公开(公告)号：US11522078B2

公开(公告)日：2022-12-06

申请号：US16629156

申请日：2018-07-06

Applicant: Indian Institute of Science

Inventor： Rohith Soman ,  Ankit Soni ,  Mayank Shrivastava ,  Srinivasan Raghavan ,  Navakant Bhat

IPC: H01L29/778 ,  H01L29/06 ,  H01L29/20 ,  H01L29/205 ,  H01L29/40 ,  H01L29/423

Abstract: A High Electron Mobility Transistor (HEMT) having a reduced surface field (RESURF) junction is provided. The HEMT includes a source electrode at a first end and a drain electrode at a second end. A gate electrode is provided between the source electrode and the drain electrode. A reduced surface field (RESURF) junction extends from the first end to the second end. The gate electrode is provided above the RESURF junction. A buried channel layer is formed in the RESURF junction on application of a positive voltage at the gate electrode. The RESURF junction includes an n-type Gallium nitride (GaN) layer and a p-type GaN layer. The n-type GaN layer is provided between the p-type GaN layer and the gate electrode.

公开(公告)号：US20220298541A1

公开(公告)日：2022-09-22

申请号：US17698397

申请日：2022-03-18

Applicant: Indian Institute of Science Education and Research

Inventor： Britto S. SANDANARAJ ,  Punita BATHLA ,  Abhijit DE ,  Aaiyas MUJAWAR

IPC: C12Q1/66 ,  G01N33/58 ,  G01N33/50

Abstract: The present disclosure relates to an assay for determining drug-target engagement in real-time. Specifically, the present disclosure provides a method for determining drug candidate-target interaction in real-time in living systems using Activity-based Reporter Gene Technology-Bioluminescence Resonance Energy Transfer (AbRGT-BRET) based assay. The said assay is useful for High Throughput Screening of compounds to a specific target.

公开(公告)号：US20220283188A1

公开(公告)日：2022-09-08

申请号：US17684777

申请日：2022-03-02

Applicant: Indian Institute of Science

Inventor： Rajesh Srinivasan ,  Eugene Christo V R ,  Prateek Katare ,  Aravind Venukumar ,  Sai Siva Gorthi ,  Nisanth KM Nambison

IPC: G01N33/72 ,  G01N21/31 ,  G01N33/49

Abstract: The present disclosure provides in vitro methods for identifying the presence or absence of haemoglobin S (HbS) or haemoglobin C (HbC) in a blood sample, kits and devices thereof. The inventors have found that HbS shows a substantial decrease in absorption under deoxygenated conditions compared to oxygenated conditions. The inventors expect HbC to show a similar decrease in absorption under deoxygenated conditions compared to oxygenated conditions. The methods, kits and devices of the disclosure employ this decrease in absorption under deoxygenated conditions to identify the presence or absence of HbS or HbC in a blood sample. The methods, kits and devices of the present disclosure are simple, low cost, and provide a rapid way to identify the presence or absence of HbS or HbC in a blood sample in a point-of-care setting.

公开(公告)号：US11428664B2

公开(公告)日：2022-08-30

申请号：US15509447

申请日：2015-09-07

Applicant: INDIAN INSTITUTE OF SCIENCE

Inventor： Vinay Kumar ,  Navakanta Bhat

IPC: G01N27/416 ,  G01N33/72

Abstract: An electrochemically active device is provided for collecting and retaining a blood sample with at least a two-electrode member connected to conductive tracks. A receptor with an integral receptor-membrane arranged on the two-electrode member, to receive non-electrochemically active heamoglobin bioanalyte and its complexes from red blood cells (RBC) of said blood sample, through a lysing agent and convert the non-electrochemically active heamoglobin bioanalyte and its complexes, into an electrochemically active bioanalyte and its electrochemically active complexes. The present invention also provides a point-of-care biosensor incorporated with the device of the present invention and method of measuring for the detection and quantitative measurement of concentrations of haemoglobin (Hb), glycated haemoglobin (GHb), methaemoglobin (MetHb) and myoglobin, in reduced volumes of blood samples, by determining redox current values in the reduced volumes of blood samples.

公开(公告)号：US11378467B2

公开(公告)日：2022-07-05

申请号：US16520449

申请日：2019-07-24

Applicant: Indian Institute of Science

Inventor： Vaishakh Kedambaimoole ,  Pavithra B. Jain ,  Manasa ,  Nagarjuna Neella ,  Rajanna Konandur ,  M M. Nayak ,  Narasimhiah Subrahmanyam Dinesh

IPC: G01K7/22 ,  H01C17/00 ,  H01C7/04 ,  G01K7/18

Abstract: The present disclosure generally relates to the field of resistive sensing. In particular, the present disclosure relates to a highly sensitive reduced graphene oxide-nickel (RGO—Ni) composite based fast response temperature sensor. Aspects of the present disclosure provide a method for fabrication of a highly sensitive reduced graphene oxide-nickel (RGO—Ni) composite-based temperature sensor. An aspect of the present disclosure provides a temperature sensor comprising: a substrate; and a composite film deposited onto said substrate, wherein the composite film comprises a reduced graphene oxide-nickel composite film. In an embodiment, the temperature sensor is cryo-compatible.

