公开(公告)号：US09384956B2

公开(公告)日：2016-07-05

申请号：US14367944

申请日：2012-10-04

Applicant: NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY ,  S.T.JAPAN INC.

Inventor： Kazumi Inagaki ,  Shin-Ichiro Fujii ,  Akiko Takatsu ,  Koichi Chiba ,  Takao Nakagawa ,  Masaaki Abe ,  Nobuyoshi Kitagawa ,  Yosuke Nakagawa

IPC: H01J49/10 ,  G01N21/71 ,  G01J3/443 ,  B05B7/04 ,  H01J49/04

CPC classification number: H01J49/105 ,  B05B7/0416 ,  G01J3/443 ,  G01N21/714 ,  H01J49/045

Abstract: A nebulizer characterized in being provided with: an inner tube, which is disposed coaxially with an outer tube in which a nebulizing outlet is formed and which, together with the outer tube, forms a gas channel therebetween; a sample channel, which is formed inside the inner tube and through which a liquid sample to be nebulized flows; and a reticular membrane disposed with a gap from the sample outlet that is formed at one end of the inner tube and in which multiple holes, through which liquid sample drops flowing out from the sample outlet pass along with a gas, are formed. Using the nebulizer, the particle size of the nebulized liquid droplets can be made uniformly fine over a broad range of sample liquid flow volumes while retention of sample liquid in the nebulizer is reduced.

Abstract translation: 一种喷雾器，其特征在于具有：内管，其与形成有喷雾出口的外管同轴设置，并且与外管一起在其间形成气体通道; 样品通道，其形成在内管内部，待雾化的液体样品通过该通道流动; 和形成在内管的一端形成有来自样品出口的间隙的网状膜，其中从样品出口流出的液体样品滴下的多个孔与气体一起形成。 使用雾化器，雾化液滴的粒径可以在宽范围的样品液体流量上均匀地精细化，同时将样品液体保留在雾化器中。

公开(公告)号：US09117642B2

公开(公告)日：2015-08-25

申请号：US14367647

申请日：2012-12-21

Applicant: Micromass UK Limited

Inventor： Stevan Bajic

IPC: H01J49/16 ,  H01J49/04 ,  H01J49/00 ,  H01J49/10

CPC classification number: G01N30/7266 ,  G01N27/44704 ,  G01N27/622 ,  H01J49/0031 ,  H01J49/045 ,  H01J49/0454 ,  H01J49/10 ,  H01J49/16 ,  H01J49/165

Abstract: A mass spectrometer is disclosed comprising a separation device arranged and adapted to emit an eluent over a period of time. The separation device preferably comprises a Capillary Electrophoresis (“CE”) separation device. The mass spectrometer further comprises a nebulizer and a target. Eluent emitted by the separation device is nebulized, in use, by the nebulizer wherein a stream of analyte droplets are directed to impact upon the target so as to ionize the analyte to form a plurality of analyte ions.

Abstract translation: 公开了一种质谱仪，其包括布置并适于在一段时间内发射洗脱液的分离装置。 分离装置优选包括毛细管电泳（“CE”）分离装置。 质谱仪还包括雾化器和靶。 由分离装置发射的洗脱液在使用中由雾化器雾化，其中分析物液滴流被引导以撞击靶，以便使分析物电离以形成多个分析物离子。

公开(公告)号：US20140353495A1

公开(公告)日：2014-12-04

申请号：US14367944

申请日：2012-10-04

Applicant: NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY ,  S.T. JAPAN INC.

