公开(公告)号：US07151597B2

公开(公告)日：2006-12-19

申请号：US10729508

申请日：2003-12-05

Applicant: Annette C. Grot ,  Thomas J. Mikes

Inventor： Annette C. Grot ,  Thomas J. Mikes

IPC: G01J1/10 ,  G01N21/55

CPC classification number: G01N21/278 ,  G01J3/10 ,  G01J2003/2866 ,  G01N21/4788 ,  G01N21/554 ,  G01N2201/08

Abstract: The optical wavelength standard comprises a diffraction grating having a diffractive surface, an input arrangement and an output optical arrangement. The input optical arrangement is located to illuminate the diffractive surface of the diffraction grating with incident light at an angle of incidence at which absorption of the incident light at a resonance wavelength generates surface plasmons. The output optical arrangement is located to receive the incident light specularly reflected from the diffractive surface of the diffraction grating as reflected light. The reflected light includes an absorption line at the resonance wavelength. The absorption line provides the wavelength reference. The resonance wavelength is defined by the angle of incidence and the physical characteristics of the diffraction grating. A desired resonance wavelength can be obtained by appropriately defining the angle of incidence and the physical characteristics of the diffraction grating. Moreover, the resonance wavelength can be changed by changing either or both of the angle of incidence and the diffraction grating.

Abstract translation: 光学波长标准包括具有衍射面的衍射光栅，输入布置和输出光学布置。 输入光学布置被定位成以入射角以入射光照射衍射光栅的衍射表面，入射光在共振波长处的入射光的吸收产生表面等离子体激元。 输出光学布置被定位为接收从衍射光栅的衍射表面镜面反射的入射光作为反射光。 反射光包括在共振波长处的吸收线。 吸收线提供波长参考。 谐振波长由入射角和衍射光栅的物理特性定义。 可以通过适当地限定入射角和衍射光栅的物理特性来获得期望的共振波长。 此外，可以通过改变入射角和衍射光栅中的一个或两个来改变谐振波长。

公开(公告)号：US20060181705A1

公开(公告)日：2006-08-17

申请号：US11404430

申请日：2006-04-13

Applicant: Brian Cunningham ,  Peter Li ,  Frank DeFilippi

Inventor： Brian Cunningham ,  Peter Li ,  Frank DeFilippi

IPC: G01J3/28

CPC classification number: G01N21/253 ,  B01L3/5085 ,  B01L2300/0645 ,  B01L2300/0654 ,  B01L2300/0829 ,  G01N21/4788 ,  G01N21/7743 ,  G01N33/54373 ,  G01N2201/0635 ,  G01N2201/08 ,  G01N2201/0833 ,  G01N2201/0846 ,  G01N2201/1248 ,  G02B5/1809 ,  G02B5/1814 ,  G02B21/06

Abstract: Method and apparatus for detecting biomolecular interactions. The use of labels is not required and the methods may be performed in a high-throughput manner. An apparatus for detecting biochemical interactions occurring on the surface of a biosensor includes a light source. A first optical fiber is coupled to the light source and illuminates the biosensor. A second optical fiber detects a wavelength reflected from the biosensor. A spectrometer determines spectra of a reflected signal from the biosensor.

公开(公告)号：US20060175555A1

公开(公告)日：2006-08-10

申请号：US11143145

申请日：2005-06-02

Applicant: Matthias Lau

Inventor： Matthias Lau

IPC: G01J1/58

CPC classification number: G01J3/02 ,  G01J1/0425 ,  G01J1/58 ,  G01J3/0256 ,  G01J3/0272 ,  G01J3/0286 ,  G01J3/0291 ,  G01J3/4406 ,  G01N21/6428 ,  G01N21/645 ,  G01N2021/6432 ,  G01N2201/08

Abstract: The invention relates to a device for measuring light-activated fluorescence of at least one coating that contains a fluorescent material, and its use for measuring fluid materials which cause fluorescence-quenching in at least one of the fluorescent coatings. To activate the fluorescence, at least one first light wave-guide is directed onto at least one coating applied to a support and the fluorescent light is directed at a detector by means of at least one-second light wave-guide, in order to determine the intensity of the fluorescent light. The end faces of the different fluorescent light wave guides are then arranged to have overlapping entry and/or exit cones and/or be of a shape substantially identical to the at least one coating containing a fluorescent material, in such a way that an accurate measurement of the fluorescence intensity can be attained, and that the light source(s), light wave guides and the detector(s) are lodged in a measuring head.

