公开(公告)号：US20060234386A1

公开(公告)日：2006-10-19

申请号：US10554698

申请日：2004-04-30

Applicant: David Burns ,  Denis Lafrance ,  Larry Lands

Inventor： David Burns ,  Denis Lafrance ,  Larry Lands

IPC: G01N33/00 ,  A61B5/00 ,  A61B5/02

CPC classification number: G01N21/359 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/6826 ,  A61B5/6838 ,  G01J3/02 ,  G01J3/027 ,  G01J3/427 ,  G01J3/44 ,  G01J3/453 ,  G01N21/4738 ,  G01N21/65 ,  G01N2021/3148 ,  G01N2021/3595 ,  G01N2201/0618 ,  G01N2201/0627 ,  G01N2201/0636 ,  G01N2201/129 ,  G01N2201/1293 ,  Y10T436/143333

Abstract: There is described a system and method for the in vivo determination of lactate levels in blood using Near-Infrared Spectroscopy (NIRS) and/or Near-infrared Raman Spectroscopy (NIR-RAMAN). The method teaches measuring lactate in vivo comprising: optically coupling a body part with a light source and a light detector the body part having tissues comprising blood vessels; injecting near-infrared (NIR) light at one or a plurality of wavelengths in the body part; detecting, as a function of blood volume variations in the body part, light exiting the body part at at least the plurality of wavelengths to generate an optical signal; and processing the optical signal as a function of the blood volume variations to obtain a lactate level in blood.

Abstract translation: 描述了使用近红外光谱（NIRS）和/或近红外拉曼光谱（NIR-RAMAN）体内测定血液中乳酸水平的系统和方法。 该方法教导在体内测量乳酸盐，其包括：将身体部分与光源光学耦合;以及光检测器，身体部位具有包含血管的组织; 在身体部分中以一个或多个波长注入近红外（NIR）光; 根据所述身体部位的血容量变化来检测以至少所述多个波长离开所述身体部位的光，以产生光信号; 并且根据血液体积变化来处理光学信号以获得血液中的乳酸盐水平。

公开(公告)号：US20060175547A1

公开(公告)日：2006-08-10

申请号：US11051388

申请日：2005-02-04

Applicant: Rocco DiFoggio ,  Paul Bergren

Inventor： Rocco DiFoggio ,  Paul Bergren

IPC: G01V5/08

CPC classification number: G01J3/02 ,  G01J3/0218 ,  G01J3/26 ,  G01J3/42 ,  G01N21/3504 ,  G01N21/3577 ,  G01N21/552 ,  G01N21/8507 ,  G01N2201/0691 ,  G01N2201/129

Abstract: The present invention provides a method and apparatus for estimating a property of a fluid downhole by exposing the fluid to modulated light downhole and sensing changes in intensity of infrared radiation from the downhole fluid to estimate the property of the downhole fluid. The present invention senses changes in intensity of light by converting the changes to transient changes in temperature of a detector, such as a pyroelectric detector. The present invention performs spectroscopic analysis of fluids by optically filtering the light allowed to impinge on a pyroelectric detector, converting the changes in temperature of the pyroelectric detector to a signal and converting the signal to estimate the property of the downhole fluid. The light source is modulated by mechanically chopping the beam or by electrically pulsing the light source or by steering the beam between different path lengths of sample or between a reference cell (filled with a reference fluid or empty) and a sample-filled cell.

Abstract translation: 本发明提供了一种用于通过将流体暴露于井下调制光并且感测来自井下流体的红外辐射的强度的变化来估计井下流体的性质来估计井下流体的性质的方法和装置。 本发明通过将变化转换成诸如热电检测器的检测器的温度的瞬时变化来感测光强度的变化。 本发明通过对允许撞击在热电检测器上的光进行光学滤波来对流体进行光谱分析，将热释电检测器的温度变化转换为信号，并转换该信号以估计井下流体的性质。 通过机械地切割光束或通过电脉冲光源或通过在不同路径长度的样品之间或在参考单元（填充有参考流体或空的）和样品填充单元之间转向光束来调制光源。

公开(公告)号：US20060167348A1

公开(公告)日：2006-07-27

申请号：US11042817

申请日：2005-01-24

Applicant: Mark Arnold ,  Jonathon Olesberg

Inventor： Mark Arnold ,  Jonathon Olesberg

IPC: A61B5/00 ,  G01J3/00

CPC classification number: G01N21/35 ,  A61B5/14532 ,  A61B5/1455 ,  A61B5/1495 ,  A61B2560/0223 ,  G01N21/1702 ,  G01N21/274 ,  G01N21/4738 ,  G01N21/552 ,  G01N2021/3595 ,  G01N2201/129

