公开(公告)号：US20080094623A1

公开(公告)日：2008-04-24

申请号：US11573799

申请日：2005-08-26

Applicant: Frank Jeroen Pieter Schuurmans ,  Michael Cornelis Van Beek ,  Marjolein Van Der Voort

Inventor： Frank Jeroen Pieter Schuurmans ,  Michael Cornelis Van Beek ,  Marjolein Van Der Voort

IPC: G01J3/457 ,  G01J3/04 ,  G01R35/00

CPC classification number: G01J3/28 ,  G01J3/04 ,  G01J3/36 ,  G01J2003/047 ,  G01J2003/1278

Abstract: The present invention provides an autonomous calibration of a multivariate based spectroscopic system that is preferably implemented as a multivariate based spectrometer. The spectroscopic system is based on a multivariate optical element that provides a spectral weighting of an incident optical signal. Spectral weighting is performed on the basis of spatial separation of spectral components and subsequent spatial filtering by means of a spatial light modulator. Calibration of the spectroscopic system is based on a dedicated calibration segment of the spatial light modulator, whose position corresponds to a characteristic calibration or reference wavelength of the incident optical signal. Preferably, the calibration or reference wavelength is given by the wavelength of the excitation radiation generated by the optical source that serves to induce scattering processes in a volume of interest.

Abstract translation: 本发明提供了基于多变量的光谱仪的多变量光谱系统的自主校准，其优选地被实现为基于多变量的光谱仪。 光谱系统基于提供入射光信号的光谱加权的多元光学元件。 基于光谱分量的空间分离和随后的空间光调制器的空间滤波进行光谱加权。 分光系统的校准基于空间光调制器的专用校准段，其位置对应于入射光信号的特征校准或参考波长。 优选地，校准或参考波长由用于感兴趣的体积中的散射过程的光源产生的激发辐射的波长给出。

公开(公告)号：US20070202543A1

公开(公告)日：2007-08-30

申请号：US11789900

申请日：2007-04-26

Applicant: Jacques Gollier ,  Garrett Piech ,  Michael Webb

Inventor： Jacques Gollier ,  Garrett Piech ,  Michael Webb

IPC: C12M1/34 ,  G01N33/53 ,  C12M3/00 ,  G01J3/04

CPC classification number: G01N21/553 ,  G01N21/7743

Abstract: An optical reader system and method are described herein that can detect a lateral and/or angular misalignment of one or more biosensors so that the biosensors can be properly re-located after being removed from and then reinserted into the optical reader system. In one embodiment, the biosensors are incorporated within the wells of a microplate.

Abstract translation: 本文描述了可以检测一个或多个生物传感器的侧向和/或角度偏移的光学读取器系统和方法，使得生物传​​感器可以在从光学读取器系统中移除并重新插入到光学读取器系统之后被适当地重新定位。 在一个实施方案中，将生物传感器并入微板的孔内。

公开(公告)号：US20070165220A1

公开(公告)日：2007-07-19

申请号：US11421903

申请日：2006-06-02

Applicant: David J. Brady ,  Prasant Potuluri ,  Michael E. Sullivan

Inventor： David J. Brady ,  Prasant Potuluri ,  Michael E. Sullivan

IPC: G01J3/04

CPC classification number: G01J3/02 ,  G01J3/0216 ,  G01J3/0218 ,  G01J3/0221 ,  G01J3/0229 ,  G01J3/2803 ,  G01J3/2846 ,  G02B2207/129

Abstract: A spatial filter for an optical system, such as an optical spectrometer, collects and spatially filters light using a fiber bundle having a plurality of fibers disposed therein. At an input end of the fiber bundle, the fibers are typically packed tightly together to optimize the collection efficiency. At an output end, the fibers are spread out from the fiber bundle and arranged within a two-dimensional output area according to a two-dimensional pattern corresponding to a coded aperture function. As a result, the two-dimensional pattern of the output end spatially filters the light collected by the input end. Corresponding methods are also described.

