公开(公告)号：US07855788B2

公开(公告)日：2010-12-21

申请号：US11991542

申请日：2006-09-06

Applicant: Masafumi Ito ,  Norihiko Nishizawa ,  Masaru Hori ,  Toshio Goto ,  Hiroyuki Kano

Inventor： Masafumi Ito ,  Norihiko Nishizawa ,  Masaru Hori ,  Toshio Goto ,  Hiroyuki Kano

IPC: G01B9/02 ,  G01J3/45

CPC classification number: G01N21/39 ,  G01J3/02 ,  G01J3/0218 ,  G01J3/0224 ,  G01J3/10 ,  G01J3/42 ,  G01J2001/4242 ,  G01N2201/0697 ,  G02B6/2861

Abstract: To achieve an apparatus capable of measuring a light absorption coefficient f a sample with high sensitivity. A ring down spectroscope uses a wavelength-variable femtosecond soliton pulse light source 1. Pulse light is input to a loop optical fiber 6 through a first light waveguide 4 and a wavelength selective switch 5. Ring down pulse light is input to a homodyne detector through the wavelength selective switch 5. On the other hand, pulse light propagating in the first light waveguide 4 is split and input to light waveguides constituting a second light waveguide 20 through an optical directional coupler 8 and a first optical switching element 12. The pulse light propagating in the second light waveguide 20 is input to the homodyne detector as reference light and used for synchronous detection. The plural light waveguides constituting the second light waveguide 20 differ in optical length in accordance with the length of the optical fiber 6, and can slightly change the optical length.

Abstract translation: 实现能够以高灵敏度测量样品的光吸收系数f的装置。 环形光谱仪使用波长可变飞秒激光脉冲光源1.脉冲光通过第一光波导4和波长选择开关5输入到环形光纤6中。环形脉冲光通过 波长选择开关5.另一方面，在第一光波导4中传播的脉冲光通过光学定向耦合器8和第一光开关元件12被分离并输入到构成第二光波导20的光波导上。脉冲光 在第二光波导20中传播的信号被输入到零差检测器作为参考光，并用于同步检测。 构成第二光波导路20的多个光波导根据光纤6的长度的光学长度不同，并且可以稍微改变光学长度。

公开(公告)号：US20100280762A1

公开(公告)日：2010-11-04

申请号：US12834370

申请日：2010-07-12

Applicant: John Maier ,  Shona Stewart ,  Jeffrey Cohen

Inventor： John Maier ,  Shona Stewart ,  Jeffrey Cohen

IPC: G01J3/44 ,  G06F19/00 ,  G01N33/48

CPC classification number: G01J3/10 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/417 ,  A61B5/7264 ,  G01J3/02 ,  G01J3/0291 ,  G01J3/0294 ,  G01J3/2823 ,  G01J3/32 ,  G01J3/44 ,  G01J2003/2826 ,  G01N21/65 ,  G01N21/658 ,  G01N2021/656 ,  G01N2201/1293 ,  G01N2201/1296 ,  G02B21/365 ,  G06F19/00 ,  G16H50/70

Abstract: A system and method for determining at least one of: a disease state, a metabolic state, a clinical outcome, and a disease progression of a test renal or prostate sample. A test Raman data set is obtained from the sample wherein said test Raman data set may comprise at least one of a plurality of Raman spectra and a plurality of spatially accurate wavelength resolved Raman images. The test Raman data set is compared to a plurality of reference Raman data sets using a chemometric technique. For analysis of renal samples, each of these reference Raman data sets may have an associated known renal sample and an associated known metabolic state, clinical outcome, and/or disease progression. For analysis of prostate samples, each of these reference Raman data sets may have an associated known prostate sample and an associated known disease state, metabolic state, clinical outcome, and/or disease progression.

