公开(公告)号：US07209773B2

公开(公告)日：2007-04-24

申请号：US10872033

申请日：2004-06-18

Applicant: Michael J. Iuliano

Inventor： Michael J. Iuliano

IPC: A61B5/00

CPC classification number: A61B5/1455 ,  A61B5/14532 ,  A61B5/14546 ,  G01J3/02 ,  G01J3/021 ,  G01J3/0216 ,  G01J3/44 ,  G01J3/447 ,  G01N21/65

Abstract: An in-vivo blood composition analyzing apparatus and method generates a laser beam at the blood vessels of the patient's eye. The Raman scattered photons from the blood vessels are collected and used to generate a Raman spectrum indicative of the blood composition. In one embodiment, a laser beam is generated with two streams of photons, the photons of one beam being entangled with the photons of the other beam. One stream is then directed at the eye and only the other beam is analyzed to obtain said Raman spectrum. Alternatively, the scattered photons from the second beam are also analyzed and the results are correlated for greater efficiency and accuracy.

Abstract translation: 体内血液成分分析装置和方法在患者眼睛的血管处产生激光束。 收集来自血管的拉曼散射的光子并用于产生指示血液组成的拉曼光谱。 在一个实施例中，用两股光子产生激光束，一束的光子与另一束光束的光子相互缠绕。 然后将一条流引导到眼睛，并且仅分析另一束以获得所述拉曼光谱。 或者，还分析来自第二光束的散射光子，并且将结果相关联以获得更高的效率和准确度。

公开(公告)号：US07202091B2

公开(公告)日：2007-04-10

申请号：US10281576

申请日：2002-10-28

Applicant: Howland D. T. Jones ,  David J. Nunez ,  Stephen J. Vanslyke ,  Robert D. Johnson ,  Edward L. Hull

Inventor： Howland D. T. Jones ,  David J. Nunez ,  Stephen J. Vanslyke ,  Robert D. Johnson ,  Edward L. Hull

IPC: G01N21/00 ,  G01N21/35

CPC classification number: G01J3/10 ,  A61B5/0075 ,  G01J3/02 ,  G01J3/0216 ,  G01J3/0218 ,  G01N21/278 ,  G01N21/4785 ,  G01N21/49 ,  G01N2201/1293 ,  Y10T436/10

Abstract: Systems and methods for establishing and/or maintaining the accuracy of a multivariate calibration model designed for quantitative optical spectroscopic measurement of attributes or analytes in bodily tissues, bodily fluids or other biological samples, which are particularly useful when the spectral absorbance of the attribute or analyte is small relative to the background. The present invention provides an optically similar reference sample to reduce the effect of instrument or environment variation on the measurement capability of the model. The optically similar reference can be a gel composition having scattering particles suspended therein. The reference gel can be directly applied to a spectroscopic instrument sampler, or can be in a container specifically designed for optimal coupling to a spectroscopic instrument.

Abstract translation: 用于建立和/或维持多变量校准模型的准确性的系统和方法，用于在身体组织，体液或其他生物样品中的属性或分析物的定量光谱测量，当属性或分析物的光谱吸收值特别有用时 相对于背景很小。 本发明提供光学相似的参考样品，以减少仪器或环境变化对模型测量能力的影响。 光学上相似的参考可以是具有悬浮在其中的散射颗粒的凝胶组合物。 参考凝胶可以直接应用于光谱仪器采样器，或者可以在专门设计用于最佳耦合到光谱仪器的容器中。

公开(公告)号：US20070030483A1

公开(公告)日：2007-02-08

申请号：US11196043

申请日：2005-08-03

Applicant: Matthew Everett ,  Yan Zhou ,  Jochen Horn ,  Keith O'Hara ,  James Foley

Inventor： Matthew Everett ,  Yan Zhou ,  Jochen Horn ,  Keith O'Hara ,  James Foley

IPC: G01J3/28

CPC classification number: G01N21/4795 ,  G01J3/02 ,  G01J3/0205 ,  G01J3/0208 ,  G01J3/0216 ,  G01J3/0224 ,  G01J3/0256 ,  G01J3/0286 ,  G01J3/18 ,  G01J3/22 ,  G02B5/1814 ,  G02B27/4244

Abstract: A compact conical diffraction Littrow spectrometer is disclosed. The distortion of the conically diffracted spectral component beams is compensated and as a result, the diffracted spectral beams can still be focused into a substantially straight line to shine onto a detector array. A spectral domain optical coherence tomography (SD-OCT) system incorporating a Littrow spectrometer or a spectrometer having one or more shared focusing element(s) and an SD-OCT system incorporating a spectrometer that is substantially polarization independent are also disclosed.