Abstract translation: 用于诸如光谱仪的光学系统的空间滤光器使用其中布置有多根纤维的纤维束聚集并空间地过滤光。 在纤维束的输入端，通常将纤维紧密包装在一起，以优化收集效率。 在输出端，根据与编码孔径函数对应的二维图案，纤维从纤维束展开并布置在二维输出区域内。 结果，输出端的二维图案对输入端收集的光进行空间滤波。 还描述了相应的方法。

公开(公告)号：US07126682B2

公开(公告)日：2006-10-24

申请号：US09832631

申请日：2001-04-11

Applicant: Robert K. Rowe ,  Russell E. Abbink ,  Stephan P. Corcoran

Inventor： Robert K. Rowe ,  Russell E. Abbink ,  Stephan P. Corcoran

IPC: G01J3/04

CPC classification number: G01J3/10 ,  G01J3/0218 ,  G01J3/12 ,  G01J3/32 ,  G01J2003/123 ,  G01J2003/1234 ,  G01N21/255

Abstract: Spectroscopic system and spectrometers including an optical bandpass filter unit having a plurality of bandpass regions and a spatial encoding unit for encoding discrete frequencies of light passing through the optical filter. The incorporation of the encoding unit allows the spectrometer system to use a detector having one or a small number of elements, rather than using a more expensive detector array typically used with filter-based spectrometers. The system can also include an integrating chamber that collects the light that is not transmitted through the bandpass filter unit, and redirects this light to strike the filter unit again, resulting in a significant increase in the optical power passing through the filter. The integrating chamber maximizes the return of the reflected light to the filter assembly and minimizes optical losses. The integrating chamber may be an orthogonal design to preserve the optical geometric characteristics of the light entering the chamber.

Abstract translation: 光谱系统和光谱仪包括具有多个带通区的光学带通滤波器单元和用于编码通过滤光器的光的离散频率的空间编码单元。 编码单元的结合允许光谱仪系统使用具有一个或少量元件的检测器，而不是使用通常与基于滤光器的光谱仪一起使用的更昂贵的检测器阵列。 该系统还可以包括积分室，其收集不透过带通滤光器单元的光，并且重新定向该光以再次撞击过滤器单元，导致通过过滤器的光功率的显着增加。 积分室使反射光的返回最大化到滤光器组件，并使光损耗最小化。 积分室可以是正交设计，以保持进入室的光的光学几何特性。

公开(公告)号：US06982788B2

公开(公告)日：2006-01-03

申请号：US10861816

申请日：2004-06-04

Applicant: Thomas W. Hagler

Inventor： Thomas W. Hagler

IPC: G01J3/04 ,  G01J3/133

CPC classification number: G01J3/02 ,  G01J3/021 ,  G01J3/0213 ,  G01J3/0229 ,  G01J3/0289 ,  G01J3/12 ,  G01J3/18 ,  G01J3/32 ,  G01J3/433 ,  G01J2001/4242 ,  G01J2003/2866

Abstract: A disc serving as a spatial radiation modulator has dispersed radiation filters thereon. Each filter has a transmittance or reflectance modulation function of the form sin2(mθ+pπ/4), where m is a positive integer and p has one of the four values 0, 1, 2, 3. A radiation beam including selected wavelength components is diffracted into an elongated image dispersed according to wavelength. Different wavelength components are focused onto different filters on the modulator and are encoded by correspond filters. Since the modulation functions of the filters are orthogonal to one another, it is possible to extract the amplitude of each wavelength component after it has been encoded or modulated by corresponding filter from the total detected signal during one measurement.