Abstract translation: 用于确定测试的肾或前列腺样品的疾病状态，代谢状态，临床结果和疾病进展中的至少一个的系统和方法。 从样品获得测试拉曼数据集，其中所述测试拉曼数据集可以包括多个拉曼光谱和多个空间上准确的波长分辨拉曼图像中的至少一个。 使用化学计量技术将测试拉曼数据集与多个参考拉曼数据集进行比较。 对于肾样品的分析，这些参考拉曼数据集中的每一个可以具有相关联的已知肾样品和相关联的已知代谢状态，临床结果和/或疾病进展。 对于前列腺样品的分析，这些参考拉曼数据集中的每一个可以具有相关联的已知前列腺样品和相关的已知疾病状态，代谢状态，临床结果和/或疾病进展。

公开(公告)号：US07826728B2

公开(公告)日：2010-11-02

申请号：US11486455

申请日：2006-07-13

Applicant: Osamu Konno ,  Yasuhiro Komiya ,  Toru Wada ,  Nobumasa Sato

Inventor： Osamu Konno ,  Yasuhiro Komiya ,  Toru Wada ,  Nobumasa Sato

IPC: G03B15/03 ,  G03B29/00 ,  A61B1/04

CPC classification number: G01J3/50 ,  A61B5/0013 ,  A61B5/4547 ,  G01J3/02 ,  G01J3/0218 ,  G01J3/0224 ,  G01J3/0264 ,  G01J3/0272 ,  G01J3/0291 ,  G01J3/10 ,  G01J3/501 ,  G01J3/508 ,  G01J3/51 ,  G06F19/00

Abstract: The image processing system is applied to dentistry, for example, and performs photography of the teeth of a patient while causing a plurality of illumination light LEDs of different wavelengths to emit light by means of a photography device when producing a crown repair or denture of the patient, whereby image data are acquired. The image data are transmitted to a dental filing system constituting a processing device where color reproduction data are determined through computation. In addition, color reproduction data are transmitted to the dental technician's office via a public switched network. Therefore, a repair material compound ratio calculation database is searched and the compound data for a material that matches the hue of the patient's teeth are found, whereby a crown repair or denture or the like that very closely matches the color of the patient's teeth is produced.

Abstract translation: 例如，图像处理系统应用于牙科，并且当产生多个不同波长的照明光LED时，通过摄影装置在产生冠状修复或义齿的同时使患者的牙齿进行摄影 患者，从而获得图像数据。 图像数据被发送到构成通过计算确定颜色再现数据的处理装置的牙科用品系统。 此外，通过公共交换网络将颜色再现数据发送到牙科技师的办公室。 因此，搜索修复材料复合比率计算数据库，并且找到与患者牙齿的色调相匹配的材料的复合数据，由此产生与患者牙齿的颜色非常接近匹配的牙冠修复或义齿等 。

公开(公告)号：US20100254415A1

公开(公告)日：2010-10-07

申请号：US12700552

申请日：2010-02-04

Applicant: Wang-Yuhl Oh ,  Benjamin J. Vakoc ,  Guillermo J. Tearney ,  Brett E. Bouma

Inventor： Wang-Yuhl Oh ,  Benjamin J. Vakoc ,  Guillermo J. Tearney ,  Brett E. Bouma

IPC: H01S3/10 ,  G21G4/00

CPC classification number: H01S3/08009 ,  G01J3/10 ,  H01S3/08013 ,  H01S3/08059 ,  H01S3/0813 ,  H01S3/083 ,  H01S3/105 ,  H01S5/005 ,  H01S5/06216 ,  H01S5/141

Abstract: Exemplary embodiments of apparatus, source arrangement and method for, e.g., providing high-speed wavelength tuning can be provided. According to one exemplary embodiment, at least one arrangement can be provided which is configured to emit an electromagnetic radiation that (i) has a spectrum whose mean frequency changes at an absolute rate that is greater than about 6000 (or 2000) terahertz per millisecond, (ii) whose mean frequency changes over a range that is greater than about 10 terahertz, and/or (iii) has an instantaneous line width that is less than about 15 gigahertz. According to another exemplary embodiment, at least one arrangement can be provided configured to, periodically and as a function of time, select at least one first electro-magnetic radiation based on a mean frequency of the at least one first electro-magnetic radiation, with the periodic selection being performed at a first characteristic period. The mean frequency can vary linearly over time, wherein the apparatus can emit at least one second electromagnetic radiation that has a spectrum whose mean frequency changes periodically as a function of time with a second characteristic period. Further, the first characteristic period can be greater than the second characteristic period.

