公开(公告)号：US09121830B2

公开(公告)日：2015-09-01

申请号：US13325808

申请日：2011-12-14

Applicant: Kihong Park ,  Ji-Hyun Kwak

Inventor： Kihong Park ,  Ji-Hyun Kwak

IPC: G01J3/30 ,  G01N21/71

CPC classification number: G01N21/718

Abstract: Disclosed is a spectrometer apparatus using a continuous wave laser and a photomultiplier tube. The spectrometer apparatus includes a continuous wave laser irradiating part to irradiate a continuous wave laser to introduced particles, a scattering light measuring part to measure a scattering light emitted from the particles due to the continuous wave laser, a triggering signal generator to generate a triggering signal if a measurement value of the scattering light measuring part is greater than a preset value or equal to the preset value, a pulse laser irradiating part to receive the triggering signal to irradiate a pulse laser to the particles, and a spectral analysis part to measure an emission light generated from the particles due to the pulse wave laser to analyze elements consisting of the particles.

Abstract translation: 公开了使用连续波激光器和光电倍增管的光谱仪装置。 光谱仪装置包括连续波激光照射部分，以将连续波激光照射到引入粒子上;散射光测量部分，用于测量由连续波激光引起的粒子散射光;触发信号发生器，用于产生触发信号 如果散射光测量部件的测量值大于预设值或预设值，则脉冲激光照射部分接收触发信号以向脉冲激光照射脉冲激光;以及光谱分析部件， 由脉冲波激光产生的颗粒产生的发射光分析由颗粒构成的元件。

公开(公告)号：US09046462B2

公开(公告)日：2015-06-02

申请号：US13704483

申请日：2011-06-17

Applicant: Brooks Hart Pate ,  Kevin K. Lehmann

Inventor： Brooks Hart Pate ,  Kevin K. Lehmann

IPC: G01J3/30 ,  G01N22/00 ,  G01N21/3586 ,  H01S3/00

CPC classification number: G01N21/3586 ,  G01J3/10 ,  G01J3/4338 ,  G01J3/44 ,  G01N21/31 ,  G01N21/62 ,  G01N21/67 ,  G01N21/69 ,  G01N22/00 ,  H01S3/0057

Abstract: A pulse train comprising chirped pulses of electromagnetic energy can be used to excite a sample, such as for spectroscopic analysis. The respective chirped pulses can include a frequency sweep across a first specified bandwidth during a respective chirped pulse duration, the respective chirped pulse duration establishing a first frequency-domain comb peak separation. A width of a frequency-domain comb peak can be established at least in part by a total duration of the pulse train, and a bandwidth of the first frequency-domain comb can be determined at least in part by the first specified bandwidth of the frequency sweep of the respective chirped pulses.

Abstract translation: 可以使用包括电磁能的啁啾脉冲的脉冲串来激发样品，例如用于光谱分析。 相应的啁啾脉冲可以包括在相应的啁啾脉冲持续时间期间穿过第一指定带宽的频率扫描，相应的啁啾脉冲持续时间建立第一频域梳状峰值间隔。 可以至少部分地由脉冲序列的总持续时间来建立频域梳状峰值的宽度，并且可以至少部分地通过频率的第一指定带宽来确定第一频域梳状的带宽 扫描各个啁啾脉冲。

公开(公告)号：US08982344B2

公开(公告)日：2015-03-17

申请号：US14134899

申请日：2013-12-19

Applicant: University of Calcutta

Inventor： Anjan Kr. Dasgupta ,  Sarita Roy

IPC: G01J3/447 ,  G01J3/30 ,  G01J4/00 ,  G01N21/25 ,  G01N21/64 ,  G01N23/22

CPC classification number: G01N21/6402 ,  G01N21/6445 ,  G01N23/22

Abstract: Technologies are generally described for systems and methods for detecting chiral properties of materials and separating materials based on their chiral properties. A chiral vector is constructed from anisotropy properties of a polarization-dependent output signal from a sample. Different types of molecules from the sample can be differentiated based on a magnitude of the chiral vector. Chiral properties of the sample can be detected based on an angle of the chiral vector. The output signal can be a fluorescent emission from the sample and can be used to detect chiral properties of a substantially opaque sample.