Abstract translation: 用作空间辐射调制器的盘在其上具有分散的辐射滤波器。 每个滤光器具有形式为sinθ2（mta + ppi / 4）的透射率或反射调制函数，其中m是正整数，p具有四个值0,1,2,3中的一个 包括所选择的波长分量的辐射束被衍射成根据波长分散的细长图像。 不同的波长分量聚焦在调制器上的不同滤波器上，并由相应的滤波器编码。 由于滤波器的调制功能彼此正交，因此可以在一次测量期间从总检测信号对相应的滤波器进行编码或调制之后提取每个波长分量的振幅。

公开(公告)号：US20050270527A1

公开(公告)日：2005-12-08

申请号：US11193853

申请日：2005-07-29

Applicant: Richard Reel

Inventor： Richard Reel

IPC: G01N21/64 ,  G01J3/04 ,  G01J3/28 ,  G01N21/03 ,  G01N21/05 ,  G01N21/27 ,  G01N21/31 ,  G01N27/447

CPC classification number: G01J3/02 ,  G01J3/0208 ,  G01J3/0229 ,  G01J3/0262 ,  G01J3/0294 ,  G01J3/04 ,  G01J3/2803 ,  G01N21/05 ,  G01N21/31 ,  G01N27/44721 ,  G01N2021/0346

Abstract: An optical system for analyzing light from a plurality of samples is provided. The optical system includes a plurality of holders adapted to have samples located therein, a collection lens, a transmission grating, and a reimaging lens. The collection lens is configured to receive and substantially collimate light from the samples. The transmission grating is configured to spectrally disperse the substantially collimated light from the collection lens. The reimaging lens is configured to receive the light from the light dispersing element and direct the light onto a light detection device. A method of optically analyzing at least one sample is also provided.

公开(公告)号：US20050018187A1

公开(公告)日：2005-01-27

申请号：US10833201

申请日：2004-04-27

Applicant: Warren Slutter ,  Jian Xiao

Inventor： Warren Slutter ,  Jian Xiao

IPC: G01J3/04 ,  G01J3/18 ,  G01N21/64 ,  G01J3/28

CPC classification number: G01J3/18 ,  G01J3/02 ,  G01J3/0229 ,  G01J3/04

Abstract: A spectrograph with a first concave spectrographic diffraction grating is positioned to receive light from an input light source. The first concave spectrographic diffraction grating is configured to provide a diffracted light output dispersing the components of the input light source in a first dispersion direction with a first angular orientation with respect to the plane of the grating. The dispersion forms the input light into an intermediate spectrum. The intermediate spectrum is formed in a focal surface by the once diffracted light. A slit is substantially positioned on the focal surface. A second concave diffraction grating is positioned to receive once diffracted light from the slit and configured to provide a twice diffracted light output, the second concave diffraction grating dispersing the components of the input light source in a second diffraction direction with a second angular orientation with respect to the plane of the grating. The second dispersion angular orientation is different from the first dispersion angular orientation. The second dispersion forms the input light into an output spectrum.

Abstract translation: 具有第一凹面光谱衍射光栅的光谱仪定位成接收来自输入光源的光。 第一凹面光谱衍射光栅被配置为提供衍射光输出，其以相对于光栅平面的第一角度取向在第一色散方向上分散输入光源的分量。 分散体将输入光形成中间光谱。 通过一次衍射光在中心光谱中形成中间光谱。 狭缝基本上位于焦点表面上。 第二凹面衍射光栅被定位成接收来自狭缝的一次衍射光并被配置成提供两次衍射光输出，第二凹面衍射光栅将输入光源的分量在第二衍射方向上以第二角度取向相对于 到光栅的平面。 第二色散角取向与第一色散角取向不同。 第二个色散将输入光形成输出光谱。

公开(公告)号：US6031609A

公开(公告)日：2000-02-29

申请号：US865409

申请日：1997-05-29

Applicant: David J. Funk ,  David S. Moore

Inventor： David J. Funk ,  David S. Moore

IPC: G01J3/453 ,  G01J3/04

CPC classification number: G01J3/4531

Abstract: Fourier transform spectrometer using a multielement liquid crystal display. A ferroelectric liquid crystal mask is used as an optical encoder for a solid-state Fourier transform spectrometer. A 1.times.64 element array was striped and used as a 1.times.4 element device. The device intersected dispersed radiation and encoded each spectral component thereof with a carrier signal by applying half-wave potentials to each of the four striped (1.times.16) liquid crystal elements which varied the transmitted amplitude of the light from 0.03% to 28% of full scale. The light was spectrally recombined and imaged onto a photomultiplier and the resulting carrier frequencies (and their amplitudes) detected by Fourier transformation of the time-varying signal. Spectra of colored-glass filters were taken to demonstrate the spectrometer.

