公开(公告)号：US10288615B2

公开(公告)日：2019-05-14

申请号：US15491305

申请日：2017-04-19

Applicant: UNIVERSITY OF CENTRAL LANCASHIRE

Inventor： Matthew James Baker ,  Peter Abel ,  Robert William Lea

IPC: G01N33/574 ,  G01N21/552 ,  G01N21/63 ,  G01N21/35 ,  G01N33/49 ,  G01J3/433 ,  G01N30/74 ,  G01N21/31

Abstract: The present invention relates to methods of diagnosing and/or prognosing proliferative disorders, especially brain cancers (e.g. gliomas). In particular, the present invention provides a means to conveniently detect malignant tumors merely by assaying or analyzing blood (particularly blood serum). Cytokines and/or angiogenesis factors in blood serum have been found to be surprisingly powerful at indicating the presence of brain cancers in a subject. Moreover, spectroscopic analysis, especially ATR-FTIR analysis, of a blood sample has been demonstrated to be surprisingly effective at producing a signature that can be correlated with the presence, extent, severity, or aggressiveness of malignant tumors in a subject.

公开(公告)号：US10281454B2

公开(公告)日：2019-05-07

申请号：US15192904

申请日：2016-06-24

Applicant: Fresenius Medical Care Holdings, Inc.

Inventor： Louis L. Barrett

IPC: G01J3/433 ,  G01N33/49 ,  G01N21/31 ,  A61M1/14 ,  A61B5/00 ,  A61B5/026 ,  A61M1/36 ,  A61B5/145 ,  A61B5/1455

Abstract: An embodiment of the disclosure provides a system for determining information on one or more constituents in a medium. The system includes N light emitters L1 . . . LN, wherein each light emitter Lx provides an amplitude modulated (AM) light at modulation frequency fx into a flow path of the medium from one side of a containment vessel for the medium. The system further includes a photodetector, for receiving the AM light from each light emitter after it passes through the flow path of the medium, and converting the AM light to an electrical signal characterized by a summation of frequency components from each modulation frequency fx. The system further includes one or more measuring circuits providing information about a concentration of one or more constituents in the medium determined from log ratios of a pair of amplitudes of fy and fz frequency components in the electrical signal.

公开(公告)号：US10274430B2

公开(公告)日：2019-04-30

申请号：US15145840

申请日：2016-05-04

Applicant: Roche Diabetes Care, Inc.

Inventor： Gertrud Albrecht ,  Edgar Baumann ,  Markus Genthner-Riegler ,  Stefan Kalveram ,  Christian Niesporek ,  Kai-Oliver Schwenker ,  Markus Serr ,  Frederic Wehowski ,  Klaus Wettengel

IPC: G01N21/75 ,  G01N33/50 ,  G01J3/433 ,  G01N21/78 ,  G01N21/84 ,  G01N33/487 ,  G01N21/15 ,  G01N21/27 ,  G01N21/47 ,  G01N21/77

Abstract: Methods, analytical devices and analytical systems are provided for determining at least one analyte concentration in a body fluid sample. The methods, which may be incorporated into the devices and systems, can include the following steps: applying a body fluid to a test carrier; illuminating the test carrier by at least one light source, where the at least one light source is modulated by using at least two modulation frequencies; receiving light remitted by the test carrier by using at least one detector; determining an analyte concentration by evaluating at least one detector signal generated by the detector, where the detector signal is demodulated with the at least two modulation frequencies to generate at least two demodulated detector signals, each demodulated signal corresponding to one of the modulation frequencies; and detecting a fault by comparing the at least two demodulated detector signals.

公开(公告)号：US20190056270A1

公开(公告)日：2019-02-21

申请号：US15768548

申请日：2017-03-02

Applicant: CI SYSTEMS (ISRAEL) LTD.