Abstract translation: 本发明涉及用于测量含有荧光材料的至少一层涂层的光激发荧光的装置及其用于测量在至少一种荧光涂层中引起荧光猝灭的流体材料的用途。 为了激活荧光，至少一个第一光波导被引导到施加到支撑件的至少一个涂层上，并且通过至少一秒光波导将荧光指向检测器，以便确定 荧光灯的强度。 然后将不同荧光光波导的端面布置成具有重叠的入口和/或出口锥体和/或具有与至少一个含有荧光材料的涂层基本相同的形状，使得精确测量 可以获得荧光强度，并且光源，光波导和检测器被放置在测量头中。

公开(公告)号：US20060132790A1

公开(公告)日：2006-06-22

申请号：US10546421

申请日：2004-02-17

Applicant: Mikhail Gutin

Inventor： Mikhail Gutin

IPC: G01B9/02

CPC classification number: G01B9/02007 ,  A61B5/0066 ,  A61B5/0068 ,  A61B5/0075 ,  A61B5/0084 ,  A61B5/411 ,  A61B5/7203 ,  A61B5/7257 ,  G01B9/02002 ,  G01B9/0201 ,  G01B9/02012 ,  G01B9/02027 ,  G01B9/02034 ,  G01B9/02091 ,  G01B2290/65 ,  G01N21/45 ,  G01N21/4795 ,  G01N2021/1787 ,  G01N2021/458 ,  G01N2021/4709 ,  G01N2021/4742 ,  G01N2201/0691 ,  G01N2201/08

Abstract: Optical coherence tomography with 3D coherence scanning is disclosed, using at least three fibers (201, 202, 203) for object illumination and collection of backscattered light. Fiber tips (1, 2, 3) are located in a fiber tip plane (71) normal to the optical axis (72). Light beams emerging from the fibers overlap at an object (122) plane, a subset of intersections of the beams with the plane defining field of view (266) of the optical coherence tomography apparatus. Interference of light emitted and collected by the fibers creates a 3D fringe pattern. The 3D fringe pattern is scanned dynamically over the object by phase shift delays (102, 104) controlled remotely, near ends of the fibers opposite the tips of the fibers, and combined with light modulation. The dynamic fringe pattern is backscattered by the object, transmitted to a light processing system (108) such as a photo detector, and produces an AC signal on the output of the light processing system (108). Phase demodulation of the AC signal at selected frequencies and signal processing produce a measurement of a 3D profile of the object.

Abstract translation: 公开了具有3D相干扫描的光学相干断层摄影，使用至少三个光纤（201,202,203）进行物体照明和收集后向散射光。 光纤尖端（1,2,3）位于垂直于光轴（72）的纤维末端平面（71）中。 从光纤出射的光束在对象（122）平面处重叠，光束与定义光学相干断层摄影装置的视场（266）的平面的交点的子集重叠。 由纤维发出和收集的光的干涉产生3D条纹图案。 通过远程控制的相移延迟（102,104）在物体上动态扫描3D条纹图案，纤维的近端与光纤的尖端相反，并与光调制组合。 动态条纹图案被物体反向散射，传输到诸如光电检测器的光处理系统（108），并且在光处理系统（108）的输出上产生AC信号。 所选频率的AC信号的相位解调和信号处理产生对象的3D轮廓的测量。