Inventor： Kazumi Inagaki ,  Shin-Ichiro Fujii ,  Akiko Takatsu ,  Koichi Chiba ,  Takao Nakagawa ,  Masaaki Abe ,  Nobuyoshi Kitagawa ,  Yosuke Nakagawa

IPC: H01J49/10 ,  G01J3/443

CPC classification number: H01J49/105 ,  B05B7/0416 ,  G01J3/443 ,  G01N21/714 ,  H01J49/045

Abstract: A nebulizer characterized in being provided with: an inner tube, which is disposed coaxially with an outer tube in which a nebulizing outlet is formed and which, together with the outer tube, forms a gas channel therebetween; a sample channel, which is formed inside the inner tube and through which a liquid sample to be nebulized flows; and a reticular membrane disposed with a gap from the sample outlet that is formed at one end of the inner tube and in which multiple holes, through which liquid sample drops flowing out from the sample outlet pass along with a gas, are formed. Using the nebulizer, the particle size of the nebulized liquid droplets can be made uniformly fine over a broad range of sample liquid flow volumes while retention of sample liquid in the nebulizer is reduced.

Abstract translation: 一种喷雾器，其特征在于具有：内管，其与形成有喷雾出口的外管同轴设置，并且与外管一起在其间形成气体通道; 样品通道，其形成在内管内部，待雾化的液体样品通过该通道流动; 和形成在内管的一端形成有来自样品出口的间隙的网状膜，其中从样品出口流出的液体样品滴下的多个孔与气体一起形成。 使用雾化器，雾化液滴的粒径可以在宽范围的样品液体流量上均匀地精细化，同时将样品液体保留在雾化器中。

公开(公告)号：US08227750B1

公开(公告)日：2012-07-24

申请号：US12387094

申请日：2009-04-27

Applicant: Yixin Zhu ,  Kerry D. Nugent

Inventor： Yixin Zhu ,  Kerry D. Nugent

IPC: B01D59/44 ,  H01J49/00

CPC classification number: H01J49/045

Abstract: An ion injection spray apparatus and method are provided for coupling a liquid chromatograph or other liquid flow device to a mass spectrometer. The ion injection spray assembly is composed in part of a chamber for voltage and gas input, a metal union for a liquid voltage junction, a gas distribution assembly, a vacuum seal and an ion spray needle. The position of the ion spray needle within this assembly is directly coupled to the outlet of the upstream liquid flow device through the metal union. The vacuum of the mass spectrometer pulls gas at atmospheric pressure though the gas distribution assembly to focus the sample liquid at the spray needle outlet and create a centrifugal gas funnel which helps to desolvate the sample ions and sweep them into the mass spectrometer over a wide range of flow rates.

Abstract translation: 提供了一种用于将液相色谱仪或其它液体流动装置耦合到质谱仪的离子注射喷射装置和方法。 离子注入喷雾组件部分地由用于电压和气体输入的腔室，用于液体电压接头的金属联接器，气体分配组件，真空密封件和离子喷射喷嘴组成。 离子喷射针在该组件内的位置通过金属联接件直接耦合到上游液体流动装置的出口。 质谱仪的真空通过气体分配组件将气体吸入大气压力，以将样品液体聚焦在喷针出口处，并产生离心气体漏斗，其有助于使样品离子脱溶质并将其在宽范围内扫入质谱仪 的流量。

公开(公告)号：US07982185B2

公开(公告)日：2011-07-19

申请号：US12474379

申请日：2009-05-29

Applicant: Craig Whitehouse ,  Victor Laiko

Inventor： Craig Whitehouse ,  Victor Laiko

IPC: H01J49/26

CPC classification number: H01J49/145 ,  H01J49/045 ,  H01J49/168

Abstract: An Atmospheric Pressure Chemical Ionization (APCI) source interfaced to a mass spectrometer is configured with a corona discharge needle positioned inside the APCI inlet probe assembly. Liquid sample flowing into the APCI inlet probe is nebulized and vaporized prior to passing through the corona discharge region all contained in the APCI inlet probe assembly Ions produced in the corona discharge region are focused toward the APCI probe centerline to maximize ion transmission through the APCI probe exit. External electric fields penetrating into the APCI probe exit end opening providing additional centerline focusing of sample ions exiting the APCI probe. The APCI probe is configured to shield the electric field from the corona discharge region while allowing penetration of an external electric field to focus APCI generated ions into an orifice into vacuum for mass to charge analysis. Ions that exit the APCI probe are directed only by external electric fields and gas flow maximizing ion transmission into a mass to charge analyzer. The new APCI probe can be configured to operate as a stand alone APCI source inlet probe, as a reagent ion gun for ionizing samples introduced on solids or liquid sample probes or through gas inlets in a multiple function ion source or as the APCI portion of a combination Electrospray and APCI multiple function ion source. Sample ions and gas phase reagent ions are generated in the APCI probe from liquid or gas inlet species or mixtures of both.

