公开(公告)号：US07077910B2

公开(公告)日：2006-07-18

申请号：US10409434

申请日：2003-04-07

Applicant: Ralph A. Chappa ,  Steven J. Porter

Inventor： Ralph A. Chappa ,  Steven J. Porter

IPC: B05C11/02 ,  B05C15/00

CPC classification number: B05D1/002 ,  A61L31/10 ,  B05B13/0242 ,  B05B13/0442 ,  B05B16/40

Abstract: The invention provides an apparatus for coating a device comprising a coating chamber and a device rotator having at least one device mount wherein the apparatus allows insertion and retraction of the device on the device mount into and out of the coating chamber. In another aspect, the invention provides a method of applying a substantially uniform coating on a device comprising the steps of providing an apparatus for coating a device, mounting the device onto the device mount, purging the coating chamber to reduce humidity in the coating chamber, maintaining a reduced humidity content in the coating chamber, inserting the device into the coating chamber, disposing a coating material on the device and rotating the device mounts about the device axis.

公开(公告)号：USRE46251E1

公开(公告)日：2016-12-27

申请号：US13588125

申请日：2012-08-17

Applicant: Ralph A. Chappa ,  Mark F. Carlson

Inventor： Ralph A. Chappa ,  Mark F. Carlson

IPC: B05D1/02 ,  B05D1/40 ,  B05C13/00 ,  B05B13/04 ,  B05B7/08 ,  B05D1/00 ,  B05B13/02

CPC classification number: B05B7/0807 ,  B05B7/0861 ,  B05B7/0869 ,  B05B13/0207 ,  B05B13/0228 ,  B05B13/0436 ,  B05B13/0442 ,  B05D1/002 ,  B05D1/02

Abstract: A method for coating a rollable device including a device rotator having a pair of rollers and spray nozzle is described. The spray nozzle produces a spray of coating material that is directed towards a gap that is between the rollers of the pair. The majority of any spray not deposited on the rollable device during a coating process passes through the gap between the rollers.

公开(公告)号：US09364349B2

公开(公告)日：2016-06-14

申请号：US12109139

申请日：2008-04-24

Applicant: Ralph A. Chappa ,  James H. Arps

Inventor： Ralph A. Chappa ,  James H. Arps

IPC: A61F2/82 ,  B05B13/04 ,  B05B13/02

CPC classification number: A61F2/82 ,  A61F2240/001 ,  B05B13/0242 ,  B05B13/0442

Abstract: The invention relates to systems and methods for applying coatings to devices. In an embodiment, the invention includes a coating apparatus including a mandrel having a lengthwise axis and an exterior surface, the exterior surface of the mandrel defining a plurality of channels disposed parallel to the lengthwise axis, the mandrel configured to rotate around the lengthwise axis; and a spray head configured to direct a stream of material at the mandrel. In an embodiment the invention includes a method of applying a coating to a medical device. Other embodiments are also included herein.

Abstract translation: 本发明涉及将涂料涂覆到装置上的系统和方法。 在一个实施例中，本发明包括涂覆设备，其包括具有纵向轴线和外表面的心轴，心轴的外表面限定平行于纵向轴线设置的多个通道，心轴构造成围绕纵向轴线旋转; 以及喷头，其配置成在心轴处引导材料流。 在一个实施方案中，本发明包括将涂层施加到医疗装置的方法。 本文还包括其它实施例。

公开(公告)号：US08459310B2

公开(公告)日：2013-06-11

申请号：US12507865

申请日：2009-07-23

Applicant: Ralph A. Chappa

Inventor： Ralph A. Chappa

IPC: B65B1/04

CPC classification number: B65B3/003 ,  A61F9/0017 ,  A61F2250/0068

Abstract: The invention relates to systems and methods for filling a medical device with an active agent composition. In an embodiment, the invention includes a method for filling a medical device with an active agent composition. The method can include applying the active agent composition to the outside surface of the medical device, the medical device comprising a housing defining a lumen and a plurality of apertures. The method can also include contacting a surface of a press member against the outside surface of the medical device thereby pushing the active agent composition through the apertures and into the lumen of the medical device. Other embodiments are also included herein.

