公开(公告)号：US20120062873A1

公开(公告)日：2012-03-15

申请号：US13153775

申请日：2011-06-06

Applicant: Shona Stewart ,  John Maier ,  Jeffrey Cohen

Inventor： Shona Stewart ,  John Maier ,  Jeffrey Cohen

IPC: G01N21/00 ,  G01J3/44 ,  G01N21/64 ,  G01J5/08

CPC classification number: A61B5/417 ,  A61B5/0075 ,  G01J3/02 ,  G01J3/0291 ,  G01J3/28 ,  G01J3/2823 ,  G01J3/36 ,  G01J3/44 ,  G01J2003/2826 ,  G01N21/35 ,  G01N21/6456 ,  G01N21/65 ,  G01N33/57415 ,  G01N2021/1765 ,  G01N2021/1793 ,  G01N2021/6423 ,  G01N2021/656 ,  G01N2201/1293 ,  G01N2201/1296 ,  G01N2800/7028

Abstract: A system and method to provide a diagnosis of the breast disease state of a test breast sample. A database containing a plurality of reference SWIR data sets is provided where each reference SWIR data set has an associated known breast sample and an associated known breast disease state. A test breast sample is irradiated with substantially monochromatic light to generate scattered photons resulting in a test SWIR data set. The test SWIR data set is compared to the plurality of reference SWIR data sets using a chemometric technique. Based on the comparison, a diagnosis of a breast disease state of the test breast sample is provided. The breast disease state includes invasive ductal carcinoma or invasive lobular carcinoma disease state.

Abstract translation: 一种用于提供测试乳房样品的乳腺疾病状态诊断的系统和方法。 提供了包含多个参考SWIR数据集的数据库，其中每个参考SWIR数据集具有相关联的已知乳房样本和相关联的已知乳腺疾病状态。 用基本上单色的光照射测试乳房样品以产生散射的光子，得到测试SWIR数据集。 使用化学计量技术将测试SWIR数据集与多个参考SWIR数据集进行比较。 基于比较，提供了测试乳房样品的乳腺疾病状态的诊断。 乳腺疾病状态包括浸润性导管癌或侵袭性小叶癌疾病状态。

公开(公告)号：US20120056093A1

公开(公告)日：2012-03-08

申请号：US13064626

申请日：2011-04-04

Applicant: Wade Poteet ,  James Ryles ,  Malcolm Philips

Inventor： Wade Poteet ,  James Ryles ,  Malcolm Philips

IPC: G01T1/20 ,  G01N21/64

CPC classification number: G01J3/4406 ,  G01J3/02 ,  G01J3/0256 ,  G01J3/0264 ,  G01J3/027 ,  G01J3/0272 ,  G01J3/0278 ,  G01J3/0289 ,  G01J3/42 ,  G01J3/443 ,  G01N21/645 ,  G01N2021/6417 ,  G01N2201/0221

Abstract: A handheld or portable detection system with a high degree of specificity and accuracy, capable of use at small and substantial standoff distances (e.g., greater than 12 inches) is utilized to identify specific substances and mixtures thereof in order to provide information to officials for identification purposes and assists in determinations related to the legality, hazardous nature and/or disposition decision of such substance(s). The system uses a synchronous detector and visible light filter to enhance detection capabilities.

Abstract translation: 利用具有高度特异性和准确性的手持式或便携式检测系统，能够以小而实质的间隔距离（例如，大于12英寸）使用，以识别特定物质及其混合物，以向官员提供信息以进行识别 目的，并协助与此类物质的合法性，危险性质和/或处置决定有关的决定。 该系统使用同步检测器和可见光滤波器来增强检测能力。

公开(公告)号：US08125638B2

公开(公告)日：2012-02-28

申请号：US12426366

申请日：2009-04-20

Applicant: Toshikazu Yamamoto ,  Tsutomu Kaneko ,  Manabu Kojima

Inventor： Toshikazu Yamamoto ,  Tsutomu Kaneko ,  Manabu Kojima

IPC: G01J3/28

CPC classification number: G01J3/02 ,  G01J3/0208 ,  G01J3/0286 ,  G01J3/0291

Abstract: An improvement is added to a spectroscope for performing wavelength dispersion of measured light with a wavelength dispersion element and receiving the light at a light reception element. The spectroscope has a first compound lens made up of a plurality of lenses for converting measured light into parallel light and emitting the parallel light to the wavelength dispersion element; a second compound lens made up of a plurality of lenses for gathering the measured light subjected to the wavelength dispersion in the wavelength dispersion element and causing the light reception element to receive the light; and a base for fixing the wavelength dispersion element, the first compound lens, and the second compound lens. The linear expansion coefficient of the compound focal length of the first compound lens, the linear expansion coefficient of the compound focal length of the second compound lens, and the linear expansion coefficient of a material forming the base are substantially equal.

