公开(公告)号：US08482729B2

公开(公告)日：2013-07-09

申请号：US12885211

申请日：2010-09-17

Applicant: Robert A. Johnson ,  Michael D. Maher ,  Bryan J. Scheele ,  Roger W. Schmitz ,  Dustin L. Kasel

Inventor： Robert A. Johnson ,  Michael D. Maher ,  Bryan J. Scheele ,  Roger W. Schmitz ,  Dustin L. Kasel

IPC: G01J3/02

CPC classification number: G01J3/10 ,  G01J3/02 ,  G01J3/0218 ,  G01J3/0264 ,  G01J3/027 ,  G01J3/0275 ,  G01J3/0291

Abstract: Devices, systems, and methods for measuring tissue oxygen saturation are disclosed. An illustrative spectrometer for interfacing an optical sensor with a display unit includes a number of measurement radiation sources, a number of radiation source fibers each optically coupled to one of the measurement radiation sources, a reflected radiation fiber optically coupled to the optical sensor, a measurement radiation output fiber including an image fiber, and a radiation mixing bar intermediate the radiation source fibers and the measurement radiation output fiber.

Abstract translation: 公开了用于测量组织氧饱和度的装置，系统和方法。 用于将光学传感器与显示单元接口的说明性光谱仪包括多个测量辐射源，每个光学耦合到测量辐射源之一的多个辐射源光纤，与光学传感器光学耦合的反射辐射光纤， 包括图像光纤的辐射输出光纤和辐射源光纤和测量辐射输出光纤之间的辐射混合条。

公开(公告)号：US20130155405A1

公开(公告)日：2013-06-20

申请号：US13817821

申请日：2011-08-11

Applicant: Toshiro Kimura ,  Kazumi Yokota ,  Taro Osumi

Inventor： Toshiro Kimura ,  Kazumi Yokota ,  Taro Osumi

IPC: G01J3/02 ,  G01J3/42

CPC classification number: G01J3/027 ,  G01J3/08 ,  G01J3/42

Abstract: In order to provide a spectrophotometer, which can detect, by means of output intensity signals obtained by a photodetector, the entry of external light at the time of sample cell replacement and the like without providing a door with an opening/closing sensor or the like, a spectrophotometer (60) is provided with: a photodetector (12); a light blocking unit (41); a storage unit (34), which stores a light blocking period where light is blocked by means of the light blocking unit (41) and output intensity signals obtained by the photodetector (12) by corresponding the light blocking periods to the output intensity signals; and a control unit (31b), which calculates transmittance or light absorbance on the basis of the output intensity signals in the light blocking periods, said output intensity signals having been stored in the storage unit (34), and output intensity signals in light entry periods. The spectrophotometer is characterized in that the storage unit (34) stores a threshold for detecting the entry of external light into the photodetector (12), and that the control unit (31c) detects the entry of the external light into the photodetector (12) on the basis of the output intensity signals in the light blocking periods, and the threshold.

Abstract translation: 为了提供一种分光光度计，其可以通过光电检测器获得的输出强度信号来检测在样品池更换等时进入外部光，而不需要提供具有打开/关闭传感器等的门 ，分光光度计（60）设置有：光电检测器（12）; 遮光单元（41）; 存储单元（34），其将通过所述遮光单元（41）阻挡光的遮光时段和由所述光检测器（12）获得的输出强度信号相对应的所述遮光时段输出到所述输出强度信号; 以及控制单元（31b），其基于所述遮光期间中的输出强度信号计算透射率或吸光度，所述输出强度信号已被存储在所述存储单元（34）中，并且输出强度信号在光入口 时期。 分光光度计的特征在于，存储单元（34）存储用于检测外部光入射到光电检测器（12）中的阈值，并且控制单元（31c）检测外部光进入光电检测器（12） 基于遮光期间的输出强度信号和阈值。

公开(公告)号：US20130114083A1

公开(公告)日：2013-05-09

申请号：US13658118

申请日：2012-10-23

Applicant: SEIKO EPSON CORPORATION

Inventor： Akira SANO

IPC: G01J3/51 ,  G02B5/28

CPC classification number: G01J3/0297 ,  G01J3/027 ,  G01J3/10 ,  G01J3/26 ,  G01J3/32 ,  G01J3/42 ,  G01J2003/2879 ,  G02B26/001

Abstract: A spectroscopic measurement apparatus includes: a wavelength tunable interference filter including a fixed substrate having a fixed reflection film, a movable substrate having a movable reflection film, and an electrostatic actuator that changes a gap value of an inter-reflection-film gap by applying a voltage to bend the movable substrate; a detector that detects a light level; and a controller that measures a spectral characteristic of light under measurement. The controller includes a filter driver that applies a drive voltage to the electrostatic actuator to change the inter-reflection-film gap, a detected light level acquisition unit that acquires light levels detected by the detector, and a target light level acquisition unit that acquires a light level corresponding to an oscillation center of the movable substrate as a target light level based on how the detected light level transitions and a natural oscillation cycle that the movable substrate has.