Abstract translation: 本发明涉及用活性剂组合物填充医疗装置的系统和方法。 在一个实施方案中，本发明包括用活性剂组合物填充医疗装置的方法。 该方法可以包括将活性剂组合物施加到医疗装置的外表面，医疗装置包括限定内腔和多个孔的壳体。 该方法还可以包括将压力构件的表面接触医疗装置的外表面，从而将活性剂组合物通过孔推入并进入医疗装置的内腔。 本文还包括其它实施例。

公开(公告)号：US20120010707A1

公开(公告)日：2012-01-12

申请号：US13242457

申请日：2011-09-23

Applicant: Toni M. Heyer ,  Dale G. Swan ,  Stephen J. Chudzik ,  Joseph A. Chinn ,  Ralph A. Chappa

Inventor： Toni M. Heyer ,  Dale G. Swan ,  Stephen J. Chudzik ,  Joseph A. Chinn ,  Ralph A. Chappa

IPC: A61F2/02 ,  A61L33/08 ,  A61L33/10 ,  A61L33/06

CPC classification number: A61L27/34 ,  A61L33/0029 ,  C08L33/06

Abstract: Polymeric coatings that include coupled biomolecules are formed on the surface of articles, such as medical devices. A coated layer that includes a synthetic polymer including a reactive group is formed on a surface and then a biomolecule is attached to the reactive group. The synthetic polymer can be an acrylate polymer or an amine-containing polymer having pendent photoreactive groups.

Abstract translation: 包括偶联的生物分子的聚合物涂层形成在诸如医疗装置的制品的表面上。 在表面上形成包括含有反应性基团的合成聚合物的涂层，然后将生物分子连接到反应性基团上。 合成聚合物可以是具有侧基光反应性基团的丙烯酸酯聚合物或含胺聚合物。

公开(公告)号：US08021680B2

公开(公告)日：2011-09-20

申请号：US10835530

申请日：2004-04-29

Applicant: Aron B. Anderson ,  Laurie R. Lawin ,  Byron C. Shen ,  Eugene de Juan ,  Signe E. Varner ,  Ralph A. Chappa

Inventor： Aron B. Anderson ,  Laurie R. Lawin ,  Byron C. Shen ,  Eugene de Juan ,  Signe E. Varner ,  Ralph A. Chappa

IPC: A61F2/00

CPC classification number: A61K31/58 ,  A61F2310/00353 ,  A61K9/0051

Abstract: The invention provides a controlled release bioactive agent delivery device that includes a body member having a direction of extension, a longitudinal axis along the direction of extension, and a proximal end and a distal end, wherein at least a portion of the body member deviates from the direction of extension, and a polymeric coated composition in contact with the body member, the polymeric coated composition including a first polymer, a second polymer, and a bioactive agent, wherein the first polymer comprises polyalkyl(meth)acrylate, aromatic poly(meth)acrylate, or a combination of polyalkyl(meth)acrylate and aromatic poly(meth)acrylate, and wherein the second polymer comprises poly(ethylene-co-vinyl acetate). The invention also provides methods of delivering a bioactive agent to a patient in a controlled release manner, as well as methods of making a controlled release bioactive agent delivery device.

Abstract translation: 本发明提供一种控制释放的生物活性剂递送装置，其包括具有延伸方向的本体构件，沿着延伸方向的纵向轴线，以及近端和远端，其中，身体构件的至少一部分偏离 所述聚合物涂覆组合物包括第一聚合物，第二聚合物和生物活性剂，其中所述第一聚合物包含（甲基）丙烯酸烷基酯，（甲基）丙烯酸烷基酯，芳族聚（甲基）丙烯酸酯， ）丙烯酸酯或聚（甲基）丙烯酸烷基酯和芳族聚（甲基）丙烯酸酯的组合，其中第二聚合物包括聚（乙烯 - 共 - 乙酸乙烯酯）。 本发明还提供了以受控释放方式将生物活性剂递送到患者的方法，以及制备受控释放的生物活性剂递送装置的方法。

公开(公告)号：US07976862B2

公开(公告)日：2011-07-12

申请号：US11203879

申请日：2005-08-15

Applicant: Aron B. Anderson ,  Laurie R. Lawin ,  Byron C. Shen ,  Eugene de Juan ,  Signe E. Varner ,  Ralph A. Chappa

Inventor： Aron B. Anderson ,  Laurie R. Lawin ,  Byron C. Shen ,  Eugene de Juan ,  Signe E. Varner ,  Ralph A. Chappa

IPC: A61F2/00

CPC classification number: A61K31/58 ,  A61F2310/00353 ,  A61K9/0051

Abstract: The invention provides implantable sustained release bioactive agent delivery devices that include a body member having a direction of extension, a longitudinal axis along the direction of extension, and a proximal end and a distal end, wherein at least a portion of the body member deviates from the direction of extension; and a polymeric coated composition in contact with a surface of the body member, the polymeric coated composition including a first polymer, a second polymer, and a bioactive agent. The polymeric coated composition is formulated to provide controlled release of bioactive agent over time when introduced into physiological conditions. Methods of preparing implantable devices configured and formulated to provide controlled release of bioactive agent are also provided.

