公开(公告)号：US11031223B2

公开(公告)日：2021-06-08

申请号：US15764791

申请日：2016-09-22

Applicant: Micromass UK Limited

Inventor： Steven Derek Pringle ,  Lajos Godorhazy ,  Daniel Simon ,  Daniel Szalay ,  Zoltan Takats ,  Tamas Karancsi

IPC: H01J49/04 ,  G01N33/483 ,  G01N21/31 ,  G01N21/65

Abstract: A method of analysis is disclosed comprising providing a sample on an insulating substrate such as a petri dish (4) and contacting e.g. the rear surface of the insulating substrate with a first electrode (9). The method further comprises contacting the sample with a second electrode (2) and applying an AC or RF voltage to the first and second electrodes (9,2) in order to generate an aerosol from the sample.

公开(公告)号：US11031222B2

公开(公告)日：2021-06-08

申请号：US15556064

申请日：2016-03-07

Applicant: Micromass UK Limited

Inventor： Steven Derek Pringle ,  Emrys Jones ,  Michael Raymond Morris ,  Julia Balog ,  James Ian Langridge ,  Keith Richardson ,  Daniel Simon ,  Lajos Godorhazy ,  Daniel Szalay ,  Zoltan Takats

IPC: G01N33/92 ,  G01N3/00 ,  G01N9/00 ,  A61B90/13 ,  H01J49/04 ,  A61B10/02 ,  A61B17/32 ,  A61B18/00 ,  A61B18/14 ,  A61B18/20 ,  G01N33/68 ,  H01J49/00 ,  H01J49/06 ,  H01J49/16 ,  A61B1/04 ,  A61B1/273 ,  A61B5/00 ,  A61B5/01 ,  A61B5/0507 ,  A61B5/055 ,  A61B6/03 ,  A61B8/13 ,  A61B10/00 ,  A61B17/00 ,  A61B18/04 ,  A61B18/18 ,  A61F13/38 ,  C12Q1/02 ,  C12Q1/04 ,  C12Q1/18 ,  C12Q1/24 ,  G01N1/22 ,  G01N27/622 ,  G01N27/624 ,  G01N30/72 ,  G01N33/487 ,  H01J49/02 ,  H01J49/10 ,  H01J49/14 ,  H01J49/24 ,  H01J49/26 ,  G16B20/00 ,  G16H10/40 ,  G16H15/00 ,  G16H50/20 ,  A61B1/00 ,  A61B1/31 ,  A61B5/145 ,  G06F19/00

Abstract: A method is disclosed comprising obtaining or acquiring chemical or other non-mass spectrometric data from one or more regions of a target using a chemical sensor. The chemical or other non-mass spectrometric data may be used to determine one or more regions of interest of the target. An ambient ionisation ion source may then be used to generate aerosol, smoke or vapour from one or more regions of the target.

公开(公告)号：US10959708B2

公开(公告)日：2021-03-30

申请号：US16459021

申请日：2019-07-01

Applicant: Micromass UK Limited

Inventor： Zoltan Takats

IPC: A61B10/02 ,  G01N1/02 ,  H01J49/16 ,  G01N27/62 ,  G01N1/04 ,  G01N1/28 ,  H01J49/04

Abstract: The present invention provides for a system, method, and device for analyzing, localizing and/or identifying tissue types. The method includes analyzing, localizing and/or identifying one or more tissue samples, characterized in that the method comprises: (a) generating gaseous tissue particles from a site in the one or more tissue samples, (b) transporting the gaseous tissue particles from the site to an analyser, (c) using the analyser for generating tissue-related data based on the gaseous tissue particles, and (d) analyzing, localizing and/or identifying the one or more tissue samples based on the tissue-related data. The invention can either be used in close conjunction with a surgical procedure, when one or more surgical tools are an integrated part of ionization, or as a separate mass spectrometric probe for the analysis of one or more tissue parts.

公开(公告)号：US10777398B2

公开(公告)日：2020-09-15

申请号：US15555860

申请日：2016-03-07

Applicant: Micromass UK Limited

Inventor： Keith Richardson ,  Steven Derek Pringle ,  Julia Balog ,  Zoltan Takats

IPC: H01J49/00 ,  H01J49/04 ,  A61B10/02 ,  A61B17/32 ,  A61B18/00 ,  A61B18/14 ,  A61B18/20 ,  G01N3/00 ,  G01N9/00 ,  G01N33/68 ,  H01J49/06 ,  H01J49/16 ,  A61B90/13 ,  A61B1/04 ,  A61B1/273 ,  A61B5/00 ,  A61B5/01 ,  A61B5/05 ,  A61B5/055 ,  A61B6/03 ,  A61B8/13 ,  A61B10/00 ,  A61B17/00 ,  A61B18/04 ,  A61B18/18 ,  A61F13/38 ,  C12Q1/02 ,  C12Q1/04 ,  C12Q1/18 ,  C12Q1/24 ,  G01N1/22 ,  G01N27/62 ,  G01N30/72 ,  G01N33/487 ,  G01N33/92 ,  H01J49/02 ,  H01J49/10 ,  H01J49/14 ,  H01J49/26 ,  G16B20/00 ,  G16H10/40 ,  G16H15/00 ,  G16H50/20 ,  A61B1/00 ,  A61B1/31 ,  A61B5/145 ,  G06F19/00