Abstract translation: 一种分光测量装置包括：波长可调干涉滤光器，包括具有固定反射膜的固定基板，具有可移动反射膜的可移动基板和通过施加相互反射膜间隙来改变间隔反射膜间隙的间隙值的静电致动器 电压使可动基板弯曲; 一个检测光线的检测器; 以及测量测量光的光谱特性的控制器。 所述控制器包括滤波器驱动器，其向所述静电致动器施加驱动电压以改变所述反射间隙;检测光级获取单元，其获取由所述检测器检测到的光电平;以及目标光级获取单元， 基于检测到的光水平的过渡以及可动基板的固有振荡周期，将与可动基板的振荡中心对应的光水平作为目标光水平。

公开(公告)号：US08374801B2

公开(公告)日：2013-02-12

申请号：US12684495

申请日：2010-01-08

Applicant: Michael Fuhrman ,  Ryan Priore ,  Oksana Olkhovyk ,  Oksana Klueva

Inventor： Michael Fuhrman ,  Ryan Priore ,  Oksana Olkhovyk ,  Oksana Klueva

IPC: G01N31/00

CPC classification number: G01N15/0227 ,  G01J3/02 ,  G01J3/027 ,  G01J3/44 ,  G01N21/65

Abstract: A system and method for determining at least one geometric property of a particle in a sample. A sample is irradiated to thereby generate Raman scattered photons. These photons are collected to generate a Raman chemical image. A first threshold is applied wherein the first threshold is such that all particles in the sample are detected. A particle in the sample is selected and a second threshold is applied so that at least one geometric property of the selected particle can be determined. At least one spectrum representative of the selected particle is analyzed to determine whether or not it is a particle of interest. The step of determining a second threshold may be iterative and automated via software so that candidate second thresholds are applied until a satisfactory result is achieved.

Abstract translation: 用于确定样品中颗粒的至少一个几何性质的系统和方法。 照射样品从而产生拉曼散射光子。 收集这些光子以产生拉曼化学图像。 应用第一阈值，其中第一阈值使得检测样品中的所有颗粒。 选择样品中的颗粒并施加第二阈值，使得可以确定所选择的颗粒的至少一个几何性质。 分析代表所选粒子的至少一个光谱，以确定其是否是感兴趣的粒子。 确定第二阈值的步骤可以是经由软件的迭代和自动化，使得应用候选的第二阈值直到达到令人满意的结果。

公开(公告)号：US20130015331A1

公开(公告)日：2013-01-17

申请号：US13545999

申请日：2012-07-11

Applicant: Holger Birk ,  Volker Seyfried

Inventor： Holger Birk ,  Volker Seyfried

IPC: G01J1/44

CPC classification number: G01J3/027 ,  G01J1/0228 ,  G01J1/18 ,  G01J1/44 ,  G01J3/2803 ,  G01J3/36

Abstract: A device for detecting light includes at least one silicon photomultiplier (SiPM) having an array of a plurality of single-photon avalanche diodes (SPADs), the array being larger in area than an incident light. The device is configured so as to at least one of activate and analyze only the SPADs upon which a specific minimum intensity of light impinges.

Abstract translation: 用于检测光的装置包括具有多个单光子雪崩二极管（SPAD）的阵列的至少一个硅光电倍增管（SiPM），该阵列的面积大于入射光。 该设备被配置为仅激活和分析仅具有特定的最小光强度的SPAD的至少一个。

公开(公告)号：US20130010474A1

公开(公告)日：2013-01-10

申请号：US13617195

申请日：2012-09-14

Applicant: Andrew Bodkin

Inventor： Andrew Bodkin

IPC: F21V17/02 ,  F21V7/06 ,  F21V7/04 ,  F21V5/04 ,  F21V7/00

CPC classification number: G02B26/02 ,  G01J3/02 ,  G01J3/0208 ,  G01J3/0216 ,  G01J3/027 ,  G01J3/0278 ,  G01J3/0289 ,  G01J3/36 ,  G01J5/06 ,  G01J5/602 ,  G01J2005/0077 ,  G01S7/4812 ,  G01S17/87 ,  G01S17/89 ,  G02B3/0006 ,  G02B17/0808 ,  G02B17/0852 ,  G02B17/0896 ,  G02B23/12 ,  G02B26/0816 ,  G02B26/0875 ,  H04N5/33 ,  H04N5/332