Abstract translation: 傅里叶变换光谱仪采用多元素液晶显示。 铁电液晶掩模用作固态傅里叶变换光谱仪的光学编码器。 1x64元素阵列被条纹化并用作1x4元素设备。 该器件通过将四分之一（1x16）液晶元件中的每一个施加半波电位，将散射的辐射与其每个光谱分量相乘，并对其进行编码，从而将光的透射振幅从满刻度的0.03％改变为28％ 。 光被光谱重组并成像到光电倍增管上，并通过时变信号的傅里叶变换检测所得到的载波频率（及其幅度）。 拍摄彩色玻璃滤光片的光谱仪来证明光谱仪。

公开(公告)号：US5748308A

公开(公告)日：1998-05-05

申请号：US595675

申请日：1996-02-02

Applicant: John M. Lindberg ,  Robert Eric Heinz

Inventor： John M. Lindberg ,  Robert Eric Heinz

IPC: G01J3/28 ,  G01J3/457 ,  G01J3/51 ,  G01N21/27 ,  G01J3/04

CPC classification number: G01J3/28 ,  G01J3/02 ,  G01J3/0208 ,  G01J3/0229 ,  G01J3/457 ,  G01J2003/1286 ,  G01J2003/2836 ,  G01J2003/2866

Abstract: The present invention provides a programmable filter for use as a standard in correlation spectrometers. Also provided is the use of the programmable standard in a process for determining the concentration of an optically absorbing compound. Also provided is a method and apparatus for noninvasively determining the concentration of an optically absorbing biological sample which incorporates the programmable standard of the invention.

Abstract translation: 本发明提供了一种用于相关光谱仪中的标准的可编程滤波器。 还提供了在用于确定光学吸收化合物的浓度的方法中使用可编程标准品。 还提供了用于非侵入性地确定结合了本发明的可编程标准的光学吸收生物样品的浓度的方法和装置。

公开(公告)号：US5631735A

公开(公告)日：1997-05-20

申请号：US648616

申请日：1996-05-16

Applicant: Yoshiroh Nagai

Inventor： Yoshiroh Nagai

IPC: G01J3/06 ,  G01J3/28 ,  G01J3/04 ,  G01F1/00

CPC classification number: G01J3/02 ,  G01J3/0229 ,  G01J3/0232 ,  G01J3/0237 ,  G01J3/06 ,  G01J3/2846 ,  G01J2003/1273

Abstract: A multi-slit type spectrometer includes a light diffracter which diffracts an incident light according to wavelengths; an optical shutter array member including a plurality of optical shutter elements arranged in correspondence with wavelength bands diffracted by the light diffracter, operable to transmit an incident ray according to an applied voltage, and made of PLZT. A zone of a given number of adjacent optical shutter elements is applied with a voltage corresponding to the wavelength bands of the rays incident upon the zone of adjacent optical shutter elements at a specified timing so that the rays respectively pass through or are reflected at the optical shutter elements. A signal processor receives the ray which has passed through or has been reflected at each optical shutter element and outputs an electrical signal according to the intensity of the received ray. A calculator calculates the intensity of the incident ray for each wavelength band in accordance with the electrical signal output from the signal processor and the specified applying timing.

Abstract translation: 多狭缝型光谱仪包括根据波长衍射入射光的光致畸变器; 光学快门阵列部件，其包括与由光致变色器衍射的波长带对应地布置的多个光学快门元件，可操作以根据施加的电压传输入射光线，并由PLZT制成。 给定数量的相邻光学快门元件的区域以指定的时刻施加与入射在相邻光学快门元件的区域上的光线的波段相对应的电压，使得光线分别通过或者被反射在光学 快门元素 信号处理器接收已经通过或已经在每个光学快门元件反射的光线，并根据所接收的光线的强度输出电信号。 计算器根据从信号处理器输出的电信号和指定的施加定时计算每个波段的入射光线的强度。