Abstract translation: 通常描述用于基于其手性性质检测材料的手性性质和分离材料的系统和方法的技术。 手性载体由来自样品的偏振相关输出信号的各向异性特性构成。 可以基于手性载体的量级来区分来自样品的不同类型的分子。 可以基于手性载体的角度来检测样品的手性性质。 输出信号可以是来自样品的荧光发射，并且可以用于检测基本上不透明样品的手性。

公开(公告)号：US08899114B2

公开(公告)日：2014-12-02

申请号：US13386338

申请日：2009-07-30

Applicant: Christopher M. Jones ,  Michael T. Pelletier ,  Robert Atkinson ,  Wei Zhang ,  Li Gao

Inventor： Christopher M. Jones ,  Michael T. Pelletier ,  Robert Atkinson ,  Wei Zhang ,  Li Gao

IPC: G01N29/04 ,  G01J3/30 ,  G01N21/59 ,  E21B49/08

CPC classification number: G01N21/59 ,  E21B49/08

Abstract: Apparatus, systems, and methods may operate to receive incident energy within a chamber defining a first part of an interaction volume that attenuates the incident energy as a function of path length to provide attenuated energy. Additional activity may include simultaneously transforming the attenuated energy characterized by a substantially exponential intensity function into resultant energy characterized by a substantially polynomial intensity function. The transformation may be accomplished using an interacted energy transformation element that defines a second part of the interaction volume, the transformation element operating to intercept the attenuated energy along a plurality of path lengths. Other activity may include transmitting the resultant energy to a receiver. Additional apparatus, systems, and methods are disclosed.

Abstract translation: 设备，系统和方法可以操作以在腔室内接收限定相互作用体积的第一部分的入射能量，该相互作用体积的衰减作为路径长度的函数来衰减入射能量以提供衰减的能量。 附加活动可以包括同时将基本上指数强度函数表征的衰减能量转换成由基本上多项式强度函数表征的合成能量。 可以使用界定相互作用体积的第二部分的相互作用的能量转换元件来实现变换，转换元件用于沿多个路径长度截取衰减的能量。 其他活动可以包括将合成的能量传输到接收器。 公开了附加装置，系统和方法。

公开(公告)号：US08890323B2

公开(公告)日：2014-11-18

申请号：US12716087

申请日：2010-03-02

Applicant: Samuel M. Stavis ,  Joshua B. Edel ,  Kevan T. Samiee ,  Harold G. Craighead

Inventor： Samuel M. Stavis ,  Joshua B. Edel ,  Kevan T. Samiee ,  Harold G. Craighead

IPC: G01R31/26 ,  G01J3/30 ,  B82Y30/00 ,  B82Y15/00 ,  B82Y10/00 ,  B82Y5/00 ,  G01N33/58 ,  B82Y20/00 ,  A61K49/00

CPC classification number: A61K49/0067 ,  A61K49/0056 ,  B82Y5/00 ,  B82Y10/00 ,  B82Y15/00 ,  B82Y20/00 ,  B82Y30/00 ,  G01N33/588 ,  Y10S438/962 ,  Y10S977/70 ,  Y10S977/774

Abstract: A nanofluidic channel fabricated in fused silica with an approximately 500 nm square cross section was used to isolate, detect and identify individual quantum dot conjugates. The channel enables the rapid detection of every fluorescent entity in solution. A laser of selected wavelength was used to excite multiple species of quantum dots and organic molecules, and the emission spectra were resolved without significant signal rejection. Quantum dots were then conjugated with organic molecules and detected to demonstrate efficient multicolor detection. PCH was used to analyze coincident detection and to characterize the degree of binding. The use of a small fluidic channel to detect quantum dots as fluorescent labels was shown to be an efficient technique for multiplexed single molecule studies. Detection of single molecule binding events has a variety of applications including high throughput immunoassays.

Abstract translation: 使用在约500nm正方形横截面的熔融二氧化硅中制造的纳米流体通道来分离，检测和识别各种量子点缀合物。 该通道可以快速检测溶液中的每个荧光实体。 使用选定波长的激光来激发多种量子点和有机分子，并且发射光谱被解析而没有显着的信号抑制。 然后将量子点与有机分子缀合并检测以证明有效的多色检测。 PCH用于分析重合检测并表征结合程度。 使用小的流体通道检测量子点作为荧光标记被证明是多重单分子研究的有效技术。 单分子结合事件的检测具有多种应用，包括高通量免疫测定。

公开(公告)号：US08879062B2

公开(公告)日：2014-11-04

申请号：US13839748

申请日：2013-03-15

Applicant: Imagineering, Inc.

