content and relatively low elastic modulus. The present invention is also related to a method for making such inherently wettable silicone hydrogel contact lenses.
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公开(公告)号：US09921340B2
公开(公告)日：2018-03-20
申请号：US14883142
申请日：2015-10-14
Applicant: Novartis AG
Inventor： Jinyu Huang , Frank Chang , Robert Scott , Arturo Norberto Medina , Venkat Shankar , Selma Kuyu , Dawn Alison Smith , Daqing Wu
CPC classification number: G02B1/043 , C08G77/20 , C08G77/42 , C08G77/442 , C08J3/075 , C08J2343/04 , C08J2383/08 , C08L83/10 , C08L101/14 , C08L83/04
Abstract: The invention provide a class of water-processable polymerizable prepolymers which comprises (1) siloxane-containing monomeric units derived at least one siloxane containing monomer having one hydrophilic group or chain and/or polysiloxane-containing crosslinking units derived from at least one hydrophilized polysiloxane or chain-extended polysiloxane crosslinker; (2) hydrophilic monomeric units derived from one or more hydrophilic vinylic monomers; and (3) from about 0.05% to about 5% by weight of polymerizable units each having a pendant or terminal, ethylenically-unsaturated group and free of any polysiloxane segment. The prepolymer comprises from about 20% to about 50% by weight of silicone relative to the total weight of the prepolymer and has a high water solubility or dispersibility of at least about 5% by weight in water and suitable for making silicone hydrogel contact lenses.
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Patent Agency Ranking
公开(公告)号：US20170306178A1
公开(公告)日：2017-10-26
申请号：US15646291
申请日：2017-07-11
Applicant: Novartis AG
Inventor： Yongxing Qiu , Newton T. Samuel , John Dallas Pruitt , Chandana Kolluru , Arturo Norberto Medina , Lynn Cook Winterton , Daqing Wu , Xinming Qian , Jared Nelson
IPC: C09D177/06 , B29D11/00 , C08G77/388 , C08J5/00 , C08J7/04 , C08L83/04 , G02B1/18 , G02C7/04 , G02B1/10 , G02B1/04 , C09D171/02 , C09D133/26 , C09D133/14 , C09D133/02 , C09D5/16
CPC classification number: C09D177/06 , B29D11/00067 , C08G77/388 , C08J5/00 , C08J7/042 , C08J2383/04 , C08J2383/08 , C08J2433/02 , C08J2433/26 , C08J2487/00 , C08L83/04 , C09D5/1637 , C09D5/1681 , C09D133/02 , C09D133/14 , C09D133/26 , C09D171/02 , G02B1/043 , G02B1/10 , G02B1/18 , G02C7/049 , G02C2202/06 , G02C2202/16 , C08L101/14
Abstract: The invention is related to a cost-effective method for making a silicone hydrogel contact lens having a crosslinked hydrophilic coating thereon. A method of the invention involves heating a silicone hydrogel contact lens in an aqueous solution in the presence of a water-soluble, highly branched, thermally-crosslinkable hydrophilic polymeric material having positively-charged azetidinium groups, to and at a temperature from about 40° C. to about 140° C. for a period of time sufficient to covalently attach the thermally-crosslinkable hydrophilic polymeric material onto the surface of the silicone hydrogel contact lens through covalent linkages each formed between one azetidinium group and one of the reactive functional groups on and/or near the surface of the silicone hydrogel contact lens, thereby forming a crosslinked hydrophilic coating on the silicone hydrogel contact lens. Such method can be advantageously implemented directly in a sealed lens package during autoclave.
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公开(公告)号：US20150099822A1
公开(公告)日：2015-04-09
申请号：US14571350
申请日：2014-12-16
Applicant: Novartis AG
Inventor： Yongxing Qiu , Newton T. Samuel , John Dallas Pruitt , Chandana Kolluru , Arturo Norberto Medina , Lynn Cook Winterton , Daqing Wu , Xinming Qian , Jared Nelson
CPC classification number: C09D177/06 , B29D11/00067 , C08G77/388 , C08J5/00 , C08J7/042 , C08J2383/04 , C08J2383/08 , C08J2433/02 , C08J2433/26 , C08J2487/00 , C08L83/04 , C09D5/1637 , C09D5/1681 , C09D133/02 , C09D133/14 , C09D133/26 , C09D171/02 , G02B1/043 , G02B1/10 , G02B1/18 , G02C7/049 , G02C2202/06 , G02C2202/16 , C08L101/14
Abstract: The invention is related to a cost-effective method for making a silicone hydrogel contact lens having a crosslinked hydrophilic coating thereon. A method of the invention involves heating a silicone hydrogel contact lens in an aqueous solution in the presence of a water-soluble, highly branched, thermally-crosslinkable hydrophilic polymeric material having positively-charged azetidinium groups, to and at a temperature from about 40° C. to about 140° C. for a period of time sufficient to covalently attach the thermally-crosslinkable hydrophilic polymeric material onto the surface of the silicone hydrogel contact lens through covalent linkages each formed between one azetidinium group and one of the reactive functional groups on and/or near the surface of the silicone hydrogel contact lens, thereby forming a crosslinked hydrophilic coating on the silicone hydrogel contact lens. Such method can be advantageously implemented directly in a sealed lens package during autoclave.
