公开(公告)号：US09966243B2

公开(公告)日：2018-05-08

申请号：US14764047

申请日：2014-01-28

Applicant: GEORGETOWN UNIVERSITY

Inventor： Kaveh Jorabchi ,  Haopeng Wang

IPC: G01N30/90 ,  H01J49/00 ,  H01J49/10 ,  H01J49/14 ,  G01N30/72 ,  H01J49/04

CPC classification number: H01J49/0031 ,  G01N30/7206 ,  G01N30/7233 ,  H01J49/04 ,  H01J49/105 ,  H01J49/145

Abstract: Plasma-assisted reaction chemical ionization (PARCI) provides highly sensitive elemental analysis by producing positively and negatively charged ions. The PARCI apparatuses, kits, and methods described in this application relate to systems that comprise a chemical reaction interface (CRI) containing reactant gas plasma and an ionization chamber that is downstream from the CRI. The ionization chamber facilitates formation of ions from element-specific products of the CRI by an electron source or an ionization gas. In particular, PARCI provides a method for conducting highly sensitive mass spectrometric elemental analysis of analyte compounds with high ionization potential elements; for example, fluorine, chlorine, and bromine.

公开(公告)号：US09848486B2

公开(公告)日：2017-12-19

申请号：US15444809

申请日：2017-02-28

Applicant: PERKINELMER HEALTH SCIENCES, INC.

Inventor： Tak Shun Cheung ,  Chui Ha Cindy Wong

IPC: H05H1/32 ,  H05H1/34 ,  H01J49/10 ,  H01J49/26 ,  H05H1/30

CPC classification number: H05H1/32 ,  H01J49/105 ,  H01J49/26 ,  H05H1/30 ,  H05H1/3405

Abstract: Certain embodiments described herein are directed to induction devices that can be used to sustain a plasma. In certain configurations, the induction device may comprise one or more radial fins electrically coupled to a base. The induction device may take numerous forms including, for example, coils and plate electrodes.

公开(公告)号：US09820370B2

公开(公告)日：2017-11-14

申请号：US15066345

申请日：2016-03-10

Applicant: Hitachi High-Tech Science Corporation

Inventor： Yoshitomo Nakagawa ,  Yutaka Ikku

IPC: H05H1/30 ,  H01J49/10

CPC classification number: H05H1/30 ,  H01J49/105

Abstract: An inductively coupled plasma generating device is configured to include a plasma torch, a high frequency induction coil and a high frequency power source. In addition, a heat transfer member, in which a first terminal is connected to the high frequency induction coil and a second terminal is connected to a cooling block, is disposed in the inductively coupled plasma generating device. The second terminal of the heat transfer member is located above the first terminal, thereby causing condensed operating fluid to fall and move toward the first terminal due to the action of gravity. Accordingly, it is possible to achieve excellent cooling capacity by improving circulation and mobility of the operating fluid.

公开(公告)号：US20170243729A1

公开(公告)日：2017-08-24

申请号：US15519286

申请日：2015-10-16

Applicant: Micromass UK Limited

Inventor： Michael Raymond MORRIS ,  Steven Derek PRINGLE ,  Richard ELLSON ,  Richard STEARNS ,  Lars MAJLOF ,  Ian SINCLAIR

IPC: H01J49/04 ,  H01J49/10 ,  H01J49/00

CPC classification number: H01J49/0454 ,  H01J49/0031 ,  H01J49/105

Abstract: A method of ionising a sample is provided, comprising providing a fluid sample, wherein the fluid sample contains an analyte, applying one or more pulses of acoustic energy to the fluid sample to cause a spray of the fluid sample to eject from the surface of the fluid sample, and applying an AC, RF or alternating voltage to the fluid sample using an electrode.

公开(公告)号：US09726611B2

公开(公告)日：2017-08-08

申请号：US14668480

申请日：2015-03-25

Applicant: Hitachi High-Tech Science Corporation

Inventor： Yoshitomo Nakagawa

IPC: G01N21/73 ,  G01N21/68 ,  G01J3/443 ,  H01J49/10 ,  H05H1/30

CPC classification number: G01N21/73 ,  G01J3/443 ,  G01N21/68 ,  H01J49/105 ,  H05H1/30

Abstract: An ICP emission spectrometer is schematically configured to include an inductively coupled plasma generation unit, a light condensing unit, a spectroscope, a detector, and a controller. The detector includes a photomultiplier and has a detector controller and an input unit. The photomultiplier has voltage dividing resistors, which make an amplification factor not to become constant immediately due to a change in an application voltage applied to the photomultiplier, but the detector controller controls an idle voltage and an idle voltage application time so that a multiplication factor becomes constant, during a period from when analysis conditions are input to the input unit in advance until a sample containing an analysis-targeted element is introduced into the inductively coupled plasma generation unit.

公开(公告)号：US20170221688A1

公开(公告)日：2017-08-03

申请号：US15418039

申请日：2017-01-27

Applicant: Agilent Technologies, Inc.

Inventor： Yoichi Nagata ,  Shusaku Tsuruga ,  Takeo Kuwabara ,  Ryosuke Tobiyama

IPC: H01J49/04 ,  H01J49/10

CPC classification number: H01J49/0422 ,  H01J49/105

Abstract: To achieve an effective gas filtering in a plasma spectrometric apparatus using a gas of a comparatively high consumption flow rate, and to improve the analytical ability, there is provided a plasma spectrometric apparatus containing a sample introducer for producing and delivering an injector gas containing an analyte sample, a plasma generator for generating plasma into which the injector gas is introduced, and an analyzer disposed subsequent to the plasma generator for analyzing the analyte sample. The plasma spectrometric apparatus contains a first gas line for supplying gas to the sample introducer, a second gas line for supplying gas to the plasma generator, and a filter located in the first gas line for removing impurities contained in the gas.