Abstract: A method of spectrometric analysis comprises obtaining one or more sample spectra for an aerosol, smoke or vapour sample. The one or more sample spectra are subjected to pre-processing and then multivariate and/or library based analysis so as to classify the aerosol, smoke or vapour sample. The results of the analysis are used for various surgical or non-surgical applications.

公开(公告)号：US10504709B2

公开(公告)日：2019-12-10

申请号：US15554626

申请日：2016-03-07

Applicant: Micromass UK Limited

Inventor： Tamas Karancsi ,  Lajos Godorhazy ,  Daniel Szalay ,  Zoltan Takats ,  Julia Balog ,  Steven Derek Pringle ,  Daniel Simon

IPC: H01J49/00 ,  H01J49/04 ,  A61B90/13 ,  A61B1/04 ,  A61B1/273 ,  A61B5/00 ,  A61B5/01 ,  A61B5/05 ,  A61B5/055 ,  A61B6/03 ,  A61B8/13 ,  A61B10/00 ,  A61B10/02 ,  A61B17/00 ,  A61B17/32 ,  A61B18/00 ,  A61B18/04 ,  A61B18/14 ,  A61B18/18 ,  A61B18/20 ,  A61F13/38 ,  C12Q1/02 ,  C12Q1/04 ,  C12Q1/18 ,  C12Q1/24 ,  G01N1/22 ,  G01N3/00 ,  G01N9/00 ,  G01N27/62 ,  G01N30/72 ,  G01N33/487 ,  G01N33/68 ,  G01N33/92 ,  H01J49/02 ,  H01J49/06 ,  H01J49/10 ,  H01J49/14 ,  H01J49/16 ,  H01J49/24 ,  H01J49/26 ,  G16B20/00 ,  G16H10/40 ,  G16H15/00 ,  G16H50/20 ,  A61B1/00 ,  A61B1/31 ,  A61B5/145 ,  G06F19/00

Abstract: An apparatus for mass spectrometry and/or ion mobility spectrometry is disclosed comprising a first device arranged and adapted to generate aerosol, smoke or vapor from a target and one or more second devices arranged and adapted to aspirate aerosol, smoke, vapor and/or liquid to or towards an analyzer. A liquid trap or separator is provided to capture and/or discard liquid aspirated by the one or more second devices.

公开(公告)号：US20160247668A1

公开(公告)日：2016-08-25

申请号：US15050286

申请日：2016-02-22

Applicant: MICROMASS UK LIMITED

Inventor： Daniel Szalay ,  Lajos Godorhazy ,  Zoltan Takats

IPC: H01J49/14 ,  H01J49/04

CPC classification number: H01J49/142 ,  H01J49/0031 ,  H01J49/0445 ,  H01J49/0454 ,  H01J49/14 ,  H01J49/16

Abstract: According to some embodiments, systems and methods for surface impact ionization of liquid phase and aerosol samples are provided. The method includes accelerating a liquid or aerosol sample, colliding the sample with a solid collision surface thereby disintegrating the sample into both molecular ionic species (e.g., gaseous molecular ions) and molecular neutral species (e.g., gaseous sample), and transporting the disintegrated sample to an ion analyzer. Some embodiments of the method further comprise discarding the molecular neutral species. Such embodiments transport substantially only the molecular ionic species to the ion analyzer.

Abstract translation: 根据一些实施例，提供了液相和气溶胶样品的表面碰撞电离的系统和方法。 该方法包括加速液体或气溶胶样品，将样品与固体碰撞表面碰撞，从而将样品分解成分子离子物质（例如气态分子离子）和分子中性物质（例如气态样品），并将分解的样品 到离子分析仪。 该方法的一些实施方案还包括丢弃分子中性物质。 这样的实施例基本上只将分子离子物质转移到离子分析器。

公开(公告)号：US11710627B2

公开(公告)日：2023-07-25

申请号：US17558925

申请日：2021-12-22

Applicant: Micromass UK Limited

Inventor： Emrys Jones ,  Steven Derek Pringle ,  Keith Richardson ,  James Ian Langridge ,  Zoltan Takats