Inventor： Dario CABIB

IPC: G01J3/45 ,  G01J3/427 ,  G01J3/433

CPC classification number: G01J3/45 ,  G01J3/0205 ,  G01J3/26 ,  G01J3/427 ,  G01J3/4338 ,  G01J3/4531 ,  G01J3/4532 ,  G01J2003/425 ,  G02B27/50

Abstract: An interference fringe pattern generator forms an interference fringe pattern from the light rays diffused from a region of an object positioned against a background. A planar array of detector pixels is arranged to capture an image of the interference fringe pattern. A storage medium records information indicative of intensity values of the image of the interference fringe pattern captured by a selected group of pixels of the planar array of detector pixels. The information is recorded as a function of the optical path difference values traversed by the diffused light rays through the interference fringe pattern generator for each of the pixels in the selected group of pixels. A processor determines the spectral characteristics of the object based on the information indicative of the intensity values recorded by the storage medium and the optical path difference values traversed by the diffused light rays.

公开(公告)号：US10132681B2

公开(公告)日：2018-11-20

申请号：US15823421

申请日：2017-11-27

Applicant: CANON KABUSHIKI KAISHA

Inventor： Naoki Kohara

IPC: G01J3/44 ,  G01J3/02 ,  H01S3/108 ,  H01S3/00 ,  G01J3/433 ,  H01S3/23 ,  G01N21/65

Abstract: A noise reduction apparatus includes a first delaying/combining unit configured to output first and second pulse light beams, and a second delaying/combining unit configured to branch the first pulse light beam into two pulse light beams to output third and fourth pulse light beams and branch the second pulse light beam into two pulse light beams to output fifth and sixth pulse light beams.

公开(公告)号：US20180245982A1

公开(公告)日：2018-08-30

申请号：US15960350

申请日：2018-04-23

Applicant: Lawrence Livermore National Security, LLC

Inventor： Charles G. Stevens ,  Joseph W. Tringe ,  Christopher T. Cunningham

IPC: G01J3/453 ,  G01J3/433 ,  G01J3/10

CPC classification number: G01J3/453 ,  G01J3/10 ,  G01J3/4338 ,  G01N21/35

Abstract: According to one embodiment, a method of forming a plasmonic condensing lens for room temperature quantum noise limited (QNL) infrared (IR) spectrometry includes: forming a silicon cone on a substrate; coating the silicon cone with a highly reflective material; and modifying the silicon cone using focused ion beam (FIB) modification to permit transmittance of light through the silicon cone.

公开(公告)号：US20180238794A1

公开(公告)日：2018-08-23

申请号：US15751095

申请日：2016-08-29

Applicant: Apple Inc.

Inventor： Miikka M. KANGAS ,  Mark Alan ARBORE ,  David I. SIMON ,  Michael J. BISHOP ,  James W. HILLENDAHL ,  Robert CHEN

IPC: G01N21/27 ,  G01J3/02 ,  G01J3/32 ,  G01J3/36 ,  G01J3/433 ,  G01J3/447 ,  G01N21/47 ,  G01N21/35

Abstract: This relates to systems and methods for measuring a concentration and type of substance in a sample at a sampling interface. The systems can include a light source, optics, one or more modulators, a reference, a detector, and a controller. The systems and methods disclosed can be capable of accounting for drift originating from the light source, one or more optics, and the detector by sharing one or more components between different measurement light paths. Additionally, the systems can be capable of differentiating between different types of drift and eliminating erroneous measurements due to stray light with the placement of one or more modulators between the light source and the sample or reference. Furthermore, the systems can be capable of detecting the substance along various locations and depths within the sample by mapping a detector pixel and a microoptics to the location and depth in the sample.

公开(公告)号：US20180233877A1

公开(公告)日：2018-08-16

申请号：US15891343

申请日：2018-02-07

Applicant: Max-Planck-Gesellschaft zur Foerderung der Wissenschaften e. V.