Abstract translation: 与质谱仪接口的大气压化学电离（APCI）源配置有位于APCI入口探针组件内部的电晕放电针。 流入APCI入口探针的液体样品在通过包含在APCI入口探针组件中的电晕放电区域之前被雾化和蒸发。 在电晕放电区域产生的离子聚焦到APCI探针中心线，以通过APCI探针出口最大化离子传输。 外部电场穿透到APCI探针出口端开口，提供离开APCI探针的样品离子的附加中心线聚焦。 APCI探针被配置为屏蔽来自电晕放电区域的电场，同时允许穿透外部电场以将APCI产生的离子聚焦到孔中以进行质量电荷分析。 离开APCI探头的离子仅由外部电场和气流引导，将离子传输最大化成质量计量分析仪。 新的APCI探针可以配置为作为独立的APCI源入口探针进行操作，作为用于将固体或液体样品探针上引入的样品或通过多功能离子源中的气体入口电离的样品的反应离子枪或作为 组合电喷雾和APCI多功能离子源。 样品离子和气相试剂离子在APCI探针中从液体或气体入口物质或两者的混合物中产生。

公开(公告)号：US20100282962A1

公开(公告)日：2010-11-11

申请号：US12161539

申请日：2007-01-19

Applicant: Xavier Machuron-Mandard ,  Olivier Vigneau

Inventor： Xavier Machuron-Mandard ,  Olivier Vigneau

IPC: H01J49/04 ,  H01J49/26

CPC classification number: H01J49/045

Abstract: This invention relates introduction of at least one additive for the analysis of at least one substance of interest using a mass spectrometer or an ion mobility spectrometer. The substance to be analyzed is injected through an API interface. The additive is introduced by adding spray gas.

Abstract translation: 本发明涉及使用质谱仪或离子迁移谱仪引入至少一种用于分析至少一种感兴趣物质的添加剂。 待分析的物质通过API接口注入。 通过添加喷雾气体引入添加剂。

公开(公告)号：US07645983B2

公开(公告)日：2010-01-12

申请号：US10139241

申请日：2002-05-07

Applicant: Atsumu Hirabayashi ,  Minoru Sakairi ,  Yasuaki Takada ,  Hideaki Koizumi ,  Kaoru Umemura

Inventor： Atsumu Hirabayashi ,  Minoru Sakairi ,  Yasuaki Takada ,  Hideaki Koizumi ,  Kaoru Umemura

IPC: H01J49/00

CPC classification number: H01J49/045

Abstract: An ion source includes a body having a gas passage and an orifice. A capillary is inserted into the gas passage so that a tip portion of the capillary extends into the orifice. A gas supplier supplies a gas into the gas passage to form a gas flow through the gas passage along the capillary and through the orifice past a tip of the capillary so that the gas flow sprays a sample solution flowing through the capillary from the tip of the capillary. A flow controller regulates a pressure of the gas in the gas passage to adjust a characteristic value F/S to a predetermined value, where F is a flow rate of the gas flow at standard conditions (20° C., 1 atmosphere), and S is a difference between a cross section of the orifice and a cross section of the tip portion of the capillary in the orifice.

