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公开(公告)号：US12154776B2
公开(公告)日：2024-11-26
申请号：US18121550
申请日：2023-03-14
Applicant: LABCYTE INC. , DH Technologies Development Pte. Ltd.
Inventor： Sammy Datwani , Don W. Arnold , Lucien P. Ghislain , Chang Liu , Thomas Covey
Abstract: A system and method are provided for loading a sample into an analytical instrument using acoustic droplet ejection (“ADE”) in combination with a continuous flow sampling probe. An acoustic droplet ejector is used to eject small droplets of a fluid sample containing an analyte into the sampling tip of a continuous flow sampling probe, where the acoustically ejected droplet combines with a continuous, circulating flow stream of solvent within the flow probe. Fluid circulation within the probe transports the sample through a sample transport capillary to an outlet that directs the analyte away from the probe to an analytical instrument, e.g., a device that detects the presence, concentration quantity, and/or identity of the analyte. When the analytical instrument is a mass spectrometer or other type of device requiring the analyte to be in ionized form, the exiting droplets pass through an ionization region, e.g., an electrospray ion source, prior to entering the mass spectrometer or other analytical instrument. The method employs active flow control and enables real-time kinetic measurements.
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公开(公告)号：US20240379338A1
公开(公告)日：2024-11-14
申请号：US18686618
申请日：2022-09-07
Applicant: DH TECHNOLOGIES DEVELOPMENT PTE. LTD.
Inventor： Bradley B. Schneider , Leigh Bedford , Chang Liu
IPC: H01J49/04 , G01N27/624 , H01J49/00
Abstract: Disclosed are methods and systems that provide for the analysis of one or more analytes of interest in an acoustic ejection mass spectrometer (AEMS) system that incorporates an open port interface (OPI) and differentiation mass spectrometry (DMS) that allows for operation of the system in a pseudo-continuous mode to scan and determine optimal DMS settings for the one or more analytes of interest, and for operation of the system in a discontinuous mode to analyze for the presence of the one or more analytes of interest in a sample.
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公开(公告)号：US20240272191A1
公开(公告)日：2024-08-15
申请号：US18439795
申请日：2024-02-13
Applicant: DH Technologies Development Pte. Ltd. , United States of America, as represented by the Secretary, Department of Health and Human Services
Inventor： Meghav Verma , Samuel Michael , John Janiszewski , Chang Liu , Thomas R. Covey
IPC: G01N35/10
CPC classification number: G01N35/1072 , G01N35/1011
Abstract: A method of processing a sample plate containing a plurality of samples includes aspirating simultaneously, from the sample plate, a first sample droplet from a first sample of the plurality of samples with a first pipette and a second sample droplet from a second sample of the plurality of samples with a second pipette. The sample plate also includes dispensing sequentially, from the first pipette and the second pipette, the first sample drop and the second sample drop into an open port interface (OPI).
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公开(公告)号：US11990325B2
公开(公告)日：2024-05-21
申请号：US17427300
申请日：2020-02-03
Applicant: DH Technologies Development Pte. Ltd.
Inventor： Thomas R. Covey , Chang Liu , Gary J. Van Berkel
CPC classification number: H01J49/0004 , H01J49/0418 , H01J49/0431 , H01J49/063
Abstract: A method for the repeated analysis of a sample bearing location. The sample bearing location may include, for instance, a sampled point in a tissue slice that is spatially and temporally correlated to the original slice. The slice may be in whole, or in part, a complete item or a portion of a complete item such as, for example, a human organ. The method improves the analysis process, such as mass spectrometry analysis, by providing a much more complete characterization of the target. The method also allows for the splitting of the sample and chemical/physical alteration of the aliquots for enhanced chemical analysis.
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公开(公告)号：US20240068997A1
公开(公告)日：2024-02-29
申请号：US18259211
申请日：2021-09-21
Applicant: DH Technologies Development Pte. Ltd.
Inventor： Gordana Ivosev , Chang Liu
CPC classification number: G01N30/8624 , B01D15/08 , G01N30/72
Abstract: The disclosed signal quality assessment is particularly useful for mass spectrometry. In an embodiment of the disclosed system, a processor utilizes a wavelet-based feature extraction for the signal quality assessment of a chromatogram signal. The signal quality assessment may be used to control operational parameters, such as a flowrate of a pump that moves liquid droplets toward an ionization device of a mass spectrometer.
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Patent Agency Ranking
公开(公告)号：US20230207299A1
公开(公告)日：2023-06-29
申请号：US17999641
申请日：2021-05-21
Applicant: DH TECHNOLOGIES DEVELOPMENT PTE. LTD.