Inventor： Thomas UDEM ,  Akira OZAWA

IPC: H01S3/11 ,  H01S3/00 ,  H01S3/067 ,  G01J3/433 ,  G01J3/02 ,  G01N21/39

CPC classification number: H01S3/1121 ,  G01J3/0218 ,  G01J3/10 ,  G01J3/4338 ,  G01J9/04 ,  G01J2003/282 ,  G01J2003/4332 ,  G01N21/39 ,  G01N2021/391 ,  G01N2021/399 ,  G01N2201/0697 ,  H01S3/0057 ,  H01S3/0675 ,  H01S3/06791 ,  H01S3/1109 ,  H01S3/1112

Abstract: A method of generating laser pulses (1) includes: creating a circulating light field in resonator device (11) having resonator length L and an intra-cavity dispersion and configured for supporting light field resonator modes, and generating a pulse train of laser pulses (1) by a mode-locking mechanism. Laser pulses (1) are generated with a repetition frequency and provide a frequency comb with carrier frequency ωo and comb modes in frequency space. The intra-cavity dispersion is selected such that round trip phases ϕ have a dependency on frequency ω according to φ  ( ω ) = π   m  ( 1 + 4   ω - ω 0 m   ω r - 1 ) + L c  ω 0 wherein m is an integer providing effective repetition rate (mωr) in combination with mode spacing ωr at optical carrier frequency (ωo), and the mode-locking mechanism provides a coupling of the resonator modes whereby frequency difference (Δn=ωn+1−ωn) between neighboring mode frequencies (ωn, ωn+1) is a linear function of mode frequency number n. Furthermore, a spectroscopy method for investigating a sample, a laser pulse source apparatus and a spectroscopy apparatus are described.

公开(公告)号：US10048196B2

公开(公告)日：2018-08-14

申请号：US15336045

申请日：2016-10-27

Applicant: NewSouth Innovations Pty Limited

Inventor： Charles Charbel Harb ,  Toby Kristian Boyson

IPC: G01N21/00 ,  G01N21/39 ,  G01N21/03 ,  G01J3/433 ,  G01J3/02

Abstract: Methods and apparatuses of generating and processing a real-time time-domain cavity ringdown spectroscopy (CRDS) signal from absorbing species in an optical detection system having an optical ringdown cavity using off-axis paths are provided. At least one modulated light signal is generated using one or more light sources, each modulated at specified modulation frequency. Each modulated signal has harmonic frequency components and is input off-axis relative to the cavity's optical axis. The cavity contains mirrors arranged in a predetermined configuration. The optical axis is defined by a path passing through centers of mirrors. The modulated light signal is resonated off axis without astigmatic optical elements to produce CRDS signal and passes at least twice through cavity and across the mirrors without interfering with itself. An overall path length through cavity is greater than path length of optical axis. A photodetector detects the CRDS signal, which is demodulated dependent upon selected harmonics.

公开(公告)号：US09903808B2

公开(公告)日：2018-02-27

申请号：US14590218

申请日：2015-01-06

Applicant: NATIONAL INSTITUTE OF STANDARDS AND TECHNOLOGY

Inventor： David F. Plusquellic ,  David A. Long ,  Kevin O. Douglass ,  Joseph T. Hodges ,  Adam J. Fleisher

IPC: G01B9/02 ,  G01J3/45 ,  H01S3/00 ,  G02F1/01 ,  G01N21/25 ,  G01J3/433 ,  G01J3/453 ,  G01N21/39

CPC classification number: G01N21/255 ,  G01J3/433 ,  G01J3/453 ,  G01N21/39 ,  G01N2021/399 ,  G02F1/01 ,  G02F2203/56 ,  H01S3/0057

Abstract: A comb source includes a continuous wave frequency source to provide a continuous wave radiation; a first modulator in optical communication with the continuous wave frequency source; a second modulator in optical communication with continuous wave frequency source; and a waveform driver in electrical communication with the first modulator and the second modulator. A process for producing an analyte spectrum includes producing a first comb from a continuous wave frequency and a first waveform; producing a reference comb and a probe comb from the first comb; subjecting a sample to the probe comb; producing a sample comb in response to subjecting the sample to the probe comb; producing a composite comb from the reference comb and the sample comb; producing a second comb from the continuous wave frequency and a second waveform; and combining the second comb and the composite comb to produce the analyte spectrum.