公开(公告)号：US20130127077A1

公开(公告)日：2013-05-23

申请号：US13713681

申请日：2012-12-13

Applicant: Novartis AG

Inventor： Yongxing Qiu

IPC: B29D11/00

CPC classification number: B29D11/00038 ,  B29D11/00 ,  C08F8/42 ,  C08F30/08 ,  C08F130/08 ,  C08F230/08 ,  C08F283/12 ,  C08F283/124 ,  C08F290/00 ,  C08F290/06 ,  C08F290/068 ,  C08F290/14 ,  C08F290/148 ,  C08F299/08 ,  C08F2810/20 ,  C08J3/28 ,  G02B1/04 ,  G02B1/043 ,  C08L51/085 ,  C08F222/06 ,  C08F236/06

Abstract: The invention provides a silicone hydrogel contact lens including a hydrolyzable polymer. The hydrolyzable polymer can be converted by hydrolysis into a hydrophilic polymer which is capable of imparting the silicone hydrogel contact lens a hydrophilic surface without post-curing surface treatment.

Abstract translation: 本发明提供了包含可水解聚合物的硅酮水凝胶隐形眼镜。 可水解聚合物可以通过水解转化成亲水聚合物，其能够赋予硅氧水凝胶隐形眼镜亲水性表面，而无需后固化表面处理。

公开(公告)号：US11256003B2

公开(公告)日：2022-02-22

申请号：US16204641

申请日：2018-11-29

Applicant: Novartis AG

Inventor： Yongxing Qiu ,  John Dallas Pruitt ,  Newton T. Samuel ,  Chung-Yuan Chiang ,  Robert Carey Tucker ,  Yuan Chang ,  Ethan Leveillee

IPC: G02B1/04 ,  C08L33/02 ,  C08L79/04 ,  C09D133/02 ,  B29D11/00 ,  G02C7/04 ,  G02B1/18 ,  C08L83/04 ,  B05D5/00 ,  B65B55/22 ,  B05D3/00 ,  B05D5/10 ,  B05D1/38 ,  B05D3/02 ,  B05D1/18 ,  B29K83/00 ,  B29K105/00

Abstract: The invention is related to contact lenses that not only comprise the much desired water gradient structural configurations, but also have a minimized uptakes of polycationic antimicrobials and a long-lasting surface hydrophilicity and wettability even after going through a 30-days lens care regime. Because of the water gradient structural configuration and a relatively-thick, extremely-soft and water-rich hydrogel surface layer, a contact lens of the invention can provide superior wearing comfort. Further, a contact lens of the invention is compatible with multipurpose lens care solutions present in the market and can endure the harsh lens care handling conditions (e.g., digital rubbings, accidental inversion of contact lenses, etc.) encountered in a daily lens care regime. As such, they are suitable to be used as weekly- or monthly-disposable water gradient contact lenses.

公开(公告)号：US10830923B2

公开(公告)日：2020-11-10

申请号：US16204729

申请日：2018-11-29

Applicant: Novartis AG

Inventor： Yongxing Qiu ,  Kasey Jon Minick ,  John Dallas Pruitt ,  Newton T. Samuel ,  Chung-Yuan Chiang ,  Kelly Kayi Tallau ,  Matthew McCollum ,  Richard Govan

IPC: G02B1/04 ,  C08L83/04 ,  C08L33/02 ,  C08L79/04 ,  C09D133/02 ,  B29D11/00 ,  G02C7/04 ,  G02B1/18 ,  B65B55/22 ,  B29K83/00 ,  B29K105/00

Abstract: The invention is related to a process for producing contact lenses that not only comprise a water gradient structural configurations, but also have a minimized uptakes of polyquaternium-1 and a long-lasting surface hydrophilicity and wettability even after being undergone a simulated 30-days lens care regime.