Inventor： Yuji Ikeda

IPC: G01J3/30 ,  G01N21/71 ,  G01N21/68 ,  G01N21/73

CPC classification number: G01N21/73 ,  G01J3/0208 ,  G01J3/0218 ,  G01J3/0294 ,  G01J3/443 ,  G01N21/68 ,  G01N21/718

Abstract: An analysis apparatus includes a plasma generation unit and an optical analysis unit. The plasma generation unit generates initial plasma by momentarily energizing a target substance to be turned into a plasma state, and maintains the target substance in the plasma state by irradiating the initial plasma with an electromagnetic wave for a predetermined period of time. The optical analysis unit identifies the target substance based on information with respect to emission intensity during a period from when the emission intensity reaches a peak due to the initial plasma until when the emission intensity increases and reaches approximately a constant value due to electromagnetic wave plasma maintained by the electromagnetic wave, or information with respect to emission intensity after the electromagnetic wave irradiation is terminated.

Abstract translation: 分析装置包括等离子体产生单元和光学分析单元。 等离子体产生单元通过暂时激励要变成等离子体状态的目标物质来产生初始等离子体，并且通过用电磁波照射初始等离子体一定时间来将目标物质维持在等离子体状态。 光分析单元基于从发射强度由于初始等离子体到达峰值的时间段的发光强度的信息来识别目标物质，直到发射强度增加并且由于电磁波等离子体维持而达到大致恒定值 通过电磁波，或者关于电磁波照射后的发光强度的信息终止。

公开(公告)号：US08879061B2

公开(公告)日：2014-11-04

申请号：US13839560

申请日：2013-03-15

Applicant: Imagineering, Inc.

Inventor： Yuji Ikeda ,  Ryoji Turuoka

IPC: G01J3/30 ,  G01J3/02 ,  G01N21/68 ,  G01N21/71 ,  G01J3/443

CPC classification number: G01J3/02 ,  G01J3/443 ,  G01N21/68 ,  G01N21/718

Abstract: The analysis apparatus 10 includes a plasma generation device 11 and an optical analysis device 13. The plasma generation device 11 generates initial plasma by energizing a substance in space to be turned into a plasma state, and maintains the plasma state by irradiating the initial plasma with electromagnetic wave for a predetermined period of time. Then, the optical analysis device 13 analyzes the target substance 15 based on a time integral value of intensity of emission from the target substance 15 in an electromagnetic wave plasma region, which is maintained by the electromagnetic wave.

Abstract translation: 分析装置10包括等离子体产生装置11和光学分析装置13.等离子体产生装置11通过对空间中的物质进行激励而产生初始等离子体等待状态，并通过用初始等离子体照射来保持等离子体状态 电磁波预定时间段。 然后，光学分析装置13基于由电磁波维持的电磁波等离子体区域中的来自目标物质15的发射强度的时间积分值来分析目标物质15。

公开(公告)号：US08823928B2

公开(公告)日：2014-09-02

申请号：US13842399

申请日：2013-03-15

Applicant: Seno Medical Instruments, Inc.

Inventor： Donald Herzog ,  Elisa Gravis ,  Bryan Clingman ,  Remie J. Smith ,  Thomas G. Miller

IPC: G01J1/00 ,  G01J1/42 ,  G01J1/04 ,  G01J3/30 ,  G01J3/36

CPC classification number: G01J1/4257 ,  A61B5/0073 ,  A61B5/0095 ,  A61B8/4281 ,  A61B2503/02 ,  A61B2576/00 ,  G01H9/00 ,  G01J1/04 ,  G01J1/42 ,  G01J3/30 ,  G01J3/36

Abstract: An optoacoustic system includes first and second light sources capable of generating pulse of light at first and second wavelengths, first and second electrically controlled optical attenuators, first and second light sync detectors, and a combiner. A power meter that is calibrated to determine power at the first and second predominant wavelength measures power at the first wavelength after the first light sync is detected and measures power at the second wavelength after the second light sync is detected. The system includes a calibration mode wherein it electrically attenuates the first optical attenuator when the power measured by the power meter at the first wavelength after the first light sync is detected is above a first level, and electrically attenuated the second optical attenuator when the power measured by the power meter at the second wavelength after the second light sync is detected is above a second level.