Abstract translation: 可以提供用于例如提供高速波长调谐的装置，源装置和方法的示例性实施例。 根据一个示例性实施例，可以提供至少一种布置，其被配置为发射电磁辐射，其中（i）具有平均频率以大于每毫秒大约6000（或2000）太赫兹的绝对速率变化的频谱， （ii）其平均频率在大于约10太赫兹的范围内变化，和/或（iii）具有小于约15千兆赫兹的瞬时线宽。 根据另一示例性实施例，可以提供至少一种布置，其被配置为周期性地和作为时间的函数，基于所述至少一个第一电磁辐射的平均频率选择至少一个第一电磁辐射， 在第一特征周期执行周期性选择。 平均频率可以随时间线性变化，其中该装置可以发射至少一个第二电磁辐射，其具有在第二特征周期内平均频率作为时间的函数周期性地改变的频谱。 此外，第一特征周期可以大于第二特征周期。

公开(公告)号：US20100254414A1

公开(公告)日：2010-10-07

申请号：US12627918

申请日：2009-11-30

Applicant: Brett Bouma ,  Seok-Hyun (Andy) Yun ,  Wang-Yuhl (William) Oh ,  Johannes deBoer ,  Guillermo Tearney

Inventor： Brett Bouma ,  Seok-Hyun (Andy) Yun ,  Wang-Yuhl (William) Oh ,  Johannes deBoer ,  Guillermo Tearney

IPC: H01S3/10

CPC classification number: G01J3/10 ,  A61B5/0059 ,  A61B5/0066 ,  G01B9/02004 ,  G01B9/02091 ,  G01J3/12 ,  G01J9/0215 ,  G01N21/4795 ,  G02B27/48 ,  H01S3/08009 ,  H01S3/08063 ,  H01S3/105 ,  H01S5/141 ,  H01S5/146 ,  H01S5/4087

Abstract: An apparatus and source arrangement for filtering an electromagnetic radiation can be provided which may include at least one spectral separating arrangement configured to physically separate one or more components of the electromagnetic radiation based on a frequency of the electromagnetic radiation. The apparatus and source arrangement may also have at least one continuously rotating optical arrangement which is configured to receive at least one signal that is associated with the one or more components. Further, the apparatus and source arrangement can include at least one beam selecting arrangement configured to receive the signal.

Abstract translation: 可以提供用于过滤电磁辐射的装置和源装置，其可以包括至少一个光谱分离装置，其被配置为基于电磁辐射的频率物理地分离电磁辐射的一个或多个部件。 装置和源装置还可以具有至少一个连续旋转的光学布置，其被配置为接收与一个或多个部件相关联的至少一个信号。 此外，装置和源装置可以包括被配置为接收信号的至少一个波束选择装置。

公开(公告)号：US20100246610A1

公开(公告)日：2010-09-30

申请号：US12582667

申请日：2009-10-20

Applicant: Sergey B. Mirov ,  Vladimir V. Fedorov ,  Igor Moskalev

Inventor： Sergey B. Mirov ,  Vladimir V. Fedorov ,  Igor Moskalev

IPC: H01S3/11 ,  H01S3/10

CPC classification number: G01N21/1702 ,  C30B29/48 ,  C30B31/00 ,  C30B31/02 ,  G01J3/10 ,  G01N21/39 ,  G01N2021/1704 ,  G01N2021/399 ,  G02F1/39 ,  G02F2001/392 ,  H01S3/0014 ,  H01S3/0604 ,  H01S3/0627 ,  H01S3/08009 ,  H01S3/08086 ,  H01S3/094038 ,  H01S3/094042 ,  H01S3/094061 ,  H01S3/09415 ,  H01S3/10092 ,  H01S3/1055 ,  H01S3/113 ,  H01S3/161 ,  H01S3/162 ,  H01S3/1623 ,  H01S3/1628 ,  H01S3/2308 ,  H01S3/2375 ,  H01S3/2383 ,  H01S2301/04

Abstract: An optical nose for detecting the presence of molecular contaminants in gaseous samples utilizes a tunable seed laser output in conjunction with a pulsed reference laser output to generate a mid-range IR laser output in the 2 to 20 micrometer range for use as a discriminating light source in a photo-acoustic gas analyzer.

