公开(公告)号：US11808704B2

公开(公告)日：2023-11-07

申请号：US15123965

申请日：2015-03-05

Applicant: ONE DROP DIAGNOSTICS SÀRL

Inventor： Luc Gervais ,  Jörg Ziegler ,  Nicolas Descharmes

IPC: G01N21/64 ,  G01N21/77 ,  B01L3/00 ,  G01N33/543

CPC classification number: G01N21/648 ,  B01L3/502715 ,  G01N21/6428 ,  G01N21/7703 ,  G01N21/7746 ,  G01N33/54306 ,  B01L2300/0627 ,  B01L2300/0654 ,  B01L2300/0816 ,  B01L2300/0877 ,  B01L2300/0887 ,  G01N2021/6439 ,  G01N2021/7736 ,  G01N2021/7786 ,  G01N2201/08

Abstract: An assay unit for carrying-out fluorescence-detected assays having a microfluidic chip with a microfluidic system to convey a sample or analyte solution through one or more microfluidic channels arranged on the chip, and a photonic system with two or more rectangular waveguide structures. The microfluidic channels and the waveguide structures cross each other at a detection site. In an assay area, where a certain microfluidic channel and a certain waveguide structure cross each other, one or more lateral surfaces of the core of the waveguide structure at least partially face an inner volume of the microfluidic channel, such that an evanescent field of light guided within the waveguide structure overlaps with a certain part of the inner volume of the microfluidic channel.

公开(公告)号：US20230349822A1

公开(公告)日：2023-11-02

申请号：US18303795

申请日：2023-04-20

Applicant: Drägerwerk AG & Co. KGaA

Inventor： Gerd PETER ,  Bernd-Michael DICKS ,  Robert JAHNS ,  Martin KROH ,  Lucas SCHNELLE

IPC: G01N33/497 ,  G01N21/03 ,  G01N21/31

CPC classification number: G01N21/31 ,  G01N21/0303 ,  G01N33/497 ,  G01N2201/0636 ,  G01N2201/08

Abstract: A gas measuring device (1000) for determining the concentration of a gas component in a breathing gas mixture includes a radiation source (1) with a illuminant (2) and a mirror arrangement (3) for emitting light radiation. A sample gas cuvette (5) is formed as a hollow body. A detector arrangement (15) with at least two bandpass filter elements (17, 18) and at least two detector elements (20, 21) receives the filtered light radiation. A control unit (42) is configured to detect signals from the detector elements (20, 21) and determine a concentration of a gas component in the breathing gas mixture. A light guide element (11) is provided in the form of a hollow body.

公开(公告)号：US20230333011A1

公开(公告)日：2023-10-19

申请号：US18024873

申请日：2021-09-15

Applicant: Agency for Science, Technology and Research

Inventor： Kapil Dev ,  Ruochong Zhang ,  Chi Lok Wong ,  Shuyan Zhang ,  Dinish Unnimadhava Kurup Soudamini Amma ,  Malini Carolene Devapiriyai Olivo

IPC: G01N21/3563 ,  G01N21/64 ,  G01N21/84 ,  G01N21/359

CPC classification number: G01N21/3563 ,  G01N21/6456 ,  G01N21/84 ,  G01N21/359 ,  G01N2201/062 ,  G01N2201/08 ,  G01N2021/8466

Abstract: An optical system for imaging. The optical system includes light emitting diodes to provide light of predetermined wavelengths. The optical system further includes a charge-coupled device to receive the light emitted by one or more light emitting diodes and reflected by an object for fluorescence imaging of the object. The optical system additionally includes a broadband light source to provide broadband light. Furthermore, the optical system includes a spectrometer to receive the broadband light emitted by the broadband light source and reflected by the object for visible-near infrared-shortwave infrared spectroscopy of the object. Additionally, the optical system includes a hyperspectral camera to receive the broadband light emitted by the broadband light source and reflected by the object for hyperspectral imaging of the object as well as a controller coupled to the light emitting diodes, the broadband light source, the charge-coupled device, the spectrometer and the hyperspectral camera.