Abstract translation: 公开了一种紧凑的圆锥衍射Littrow光谱仪。 对锥形衍射光谱分量光束的失真进行补偿，结果衍射的光束束仍可被聚焦成基本上直线以照射到检测器阵列上。 还公开了包含Littrow光谱仪或具有一个或多个共享聚焦元件的光谱仪的光谱相干光学相干断层扫描（SD-OCT）系统和包含基本上偏振无关的光谱仪的SD-OCT系统。

公开(公告)号：US20060203213A1

公开(公告)日：2006-09-14

申请号：US11418348

申请日：2006-05-04

Applicant: Hiroyoshi Kobayashi

Inventor： Hiroyoshi Kobayashi

IPC: G03B27/00

CPC classification number: G01J3/50 ,  G01J3/0205 ,  G01J3/0216 ,  G01J3/10 ,  G01J3/501 ,  G01N21/251 ,  G01N2021/4742

Abstract: A multi-spectrum image capturing device includes a multi-spectrum illuminating device comprising LED's for emitting lights of different wavelengths from one another, a plurality of optical rods for relaying the lights emitted from the LED's, an optical diffusion element for diffusively reflecting the lights from the optical rods by a white diffusion surface and an aluminum-coated reflecting surface to be irradiated at an angle of about 60° with respect to an image-capturing optical axis, and an optical sheet for further diffusing the lights from the optical diffusion element, and also includes an image-capturing optical system and a CCD for forming an image based on lights reflected from an irradiated surface under illumination by the multi-spectrum illuminating device to capture the formed image. An image output captured by the CCD is analyzed to measure color components of the irradiated surface.

Abstract translation: 多光谱图像捕获装置包括：多光谱照明装置，包括用于发射彼此不同波长的光的LED，用于中继从LED发射的光的多个光棒;用于漫射反射光的光漫射元件 通过白色扩散表面的光学棒和相对于图像捕获光轴以约60°的角度照射的铝涂覆的反射表面，以及用于进一步扩散来自光学漫射元件的光的光学片， 并且还包括图像拍摄光学系统和CCD，用于通过多光谱照明装置在照射下从照射表面反射的光形成图像以捕获形成的图像。 分析由CCD捕获的图像输出来测量被照射表面的颜色分量。

公开(公告)号：US07079238B2

公开(公告)日：2006-07-18

申请号：US10437829

申请日：2003-05-13

Applicant: Mehdi Vaez-Iravani ,  Stanley Stokowski ,  Guoheng Zhao

Inventor： Mehdi Vaez-Iravani ,  Stanley Stokowski ,  Guoheng Zhao

IPC: G01N21/00

CPC classification number: G01J3/44 ,  G01J3/0216 ,  G01J3/0229 ,  G01N21/21 ,  G01N21/47 ,  G01N21/474 ,  G01N21/8806 ,  G01N21/94 ,  G01N21/9501 ,  G01N2021/8825 ,  G01N2021/8845 ,  G01N2021/8848 ,  G01N2201/065

Abstract: A curved mirrored surface is used to collect radiation scattered by a sample surface and originating from a normal illumination beam and an oblique illumination beam. The collected radiation is focused to a detector. Scattered radiation originating from the normal and oblique illumination beams may be distinguished by employing radiation at two different wavelengths, by intentionally introducing an offset between the spots illuminated by the two beams or by switching the normal and oblique illumination beams on and off alternately. Beam position error caused by change in sample height may be corrected by detecting specular reflection of an oblique illumination beam and changing the direction of illumination in response thereto. Butterfly-shaped spatial filters may be used in conjunction with curved mirror radiation collectors to restrict detection to certain azimuthal angles.

公开(公告)号：US07049597B2

公开(公告)日：2006-05-23

申请号：US10325129

申请日：2002-12-20

Applicant: Andrew Bodkin

Inventor： Andrew Bodkin

IPC: G01J5/08

CPC classification number: H04N5/332 ,  G01J3/02 ,  G01J3/0208 ,  G01J3/0216 ,  G01J3/027 ,  G01J3/0278 ,  G01J3/0289 ,  G01J3/36 ,  G01J5/06 ,  G01J5/602 ,  G01J2005/0077 ,  G01S7/4812 ,  G01S17/87 ,  G01S17/89 ,  G02B17/0808 ,  G02B17/0852 ,  G02B17/0896 ,  G02B23/12 ,  H04N5/33

Abstract: A common aperture, multi-mode optical imager for imaging electromagnetic radiation bands from a field of two or more different wavelengths is described. Fore-optics are provided to gather and direct electromagnetic radiation bands forming an image into an aperture of the multi-mode optical imager. The image is divided into two different wavelength bands, such as visible light and long-wave infrared. The first wavelength band (e.g., visible light) is detected by a first detector, such as a CCD array, for imaging thereof. The second wavelength band (e.g., long-wave infrared) is detected by a second detector, such as an uncooled microbolometer array, for imaging thereof. Additional optics may be provided for conditioning of the first and second wavelength bands, such as such as for changing the magnification, providing cold shielding, filtering, and/or further spectral separation.