Abstract: A method for generating a net analyte signal calibration model for use in detecting and/or quantifying the amount of an analyte in a test subject. The net analyte signal can be generated by providing a set of in vivo infrared spectra for a test subject during a period in which an analyte concentration is essentially constant; calculating an optimal subspace of spectra that at least substantially describes all non-analyte dependent spectral variance in the in vivo spectra; providing a pure component infrared spectrum for the analyte; and calculating a net analyte signal spectrum from a data set comprising the optimal subspace spectra and the pure analyte spectrum. The net analyte signal calibration model can be used, for example, in measuring the concentration of analyte in a test subject, and/or for evaluating the analytical significance of an in vivo multivariate calibration model.

Abstract translation: 一种用于产生用于检测和/或定量测试对象中的分析物的量的净分析物信号校准模型的方法。 净分析物信号可以通过在分析物浓度基本恒定的期间内为测试对象提供一组体内红外光谱来产生; 计算光谱的最佳子空间，其至少基本上描述体内光谱中的所有非分析物相关的光谱方差; 为分析物提供纯分量红外光谱; 以及从包括最佳子空间光谱和纯分析物光谱的数据集计算净分析物信号光谱。 净分析物信号校准模型可用于例如测量受试者中分析物的浓度，和/或用于评估体内多变量校准模型的分析意义。

公开(公告)号：US20050286049A1

公开(公告)日：2005-12-29

申请号：US11169824

申请日：2005-06-28

Applicant: Thomas Hagler

Inventor： Thomas Hagler

IPC: G01J3/18 ,  G01J3/28 ,  G01J3/42 ,  G01N21/31

CPC classification number: G01N21/552 ,  G01J3/02 ,  G01J3/0202 ,  G01J3/0208 ,  G01J3/0229 ,  G01J3/0291 ,  G01J3/0294 ,  G01J3/18 ,  G01J3/28 ,  G01J3/42 ,  G01N21/274 ,  G01N21/31 ,  G01N2021/317 ,  G01N2201/129

Abstract: An encoder spectrograph is used to analyze radiation from one or more samples in various configurations. The radiation is analyzed by spatially modulating the radiation after it has been dispersed by wavelength or imaged along a line. Dual encoder spectrographs may be used to encode radiation using a single modulator.

Abstract translation: 编码器光谱仪用于分析来自一种或多种不同配置样品的辐射。 通过在辐射被波长分散或沿着一条线成像后，通过空间调制辐射来分析辐射。 双编码器光谱仪可用于使用单个调制器对辐射进行编码。

公开(公告)号：US20050032231A1

公开(公告)日：2005-02-10

申请号：US10635051

申请日：2003-08-06

Applicant: Paris Smaragdis

Inventor： Paris Smaragdis

IPC: G01N21/35 ,  G01N21/62

CPC classification number: G01N21/359 ,  G01N21/3577 ,  G01N2201/129 ,  Y10T436/21

Abstract: A system for analyzing a mixture of chemical components. First, a liquid or gas chromatograph produces samples of the mixture. The samples include overlapping components. A spectrometer measures wavelength of each sample. A memory stores the measured wavelengths of each sample as rows in a first matrix. Independent component analysis is applied to the first matrix to obtain a second matrix and a third matrix. Columns of the first matrix are elution profiles of distinct component groups, and rows of the third matrix are corresponding spectra of the distinct component groups.

Abstract translation: 用于分析化学成分混合物的系统。 首先，液体或气相色谱仪产生混合物的样品。 样品包括重叠组分。 光谱仪测量每个样品的波长。 存储器将每个样本的测量波长作为第一矩阵中的行存储。 将独立分量分析应用于第一矩阵以获得第二矩阵和第三矩阵。 第一个矩阵的列是不同组件组的洗脱曲线，第三个矩阵的行是不同组件组的相应光谱。

公开(公告)号：US20040251177A1

公开(公告)日：2004-12-16

申请号：US10481149

申请日：2004-06-28

Inventor： Bo Lofqvist ,  Jesper Pram Nielsen

IPC: B07C005/00

CPC classification number: B07C5/34 ,  G01N21/3563 ,  G01N21/359 ,  G01N2201/129

Abstract: A method of sorting sorting objects within a bulk of objects from a heterogeneous population is provided. The bulk of objects to be sorted has an inherent variation, and at least one class, having less variation than the originally inherent variation of the bulk, is separated from the bulk. This lesser variation represents a quality of composition with reference to any organic material of the objects within the bulk. The method comprises the steps of distributing each of the objects to be separated as a separate object in a sorting device; exposing the separate object to energy emittedfrom at least one energy source; recording from at least one point of the separateobject by meansof at least one sensor a first multivariate signal; predicting orclassifying, by means of a calibration method previously performed on a subset of the population, between the first multivariate signal and the quality of composition, a second signal expressing the magnitude of at least one quality variable of univariate variation; and separating the separate object from the sorting device to the at least one collected class in dependence on the magnitude of the at least one quality variable of the second signal from the at least one point.

