公开(公告)号：US10068755B2

公开(公告)日：2018-09-04

申请号：US15361968

申请日：2016-11-28

Applicant: Micromass UK Limited

Inventor： Jeffery Mark Brown ,  Kevin Giles ,  Daniel James Kenny ,  Paul Murray ,  Keith Richardson

IPC: H01J49/00 ,  G01N27/62

CPC classification number: H01J49/0059 ,  G01N27/624 ,  H01J49/0027 ,  H01J49/0031 ,  H01J49/062 ,  H01J49/10 ,  H01J49/26 ,  H01J49/40 ,  H01J49/422 ,  H01J49/4245

Abstract: A method of mass spectrometry is disclosed comprising directing first photons from a laser onto ions located within a 2D or linear ion guide or ion trap. The frequency of the first photons is scanned and first photons and/or second photons emitted by the ions are detected. The ions are then mass analysed using a Time of Flight mass analyser.

公开(公告)号：US20180144921A1

公开(公告)日：2018-05-24

申请号：US15570537

申请日：2016-04-29

Applicant: Micromass UK Limited ,  LECO Corporation

Inventor： John Brian Hoyes ,  Keith Richardson ,  Anatoly Verenchikov ,  Mikhail Yavor

IPC: H01J49/40 ,  H01J49/42

Abstract: A method of time-of-flight mass spectrometry is disclosed comprising: providing two ion mirrors (42) that are spaced apart in a first dimension (X-dimension) and that are each elongated in a second dimension (Z-dimension) orthogonal to the first dimension; introducing packets of ions (47) into the space between the mirrors using an ion introduction mechanism (43) such that the ions repeatedly oscillate in the first dimension (X-dimension) between the mirrors (42) as they drift through said space in the second dimension (Z-dimension); oscillating the ions in a third dimension (Y-dimension) orthogonal to both the first and second dimensions as the ions drift through said space in the second dimension (Z-dimension); and receiving the ions in or on an ion receiving mechanism (44) after the ions have oscillated multiple times in the first dimension (X-dimension); wherein at least part of the ion introduction mechanism (43) and/or at least part of the ion receiving mechanism (44) is arranged between the mirrors (42).

公开(公告)号：US09728383B2

公开(公告)日：2017-08-08

申请号：US14892815

申请日：2014-06-09

Applicant: Micromass UK Limited

Inventor： Martin Raymond Green ,  Keith Richardson

IPC: H01J49/04 ,  H01J49/00 ,  G01N27/62

CPC classification number: H01J49/0031 ,  G01N27/622 ,  H01J49/0009 ,  H01J49/0072

Abstract: A method of mass or ion mobility spectrometry is disclosed comprising: providing an ion source for generating analyte ions and reference ions; providing a mass analyzer or ion mobility separator (IMS); providing an ion trap between the ion source and the mass analyzer or IMS; guiding reference ions from the ion source into the ion trap and trapping the reference ions in the ion trap; guiding the analyte ions from the ion source into the mass analyzer or IMS, wherein the analyte ions bypass the ion trap; and releasing reference ions from the ion trap into the mass analyzer or IMS for analysis.

公开(公告)号：US09664647B2

公开(公告)日：2017-05-30

申请号：US14360121

申请日：2012-11-22

Applicant: Micromass UK Limited

Inventor： Michael Raymond Morris ,  Steven Derek Pringle ,  Keith Richardson ,  Ian Sinclair

IPC: H01J49/10 ,  G01N29/02 ,  H01J49/04 ,  H01J49/00

CPC classification number: H01J49/10 ,  G01N29/02 ,  G01N2291/011 ,  G01N2291/02818 ,  H01J49/0027 ,  H01J49/0454

Abstract: An ion source for a mass spectrometer is disclosed comprising an ultrasonic transducer which focuses ultrasonic energy onto a surface of a sample fluid without directly contacting the sample fluid.

公开(公告)号：US20170076927A1

公开(公告)日：2017-03-16

申请号：US15125328

申请日：2015-03-10

Applicant: Micromass UK Limited

Inventor： Martin Raymond Green ,  Kevin Giles ,  Keith Richardson ,  Jason Lee Wildgoose

IPC: H01J49/00 ,  G01N27/62

CPC classification number: H01J49/0036 ,  G01N27/622 ,  H01J49/0031 ,  H01J49/004 ,  H01J49/005

