公开(公告)号：US11111269B2

公开(公告)日：2021-09-07

申请号：US16005642

申请日：2018-06-11

Applicant: Biogen MA Inc.

Inventor： Sanchayita Ghose ,  Yinying Tao

IPC: C07K1/22 ,  C07K16/06 ,  C07K1/20

Abstract: Various aspects and embodiments of the present disclosure relate to the purification antibodies by hydrophobic interaction chromatography under no-salt conditions.

公开(公告)号：US11083791B2

公开(公告)日：2021-08-10

申请号：US16441974

申请日：2019-06-14

Applicant: BIOGEN MA INC.

Inventor： Alexey A. Lugovskoy ,  Frederick R. Taylor ,  Karen McLachlan

IPC: A61K39/395 ,  C07K16/28 ,  A61K45/06 ,  C07K16/30

Abstract: This invention relates to alpha-4 binding antibodies, and fragments thereof.

公开(公告)号：US20210238289A1

公开(公告)日：2021-08-05

申请号：US15734915

申请日：2019-05-31

Applicant: BIOGEN MA INC.

Inventor： Janine Lisa FERRANT-ORGETTAS ,  Robert Blake PEPINSKY ,  Ellen Duggan CAHIR-MCFARLAND ,  Nadia Giselle D'LIMA ,  Joseph Walter ARNDT ,  Karl John Mortley HANF ,  Thomas Owen CAMERON ,  Ellen Garber STARK

IPC: C07K16/28 ,  A61K39/00

Abstract: The invention relates to anti-VLA-4 antibodies and binding fragments thereof. The invention further includes polynucleotides encoding said antibodies and binding fragments thereof and methods of manufacturing said antibodies and binding fragments thereof. The invention further includes methods of treating patients suffering from multiple sclerosis and/or epilepsy by administration of said antibodies and binding fragments thereof. The invention further includes methods of reducing the susceptibility to scrambling of a recombinant anti-alpha 4 antibody or a binding fragment thereof.

公开(公告)号：US11040119B2

公开(公告)日：2021-06-22

申请号：US14774510

申请日：2014-03-12

Applicant: Biogen MA Inc.

Inventor： Ajay Verma ,  Jack Hoppin

IPC: A61K51/04 ,  A61B5/00 ,  G01N33/60 ,  G01N33/68

Abstract: The invention provides compositions and methods for evaluating neuromuscular function in a subject, e.g., a subject at risk for or suffering from a neuromuscular disorder.

公开(公告)号：US10955422B2

公开(公告)日：2021-03-23

申请号：US15120573

申请日：2015-02-27

Applicant: Biogen MA Inc.

Inventor： Tatiana Plavina ,  John P. Carulli ,  Leonid Gorelik ,  Teresa Compton

IPC: G01N33/53 ,  G01N33/68 ,  C12Q1/6883

Abstract: The invention relates to methods of assessing a patient's risk of developing Progressive Multifocal Leukoencephalopathy (PML).

公开(公告)号：US10947262B2

公开(公告)日：2021-03-16

申请号：US16309622

申请日：2017-06-13

Applicant: BIOGEN MA INC.

Inventor： Robert S. Gronke ,  Ratnesh S. Joshi

IPC: C07H1/06 ,  C07H1/00 ,  B01D15/30 ,  B01D15/42 ,  C07H21/02 ,  C07H21/04

Abstract: The invention herein describes a method to purify a target oligonucleotide using hydrophobic interaction chromatography (HIC). The method includes adding a salt to a mixture of the target oligonucleotide and product-related impurities, applying the diluted mixture, at a particular dynamic loading capacity, to the hydrophobic interaction chromatography resin (or hydrophobic adsorbent), washing the hydrophobic adsorbent with an aqueous salt solution, eluting the target oligonucleotide with a eluting solution, and collecting the eluent comprising the target oligonucleotide.

公开(公告)号：US20210025900A1

公开(公告)日：2021-01-28

申请号：US16923043

申请日：2020-07-07

Applicant: Biogen MA Inc.

Inventor： Meena Subramanyam ,  Lakshimi Amaravadi ,  Eric Wakshull ,  Frances Lynn ,  Michael Panzara ,  Robin McDaid Barbour ,  Julie Elizabeth Taylor

IPC: G01N33/68 ,  C07K16/28

Abstract: The invention relates to methods and products for the identification of a clinically significant immune response in subjects treated with a therapeutic protein. Aspects of the invention relate to methods and compositions for identifying a clinically significant immune response in patients treated with therapeutic amounts of a VLA4 binding antibody (e.g., natalizumab).

公开(公告)号：US20200376018A1

公开(公告)日：2020-12-03

申请号：US16708739

申请日：2019-12-10

Applicant: Biogen MA Inc. ,  Cold Spring Harbor Laboratory

Inventor： C. Frank Bennett ,  Gene Hung ,  Frank Rigo ,  Adrian R. Krainer ,  Yimin Hua ,  Marco A. Passini ,  Lamya Shihabuddin ,  Seng H. Cheng ,  Katherine W. Klinger

IPC: A61K31/7088 ,  C12N15/113

Abstract: Disclosed herein are compounds, compositions and methods for modulating splicing of SMN2 mRNA in a subject. Also provided are uses of disclosed compounds and compositions in the manufacture of a medicament for treatment of diseases and disorders, including spinal muscular atrophy.

公开(公告)号：US20200276303A1

公开(公告)日：2020-09-03

申请号：US16708695

申请日：2019-12-10

Applicant: Biogen MA Inc.

Inventor： Diego Cadavid ,  Sha Mi

IPC: A61K39/395 ,  C07K16/28 ,  A61B3/00 ,  A61B5/11 ,  A61B5/00 ,  A61K31/56 ,  A61K38/21 ,  G01R33/48

Abstract: Methods and compositions for enhancing one or more of: myelination, re-myelination, oligodendrocyte numbers, or neuroaxonal protection, while ameliorating an inflammatory condition in a human subject are disclosed. In certain embodiments, the methods and compositions described herein include a reparative agent (e.g., a LINGO-1 antagonist) and an immunomodulatory agent, in combination. Thus, methods, compositions and kits described herein can be useful for treating a CNS demyelinating disease.

公开(公告)号：US20200262895A1

公开(公告)日：2020-08-20

申请号：US16580152

申请日：2019-09-24

Applicant: Biogen MA Inc. ,  Biogen International Neuroscience GmbH

Inventor： Paul H. Weinreb ,  Feng Chen ,  Ellen A. Garber Stark ,  Jan Grimm ,  Fabio Montrasio

IPC: C07K16/18 ,  A61K39/395 ,  A61K45/06 ,  A61K49/00 ,  A61K49/16 ,  G01N33/68

Abstract: Provided are novel human tau-specific antibodies as well as fragments, derivatives and variants thereof as well as methods related thereto. Assays, kits, and solid supports related to antibodies specific for tau are also disclosed. The antibody, immunoglobulin chain(s), as well as binding fragments, derivatives and variants thereof can be used in pharmaceutical and diagnostic compositions for tau targeted immunotherapy and diagnosis, respectively.