Abstract translation: 提供了从异构群体中排序大量对象内的排序对象的方法。 要排序的物体的大部分具有固有的变化，并且具有比原始固有变体的变化小的变化的至少一个等级与本体分离。 这种较小的变化表示参考本体内物体的任何有机材料的组合质量。 该方法包括以下步骤：将分离的每个物体作为分离装置中的单独物体分配; 将单独的物体暴露于从至少一个能量源发射的能量; 通过至少一个传感器，通过第一多变量信号从分离对象的至少一个点记录; 通过先前在群体子集上执行的校准方法，在第一多变量信号和组合质量之间预测或分类，表示至少一个单变量质量变量的量值的第二信号; 并且根据来自所述至少一个点的所述第二信号的所述至少一个质量变量的大小，将所述分离对象与所述分类装置分离为所述至少一个收集的类。

公开(公告)号：US20040111232A1

公开(公告)日：2004-06-10

申请号：US10444045

申请日：2003-05-22

Inventor： Matthew Butler ,  Grant Plummer

IPC: G01K001/00

CPC classification number: G01J3/453 ,  G01J3/0264 ,  G01J3/28 ,  G01N21/3518 ,  G01N2021/1793 ,  G01N2201/1211 ,  G01N2201/129

Abstract: A fourth embodiment of the present invention is a method of generating a temperature compensated absorbance spectrum. The method includes the steps of: a. providing a sample spectrum and an estimated temperature of a backdrop object; b. from a set of known temperature spectra related to a known background temperature, selecting at least two known temperature spectra representing a background temperature above and below the estimated temperature; c. comparing the sample spectrum to the known temperature spectra in order to determine a sample background spectrum; and d. calculating an absorbance spectrum from the sample spectrum and the background spectrum.

Abstract translation: 本发明的第四实施例是产生温度补偿吸收光谱的方法。 该方法包括以下步骤：a。 提供样本谱和背景物体的估计温度; b。 从与已知背景温度相关的一组已知温度谱中，选择表示背景温度高于和低于估计温度的至少两个已知温度光谱; C。 将样品光谱与已知的温度光谱进行比较，以确定样品背景光谱; 和d。 从样品光谱和背景光谱计算吸收光谱。

公开(公告)号：US06512577B1

公开(公告)日：2003-01-28

申请号：US09524329

申请日：2000-03-13

Applicant: Richard M. Ozanich

Inventor： Richard M. Ozanich

IPC: G01J342

CPC classification number: G01J3/02 ,  G01J3/0218 ,  G01J3/0224 ,  G01J3/28 ,  G01J3/36 ,  G01J3/42 ,  G01J3/501 ,  G01J3/51 ,  G01J3/513 ,  G01J3/524 ,  G01N21/3563 ,  G01N21/359 ,  G01N33/025 ,  G01N2021/3155 ,  G01N2021/8466 ,  G01N2201/129 ,  Y10S250/91

Abstract: This disclosure is of 1) the utilization of the spectrum from 250 nm to 1150 nm for measurement or prediction of one or more parameters, e.g., brix, firmness, acidity, density, pH, color and external and internal defects and disorders including, for example, surface and subsurface bruises, scarring, sun scald, punctures, in N—H, C—H and O—H samples including fruit; 2) an apparatus and method of detecting emitted light from samples exposed to the above spectrum in at least one spectrum range and, in the preferred embodiment, in at least two spectrum ranges of 250 to 499 nm and 500 nm to 1150 nm; 3) the use of the chlorophyl band, peaking at 680 nm, in combination with the spectrum from 700 nm and above to predict one or more of the above parameters; 4) the use of the visible pigment region, including xanthophyll, from approximately 250 nm to 499 nm and anthocyanin from approximately 500 to 550 nm, in combination with the chlorophyl band and the spectrum from 700 nm and above to predict the all of the above parameters.