Abstract: A method of mass spectrometry is disclosed that comprises predicting 1 one or more first reaction products which may result from subjecting an analyte to one or more reactions of interest, calculating 2 one or more first masses or mass to charge ratios and one or more first ion mobility values, collision cross sections or interaction cross sections of at least some first reaction product ions which may be generated from the one or more first reaction products under first conditions, and calculating one or more second masses or mass to charge ratios and one or more second ion mobility values, collision cross sections or interaction cross sections of at least some second reaction product ions which may be generated from the one or more first reaction products under second different conditions. The method further comprises generating third ions from a sample under the first conditions, generating fourth ions from the sample under the second conditions, experimentally determining 3 one or more third masses or mass to charge ratios and one or more third ion mobility values, collision cross sections or interaction cross sections of at least some of the third ions, and experimentally determining one or more fourth masses or mass to charge ratios and one or more fourth ion mobility values, collision cross sections or interaction cross sections of at least some of the fourth ions. The first, second, third and/or fourth mass or mass to charge ratios and/or the first, second, third and/or fourth ion mobility values, collision cross sections or interaction cross sections are compared 4 in order to confirm the presence and/or absence of one or more reaction products of interest in the sample.

Abstract translation: 公开了一种质谱法，其包括预测1种或多种第一反应产物，其可能由分析物经受一次或多次感兴趣的反应而产生，计算2个一个或多个第一质量或质量与电荷比，以及一种或多种第一离子 可以在第一条件下从一个或多个第一反应产物产生的至少一些第一反应产物离子的迁移值，碰撞横截面或相互作用横截面，以及计算一个或多个第二质量或质荷比和一个或多个 第二离子迁移率值，碰撞横截面或至少一些第二反应产物离子的相互作用截面，其可以在第二不同条件下从一种或多种第一反应产物产生。 该方法还包括在第一条件下从样品中产生第三离子，在第二条件下从样品产生第四离子，通过实验确定3个一个或多个第三质量或质荷与比例和一个或多个第三离子迁移值，碰撞交叉 至少部分第三离子的截面或相互作用横截面，并且实验地确定一个或多个第四质量或质量与电荷比以及第四离子迁移值中的至少一些的第四离子迁移率值，碰撞截面或相互作用横截面 离子。 比较第一，第二，第三和/或第四质量或质量与电荷比和/或第一，第二，第三和/或第四离子迁移率值，碰撞横截面或相互作用横截面，以确认存在和 /或样品中不存在一种或多种感兴趣的反应产物。

公开(公告)号：US09564301B2

公开(公告)日：2017-02-07

申请号：US15224989

申请日：2016-08-01

Applicant: Micromass UK Limited

Inventor： Martin Raymond Green ,  Jason Lee Wildgoose ,  Steven Derek Pringle ,  Keith Richardson

IPC: H01J49/00 ,  G01R29/26

CPC classification number: H01J49/0031 ,  G01R29/26 ,  H01J49/025

Abstract: A control system and method of determining a signal to noise (S/N) ratio of an ion detector system, including an ion detector, electron multiplier or photomultiplier, operates by determining an area of a noise peak, determining an area of a signal peak and determining a ratio of the area of the signal peak to the area of the noise peak. Based thereon, the signal to noise ratio can be optimized. The system has particular applicability for use in mass spectrometry.

Abstract translation: 确定离子检测器系统（包括离子检测器，电子倍增器或光电倍增管）的信噪比（S / N）比的控制系统和方法通过确定噪声峰值的面积来确定信号峰值的面积 并且确定信号峰值的面积与噪声峰值的面积的比率。 基于此，可以优化信噪比。 该系统特别适用于质谱分析。

公开(公告)号：US20160268114A1

公开(公告)日：2016-09-15

申请号：US15035952

申请日：2014-11-11

Applicant: MICROMASS UK LIMITED

Inventor： Kevin Giles ,  Martin Raymond Green ,  Keith Richardson ,  Jason Lee Wildgoose

IPC: H01J49/06 ,  H01J49/38 ,  G01N27/62

CPC classification number: H01J49/06 ,  G01N27/622 ,  H01J49/004

Abstract: A method of mass spectrometry or ion mobility spectrometry is disclosed comprising: providing ions towards an ion storage region; selecting a target maximum charge desired to be stored within the ion storage region at any given time; and reducing the ion current passing to the ion storage region such that the ions entering the ion storage region do not cause the total charge within the storage region to rise above said target maximum charge. The step of reducing the ion current passing to the ion storage region comprises: temporally separating the ions according to their ion mobility in an ion mobility separator; and mass filtering the ions according to mass to charge ratio with a mass filter. Said steps of separating and mass filtering the ions result in substantially only target ions having selected combinations of ion mobility and mass to charge ratio being transmitted towards the ion storage region. The method further comprises accumulating the target ions within the ion storage region during an ion accumulation period.