Abstract translation: 本发明提供了可植入的缓释生物活性剂递送装置，其包括具有延伸方向的本体构件，沿着延伸方向的纵向轴线，以及近端和远端，其中，身体构件的至少一部分偏离 延伸方向; 以及与本体构件的表面接触的聚合物涂覆的组合物，所述聚合物涂覆的组合物包含第一聚合物，第二聚合物和生物活性剂。 配制聚合物涂覆的组合物以在引入生理条件时随时间提供生物活性剂的受控释放。 还提供了配制和配制以提供生物活性剂的受控释放的可植入装置的制备方法。

公开(公告)号：US20110104392A1

公开(公告)日：2011-05-05

申请号：US12980920

申请日：2010-12-29

Applicant: Mark F. Carlson ,  Steven J. Porter ,  Sean M. Stucke ,  Ralph A. Chappa

Inventor： Mark F. Carlson ,  Steven J. Porter ,  Sean M. Stucke ,  Ralph A. Chappa

IPC: C08J7/04

CPC classification number: B05C3/109 ,  B05C9/14 ,  B05D1/18 ,  B05D3/061 ,  B05D2258/02

Abstract: This invention provides a coating apparatus and methods for coating a device, such as an industrially or medically applicable device. The apparatus is suitable for providing a coating using a photoactivatable compound and a polymerizable compound. In another aspect, the apparatus and methods are useful for coating a device wherein the surface of the device has small pores or apertures. The apparatus includes of containers suitable for holding the object to be coated and the coating solution, a gas supply source for supplying gas to solution, an irradiation station for providing light used in the coating process, and a conveyor mechanism to direct the containers to and from the irradiation station.

Abstract translation: 本发明提供一种涂覆装置和涂覆装置的方法，例如工业上或医学上适用的装置。 该装置适用于使用可光活化化合物和可聚合化合物提供涂层。 在另一方面，该装置和方法可用于涂覆装置，其中该装置的表面具有小的孔或孔。 该装置包括适于保持待涂覆物体和涂布溶液的容器，用于向溶液供应气体的气体供应源，用于提供在涂布过程中使用的光的照射台，以及输送机构， 从照射站。

公开(公告)号：US07824704B2

公开(公告)日：2010-11-02

申请号：US11203981

申请日：2005-08-15

Applicant: Aron B. Anderson ,  Laurie R. Lawin ,  Byron C. Shen ,  Eugene de Juan ,  Signe E. Varner ,  Ralph A. Chappa

Inventor： Aron B. Anderson ,  Laurie R. Lawin ,  Byron C. Shen ,  Eugene de Juan ,  Signe E. Varner ,  Ralph A. Chappa

IPC: A61F2/00

CPC classification number: A61K31/58 ,  A61F2310/00353 ,  A61K9/0051

Abstract: The invention provides retrievable devices for sustained delivery of bioactive agent to a site within a patient, the devices including a body member having a direction of extension, a longitudinal axis along the direction of extension, and a proximal end and a distal end, wherein at least a portion of the body member deviates from the direction of extension; a cap at the proximal end of the body member; and a polymeric coated composition in contact with a surface of the body member, the polymeric coated composition including a first polymer, a second polymer, and a bioactive agent.

Abstract translation: 本发明提供了用于将生物活性剂持续递送到患者内的部位的可回收装置，所述装置包括具有延伸方向的本体构件，沿着延伸方向的纵向轴线，以及近端和远端，其中， 身体构件的至少一部分偏离延伸方向; 在主体构件的近端处的帽; 以及与本体构件的表面接触的聚合物涂覆的组合物，所述聚合物涂覆的组合物包含第一聚合物，第二聚合物和生物活性剂。

公开(公告)号：US07709049B2

公开(公告)日：2010-05-04

申请号：US11223811

申请日：2005-09-09

Applicant: Ralph A. Chappa

Inventor： Ralph A. Chappa

IPC: A61L33/00 ,  A41D19/00 ,  B05D7/00 ,  A61F2/00

CPC classification number: A61L27/54 ,  A61L27/34 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/602

Abstract: The present invention relates to methods, devices, and coatings, wherein active agent release is determined by deposition rate of a coating or material. In an embodiment, the invention includes a method for coating a medical device, including identifying active agent elution rates for a coating composition applied to substrates at a plurality of coating deposition rates, selecting one of the coating deposition rates, and applying the coating composition to the medical device at the selected deposition rate. In an embodiment, the invention includes a combination including a medical device and a composition for coating the surface of a medical device with an active agent in a manner that permits the coated surface to release the active agent over time when implanted in vivo.

Abstract translation: 本发明涉及方法，装置和涂层，其中通过涂层或材料的沉积速率确定活性剂释放。 在一个实施方案中，本发明包括用于涂覆医疗装置的方法，包括鉴定以多种涂布沉积速率施加到基材上的涂料组合物的活性剂洗脱速率，选择一种涂布沉积速率，以及将涂料组合物施用于 医疗器械以选定的沉积速率。 在一个实施方案中，本发明包括一种组合，其包括医疗装置和用于用活性剂涂覆医疗装置的表面的组合物，使得当植入体内时涂覆的表面随时间推移释放活性剂。