Abstract translation: 用于检测气态样品中分子污染物的存在的光学鼻子利用可调谐种子激光器输出结合脉冲参考激光输出，以产生2至20微米范围内的中等范围IR激光输出，用作鉴别光源 在光声气体分析仪中。

公开(公告)号：US07800753B1

公开(公告)日：2010-09-21

申请号：US12399743

申请日：2009-03-06

Applicant: William F. Hug ,  Ray D. Reid

Inventor： William F. Hug ,  Ray D. Reid

IPC: G01J3/44

CPC classification number: G01N21/65 ,  G01J3/10 ,  G01J3/36 ,  G01J3/44 ,  G01N21/645 ,  G01N27/44721 ,  G01N2021/6421 ,  G01N2021/6471 ,  G01N2201/0612 ,  G01N2201/067

Abstract: Spectroscopic chemical analysis methods and apparatus are disclosed which employ deep ultraviolet (e.g. in the 200 nm to 300 nm spectral range) electron beam pumped wide bandgap semiconductor lasers, incoherent wide bandgap semiconductor light emitting devices, and hollow cathode metal ion lasers to perform non-contact, non-invasive detection of unknown chemical analytes. These deep ultraviolet sources enable dramatic size, weight and power consumption reductions of chemical analysis instruments. Chemical analysis instruments employed in some embodiments include capillary and gel plane electrophoresis, capillary electrochromatography, high performance liquid chromatography, flow cytometry, flow cells for liquids and aerosols, and surface detection instruments. In some embodiments, Raman spectroscopic detection methods and apparatus use ultra-narrow-band angle tuning filters, acousto-optic tuning filters, and temperature tuned filters to enable ultra-miniature analyzers for chemical identification. In some embodiments Raman analysis is conducted simultaneously with native fluorescence spectroscopy to provide high levels of sensitivity and specificity in the same instrument.

Abstract translation: 公开了使用深紫外线（例如在200nm至300nm光谱范围内）的电子束泵浦宽带隙半导体激光器，非相干宽带隙半导体发光器件和空心阴极金属离子激光器的光谱化学分析方法和装置， 接触，未知化学分析物的非侵入性检测。 这些深紫外线源可以显着降低化学分析仪器的体积，重量和功耗。 在一些实施方案中使用的化学分析仪器包括毛细管和凝胶平面电泳，毛细管电色谱，高效液相色谱，流式细胞术，液体和气溶胶流动池以及表面检测仪器。 在一些实施例中，拉曼光谱检测方法和装置使用超窄带角度调谐滤波器，声光调谐滤波器和温度调节滤波器，以使超微型分析仪能够进行化学鉴定。 在一些实施方案中，拉曼分析与天然荧光光谱同时进行，以在同一仪器中提供高水平的灵敏度和特异性。

公开(公告)号：US07787728B2

公开(公告)日：2010-08-31

申请号：US10599233

申请日：2005-02-02

Applicant: Bernard Patrick Masterson ,  Eric C. Huelson ,  Ian S. Smith

Inventor： Bernard Patrick Masterson ,  Eric C. Huelson ,  Ian S. Smith

IPC: G02B6/02

CPC classification number: G01J3/433 ,  G01J3/02 ,  G01J3/0218 ,  G01J3/0297 ,  G01J3/10 ,  G01J3/42 ,  G01N21/39

Abstract: An optical mode noise averaging device including a multimode optical fiber and means for averaging a modal noise induced signal level variation of light propagating within the multimode optical fiber. The device may average modal noise induced signal level variations by cyclically varying an index of refraction of the multimode optical fiber over a select period of time, scrambling a light distribution within the multimode optical fiber, or both. The index of refraction of the multimode optical fiber may be cyclically varied by cyclically varying the temperature of the multimode optical fiber. Alternatively, the index for refraction may be varied or the light distribution within the multimode optical fiber may be scrambled by cyclically manipulating the multimode optical fiber.

Abstract translation: 一种包括多模光纤的光模式噪声平均装置和用于平均在多模光纤内传播的光的模态噪声感应信号电平变化的装置。 该器件可以通过在选择的时间周期周期性地改变多模光纤的折射率，扰乱多模光纤内的光分布，或两者来均衡模态噪声感应信号电平变化。 多模光纤的折射率可以通过周期性地改变多模光纤的温度来循环地变化。 或者，可以改变折射率，或者通过循环地操作多模光纤可以扰乱多模光纤内的光分布。

公开(公告)号：US07787120B2

公开(公告)日：2010-08-31

申请号：US12146920

申请日：2008-06-26

Applicant: Motohiro Yamazaki ,  Ryoji Inaba ,  Kosaku Toyosaki ,  Shintaro Kubo ,  Takashi Gomi ,  Katsunobu Hama ,  Kiyotoshi Mori ,  Hideyuki Akiyama