Abstract translation: 公开了一种质谱法或离子迁移光谱法，其包括：向离子存储区提供离子; 在任何给定时间选择期望存储在离子存储区域内的目标最大电荷; 并且减少通过离子存储区域的离子电流，使得进入离子存储区域的离子不会使存储区域内的总电荷升高到高于目标最大电荷。 降低通过离子存储区域的离子电流的步骤包括：在离子迁移率分离器中根据其离子迁移率暂时分离离子; 并根据质量与质量过滤器的质荷比质量过滤离子。 分离和质量过滤离子的所述步骤基本上仅导致具有选择的离子迁移率和质荷比的组合的目标离子被传输到离子存储区域。 该方法还包括在离子累积期间在离子存储区内积聚目标离子。

公开(公告)号：US20160126074A1

公开(公告)日：2016-05-05

申请号：US14892815

申请日：2014-06-09

Applicant: MICROMASS UK LIMITED

Inventor： Martin Raymond Green ,  Keith Richardson

IPC: H01J49/00 ,  G01N27/62

CPC classification number: H01J49/0031 ,  G01N27/622 ,  H01J49/0009 ,  H01J49/0072

Abstract: A method of mass or ion mobility spectrometry is disclosed comprising: providing an ion source for generating analyte ions and reference ions; providing a mass analyser or ion mobility separator (IMS); providing an ion trap between the ion source and the mass analyser or IMS; guiding reference ions from the ion source into the ion trap and trapping the reference ions in the ion trap; guiding the analyte ions from the ion source into the mass analyser or IMS, wherein the analyte ions bypass the ion trap; and releasing reference ions from the ion trap into the mass analyser or IMS for analysis.

Abstract translation: 公开了一种质量或离子迁移谱的方法，包括：提供用于产生分析物离子和参考离子的离子源; 提供质量分析器或离子迁移分离器（IMS）; 在离子源和质量分析器或IMS之间提供离子阱; 将参考离子从离子源引导到离子阱中并将参考离子捕获在离子阱中; 将分析物离子从离子源引导到质量分析器或IMS中，其中分析物离子绕过离子阱; 并将离子阱中的参考离子释放到质量分析器或IMS中进行分析。

公开(公告)号：US20160027626A1

公开(公告)日：2016-01-28

申请号：US14776036

申请日：2014-03-14

Applicant: MICROMASS UK LIMITED

Inventor： Richard Chapman ,  Jeffery Mark Brown ,  Paul Murray ,  Keith Richardson ,  Emmy Maria Hoyes

IPC: H01J49/00

CPC classification number: H01J49/0004 ,  H01J49/0031 ,  H01J49/0036

Abstract: A method of ion imaging is disclosed comprising scanning a sample and acquiring first mass spectral data related to a first pixel location at a first spatial resolution and determining whether or not the first mass spectral data satisfies a condition. If it is determined that the first mass spectral data does satisfy the condition then the first mass spectral data is stored, recorded or prioritized. If it is determined that the first mass spectral data does not satisfy the condition then the first mass spectral data is discarded or downgraded. Scanning of the sample then continues at the first spatial resolution and further mass spectral data related to further pixel locations is acquired.

Abstract translation: 公开了一种离子成像方法，包括扫描样本并以第一空间分辨率获取与第一像素位置相关的第一质谱数据，并确定第一质谱数据是否满足条件。 如果确定第一质谱数据确实满足条件，则存储，记录或优先化第一质谱数据。 如果确定第一质谱数据不满足条件，则第一质谱数据被丢弃或降级。 样本的扫描然后以第一空间分辨率继续进行，并且获取与另外的像素位置相关的进一步的质谱数据。

公开(公告)号：US20150380230A1

公开(公告)日：2015-12-31

申请号：US14847574

申请日：2015-09-08

Applicant: Micromass UK Limited

Inventor： Keith Richardson

IPC: H01J49/40 ,  H01J49/00

CPC classification number: H01J49/401 ,  H01J49/0027 ,  H01J49/0031 ,  H01J49/004 ,  H01J49/40

Abstract: A method of mass spectrometry is disclosed comprising separating ions according to one or more physico-chemical properties. Ions which are onwardly transmitted to a Time of Flight mass analyser are controlled by attenuating ions which would otherwise be transmitted to the Time of Flight mass analyser and cause saturation of an ion detector and which have been determined or which are predicted to have a relatively high intensity.

Abstract translation: 公开了一种质谱法，其包括根据一种或多种物理化学性质分离离子。 向上传播到飞行时间质量分析器的离子通过衰减离子来控制，否则离子将否则将被传输到飞行时间质量分析器并引起离子检测器的饱和，并且已被确定或预测具有相对较高的 强度。