Abstract: A shutter includes micro-optics having first and second concentrator arrays. A transducer laterally displaces one of the first and second concentrator arrays between transmissive and shuttered modes. In the transmissive mode, the arrays of concentrators are optically aligned to permit electromagnetic energy passing through the first array of concentrators to pass through the second array of concentrators. In the shuttered mode, the electromagnetic radiation is blocked from passing through the second array of concentrators. The concentrators may be compound parabolic concentrators, or lenslets positioned on opposing plates with pinholes printed therethrough. The shutter may increase f-number of radiation passing therethrough, and may be used in a limited f-cone radiation source with shuttering abilities, for example reducing f-cone of radiation output from the radiation source.

Abstract translation: 快门包括具有第一和第二集中器阵列的微光学器件。 换能器在透射和快门模式之间横向移位第一和第二聚光器阵列中的一个。 在透射模式中，聚光器阵列被光学对准以允许通过第一集中器阵列的电磁能量穿过第二阵列的聚光器。 在快门模式中，电磁辐射被阻止通过第二阵列的聚光器。 集中器可以是复合抛物面聚光器，或者位于相对的板上的小透镜，其中针孔印刷在其中。 快门可以增加通过其中的f数量的辐射，并且可以用于具有快门能力的有限的f-锥体辐射源，例如减小从辐射源输出的辐射的f锥。

公开(公告)号：US08325337B2

公开(公告)日：2012-12-04

申请号：US12668844

申请日：2008-07-14

Applicant: Joseph V. Sinfield ,  Oliver Colic

Inventor： Joseph V. Sinfield ,  Oliver Colic

IPC: G01J3/44 ,  C12M1/34 ,  G01N21/64

CPC classification number: G01J3/44 ,  G01J3/02 ,  G01J3/0202 ,  G01J3/021 ,  G01J3/0218 ,  G01J3/027 ,  G01J3/0291 ,  G01N21/64 ,  G01N21/65

Abstract: System, method, and apparatus for determining the composition of a sample of material. In one embodiment, the method pertains to the counting of photons that were inelastically scattered by the sample, and for minimizing the effects of fluorescent or phosphorescent photons. In yet another embodiment of the invention, a sample is illuminated by a repetitive pulse of monochromatic light, and the resultant scattered photons from the samples are collected and counted during a predetermined integration period. Yet other embodiments pertain to a low-cost, computer-controlled system for repetitively counting inelastically scattered photons so as to create a Raman histogram and a Raman spectrogram of the photons.

Abstract translation: 用于确定材料样品的组成的系统，方法和装置。 在一个实施方案中，该方法涉及由样品非弹性散射的光子的计数，并且用于使荧光或磷光光子的影响最小化。 在本发明的另一个实施例中，通过单色光的重复脉冲照射样品，并且在预定的积分期间收集并计数来自样品的所得散射光子。 其他实施例涉及用于重复计数非弹性散射的光子的低成本的计算机控制系统，以便产生光子的拉曼直方图和拉曼光谱图。

公开(公告)号：US20120268737A1

公开(公告)日：2012-10-25

申请号：US13541883

申请日：2012-07-05

Applicant: Victor Mazzio

Inventor： Victor Mazzio

IPC: G01J3/44

CPC classification number: G01J3/44 ,  G01J3/02 ,  G01J3/0202 ,  G01J3/0208 ,  G01J3/021 ,  G01J3/027 ,  G01J3/0291 ,  G01J3/4412

Abstract: An improved Raman microspectrometer system extends the optical reach and analysis range of an existing Raman microspectrometer to allow analysis and/or repair of an oversized sample. The improved Raman microspectrometer system includes an extender for extending the optical reach of the existing microspectrometer and a supplemental stage which extends the analysis range of the existing microspectrometer by providing travel capabilities for non-destructive analysis of an entire oversized sample. Such an arrangement decreases manufacturing costs associated with testing oversized samples such as mammography panels, enabling analysis and/or repair to be performed without destruction.