Inventor： Motohiro Yamazaki ,  Ryoji Inaba ,  Kosaku Toyosaki ,  Shintaro Kubo ,  Takashi Gomi ,  Katsunobu Hama ,  Kiyotoshi Mori ,  Hideyuki Akiyama

IPC: G01J3/10 ,  G01J3/36 ,  G01N21/33

CPC classification number: G01J3/10 ,  G02B5/283 ,  G02B27/1006 ,  G02B27/1086 ,  G02B27/145 ,  G02B27/148

Abstract: Detection sensitivity is improved by increasing the amount of light of beams that irradiate a sample cell without causing saturation of a detector with ultraviolet beams or visible beams. This spectrophotometer includes a sample cell, which stores a sample to be measured, a visible light source and an ultraviolet light source each for supplying an incident beam that enters the sample, a spectroscope, which disperses a beam that has passed through the sample, an optical detector, which detects beams dispersed from such beam (spectrum), and a dichroic element which reflects or transmits ultraviolet beams from the ultraviolet light source and which transmits or reflects visible beams from the visible light source. Optics are configured such that ultraviolet beams and visible beams that have passed through or have been reflected by the dichroic element enter the sample cell.

Abstract translation: 通过增加照射样品池的光束的光量而不会使紫外线束或可见光束的检测器饱和而提高检测灵敏度。 该分光光度计包括存储待测样品，可见光源和紫外光源的样品池，每个用于提供进入样品的入射光束，分散已经通过样品的光束的分光器， 检测从这种光束（光谱）分散的光束的光检测器，以及从紫外光源反射或透射紫外光束并从可见光源透射或反射可见光束的二向色元件。 光学构造使得已经通过或已被二色性元件反射的紫外光束和可见光束进入样品池。

公开(公告)号：US20100208275A1

公开(公告)日：2010-08-19

申请号：US12770379

申请日：2010-04-29

Applicant: Noam BABAYOFF

Inventor： Noam BABAYOFF

IPC: G01B11/24 ,  H04N7/18

CPC classification number: H04N13/15 ,  A61B1/00009 ,  A61B1/00096 ,  A61B1/0615 ,  A61B1/0638 ,  A61B1/0646 ,  A61B1/0676 ,  A61B1/0684 ,  A61B1/24 ,  A61B1/247 ,  A61B5/0068 ,  A61B5/0088 ,  A61B5/1077 ,  A61B5/1079 ,  A61C9/0053 ,  A61C9/0066 ,  A61C19/04 ,  G01B11/24 ,  G01B11/25 ,  G01J3/02 ,  G01J3/0205 ,  G01J3/0208 ,  G01J3/0216 ,  G01J3/0218 ,  G01J3/0224 ,  G01J3/0243 ,  G01J3/0256 ,  G01J3/10 ,  G01J3/462 ,  G01J3/50 ,  G01J3/501 ,  G01J3/508 ,  G01J3/51 ,  G01N21/255 ,  G06F19/00 ,  G06T7/0012 ,  G06T7/12 ,  G06T7/90 ,  G06T2207/10024 ,  G06T2207/10028 ,  G06T2207/30036 ,  H01L27/14868 ,  H04N13/207 ,  H04N13/257 ,  H04N13/271 ,  H04N13/296

Abstract: Provided is a device for determining the surface topology and associated color of a structure, such as a teeth segment, including a scanner for providing depth data for points along a two-dimensional array substantially orthogonal to the depth direction, and an image acquisition means for providing color data for each of the points of the array, while the spatial disposition of the device with respect to the structure is maintained substantially unchanged. A processor combines the color data and depth data for each point in the array, thereby providing a three-dimensional color virtual model of the surface of the structure. A corresponding method for determining the surface topology and associated color of a structure is also provided.

Abstract translation: 提供了一种用于确定诸如齿段的结构的表面拓扑结构和相关联颜色的装置，所述结构包括扫描器，用于为沿着与深度方向基本正交的二维阵列的点提供深度数据;以及图像获取装置， 为阵列的每个点提供颜色数据，同时相对于结构的设备的空间布置基本上保持不变。 处理器组合阵列中每个点的颜色数据和深度数据，从而提供结构表面的三维颜色虚拟模型。 还提供了用于确定结构的表面拓扑和相关联颜色的相应方法。