IPC: G01N30/72 ,  H01J49/04 ,  A61B10/02 ,  A61B18/00 ,  A61B18/14 ,  A61B18/20 ,  G01N3/00 ,  G01N9/00 ,  G01N33/68 ,  H01J49/00 ,  H01J49/06 ,  H01J49/16 ,  G16B20/50 ,  G01N27/623 ,  A61B90/13 ,  A61B1/04 ,  A61B1/273 ,  A61B5/00 ,  A61B5/01 ,  A61B5/0507 ,  A61B5/055 ,  A61B6/03 ,  A61B8/13 ,  A61B10/00 ,  A61B17/00 ,  A61B18/04 ,  A61B18/18 ,  A61F13/38 ,  C12Q1/02 ,  C12Q1/04 ,  C12Q1/18 ,  C12Q1/24 ,  G01N1/22 ,  G01N27/624 ,  G01N33/487 ,  G01N33/92 ,  H01J49/02 ,  H01J49/10 ,  H01J49/14 ,  H01J49/24 ,  H01J49/26 ,  G16B20/00 ,  A61B17/32 ,  G16H10/40 ,  G16H15/00 ,  G16H50/20 ,  A61B1/00 ,  A61B1/31 ,  A61B5/145

CPC classification number: H01J49/049 ,  A61B1/041 ,  A61B1/2736 ,  A61B5/0066 ,  A61B5/0075 ,  A61B5/015 ,  A61B5/055 ,  A61B5/0507 ,  A61B6/032 ,  A61B6/037 ,  A61B8/13 ,  A61B10/00 ,  A61B10/0041 ,  A61B10/0233 ,  A61B10/0283 ,  A61B17/00 ,  A61B18/00 ,  A61B18/04 ,  A61B18/042 ,  A61B18/14 ,  A61B18/1445 ,  A61B18/1815 ,  A61B18/20 ,  A61B90/13 ,  A61F13/38 ,  C12Q1/025 ,  C12Q1/04 ,  C12Q1/18 ,  C12Q1/24 ,  G01N1/2202 ,  G01N3/00 ,  G01N9/00 ,  G01N27/623 ,  G01N27/624 ,  G01N30/724 ,  G01N33/487 ,  G01N33/6848 ,  G01N33/6851 ,  G01N33/92 ,  G16B20/50 ,  H01J49/0004 ,  H01J49/0027 ,  H01J49/0031 ,  H01J49/0036 ,  H01J49/025 ,  H01J49/044 ,  H01J49/0404 ,  H01J49/0409 ,  H01J49/0422 ,  H01J49/0445 ,  H01J49/0459 ,  H01J49/0463 ,  H01J49/0468 ,  H01J49/061 ,  H01J49/068 ,  H01J49/10 ,  H01J49/14 ,  H01J49/16 ,  H01J49/164 ,  H01J49/24 ,  H01J49/26 ,  A61B1/00013 ,  A61B1/31 ,  A61B5/14542 ,  A61B17/320068 ,  A61B2010/0083 ,  A61B2017/320069 ,  A61B2018/00577 ,  A61B2018/00589 ,  A61B2018/00994 ,  A61B2218/002 ,  A61B2218/008 ,  G01N33/48735 ,  G01N2001/2223 ,  G01N2333/195 ,  G01N2405/00 ,  G01N2405/04 ,  G01N2405/08 ,  G01N2570/00 ,  G01N2800/26 ,  G16B20/00 ,  G16H10/40 ,  G16H15/00 ,  G16H50/20

Abstract: A method of analysis using mass spectrometry and/or ion mobility spectrometry is disclosed comprising: (a) using a first device to generate smoke, aerosol or vapour from a target in vitro or ex vivo cell population; (b) mass analysing and/or ion mobility analysing said smoke, aerosol or vapour, or ions derived therefrom, in order to obtain spectrometric data; and (c) analysing said spectrometric data in order to identify and/or characterise said target cell population or one or more cells and/or compounds present in said target cell population.

公开(公告)号：US11515136B2

公开(公告)日：2022-11-29

申请号：US17012865

申请日：2020-09-04

Applicant: Micromass UK Limited

Inventor： Keith Richardson ,  Steven Derek Pringle ,  Julia Balog ,  Zoltan Takats

IPC: H01J49/00 ,  H01J49/04 ,  A61B10/02 ,  A61B17/32 ,  A61B18/00 ,  A61B18/14 ,  A61B18/20 ,  G01N3/00 ,  G01N9/00 ,  G01N33/68 ,  H01J49/06 ,  H01J49/16 ,  A61B90/13 ,  A61B1/04 ,  A61B1/273 ,  A61B5/00 ,  A61B5/01 ,  A61B5/0507 ,  A61B5/055 ,  A61B6/03 ,  A61B8/13 ,  A61B10/00 ,  A61B17/00 ,  A61B18/04 ,  A61B18/18 ,  A61F13/38 ,  C12Q1/02 ,  C12Q1/04 ,  C12Q1/18 ,  C12Q1/24 ,  G01N1/22 ,  G01N27/622 ,  G01N27/624 ,  G01N30/72 ,  G01N33/487 ,  G01N33/92 ,  H01J49/02 ,  H01J49/10 ,  H01J49/14 ,  H01J49/24 ,  H01J49/26 ,  G16B20/00 ,  G16H10/40 ,  G16H15/00 ,  G16H50/20 ,  A61B1/00 ,  A61B1/31 ,  A61B5/145