Abstract translation: 增加了用于利用波长色散元件进行测量光的波长色散并在光接收元件处接收光的分光镜。 该分光镜具有由多个透镜构成的第一复合透镜，用于将测量的光转换成平行光并将平行光发射到波长色散元件; 由多个透镜构成的第二复合透镜，用于聚集经受波长色散元件中的波长色散的测量光，并使光接收元件接收光; 以及用于固定波长色散元件，第一复合透镜和第二复合透镜的基座。 第一复合透镜的复合焦距的线膨胀系数，第二复合透镜的复合焦距的线膨胀系数和形成基底的材料的线膨胀系数基本相等。

公开(公告)号：US08120853B2

公开(公告)日：2012-02-21

申请号：US13180922

申请日：2011-07-12

Applicant: Alexander Jacobson ,  Zvi Bleier

Inventor： Alexander Jacobson ,  Zvi Bleier

IPC: G02B1/10 ,  G01B9/02 ,  G01J3/45

CPC classification number: G01J3/02 ,  G01J3/0202 ,  G01J3/0286 ,  G01J3/453 ,  G02B7/008 ,  G02B7/181 ,  Y10T29/49826

Abstract: A monolithic frame for optics used in interferometers where the material of the monolithic frame may have a substantially different coefficient of thermal expansion from the beamsplitter and compensator without warping, bending or distorting the optics. This is accomplished through providing a securing apparatus holding the optics in place while isolating the expansion thereof from the expansion of the frame. Stability in optical alignment is therefore achieved without requiring a single material or materials of essentially identical coefficients of thermal expansion. The present invention provides stability in situations where it is not possible to utilize a single material for every component of the interferometer.

Abstract translation: 用于干涉仪的光学单片框架，其中整体框架的材料可能具有与分束器和补偿器基本上不同的热膨胀系数，而不会使光学器件翘曲，弯曲或变形。 这通过提供将光学器件保持在适当位置的固定装置来实现，同时隔离其与框架的膨胀的膨胀。 因此，在不需要单一材料或基本上相同的热膨胀系数的材料的情况下实现光学对准的稳定性。 本发明在不可能对干涉仪的每个部件使用单一材料的情况下提供稳定性。

公开(公告)号：US08120772B2

公开(公告)日：2012-02-21

申请号：US12611176

申请日：2009-11-03

Applicant: Marcus T. Cicerone ,  Young Jong Lee

Inventor： Marcus T. Cicerone ,  Young Jong Lee

IPC: G01J3/44

CPC classification number: G01J3/4412 ,  G01J3/02 ,  G01J3/0208 ,  G01J3/0218 ,  G01J3/0229 ,  G01J3/0237 ,  G01J3/027 ,  G01J11/00 ,  G01N2021/653

Abstract: Methods and systems are described for suppressing nonresonant background in broadband coherent anti-Stokes Raman scattering (CARS) microscopy and spectroscopy. The methods and systems improve sensitivity and signal to noise ratio in CARS.

Abstract translation: 描述了用于抑制宽带相干反斯托克斯拉曼散射（CARS）显微镜和光谱学中的非共振背景的方法和系统。 方法和系统提高CARS的灵敏度和信噪比。

公开(公告)号：US08120002B2

公开(公告)日：2012-02-21

申请号：US12374006

申请日：2007-07-05

Applicant: Erik Martinus Hubertus Petrus Van Dijk ,  Marinus Iosif Boamfa ,  Reinhold Wimberger-Friedl

Inventor： Erik Martinus Hubertus Petrus Van Dijk ,  Marinus Iosif Boamfa ,  Reinhold Wimberger-Friedl