Abstract translation: 本发明涉及制备其上具有交联亲水性涂层的硅氧水凝胶隐形眼镜的成本有效的方法。 本发明的方法涉及在具有带正电荷的氮杂环丁烷基团的水溶性，高度支化，热交联的亲水性聚合物材料存在下，在约40℃的温度下，在水溶液中加热硅酮水凝胶隐形眼镜 在约140℃下进行足够的时间以将可热交联的亲水聚合物材料共价连接到硅氧烷水凝胶隐形眼镜的表面上，通过共价连接，每个共价键在一个氮杂环丁烷基团和一个反应性官能团之间形成， 和/或靠近硅酮水凝胶隐形眼镜的表面，从而在硅氧水凝胶隐形眼镜上形成交联的亲水涂层。 这种方法可以有利地在高压釜中直接在密封的透镜包装中实现。
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公开(公告)号：US20200157378A1
公开(公告)日：2020-05-21
申请号：US16720932
申请日：2019-12-19
Applicant: Novartis AG
Inventor： Yongxing Qiu , Newton T. Samuel , John Dallas Pruitt , Chandana Kolluru , Arturo Norberto Medina , Lynn Cook Winterton , Daqing Wu , Xinming Qian , Jared Nelson
IPC: C09D177/06 , C09D171/02 , C09D133/26 , C09D133/14 , C09D133/02 , C09D5/16 , C08J5/00 , C08G77/388 , C08L83/04 , C08J7/04 , G02B1/18 , G02B1/10 , G02C7/04 , G02B1/04 , B29D11/00
Abstract: The invention is related to a cost-effective method for making a silicone hydrogel contact lens having a crosslinked hydrophilic coating thereon. A method of the invention involves heating a silicone hydrogel contact lens in an aqueous solution in the presence of a water-soluble, highly branched, thermally-crosslinkable hydrophilic polymeric material having positively-charged azetidinium groups, to and at a temperature from about 40° C. to about 140° C. for a period of time sufficient to covalently attach the thermally-crosslinkable hydrophilic polymeric material onto the surface of the silicone hydrogel contact lens through covalent linkages each formed between one azetidinium group and one of the reactive functional groups on and/or near the surface of the silicone hydrogel contact lens, thereby forming a crosslinked hydrophilic coating on the silicone hydrogel contact lens. Such method can be advantageously implemented directly in a sealed lens package during autoclave.
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公开(公告)号：US10563090B2
公开(公告)日：2020-02-18
申请号：US16397255
申请日：2019-04-29
Applicant: Novartis AG
Inventor： Yongxing Qiu , Newton T. Samuel , John Dallas Pruitt , Chandana Kolluru , Arturo Norberto Medina , Lynn Cook Winterton , Daqing Wu , Xinming Qian , Jared Nelson
IPC: C08L83/04 , C09D177/06 , B29D11/00 , G02B1/04 , G02C7/04 , G02B1/10 , G02B1/18 , C08J7/04 , C08G77/388 , C08J5/00 , C09D5/16 , C09D133/02 , C09D133/14 , C09D133/26 , C09D171/02
Abstract: The invention is related to a cost-effective method for making a silicone hydrogel contact lens having a crosslinked hydrophilic coating thereon. A method of the invention involves heating a silicone hydrogel contact lens in an aqueous solution in the presence of a water-soluble, highly branched, thermally-crosslinkable hydrophilic polymeric material having positively-charged azetidinium groups, to and at a temperature from about 40° C. to about 140° C. for a period of time sufficient to covalently attach the thermally-crosslinkable hydrophilic polymeric material onto the surface of the silicone hydrogel contact lens through covalent linkages each formed between one azetidinium group and one of the reactive functional groups on and/or near the surface of the silicone hydrogel contact lens, thereby forming a crosslinked hydrophilic coating on the silicone hydrogel contact lens. Such method can be advantageously implemented directly in a sealed lens package during autoclave.
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公开(公告)号：US20190309188A1
公开(公告)日：2019-10-10
申请号：US16397255
申请日：2019-04-29
Applicant: Novartis AG
Inventor： Yongxing Qiu , Newton T. Samuel , John Dallas Pruitt , Chandana Kolluru , Arturo Norberto Medina , Lynn Cook Winterton , Daqing Wu , Xinming Qian , Jared Nelson
IPC: C09D177/06 , C08L83/04 , G02B1/04 , C09D133/02 , C09D133/14 , C09D133/26 , C09D171/02 , C08J5/00 , C08G77/388 , G02C7/04 , B29D11/00 , G02B1/10 , G02B1/18 , C08J7/04 , C09D5/16
Abstract: The invention is related to a cost-effective method for making a silicone hydrogel contact lens having a crosslinked hydrophilic coating thereon. A method of the invention involves heating a silicone hydrogel contact lens in an aqueous solution in the presence of a water-soluble, highly branched, thermally-crosslinkable hydrophilic polymeric material having positively-charged azetidinium groups, to and at a temperature from about 40° C. to about 140° C. for a period of time sufficient to covalently attach the thermally-crosslinkable hydrophilic polymeric material onto the surface of the silicone hydrogel contact lens through covalent linkages each formed between one azetidinium group and one of the reactive functional groups on and/or near the surface of the silicone hydrogel contact lens, thereby forming a crosslinked hydrophilic coating on the silicone hydrogel contact lens. Such method can be advantageously implemented directly in a sealed lens package during autoclave.
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