公开(公告)号：US20220176817A1

公开(公告)日：2022-06-09

申请号：US17437003

申请日：2020-01-14

Applicant: INDIAN INSTITUTE OF SCIENCE ,  FAURECIA INDIA PRIVATE LIMITED

Inventor： Pradipta BISWAS ,  Sachin DESHMUKH ,  Gowdham PRABHAKAR ,  Modiksha MADAN ,  Aparna RAMAKRISHNAN ,  Vinay Krishna SHARMA

IPC: B60K35/00 ,  G06F3/01 ,  G06F3/04812 ,  G06F3/0488 ,  G06N3/08

Abstract: A system for man-machine interaction for a vehicle is disclosed. The proposed system includes an interactive reflected display on a windscreen of the vehicle; an eye tracking module including an eye gaze tracker for tracking eye gaze direction of a user, and a training unit to train the tracking module using a neural network to predict a real-time set of coordinates for eye gaze direction of the user based on a created reference data set of coordinates of the display; a finger tracking module to detect presence of a finger of the user and track movement of the finger; a cursor module configured to, on the basis of a received input, move a cursor on the display to an area of interest on the display; and a wireless switch module operatively coupled to the display for selecting a target in the area of interest on the display.

公开(公告)号：US11244094B2

公开(公告)日：2022-02-08

申请号：US16319221

申请日：2017-07-18

Applicant: INDIAN INSTITUTE OF SCIENCE ,  ROBERT BOSCH ENGINEERING AND BUSINESS SOLUTIONS PRIVATE LIMITED

Inventor： Dipanjan Gope ,  Gourav Chatterjee ,  Arkaprovo Das ,  Sreenivasulu Reddy Vedicherla

IPC: G06F30/23 ,  G06F17/16 ,  G06T17/20 ,  G06F111/10

Abstract: Techniques for electromagnetic modelling of EM structures are described. Krylov subspace of a second EM structure is augmented with Eigen vectors of a first EM structure to form an augmented space. The second EM structure is a design variant of the first EM structure and the first EM structure is already EM modelled and simulated. Thereafter, Maxwell's equations for the second EM structure are solved using the augmented space.

公开(公告)号：US11149058B2

公开(公告)日：2021-10-19

申请号：US16085360

申请日：2016-11-17

Applicant: Department of Biotechnology ,  Indian Institute of Science Education and Research Bhopal

Inventor： Vishal Rai ,  Srinivasa Rao Adusumalli

IPC: C07K1/107 ,  C07K14/805 ,  C07K1/13 ,  C07K1/22 ,  C07K1/00 ,  C07K1/02

Abstract: A multifunctional chemical agents comprising functional agents Fn1, Fn2 and linkers, for the linchpin directed (LDM), protein directed (PDPM) modifications of proteins, and Fn1 accelerated kinetic labeling by Fn2.

公开(公告)号：US20210262041A1

公开(公告)日：2021-08-26

申请号：US17266206

申请日：2019-08-08

Applicant: INDIAN INSTITUTE OF SCIENCE EDUCATION AND RESEARCH

Inventor： Sanjeev GALANDE ,  Rutika NAIK

IPC: C12Q1/6886

Abstract: The present invention provides an in-vitro process for profiling a combined expression pattern of SATB (special AT-rich sequence-binding protein-1) family chromatin organizers i.e. SATB-1 and SATB-2 as a biomarker tool for cancer prognosis to assess cancer aggressiveness and it progression in an array of cancer types. The combined expression pattern of SATB is established by the method of Kaplan Meier survival analysis of a dataset of patients from a plurality of cancer types. Further, the present invention provides a prognostic kit to evaluate the progression of cancer by using the combined expression pattern of SATB-1 and SATB-2 as a biomarker tool for cancer prognosis.

公开(公告)号：US20200258647A1

公开(公告)日：2020-08-13

申请号：US16643430

申请日：2018-09-03

Applicant: Indian Institute of Science

Inventor： Souvik Ghosh ,  Ambarish Ghosh

IPC: G21K1/00 ,  G02B5/00

Abstract: The present subject matter described herein relates to a Magnetically Augmented Plasmonic Tweezer (MAPT), a method for fabrication of the MAPT, and a method for trapping and maneuvering one or more colloidal particles inside a fluid. The fluid may correspond to a fluid inside a microfluidic device or a biological fluid. The MAPT can comprise a helical support structure to provide maneuverability in fluid. Further, a magnetic component is integrated in the MAPT for motion control. Plasmonic nanostmctures are integrated in the MAPT for optical trapping of particles.