Abstract translation: 本公开是1）利用250nm至1150nm的光谱来测量或预测一个或多个参数，例如白利糖度，硬度，酸度，密度，pH，颜色以及外部和内部缺陷和障碍，包括对于 例如，包括水果在内的NH，CH和OH样品中的表面和地下瘀伤，疤痕，晒伤，穿刺; 2）一种在至少一个光谱范围内检测暴露于上述光谱的样品的发射光的装置和方法，在优选实施例中，在250至499nm和500nm至1150nm的至少两个光谱范围内; 3）使用700nm以上的光谱，结合680nm的峰值峰值，预测一个或多个上述参数; 4）使用约250nm至499nm的可见颜料区域（包括叶黄素）和约500至550nm的花色素苷，与叶绿素谱带和700nm及以上的光谱结合使用，以预测上述全部 参数。

公开(公告)号：US06354145B1

公开(公告)日：2002-03-12

申请号：US09355297

申请日：1999-07-28

Applicant: Magnus Fransson ,  Lars Karlsson ,  Bengt Lagerholm ,  Anders Sparén

Inventor： Magnus Fransson ,  Lars Karlsson ,  Bengt Lagerholm ,  Anders Sparén

IPC: G01N3108

CPC classification number: G01N30/8651 ,  G01N30/8658 ,  G01N30/8682 ,  G01N2030/8804 ,  G01N2030/8886 ,  G01N2201/129

Abstract: The present invention relates to a method for analyzing mixtures of components by a process selected from the group consisting of flow based separation processes and flow analysis processes. The method comprising the steps of: obtaining measurement signals by measuring process conditions at a plurality of positions throughout the system; applying signal processing to the measurement signals, said signal processing comprising multivariate data analysis for condensing the plurality of measurement signals to a smaller number of main signals being non-correlated; logging said main signals; and displaying said main signals versus time, where changes of said system conditions are indicated by one or more of the displayed main signals; detecting any error occurrence during an on going process, and determining what part of said system cause said error.

Abstract translation: 本发明涉及通过选自流体分离方法和流动分析方法的方法分析组分混合物的方法。 该方法包括以下步骤：通过测量整个系统中的多个位置处的处理条件来获得测量信号;对测量信号应用信号处理，所述信号处理包括多变量数据分析，用于将多个测量信号冷凝到较小数量的 主信号不相关;记录主信号; 以及显示所述主信号与时间的关系，其中所述系统条件的变化由所显示的主信号中的一个或多个指示;检测正在进行的过程中的任何错误发生，以及确定所述系统的哪一部分引起所述错误。

公开(公告)号：US20020011567A1

公开(公告)日：2002-01-31

申请号：US09804613

申请日：2001-03-12

Inventor： Richard M. Ozanich

IPC: H01T019/04

CPC classification number: G01J3/02 ,  G01J3/0218 ,  G01J3/0224 ,  G01J3/28 ,  G01J3/36 ,  G01J3/42 ,  G01J3/501 ,  G01J3/51 ,  G01J3/513 ,  G01J3/524 ,  G01N21/3563 ,  G01N21/359 ,  G01N33/025 ,  G01N2021/3155 ,  G01N2021/8466 ,  G01N2201/129 ,  Y10S250/91

Abstract: This disclosure is of 1) the utilization of the spectrum from 250 nm to 1150 nm for measurement or prediction of one or more parameters, e.g., brix, firmness, acidity, density, pH, color and external and internal defects and disorders including, for example, surface and subsurface bruises, scarring, sun scald, punctures, in NnullH, CnullH and OnullH samples including fruit; 2) an apparatus and method of detecting emitted light from samples exposed to the above spectrum in at least one spectrum range and, in the preferred embodiment, in at least two spectrum ranges of 250 to 499 nm and 500 nm to 1150 nm; 3) the use of the chlorophyl band, peaking at 680 nm, in combination with the spectrum from 700 nm and above to predict one or more of the above parameters; 4) the use of the visible pigment region, including xanthophyll, from approximately 250 nm to 499 nm and anthocyanin from approximately 500 to 550 nm, in combination with the chlorophyl band and the spectrum from 700 nm and above to predict the all of the above parameters.

Abstract translation: 本公开是1）利用250nm至1150nm的光谱来测量或预测一个或多个参数，例如白利糖度，硬度，酸度，密度，pH，颜色以及外部和内部缺陷和障碍，包括对于 例如，包括水果在内的NH，CH和OH样品中的表面和地下瘀伤，疤痕，晒伤，穿刺; 2）一种在至少一个光谱范围内检测暴露于上述光谱的样品的发射光的装置和方法，在优选实施例中，在250至499nm和500nm至1150nm的至少两个光谱范围内; 3）使用700nm以上的光谱，结合680nm的峰值峰值，预测一个或多个上述参数; 4）使用约250nm至499nm的可见颜料区域（包括叶黄素）和约500至550nm的花色素苷，与叶绿素谱带和700nm及以上的光谱结合使用，以预测上述全部 参数。