公开(公告)号：US07016556B2

公开(公告)日：2006-03-21

申请号：US10868108

申请日：2004-06-15

Applicant: John Kai Andersen ,  Newton C. Frateschi

Inventor： John Kai Andersen ,  Newton C. Frateschi

IPC: G02B6/00

CPC classification number: H01S5/026 ,  G01J3/0205 ,  G01J3/0216 ,  G01J3/0259 ,  G01J3/12 ,  H01S5/0687

Abstract: An optical device includes an optical waveguide through which light propagates and a micro-resonator structure including an optical sensor. The micro-resonator is configured to resonate at a wavelength of light that may be transmitted through the optical waveguide. When light at that wavelength is transmitted through the optical waveguide, it resonates in the resonator and is detected by the optical sensor to produce an electrical signal. The optical resonator may be a micro-cylinder, disc or ring resonator and may be coupled to the waveguide via evanescent coupling or leaky-mode coupling. Multiple resonators may be implemented proximate to the waveguide to allow multiple wavelengths to be detected. When the waveguide is coupled to a tunable laser, signals provided by the optical sensor may be used to tune the wavelength of the laser.

公开(公告)号：US06995840B2

公开(公告)日：2006-02-07

申请号：US10384374

申请日：2003-03-06

Applicant: Thomas W. Hagler

Inventor： Thomas W. Hagler

IPC: G01J3/06

CPC classification number: G01J3/02 ,  G01J3/0202 ,  G01J3/0208 ,  G01J3/021 ,  G01J3/0216 ,  G01J3/0218 ,  G01J3/0229 ,  G01J3/027 ,  G01J3/0289 ,  G01J3/06 ,  G01J3/1804 ,  G01J3/2846 ,  G01J3/42 ,  G01J2001/4242 ,  G01J2003/1217

Abstract: Method and apparatus for analyzing radiation using analyzers and encoders employing the spatial modulation of radiation dispersed by wavelength or imaged along a line.

Abstract translation: 使用分析器和编码器分析辐射的方法和装置，其采用通过波长分散的辐射的空间调制或沿着线成像。

公开(公告)号：US20050270536A1

公开(公告)日：2005-12-08

申请号：US11144183

申请日：2005-06-02

Applicant: Ronny Ludwig

Inventor： Ronny Ludwig

IPC: G01D11/24 ,  G01J3/02 ,  G01J5/12 ,  G01N21/00 ,  G01N21/17 ,  G01N21/25 ,  G01N21/35 ,  G01N33/00

CPC classification number: G01J3/02 ,  G01J3/0216 ,  G01J3/0291 ,  G01N21/3518

Abstract: A spectroscopic gas sensor is provided, in particular to detect at least one gas component in the ambient air, and a method for the manufacture of a spectroscopic gas sensor of this type. The gas sensor includes the following: at least one radiation detection device for detecting a radiation spectrum that is characteristic for the at least one gas component; a package for receiving the at least one radiation detection device, having at least one package wall end section; and at least one optical component having at least one connecting section that is connectable to the at least one package wall end section by hot-caulking the at least one package wall end section.

Abstract translation: 提供了一种分光气体传感器，特别是用于检测环境空气中的至少一种气体成分，以及这种类型的分光气体传感器的制造方法。 气体传感器包括以下：用于检测对于至少一种气体成分具有特征的辐射光谱的至少一个辐射检测装置; 用于接收所述至少一个辐射检测装置的包装，具有至少一个包装壁端部; 以及具有至少一个连接部分的至少一个光学部件，所述至少一个连接部分可通过热铆接所述至少一个封装壁端部而连接到所述至少一个封装壁端部。

公开(公告)号：US20050219511A1

公开(公告)日：2005-10-06

申请号：US11118903

申请日：2005-04-29

Applicant: Wayne Jung ,  Russell Jung ,  Alan Loudermilk

Inventor： Wayne Jung ,  Russell Jung ,  Alan Loudermilk

IPC: G01J3/02 ,  G01J3/04 ,  G01J3/51 ,  G01N21/03

CPC classification number: G01J3/02 ,  G01J3/0205 ,  G01J3/0216 ,  G01J3/0218 ,  G01J3/0229 ,  G01J3/027 ,  G01J3/0272 ,  G01J3/0278 ,  G01J3/04 ,  G01J3/508 ,  G01J3/51 ,  G01J3/513 ,  G01J2003/2866 ,  G01N21/03

Abstract: Optical characteristic measuring systems and methods such as for determining the color or other optical characteristics of an object are disclosed. Perimeter receiver fiber optics are spaced apart from a source fiber optic and receive light from the surface of the object being measured. Light from the perimeter fiber optics pass to a variety of filters. The system utilizes the perimeter receiver fiber optics to determine information regarding the height and angle of the probe with respect to the object being measured. Under processor control, the optical characteristics measurement may be made at a predetermined height and angle. Various color spectral photometer arrangements are disclosed. Translucency, fluorescence, gloss and/or surface texture data also may be obtained. Audio feedback may be provided to guide operator use of the system. The probe may have a removable or shielded tip for contamination prevention. A method of producing prostheses based on measured data also is disclosed. Measured data also may be stored and/or organized as part of a data base.