公开(公告)号：US20060044560A1

公开(公告)日：2006-03-02

申请号：US11200086

申请日：2005-08-10

Applicant: Hiromi Takahashi

Inventor： Hiromi Takahashi

IPC: G01N21/00

CPC classification number: G01N21/552 ,  G01N2201/066 ,  G01N2201/08

Abstract: The device for measuring an optical absorption characteristic of a sample according to the present invention comprising a light source, a optical wave-guide having light input surface(s) and light output surface(s) that are opposite to each other, and a light reflecting surface on which a sample to be measured is disposed, through which the light passes and is reflected by a total reflection on the sample, one or more light transmitting means arranged between the light output surface of the optical wave-guide and the light input surface of the optical wave-guide so that the light is again entered into the optical wave-guide, and a processing device which receives the light re-exited from the optical wave-guide through the output surface and detects the optical absorption characteristics of the sample on the basis of the light received, whereby the light which passes through the optical wave-guide is conducted to the optical wave-guide again, the light is again entered the optical wave-guide, and the light is again reflected on the sample (FIG. 1).

Abstract translation: 根据本发明的用于测量样品的光吸收特性的装置，包括光源，具有彼此相对的光输入表面和光输出表面的光波导，以及光 配置有被测定样品的反射面，光通过该反射面，被样品的全反射反射，配置在光波导的光输出面和光输入面之间的一个或多个光传输单元 表面，使得光再次进入光波导，以及处理装置，其接收从光波导通过输出表面重新退出的光，并检测光波导的光吸收特性 基于受光的样品，通过光波导的光再次传导到光波导，光再次进入光波导， 引导，并且光再次反映在样品上（图1）。 1）。

公开(公告)号：US20060037572A1

公开(公告)日：2006-02-23

申请号：US11197833

申请日：2005-08-04

Applicant: Azer Yalin ,  Bryan Willson ,  Morgan Defoort ,  George Collins

Inventor： Azer Yalin ,  Bryan Willson ,  Morgan Defoort ,  George Collins

IPC: F02P23/00 ,  G01J3/30

CPC classification number: F02D35/022 ,  F02P17/12 ,  F02P23/04 ,  G01N21/718 ,  G01N2201/08

Abstract: A spark delivery system for generating a spark using a laser beam is provided, and includes a laser light source and a laser delivery assembly. The laser delivery assembly includes a hollow fiber and a launch assembly comprising launch focusing optics to input the laser beam in the hollow fiber. The laser delivery assembly further includes exit focusing optics that demagnify an exit beam of laser light from the hollow fiber, thereby increasing the intensity of the laser beam and creating a spark. Other embodiments use a fiber laser to generate a spark. Embodiments of the present invention may be used to create a spark in an engine. Yet other embodiments include collecting light from the spark or a flame resulting from the spark and conveying the light for diagnostics. Methods of using the spark delivery systems and diagnostic systems are provided.

Abstract translation: 提供了一种用于使用激光束产生火花的火花放电系统，并且包括激光源和激光输送组件。 激光输送组件包括中空纤维和发射组件，其包括发射聚焦光学器件以将激光束输入中空纤维中。 激光输送组件还包括离开聚焦光学器件，其将激光的出射光束从中空纤维上缩小，从而增加激光束的强度并产生火花。 其他实施例使用光纤激光器产生火花。 本发明的实施例可用于在发动机中产生火花。 还有其他实施例包括收集来自火花的火光或火花产生的火焰并传送光用于诊断。 提供了使用火花放电系统和诊断系统的方法。

公开(公告)号：US20050254237A1

公开(公告)日：2005-11-17

申请号：US11020122

申请日：2004-12-27

Applicant: Gunther Nath ,  Klaus Dunkel

Inventor： Gunther Nath ,  Klaus Dunkel

IPC: F21L4/00 ,  F21L4/06 ,  F21L14/00 ,  F21S4/00 ,  F21V7/22 ,  F21V8/00 ,  F21V9/08 ,  F21V21/22 ,  G01J3/10 ,  G01N21/64