公开(公告)号：US11781166B2

公开(公告)日：2023-10-10

申请号：US17708387

申请日：2022-03-30

Applicant: International Business Machines Corporation

Inventor： Amos Cahan ,  Guy M. Cohen ,  Theodore G. van Kessel ,  Sufi Zafar

IPC: G01N27/02 ,  C12Q1/02 ,  C12Q1/18 ,  G01N21/59 ,  G01N27/04 ,  G01N15/06 ,  C12M1/12 ,  C12M1/34 ,  C12M1/00 ,  C12M3/00 ,  C12M1/18

CPC classification number: C12Q1/02 ,  C12M1/18 ,  C12M1/3453 ,  C12M3/00 ,  C12M23/34 ,  C12M25/14 ,  C12M31/02 ,  C12M41/36 ,  C12Q1/18 ,  G01N15/0656 ,  G01N21/59 ,  G01N27/04 ,  C12N2533/76 ,  G01N27/02 ,  G01N2201/08

Abstract: A structure for culturing cells includes growth medium regions on a surface of the structure. Each of the growth medium regions includes a growth medium surface configured to receive and promote growth in a cell that is being cultured. The structure includes a non-growth medium. The non-growth medium includes a non-growth medium surface configured to receive the cell that is being cultured.

公开(公告)号：US11747396B2

公开(公告)日：2023-09-05

申请号：US16943353

申请日：2020-07-30

Applicant: OpenLight Photonics, Inc.

Inventor： Steven William Keck ,  Crispin Cruz Mapagay ,  Mark Stenholm

IPC: G01R31/317 ,  G02B6/42 ,  G01N21/31

CPC classification number: G01R31/3171 ,  G01N21/31 ,  G02B6/4226 ,  G01N2201/06113 ,  G01N2201/08

Abstract: A hybrid optical-electrical automated testing equipment (ATE) system can implement a workpress assembly that can interface with a device under test (DUT) and a load board that holds the DUT during testing, analysis, and calibration. A test hand can actuate to position the DUT on a socket and align one or more alignment features. The workpress assembly can include two optical interfaces that are optically coupled such that light can be provided to a side of the DUT that is facing away from the load board, thereby enabling the ATE system to perform simultaneous optical and electrical testing of the DUT.

公开(公告)号：US20230258565A1

公开(公告)日：2023-08-17

申请号：US18157590

申请日：2023-01-20

Applicant: EZCONN CORPORATION

Inventor： CHIN-TSUNG WU

IPC: G01N21/64

CPC classification number: G01N21/6428 ,  G01N2021/6439 ,  G01N2201/08

Abstract: An apparatus for spectral analysis comprises a first lens holder comprising a first lens, a second lens holder comprising a second lens, a first optical fiber, and a spectrometer. The first lens and the second lens are for receiving a scattered light beam and focusing it to a point. The first optical fiber is arranged between the first lens holder and the second lens holder. The first optical fiber receives a first light beam focused by the first lens, transmits the first light beam through, and then projects the first light beam on the second lens. The spectrometer is positioned on a side of the second lens holder opposite the first optical fiber. The second lens focuses the first light beam received from the first optical fiber and projects the first light beam onto the spectrometer so that the spectrometer can analyze the first light beam.

公开(公告)号：US20230236114A1

公开(公告)日：2023-07-27

申请号：US17734830

申请日：2022-05-02

Applicant: Southwest Research Institute

Inventor： Thomas Moore ,  Kurt D. Retherford ,  Charity Phillips-Lander

IPC: G01N21/31 ,  G01N21/85

CPC classification number: G01N21/31 ,  G01N21/85 ,  G01N2201/0636 ,  G01N2201/08 ,  G01N2201/0612

Abstract: A seamless fumed silica monolithic integrating cavity device tailored to analyzing a flowed sample. The device is configured to facilitate optical measurements taken from a sample flowed through a cavity of the device. The cavity is defined by a fumed silica monolith with the added feature of a fused quartz lining on the surface of the monolith. This provides an intermediate surface that allows for cleaning and reuse of the highly effective diffuse light scattering fumed silica monolith. The lining may be placed under pressure or vacuum to structurally enhance mechanical integrity of the underlying monolith. Thus, continued or reliably repeated use of the device may be appreciated as well as use in more industrial environments that are prone to vibration. Additionally, while well suited for flow-based sample analysis, a valve of the cavity may be utilized for holding a sample in a temporarily static state for measurement.