公开(公告)号：US20170084435A1

公开(公告)日：2017-03-23

申请号：US15268097

申请日：2016-09-16

Applicant: BAYLOR UNIVERSITY

Inventor： Touradj SOLOUKI

IPC: H01J49/00 ,  H01J49/10

CPC classification number: H01J49/0004 ,  H01J49/0463 ,  H01J49/105

Abstract: The present disclosure provides a system and method for mass spectrometry imaging in a multi-stage ionization applying different technologies by decoupling the desorption and ionization events. At a first stage, a primary beam, such as an ion beam, desorbs one or more molecules of a targeted sample, and at a second stage the desorbed molecules are ionized. The system and method can act independent of a matrix application to the target sample for a direct analysis and has the spatial resolution needed to operate in nano-meters resolution for a cell-by-cell analysis, if desired. The first stage desorption applies a first technique that allows neutral molecules of the target sample to become desorbed from the surface without requiring the molecules to be ionized during the desorption. The second stage ionizes the neutral molecules after the desorption in the first stage, when the defined target molecules have been volatilized.

公开(公告)号：US20170045460A1

公开(公告)日：2017-02-16

申请号：US15172886

申请日：2016-06-03

Applicant: PERKINELMER HEALTH SCIENCES, INC.

Inventor： Peter J. Morrisroe

IPC: G01N21/73

CPC classification number: G01N21/73 ,  G01J3/443 ,  G01N21/68 ,  G01N2201/126 ,  H01J49/105

Abstract: A device for sustaining a plasma in a torch is provided. In certain examples, the device comprises a first electrode configured to couple to a power source and constructed and arranged to provide a loop current along a radial plane of the torch. In some examples, the radial plane of the torch is substantially perpendicular to a longitudinal axis of the torch.

Abstract translation: 提供了一种用于在割炬中维持等离子体的装置。 在某些示例中，该装置包括被配置为耦合到电源并被构造和布置成沿着焊炬的径向平面提供回路电流的第一电极。 在一些示例中，焊炬的径向平面基本上垂直于焊炬的纵向轴线。

公开(公告)号：US20170018417A1

公开(公告)日：2017-01-19

申请号：US15301218

申请日：2015-03-27

Applicant: HORIBA JOBIN YVON SAS

Inventor： Patrick CHAPON ,  Agnes TEMPEZ ,  Sebastien LEGENDRE

IPC: H01J49/10 ,  H01J49/00 ,  H01J49/40 ,  H01J49/24

CPC classification number: H01J49/105 ,  H01J49/0031 ,  H01J49/24 ,  H01J49/40

Abstract: A system and a process for measuring, by glow discharge spectrometry, the elemental and/or molecular chemical composition of an organic solid sample (10). The sample (10) is positioned so as to seal a glow discharge plasma reactor (2), a gaseous mixture including at least one inert gas and gaseous oxygen is injected into the reactor (2), the concentration of gaseous oxygen being between 0.1% and 15% by weight of the gaseous mixture, an electric discharge of radiofrequency type is applied to the electrodes of the plasma reactor (2) in order to generate a glow discharge plasma, and the solid sample (10) is exposed to the plasma so as to etch an erosion crater in the solid sample (10); at least one signal representative of an ionized species of negative charge is selected and measured using a mass spectrometer (4).

Abstract translation: 通过辉光放电光谱测定有机固体样品（10）的元素和/或分子化学组成的系统和方法。 定位样品（10）以密封辉光放电等离子体反应器（2），将包含至少一种惰性气体和气态氧的气体混合物注入反应器（2）中，气态氧浓度在0.1％ 和15重量％的气体混合物，为了产生辉光放电等离子体，将等离子体反应器（2）的电极施加射频型放电，并将固体样品（10）暴露于等离子体 蚀刻固体样品（10）中的侵蚀坑; 使用质谱仪（4）选择和测量代表负电荷的离子化物质的至少一个信号。

公开(公告)号：US09536725B2

公开(公告)日：2017-01-03

申请号：US14171981

申请日：2014-02-04

Applicant: Clemson University ,  Lawrence Berkeley National Laboratory ,  Pacific Northwest National Laboratory

Inventor： R. Kenneth Marcus ,  Charles Derrick Quarles, Jr. ,  Richard E. Russo ,  David W. Koppenaal ,  Charles J. Barinaga ,  Anthony J. Carado

IPC: H01J49/10 ,  G01J3/443 ,  H01J27/16 ,  H01J49/14 ,  H01J49/16

CPC classification number: H01J27/022 ,  G01J3/443 ,  H01J27/16 ,  H01J49/105 ,  H01J49/145 ,  H01J49/165

Abstract: A liquid sampling, atmospheric pressure, glow discharge (LS-APGD) device as well as systems that incorporate the device and methods for using the device and systems are described. The LS-APGD includes a hollow capillary for delivering an electrolyte solution to a glow discharge space. The device also includes a counter electrode in the form of a second hollow capillary that can deliver the analyte into the glow discharge space. A voltage across the electrolyte solution and the counter electrode creates the microplasma within the glow discharge space that interacts with the analyte to move it to a higher energy state (vaporization, excitation, and/or ionization of the analyte).

Abstract translation: 描述了液体采样，大气压，辉光放电（LS-APGD）装置以及结合装置的系统和使用装置和系统的方法。 LS-APGD包括用于将电解质溶液输送到辉光放电空间的中空毛细管。 该装置还包括可以将分析物输送到辉光放电空间中的第二中空毛细管形式的对电极。 电解质溶液和对电极之间的电压在辉光放电空间内产生与分析物相互作用以将其移动到更高能量状态（分析物的蒸发，激发和/或电离）的微质。