CPC classification number: G01N21/6447 ,  F21L4/00 ,  F21L4/06 ,  F21V7/22 ,  F21V9/08 ,  F21V21/22 ,  F21V29/67 ,  G01J3/0283 ,  G01J3/0291 ,  G01J3/10 ,  G01N2201/0221 ,  G01N2201/06 ,  G01N2201/06186 ,  G01N2201/08 ,  G02B6/0006

Abstract: Crime scene lighting devices are used in forensic criminology for illumination and investigation at crime scenes using fluorescence excitation. High radiation powers are required both for white light in the so-called general search and for the criminologically relevant UVA-blue-green range. Moreover, it should be possible for the crime scene investigator to use the forensic lighting device portably and independent from the public power supply. The present disclosure relates to a suitable crime scene light device with a mercury ultra high pressure lamp as the light source, a light guide and terminals for operating the lamp selectively with an accumulator or the public power supply system. A suitable carrier bag, a so-called lorgnette with various longpass filters and a cross-section converter for visualizing shoeprints form useful accessories of the forensic lighting device.

Abstract translation: 犯罪现场照明装置用于法医犯罪学，用于使用荧光激发的犯罪现场进行照明和调查。 对于所谓的一般搜索中的白光以及与犯罪学相关的UVA-蓝绿色范围，需要高辐射功率。 此外，犯罪现场调查人员应该可靠地使用法医照明装置，独立于公共电源。 本公开涉及一种具有汞超高压灯作为光源的合适的犯罪现场灯装置，用于选择性地使用蓄电池或公共供电系统来操作灯的导光体和端子。 合适的载体袋，所谓的具有各种长通滤光器的lorgnette和用于可视化shoeprint的横截面转换器形成了法医照明装置的有用附件。

公开(公告)号：US20050140972A1

公开(公告)日：2005-06-30

申请号：US10977757

申请日：2004-10-28

Applicant: Kwang Bum Park ,  Joon Shik Park ,  Kyu Sik Shin ,  Hyo Derk Park

Inventor： Kwang Bum Park ,  Joon Shik Park ,  Kyu Sik Shin ,  Hyo Derk Park

IPC: G01N21/01 ,  B01F5/06 ,  B01F13/00 ,  B01L3/00 ,  G01N1/10 ,  G01N21/00

CPC classification number: B01F5/0646 ,  B01F5/0647 ,  B01F13/0059 ,  B01L3/502707 ,  B01L2300/0654 ,  B01L2300/0816 ,  B01L2300/0867 ,  B01L2300/0887 ,  B01L2300/1827 ,  G01N2201/08

Abstract: The present invention provides an apparatus for solution component analysis and fabricating method thereof, by which a mixing channel, reaction channel, and measurement channel are formed as continuous micro-grooves on one substrate to implement the miniature apparatus for analyzing solution components, by which the apparatus is provided with portability facilitating access to a spot outside a laboratory to perform an instant sample analysis, and by which an optical system configuration for sample analysis can be simplified in a manner of facilitating an optical transfer by forming a transparent silicon oxide (SiO2) layer between a micro channel of the apparatus and an optical fiber to insert the optical fiber therein.

Abstract translation: 本发明提供了一种溶液成分分析装置及其制造方法，通过该装置将混合通道，反应通道和测量通道形成为一个基板上的连续微槽，以实现用于分析溶液成分的微型装置， 设备具有便于访问实验室外的点的便携性，以进行即时样本分析，并且可以通过形成透明氧化硅（SiO 2）促进光学转移的方式来简化用于样本分析的光学系统配置， 在装置的微通道和光纤之间插入光纤。

公开(公告)号：US20050089260A1

公开(公告)日：2005-04-28

申请号：US10693519

申请日：2003-10-27

Applicant: Shelly Mechery ,  Jagdish Singh

Inventor： Shelly Mechery ,  Jagdish Singh

IPC: C03B19/12 ,  C03C1/00 ,  C03C11/00 ,  G01N21/77 ,  G01N21/78 ,  G01N31/22 ,  G01N33/00 ,  G02B6/06 ,  G02B6/42 ,  G02B6/00