IPC: G01N21/86

CPC classification number: G01N21/6428 ,  G01J3/02 ,  G01J3/021 ,  G01J3/10 ,  G01J3/36 ,  G01J3/4406 ,  G01N21/645 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2021/6441 ,  G01N2021/6463

Abstract: A detection system for detecting luminescence sites on a substrate and including an irradiation unit for generating at least one excitation irradiation beam for exciting luminescence sites on the substrate; a first optical element, e.g. refractive element adapted for receiving at least two irradiation beams of different wavelengths or wavelength ranges, the at least two irradiation beams being excitation irradiation beam(s) to be focused on a substrate and/or luminescence irradiation beam(s) to be collected from the excited luminescence sites on the substrate; and an optical compensator for adjusting at least one of the at least two irradiation beams of different wavelengths or wavelength ranges so as to reduce or compensate for optical aberrations.

Abstract translation: 一种用于检测衬底上发光部位的检测系统，包括用于产生用于激发衬底上的发光部位的至少一个激发照射束的照射单元; 第一光学元件，例如。 用于接收不同波长或波长范围的至少两个照射光束的折射元件，所述至少两个照射光束是要聚焦在基底上的激发照射光束和/或从所述至少两个照射光束收集的发光照射光束 基底上激发的发光位点; 以及用于调整不同波长或波长范围的至少两个照射束中的至少一个的光学补偿器，以便减少或补偿光学像差。

公开(公告)号：US08109634B2

公开(公告)日：2012-02-07

申请号：US12398255

申请日：2009-03-05

Applicant: Tamir Gil

Inventor： Tamir Gil

IPC: A61B3/14 ,  A61B3/10 ,  A61B3/00

CPC classification number: G01J3/0208 ,  A61B3/10 ,  A61B5/14555 ,  G01J3/02 ,  G01J3/0256 ,  G01J3/2823 ,  G01J3/36 ,  G01J2003/1213

Abstract: Obtaining spectral images of an eye includes taking an optical system that images eye tissue onto a digital sensor array and optically fitting a multi-spectral filter array and the digital sensor array, wherein the multi-spectral filter array is disposed between the digital sensor array and an optics portion of the optical system. The resulting system facilitates acquisition of a snap-shot image of the eye tissue with the digital sensor array. The snap shot images support estimation of blood oxygen saturation in a retinal tissue. The resulting system can be based on a non-mydriatic fundus camera designed to obtain the retinal images without administration of pupil dilation drops.

Abstract translation: 获得眼睛的光谱图像包括拍摄将眼睛组织成像到数字传感器阵列上的光学系统，以及光学拟合多光谱滤光器阵列和数字传感器阵列，其中多光谱滤光器阵列设置在数字传感器阵列和 光学系统的光学部分。 所得到的系统便于利用数字传感器阵列获取眼睛组织的快照图像。 快照图像支持视网膜组织中血氧饱和度的估计。 所得到的系统可以基于设计用于获得视网膜图像的非散瞳眼底照相机，而不施加瞳孔扩张液滴。

公开(公告)号：US20120026494A1

公开(公告)日：2012-02-02

申请号：US13016966

申请日：2011-01-29

Applicant: Manfred Fink ,  Philip Varghese

Inventor： Manfred Fink ,  Philip Varghese

IPC: G01J3/44

CPC classification number: G01J3/44 ,  G01J3/02 ,  G01J3/0286 ,  G01J3/0291 ,  G01N21/15 ,  G01N21/65 ,  G01N2021/651

Abstract: A Raman head is provided capable of operating at high surrounding pressures. The Raman head has housing having a first, sealed chamber filled with an incompressible liquid and a second chamber that is open to the surrounding environment. At least one bellows can be used to equalize pressure between the first sealed chamber and the surrounding environment. A planar side of a pair of plano-concave lens is positioned within the first chamber and the concave side of each plano-concave lens is positioned within the second chamber of the Raman head. Light emitted as a result of a laser beam in communication with the pair of plano-concave lens can be analyzed by a Raman analyzer.