公开(公告)号：US20200017713A1

公开(公告)日：2020-01-16

申请号：US16582624

申请日：2019-09-25

Applicant: Novartis AG

Inventor： Yongxing Qiu ,  John Dallas Pruitt ,  Sibichen J. Thekveli ,  Robert Carey Tucker ,  Jared Nelson

IPC: C09D177/06 ,  B29D11/00 ,  G02B1/04 ,  G02C7/04 ,  G02B1/10 ,  G02B1/18 ,  C08J7/04 ,  C08L83/04 ,  C08G77/388 ,  C08J5/00 ,  C09D5/16 ,  C09D133/02 ,  C09D133/14 ,  C09D133/26 ,  C09D171/02

Abstract: The invention is related to a hydrated silicone hydrogel contact lens having a layered structural configuration: a lower water content silicone hydrogel core (or bulk material) completely covered with a layer of a higher water content hydrogel totally or substantially free of silicone. A hydrated silicone hydrogel contact lens of the invention possesses high oxygen permeability for maintaining the corneal health and a soft, water-rich, lubricious surface for wearing comfort.

公开(公告)号：US10526470B2

公开(公告)日：2020-01-07

申请号：US15704176

申请日：2017-09-14

Applicant: Novartis AG

Inventor： Chung-Yuan Chiang ,  Yongxing Qiu ,  Kelly Kayi Tallau ,  Angela Driver-Scott

IPC: C08K5/3412 ,  C08K5/00 ,  C08G73/02 ,  C07D205/04 ,  C08G65/08 ,  C08K3/32 ,  C08L79/00 ,  C08L71/02 ,  B29D11/00 ,  C08G73/00 ,  C09D4/00

Abstract: The invention is related to a cost-effective method for producing water-soluble thermally-crosslinkable hydrophilic polymeric materials. Resultant materials can find particular use in preparing a packaging solution used for packaging and autoclaving medical devices, especially contact lenses. Those packaging solutions are especially suitable for forming a relatively-thick and soft hydrogel coatings on contact lenses or medical devices according to an in-package-crosslinking (IPC) processes. The resultant non-silicone hydrogel coatings can have a superior lubricity (a friction rating of 0) with minimized or no surface cracking.

公开(公告)号：US10449740B2

公开(公告)日：2019-10-22

申请号：US15376708

申请日：2016-12-13

Applicant: Novartis AG

Inventor： Xinming Qian ,  Jared Nelson ,  Robert Carey Tucker ,  Steve Yun Zhang ,  Daqing Wu ,  Leroy Wainaina Muya ,  Dharmesh Patel ,  Zach Munoz ,  Yongxing Qiu ,  Chung-Yuan Chiang ,  Ritu Shrestha ,  Kelly Kayi Tallau

IPC: B29D11/00 ,  G02B1/04 ,  G02C7/04 ,  B29K83/00 ,  B29K105/00

Abstract: The present invention generally relates to a method for producing silicone hydrogel contact lenses having a stable lubricious coating thereon without involving use of organic solvent in post-curing processes.

公开(公告)号：US10364365B2

公开(公告)日：2019-07-30

申请号：US15348346

申请日：2016-11-10

Applicant: Novartis AG

Inventor： Richard Charles Breitkopf ,  Ellen A. Day ,  Yongxing Qiu ,  Ritu Shrestha

IPC: C09D11/107 ,  B29D11/00 ,  C09D11/03 ,  C09D11/10 ,  C09D11/101 ,  G02C7/04 ,  C09D11/033 ,  C09D11/037

Abstract: The present invention provides an actinically or thermally curable ink for making colored silicone hydrogel contact lenses. The ink of the invention comprises at least a pigment, a polymeric dispersant, a solvent and an actinically or thermally curable silicone-containing binder polymer including ethylenically unsaturated groups and segments derived from at least one silicone-containing vinylic monomer or macromere. The ink of the invention is characterized by having capability to be cured actinically or thermally to form a colored coat on a silicone hydrogel contact lens, wherein the ink is characterized by having an longer print life using a pad-printing system by at least 30% comparing to the ink which has the same composition except of no polymeric dispersant, wherein ink life is a number of printed parts that can be achieved in a print cycle.