Abstract translation: 光声系统包括能够产生第一和第二波长的光脉冲的第一和第二光源，第一和第二电控光衰减器，第一和第二光同步检测器以及组合器。 被校准以确定第一和第二主要波长的功率的功率计测量在检测到第一光同步之后的第一波长处的功率，并且在检测到第二光同步之后测量第二波长处的功率。 该系统包括校准模式，其中当在检测到第一光同步之后由功率计在第一波长处测量的功率高于第一电平时，其电衰减第一光衰减器，并且当测量的功率被电衰减时，第二光衰减器 在检测到第二光同步之后的第二波长处的功率计高于第二电平。

公开(公告)号：US08767203B2

公开(公告)日：2014-07-01

申请号：US13217699

申请日：2011-08-25

Applicant: Se-Yeon Kim ,  Hun Jung Yi ,  Sangpyoung Jeon ,  Hyojin Yun

Inventor： Se-Yeon Kim ,  Hun Jung Yi ,  Sangpyoung Jeon ,  Hyojin Yun

IPC: G01J3/30

CPC classification number: H05H1/0031 ,  H05H1/2406 ,  H05H2001/2431

Abstract: A plasma generating unit for a process monitoring device includes a hollow first electrode extending in a length direction and a second electrode extending in the length direction and positioned within and displaced from the first electrode with a distance therebetween. The first electrode has an inner diameter and the second electrode has an outer diameter selected to vary the distance between the electrodes in the length direction so that the plasma generating unit generates a plasma by ionizing a gas flowing between the electrodes at a different position in the length direction based on a pressure of the gas.

Abstract translation: 一种用于过程监测装置的等离子体产生装置包括沿长度方向延伸的中空第一电极和沿长度方向延伸的第二电极，并且位于第一电极内并且与第一电极相距一定距离。 所述第一电极具有内径，并且所述第二电极具有选择的外径以改变所述电极之间的长度方向上的距离，使得所述等离子体产生单元通过在所述电极中的不同位置处电离在所述电极之间流动的气体来产生等离子体 基于气体的压力的长度方向。

公开(公告)号：US08681247B1

公开(公告)日：2014-03-25

申请号：US13106758

申请日：2011-05-12

Applicant: Sean B. Pieper ,  Christopher J. Lesiak ,  Ahmed Bouzid

Inventor： Sean B. Pieper ,  Christopher J. Lesiak ,  Ahmed Bouzid

IPC: H04N5/217 ,  H04N17/00 ,  H04N9/73 ,  H04N5/222 ,  G01J3/30 ,  F21V9/16 ,  A61B6/00

CPC classification number: G01N21/6456 ,  G01J3/28 ,  G01J3/4406 ,  G01N2021/6493

Abstract: Systems and methods for flattening the image across the entire field by correcting the image for both the fluorescence and scatter spatial variations. Images of a stable fluorescence target and a scattering target are separately acquired in an imaging system. From these target images, a pixel remapping function, e.g., including two correcting pixel slopes, is calculated for subsequent image pixel remapping. An image of a sample under investigation is then acquired by the imaging system and the sample image is remapped based on the pixel remapping function for the imaging system to form a corrected (field flattened) image. Which correction pixel slope to be used is determined based on whether a sample image pixel value is higher or lower than a threshold value.

Abstract translation: 通过校正荧光和散射空间变化的图像来平整整个场的图像的系统和方法。 在成像系统中分别获得稳定的荧光目标和散射目标的图像。 从这些目标图像中，为随后的图像像素重新映射计算像素重新映射功能，例如包括两个校正像素斜率。 然后由成像系统获取被研究样本的图像，并且基于成像系统的像素重新映射功能重新映射样本图像以形成校正（场平坦化）图像。 基于样本图像像素值是高于还是低于阈值来确定要使用的哪个校正像素斜率。