Inventor： Thomas R Covey , Gordana Ivosev , Peter Kovarik , Chang Liu
CPC classification number: H01J49/0454 , H01J49/0418 , H01J49/0036
Abstract: A trace of intensity versus time values is received for a series of samples produced by a mass spectrometer. Also, a series of ejections times corresponding to the series of samples produced by a sample introduction system is received. A series of expected peak times corresponding to the series of ejection times are calculated using a known delay time from ejection to mass analysis. At least one isolated peak of the trace is identified using the series of expected peak times. A peak profile is calculated by fitting a mixture of at least two different distribution functions to the at least one isolated peak. For at least one time of the series of expected peak times, an area of a peak at the one time is calculated by fitting the peak profile to the trace at the one time and calculating an area of the fitted peak profile.
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公开(公告)号：US11637006B2
公开(公告)日：2023-04-25
申请号：US17410758
申请日：2021-08-24
Applicant: Labcyte, Inc. , DH Technologies Development Pte. Ltd.
Inventor： Sammy Datwani , Don W. Arnold , Lucien P. Ghislain , Chang Liu , Thomas Covey
Abstract: A system and method are provided for loading a sample into an analytical instrument using acoustic droplet ejection (“ADE”) in combination with a continuous flow sampling probe. An acoustic droplet ejector is used to eject small droplets of a fluid sample containing an analyte into the sampling tip of a continuous flow sampling probe, where the acoustically ejected droplet combines with a continuous, circulating flow stream of solvent within the flow probe. Fluid circulation within the probe transports the sample through a sample transport capillary to an outlet that directs the analyte away from the probe to an analytical instrument, e.g., a device that detects the presence, concentration quantity, and/or identity of the analyte. When the analytical instrument is a mass spectrometer or other type of device requiring the analyte to be in ionized form, the exiting droplets pass through an ionization region, e.g., an electrospray ion source, prior to entering the mass spectrometer or other analytical instrument. The method employs active flow control and enables real-time kinetic measurements.
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公开(公告)号：US11450519B2
公开(公告)日：2022-09-20
申请号：US16972925
申请日：2019-06-07
Applicant: DH Technologies Development Pte. Ltd.
Inventor： Thomas R Covey , Chang Liu
Abstract: Sampling probes and interfaces for mass spectrometry systems and methods are described to analyze a composition of a substance. The system includes a liquid reservoir containing solvent; a gas reservoir containing nebulizer gas; a conduit that is in fluid communication with the liquid reservoir, the conduit comprising a first and second portion and a junction portion, the first and second portion being joined at the junction portion, and defining an angle therebetween at the junction and the junction portion contains an aperture that is open to the atmosphere. A nebulizer conduit that is co-axial and partially surrounds the second portion and completely surrounds an end of the second portion can also be present, the nebulizer conduit being fluidly connected to the gas reservoir and that allows a gas to flow from the gas reservoir over an external surface of the second portion and the end of the second portion.
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49.发明授权公开(公告)号：US11348780B2
公开(公告)日：2022-05-31
申请号：US16765910
申请日：2018-11-20
Applicant: DH Technologies Development Pte. Ltd.
Inventor： Don W Arnold , Thomas R. Covey , Chang Liu
Abstract: An ultrasonic transmitter (95) and detector (e.g., integrated as an ultrasound transducer) utilized in a feedback control system automatically monitors and/or detects surface profile (e.g., shape) of the liquid-air interface and adjusts the flow rate of sampling liquid to ensure that experimental conditions remain consistent at the time of sample introduction during serial samplings. The feedback control can provide for automated adjustment of the surface profile of the liquid-air interface in accordance with changes in desired set point according to an experimental workflow (e.g., automated adjustment between an interface corresponding to a vortex sampling set point and an overflow cleaning set point). Improvements in desorption efficiency and quality of mass spectrometry data by degassing of the liquid solvent utilized within the sampling interfaces, and/or utilization in a feedback control system for generating data indicative of a surface profile of the liquid-air interface within the interface's sampling port may be realized.
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50.发明授权公开(公告)号：US11232939B2
公开(公告)日：2022-01-25
申请号：US16765958
申请日：2018-11-20
Applicant: DH Technologies Development Pte. Ltd.
Inventor： Don W Arnold , Thomas R. Covey , Chang Liu , Bogdan Morosan
Abstract: Mass spectrometer based analytical systems and methods in which a feedback control system can be utilized to control the flow of liquid within a sampling probe to adjust and/or maintain the surface profile (e.g., shape) of the liquid-air interface within an open sampling port of the sampling probe. The feedback control systems can automatically monitor and/or detect the surface profile of the liquid-air interface and adjust the flow rate of the sampling liquid to ensure that experimental conditions remain consistent at the time of sample introduction during serial samplings. These can provide stable and reproducible analyte flows of consistent dilution to the ion source, increasing reproducibility and/or accuracy of data generated by MS analysis. Can be used with a change in the desired set point according to the particular experimental workflow (e.g., automated adjustment between an interface corresponding to a sampling set point and a cleaning set point).
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