CPC classification number: G01N21/783 ,  C03B19/12 ,  C03C1/006 ,  C03C11/00 ,  G01N31/22 ,  G01N33/0037 ,  G01N2021/772 ,  G01N2021/7773 ,  G01N2201/08 ,  G01N2201/084 ,  G02B6/06 ,  G02B6/4298 ,  Y02A50/245 ,  Y10T436/177692

Abstract: A sensing element, a method of making a sensing element, and a fiber optic sensor incorporating the sensing element are described. The sensor can be used for the quantitative detection of NO2 in a mixture of gases. The sensing element can be made by incorporating a diazotizing reagent which reacts with nitrous ions to produce a diazo compound and a coupling reagent which couples with the diazo compound to produce an azo dye into a sol and allowing the sol to form an optically transparent gel. The sensing element changes color in the presence of NO2 gas. The temporal response of the absorption spectrum at various NO2 concentrations has also been recorded and analyzed. Sensors having different design configurations are described. The sensing element can detect NO2 gas at levels of parts per billion.

Abstract translation: 描述了感测元件，制造感测元件的方法和结合有感测元件的光纤传感器。 传感器可用于气体混合物中NO 2的定量检测。 感测元件可以通过掺入与氮亚离子反应产生重氮化合物的重氮化试剂和与重氮化合物偶联以产生偶氮染料成溶胶并使溶胶形成光学透明凝胶的偶联试剂来制备。 感测元件在NO 2气体存在下改变颜色。 还记录和分析了各种NO 2 2浓度下的吸收光谱的时间响应。 描述具有不同设计构造的传感器。 感测元件可以以十亿分之几的水平检测NO 2气体。

公开(公告)号：US20050016852A1

公开(公告)日：2005-01-27

申请号：US10823382

申请日：2004-04-12

Applicant: Varouj Amirkhanian ,  Bob Heitel ,  Ming-Sun Liu ,  Paul Mooney

Inventor： Varouj Amirkhanian ,  Bob Heitel ,  Ming-Sun Liu ,  Paul Mooney

IPC: B01L99/00 ,  G01N21/64 ,  G01N27/447 ,  A61B17/10 ,  C12M1/00

CPC classification number: G01N27/44782 ,  G01N27/44721 ,  G01N2021/6463 ,  G01N2021/6484 ,  G01N2201/08

Abstract: The present invention provides for an interface mechanism in a bio-separation instrument that makes interface connections to a multi-channel cartridge. The interface mechanism precisely positions the cartridge in relation to the support elements in the instrument (e.g., high-voltage, gas pressure, incident radiation and detector), and makes automated, reliable and secured alignments and connections between various components in the cartridge and the support elements in the supporting instrument. The interface mechanism comprises pneumatically or electromechanically driven actuators for engaging support elements in the instrument to components on the cartridge. After the cartridge has been securely received by the interface mechanism, the connection sequence is initiated. The interface provides separate high voltage and optical connections for each separation channel in the cartridge, thus providing channel-to-channel isolation from cross talk both electrically and optically.

Abstract translation: 本发明提供了生物分离仪器中的接口机构，其使接口连接到多通道盒。 接口机构将盒相对于仪器中的支撑元件（例如，高压，气体压力，入射辐射和检测器）精确定位，并且使得盒中的各种部件之间的自动化，可靠和可靠的对准和连接 配套仪器中的支撑元件。 接口机构包括气动或机电驱动的致动器，用于将仪器中的支撑元件接合到盒上的部件。 在通过接口机构安全接收到盒式磁带后，启动连接顺序。 该接口为盒中的每个分离通道提供单独的高电压和光学连接，从而提供电气和光学上的串扰通道间通道隔离。