Abstract translation: 改进的拉曼显微光谱仪系统扩展了现有拉曼显微光谱仪的光学范围和分析范围，以便对超大样品进行分析和/或修复。 改进的拉曼显微光谱仪系统包括扩展器，用于扩展现有显微光度计的光学范围，以及补充级，通过提供用于整个超大样本的非破坏性分析的行进能力来扩展现有微光谱仪的分析范围。 这样的布置降低了与测试超大样本（例如乳房X线照相面板）相关联的制造成本，使得能够进行分解和/或修复而不破坏。

公开(公告)号：US20120257037A1

公开(公告)日：2012-10-11

申请号：US13439954

申请日：2012-04-05

Applicant: Valerica Raicu ,  Thomas John Mozer ,  Uwe Richard Muller

Inventor： Valerica Raicu ,  Thomas John Mozer ,  Uwe Richard Muller

IPC: H04N7/18 ,  G06K9/00

CPC classification number: G01J3/2803 ,  G01J3/027 ,  G01J3/0294 ,  G01J3/06 ,  G01J3/4406 ,  G01N15/1434 ,  G01N15/1463 ,  G01N15/1475 ,  G01N2015/1006 ,  G02B21/002 ,  G02B21/0076 ,  G02B21/16 ,  G02B27/0927 ,  G02B27/0983

Abstract: A system and method of implementing a two-stage scanning technique with a high-speed microscope. The microscope is operable to provide spectrally resolved, multi-dimensional images from a single scan of a sample. The microscope may include one of a multi-beam point scanning microscope, a single beam line scanning microscope, and a multi-beam line scanning microscope. The sample is first tagged such that, if the sample has a particular makeup, it emits energy at particular wavelengths upon receiving excitation beams. The microscope is used to perform a first, wide area scan. If the sample is determined to have emitted energy having particular characteristics, the microscope performs a second, focused scan of the area that emitted the energy having the particular characteristics. The two-stage scanning technique is automated and may be used to quickly identify rare cells, microbes, viruses, and other components within one or more samples.

Abstract translation: 用高速显微镜实现两级扫描技术的系统和方法。 显微镜可操作以从样品的单次扫描提供光谱分辨的多维图像。 显微镜可以包括多光束点扫描显微镜，单束线扫描显微镜和多光束线扫描显微镜中的一个。 样品首先被标记，使得如果样品具有特定的组成，则在接收到激发光束时，其以特定波长发射能量。 显微镜用于执行第一次广域扫描。 如果确定样品具有具有特定特征的发射能量，则显微镜对发射具有特定特征的能量的区域进行第二次聚焦扫描。 两级扫描技术是自动化的，可用于快速识别一个或多个样品中的稀有细胞，微生物，病毒和其他成分。

公开(公告)号：US08274725B2

公开(公告)日：2012-09-25

申请号：US12880818

申请日：2010-09-13

Applicant: Andrew Bodkin

Inventor： Andrew Bodkin

IPC: G02B26/02

CPC classification number: G02B26/02 ,  G01J3/02 ,  G01J3/0208 ,  G01J3/0216 ,  G01J3/027 ,  G01J3/0278 ,  G01J3/0289 ,  G01J3/36 ,  G01J5/06 ,  G01J5/602 ,  G01J2005/0077 ,  G01S7/4812 ,  G01S17/87 ,  G01S17/89 ,  G02B3/0006 ,  G02B17/0808 ,  G02B17/0852 ,  G02B17/0896 ,  G02B23/12 ,  G02B26/0816 ,  G02B26/0875 ,  H04N5/33 ,  H04N5/332

Abstract: A shutter includes micro-optics having first and second concentrator arrays. A transducer laterally displaces one of the first and second concentrator arrays between transmissive and shuttered modes. In the transmissive mode, the arrays of concentrators are optically aligned to permit electromagnetic energy passing through the first array of concentrators to pass through the second array of concentrators. In the shuttered mode, the electromagnetic radiation is blocked from passing through the second array of concentrators. The concentrators may be compound parabolic concentrators, or lenslets positioned on opposing plates with pinholes printed therethrough. The shutter may increase f-number of radiation passing therethrough, and may be used in a limited f-cone radiation source with shuttering abilities, for example reducing f-cone of radiation output from the radiation source.

Abstract translation: 快门包括具有第一和第二聚光器阵列的微光学器件。 换能器在透射和快门模式之间横向移位第一和第二聚光器阵列中的一个。 在透射模式中，聚光器阵列被光学对准以允许通过第一集中器阵列的电磁能量穿过第二阵列的聚光器。 在快门模式中，电磁辐射被阻止通过第二阵列的聚光器。 集中器可以是复合抛物面聚光器，或者位于相对的板上的小透镜，其中针孔印刷在其中。 快门可以增加通过其中的f数量的辐射，并且可以用于具有快门能力的有限的f-锥体辐射源，例如减小从辐射源输出的辐射的f锥。