Abstract translation: 提供能够在高周围压力下操作的拉曼头。 拉曼头具有壳体，其具有填充有不可压缩液体的第一密封室和对周围环境开放的第二室。 可以使用至少一个波纹管来均衡第一密封室和周围环境之间的压力。 一对平凹透镜的平面侧位于第一室内，并且每个平凹透镜的凹面位于拉曼头的第二室内。 作为与一对平凹透镜连通的激光束发射的光可以通过拉曼分析仪进行分析。

公开(公告)号：US08107069B2

公开(公告)日：2012-01-31

申请号：US12556200

申请日：2009-09-09

Applicant: Peidong Wang ,  Daryoosh Vakhshoori ,  Yu Shen ,  Kevin J. Knopp ,  Masud Azimi

Inventor： Peidong Wang ,  Daryoosh Vakhshoori ,  Yu Shen ,  Kevin J. Knopp ,  Masud Azimi

IPC: G01J3/44

CPC classification number: G01N21/65 ,  G01J3/02 ,  G01J3/0218 ,  G01J3/0272 ,  G01J3/0291 ,  G01J3/44 ,  G01J2003/1213 ,  G01N2021/656

Abstract: The apparatus disclosed herein features: (a) a handheld, portable spectrometer that includes a radiation source configured to direct incident radiation to a sample, a detector configured to receive signal radiation from the sample, and a housing enclosing the radiation source and the detector; (b) an extended member attachable to the housing and having an interior channel to define a path for directing radiation from the source to the sample and for receiving radiation from the sample at the detector; (c) and a vial receptacle configured to hold a different sample and positioned to receive radiation from the source, where the detector is positioned to receive radiation from the different sample and the housing is configured to support the vial receptacle and attach to the extended member at the same time.

Abstract translation: 本文公开的装置特征在于：（a）手持式便携式光谱仪，其包括被配置为将入射辐射引导到样品的辐射源，被配置为从样品接收信号辐射的检测器和包围辐射源和检测器的壳体; （b）可附接到壳体并具有内部通道以限定用于将辐射从源引导到样品并用于在检测器处接收来自样品的辐射的路径的延伸构件; （c）和小瓶容器，其被配置为保持不同的样品并定位成接收来自所述源的辐射，其中所述检测器被定位成接收来自所述不同样品的辐射，并且所述壳体被配置为支撑所述小瓶容器并附接到所述延伸构件 与此同时。

公开(公告)号：US08107059B2

公开(公告)日：2012-01-31

申请号：US11950629

申请日：2007-12-05

Applicant: In-duk Hwang ,  Kun-kook Park ,  Hong-sig Kim ,  Soo-kwan Kim

Inventor： In-duk Hwang ,  Kun-kook Park ,  Hong-sig Kim ,  Soo-kwan Kim

IPC: G01N33/48

CPC classification number: G01J3/02 ,  A61B5/0075 ,  A61B5/145 ,  A61B5/14532 ,  G01J3/021 ,  G01J3/0218 ,  G01J3/0291 ,  G01J3/10 ,  G01J3/44 ,  G01N21/359 ,  G01N21/49 ,  G01N21/65 ,  G01N2021/399 ,  G01N2021/4742 ,  G01N2021/656

Abstract: A non-invasive probe for measuring body components, and a non-invasive body component measurement system including the non-invasive probe is provided. The non-invasive probe includes an input light transferring unit for transferring an input light emitted from a light source; a light splitting unit for splitting the input light into a plurality of living body incident lights; a light condensing unit for condensing the plurality of living body incident lights, so that the plurality of living body incident lights can be irradiated onto a plurality of measuring points, each measuring point corresponding to one of the plurality of living body incident lights; and an output light transferring unit for transferring a plurality of output lights, which each correspond to the one of the plurality of measuring points and, which are obtained by irradiating the plurality of living body incident lights, to a spectrometer that classifies the output lights by wavelength.

Abstract translation: 提供了一种用于测量身体成分的非侵入性探针，以及包括非侵入性探针的非侵入性身体成分测量系统。 非侵入性探针包括用于传送从光源发射的输入光的输入光传输单元; 分光单元，用于将输入光分成多个生物体入射光; 用于使多个生物体入射光聚光的聚光单元，使得能够将多个生物体入射光照射在与多个生物体入射光中的一个相对应的多个测量点上; 以及输出光传输单元，用于将多个输出光分别对应于多个测量点中的一个，并且通过将多个生物体入射光照射而获得的多个输出光输送到将输出光分类的光谱仪 波长。