Abstract: A method of spectrometric analysis comprises obtaining one or more sample spectra for an aerosol, smoke or vapour sample. The one or more sample spectra are subjected to pre-processing and then multivariate and/or library based analysis so as to classify the aerosol, smoke or vapour sample. The results of the analysis are used for various surgical or non-surgical applications.

公开(公告)号：US20220367166A1

公开(公告)日：2022-11-17

申请号：US17746308

申请日：2022-05-17

Applicant: Micromass UK Limited

Inventor： Zoltan Takats ,  Emrys Jones ,  James Ian Langridge ,  Michael Raymond Morris ,  Tamas Karancsi ,  Steven Derek Pringle ,  Julia Balog ,  Daniel Simon ,  Lajos Godorhazy ,  Daniel Szalay ,  Keith Richardson ,  Phillip Robert Bennett ,  David Alan Macintyre ,  Pamela Pruski

IPC: H01J49/04 ,  A61B10/02 ,  A61B17/32 ,  A61B18/00 ,  A61B18/14 ,  A61B18/20 ,  G01N3/00 ,  G01N9/00 ,  G01N33/68 ,  H01J49/00 ,  H01J49/06 ,  H01J49/16 ,  A61B90/13 ,  A61B1/04 ,  A61B1/273 ,  A61B5/00 ,  A61B5/01 ,  A61B5/0507 ,  A61B5/055 ,  A61B6/03 ,  A61B8/13 ,  A61B10/00 ,  A61B17/00 ,  A61B18/04 ,  A61B18/18 ,  A61F13/38 ,  C12Q1/02 ,  C12Q1/04 ,  C12Q1/18 ,  C12Q1/24 ,  G01N1/22 ,  G01N27/622 ,  G01N27/624 ,  G01N30/72 ,  G01N33/487 ,  G01N33/92 ,  H01J49/02 ,  H01J49/10 ,  H01J49/14 ,  H01J49/24 ,  H01J49/26

Abstract: A method is disclosed comprising providing a biological sample on a swab, directing a spray of charged droplets onto a surface of the swab in order to generate a plurality of analyte ions, and analysing the analyte ions.

公开(公告)号：US20220115222A1

公开(公告)日：2022-04-14

申请号：US17558925

申请日：2021-12-22

Applicant: Micromass UK Limited

Inventor： Emrys Jones ,  Steven Derek Pringle ,  Keith Richardson ,  James Ian Langridge ,  Zoltan Takats

IPC: H01J49/04 ,  A61B10/02 ,  H01J49/16 ,  G01N1/22 ,  G01N3/00 ,  G01N33/92 ,  H01J49/10 ,  H01J49/14 ,  G16B20/50 ,  A61B18/00 ,  A61B18/14 ,  A61B18/20 ,  H01J49/02 ,  H01J49/06 ,  A61B1/273 ,  A61B10/00 ,  C12Q1/04 ,  H01J49/00 ,  A61B5/01 ,  A61B5/055 ,  A61B17/00 ,  C12Q1/18 ,  G01N9/00 ,  A61B90/13 ,  A61B18/04 ,  C12Q1/24 ,  G01N33/68 ,  A61B5/00 ,  A61B6/03 ,  A61B8/13 ,  A61F13/38 ,  G01N30/72 ,  A61B5/0507 ,  G01N27/622 ,  H01J49/24 ,  H01J49/26 ,  A61B1/04 ,  A61B18/18 ,  G01N27/624 ,  G01N33/487 ,  C12Q1/02 ,  G16H15/00 ,  A61B1/31 ,  G16H50/20 ,  A61B17/32 ,  A61B1/00 ,  G16H10/40 ,  A61B5/145 ,  G16B20/00

Abstract: A method of analysis using mass spectrometry and/or ion mobility spectrometry is disclosed comprising: (a) using a first device to generate smoke, aerosol or vapour from a target in vitro or ex vivo cell population; (b) mass analysing and/or ion mobility analysing said smoke, aerosol or vapour, or ions derived therefrom, in order to obtain spectrometric data; and (c) analysing said spectrometric data in order to identify and/or characterise said target cell population or one or more cells and/or compounds present in said target cell population.