公开(公告)号：US10308835B2

公开(公告)日：2019-06-04

申请号：US15646291

申请日：2017-07-11

Applicant: Novartis AG

Inventor： Yongxing Qiu ,  Newton T. Samuel ,  John Dallas Pruitt ,  Chandana Kolluru ,  Arturo Norberto Medina ,  Lynn Cook Winterton ,  Daqing Wu ,  Xinming Qian ,  Jared Nelson

IPC: C09D177/06 ,  G02B1/04 ,  G02C7/04 ,  G02B1/10 ,  G02B1/18 ,  C08J7/04 ,  B29D11/00 ,  C08L83/04 ,  C08G77/388 ,  C08J5/00 ,  C09D5/16 ,  C09D133/02 ,  C09D133/14 ,  C09D133/26 ,  C09D171/02

Abstract: The invention is related to a cost-effective method for making a silicone hydrogel contact lens having a crosslinked hydrophilic coating thereon. A method of the invention involves heating a silicone hydrogel contact lens in an aqueous solution in the presence of a water-soluble, highly branched, thermally-crosslinkable hydrophilic polymeric material having positively-charged azetidinium groups, to and at a temperature from about 40° C. to about 140° C. for a period of time sufficient to covalently attach the thermally-crosslinkable hydrophilic polymeric material onto the surface of the silicone hydrogel contact lens through covalent linkages each formed between one azetidinium group and one of the reactive functional groups on and/or near the surface of the silicone hydrogel contact lens, thereby forming a crosslinked hydrophilic coating on the silicone hydrogel contact lens. Such method can be advantageously implemented directly in a sealed lens package during autoclave.

公开(公告)号：US10100219B2

公开(公告)日：2018-10-16

申请号：US15216125

申请日：2016-07-21

Applicant: Novartis AG

Inventor： Troy Vernon Holland ,  Frank Chang ,  Yongxing Qiu ,  John Dallas Pruitt ,  Chung-Yuan Chiang ,  Venkat Shankar ,  Robert Scott ,  Yash Kapoor

IPC: C09D133/24 ,  C07D205/04 ,  C08F220/56 ,  B29D11/00 ,  C08F224/00 ,  C09D137/00 ,  C08F283/12 ,  C09D151/08 ,  C08F220/54 ,  C09D133/26 ,  C09D139/04 ,  C08F20/00 ,  C08F26/00

Abstract: The invention is related to azetidinium-containing copolymers and vinylic monomers and their uses in formation of non-silicone hydrogel coatings on silicone hydrogel contact lenses.

公开(公告)号：US20170183520A1

公开(公告)日：2017-06-29

申请号：US15348346

申请日：2016-11-10

Applicant: Novartis AG

Inventor： Richard Charles Breitkopf ,  Ellen A. Day ,  Yongxing Qiu ,  Ritu Shrestha

IPC: C09D11/107 ,  C09D11/033 ,  G02C7/04 ,  C09D11/037

CPC classification number: C09D11/107 ,  B29D11/00038 ,  B29D11/00923 ,  C09D11/03 ,  C09D11/033 ,  C09D11/037 ,  C09D11/10 ,  C09D11/101 ,  G02C7/046 ,  G02C7/049

Abstract: The present invention provides an actinically or thermally curable ink for making colored silicone hydrogel contact lenses. The ink of the invention comprises at least a pigment, a polymeric dispersant, a solvent and an actinically or thermally curable silicone-containing binder polymer including ethylenically unsaturated groups and segments derived from at least one silicone-containing vinylic monomer or macromere. The ink of the invention is characterized by having capability to be cured actinically or thermally to form a colored coat on a silicone hydrogel contact lens, wherein the ink is characterized by having an longer print life using a pad-printing system by at least 30% comparing to the ink which has the same composition except of no polymeric dispersant, wherein ink life is a number of printed parts that can be achieved in a print cycle.