公开(公告)号：US11703388B2

公开(公告)日：2023-07-18

申请号：US16479132

申请日：2018-01-16

Applicant: Agilent Technologies, Inc.

Inventor： Hugh Charles Stevenson ,  David Death ,  Eran Lande

IPC: G01J3/42 ,  G01N21/03 ,  G01N21/27

CPC classification number: G01J3/42 ,  G01N21/0332 ,  G01N21/274 ,  G01N2021/0367 ,  G01N2201/08

Abstract: A method of optical analysis comprises receiving light at an optical spectrometer module from a light source, distributing the received light into two or more light beams with a light distribution component of the optical spectrometer module, concurrently exposing each of a reference and one or more test samples to one of the two or more light beams, and concurrently measuring a property of the light associated with each of the reference sample and one or more test samples with a corresponding detector.

公开(公告)号：US20230204515A1

公开(公告)日：2023-06-29

申请号：US18087341

申请日：2022-12-22

Applicant: HORIBA INSTRUMENTS INCORPORATED

Inventor： Nicolas VEZARD ,  Beth FINAMORE ,  Aashish TULADHAR

IPC: G01N21/65 ,  G01N21/64

CPC classification number: G01N21/65 ,  G01N21/6428 ,  G01N2201/06113 ,  G01N2201/0633 ,  G01N2201/0636 ,  G01N2201/08 ,  G01N2201/0635 ,  G01N2201/127

Abstract: A microplate reader simultaneously obtains Raman measurements from samples contained in non-adjacent wells. At least two Raman probes are positioned perpendicularly above or below the microplate to simultaneously acquire Raman spectra data of the non-adjacent liquid samples. Each probe is coupled to a laser and a spectrometer and includes a lens focusing laser light within the sample and collecting light from the sample for the spectrometer. The spectrometer may include a 2D imaging sensor (sCMOS or CCD) to image light from multiple probes simultaneously, spaced from one another to reduce crosstalk. A positioner moves the microplate plate or probes to acquire data from a different subset of non-adjacent samples, and may also vary laser focus within wells during data acquisition. Multiple fluorescence probes may simultaneously acquire fluorescence data from the same samples, or non-adjacent samples. Probes may be fiber-coupled and positioned within a reaction chamber of a liquid handling system.

公开(公告)号：US11674960B2

公开(公告)日：2023-06-13

申请号：US17344870

申请日：2021-06-10

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Axel Scherer ,  Samuel Njoroge ,  Jingqing Huang

IPC: G01N33/543 ,  G01N33/566 ,  A61B5/1459 ,  G01N21/41 ,  G01N33/552 ,  A61B5/1491

CPC classification number: G01N33/566 ,  A61B5/1459 ,  G01N21/41 ,  G01N33/54373 ,  G01N33/552 ,  A61B5/1491 ,  A61B2562/0233 ,  A61B2562/043 ,  G01N2201/068 ,  G01N2201/08

Abstract: An implantable diagnostic device in accordance with the present disclosure provides various benefits such as a compact size thereby allowing implanting of the device inside animate objects; low cost due to incorporation of inexpensive detection circuitry and the use of conventional IC fabrication techniques; re-usability by heating thereby allowing multiple diagnostic tests to be performed without discarding the device; and a configuration that allows performing of simultaneous and/or sequential diagnostic tests for detecting one or more similar or dissimilar target molecules concurrently or at different times.