Abstract translation: 离子源包括具有气体通道和孔的主体。 毛细管插入到气体通道中，使得毛细管的尖端部分延伸到孔中。 气体供应商将气体供应到气体通道中以形成沿着毛细管的气体通道的气流，并且通过孔经过毛细管的尖端，使得气流从其中的尖端喷射流过毛细管的样品溶液 毛细管。 流量控制器调节气体通道中的气体的压力，以将特征值F / S调节到预定值，其中F是在标准条件（20℃，1个大气压）下气流的流量，以及 S是孔口的截面与孔口中的毛细管的尖端部分的横截面之间的差异。

公开(公告)号：US07259368B2

公开(公告)日：2007-08-21

申请号：US11361125

申请日：2006-02-24

Applicant: William D. Frazer ,  Steven M. Fischer ,  Robert K. Crawford

Inventor： William D. Frazer ,  Steven M. Fischer ,  Robert K. Crawford

IPC: B01D59/44 ,  H01J49/00

CPC classification number: H01J49/165 ,  H01J49/045

Abstract: The present invention relates to an apparatus for delivering ions to a vacuum chamber. The apparatus comprises an ionization chamber, an ionization region within the ionization chamber, a vacuum interface at a vacuum interface voltage and a vacuum chamber, wherein the ionization chamber communicates with the vacuum chamber through the vacuum interface. Sample is introduced into the ionization chamber from an electrospray assembly at approximately ground potential. Two electrodes are provided within the chamber such that three electric fields are generated, a first field extending from the electrospray assembly to the first electrode, a second field extending from the second electrode to the first electrode, and a third field extending from the second electrode to the vacuum interface. Ions are forced to travel through the fields in order before entering the vacuum chamber. In addition, the invention provides a method of delivering ions to a vacuum chamber.

Abstract translation: 本发明涉及一种用于将离子输送到真空室的装置。 该装置包括电离室，电离室内的电离区域，真空界面电压下的真空界面和真空室，其中电离室通过真空界面与真空室连通。 将样品从大约接地电位的电喷雾组件引入电离室。 在室内提供两个电极，使得产生三个电场，从电喷雾组件延伸到第一电极的第一场，从第二电极延伸到第一电极的第二场和从第二电极延伸的第三场 到真空界面。 在进入真空室之前，离子被迫穿过田野。 此外，本发明提供了将离子输送到真空室的方法。

公开(公告)号：US07145137B2

公开(公告)日：2006-12-05

申请号：US11019098

申请日：2004-12-22

Applicant: Akbar Montaser ,  Craig S. Westphal ,  Kaveh Kahen ,  William F. Rutkowski ,  Billy W. Acon

Inventor： Akbar Montaser ,  Craig S. Westphal ,  Kaveh Kahen ,  William F. Rutkowski ,  Billy W. Acon

IPC: H01J49/00

CPC classification number: H01J49/105 ,  G01N21/714 ,  H01J49/045

Abstract: A nebulizer adapted for adjusting a position of a capillary tube contained within the nebulizer is provided. The nebulizer includes an elongated tubular shell having a gas input port and a gas output port, a capillary adjustment adapter for displacing the capillary tube in a lateral direction via a rotational force, and a connector for connecting the elongated tubular shell, the capillary adjustment adapter and the capillary tube.

Abstract translation: 提供适于调节包含在雾化器内的毛细管的位置的雾化器。 喷雾器包括细长的管状壳体，其具有气体输入端口和气体输出端口，用于经由旋转力沿横向移动毛细管的毛细管调节适配器，以及用于连接细长管状壳体，毛细管调节适配器 和毛细管。

公开(公告)号：US06998605B1

公开(公告)日：2006-02-14

申请号：US09579276

申请日：2000-05-25

Applicant: William D. Frazer ,  Steven M. Fischer ,  Robert K. Crawford

Inventor： William D. Frazer ,  Steven M. Fischer ,  Robert K. Crawford

IPC: B01D59/44 ,  H01J49/00

CPC classification number: H01J49/165 ,  H01J49/045

Abstract: The present invention relates to an apparatus for delivering ions to a vacuum chamber. The apparatus comprises an ionization chamber, an ionization region within the ionization chamber, a vacuum interface at a vacuum interface voltage and a vacuum chamber, wherein the ionization chamber communicates with the vacuum chamber through the vacuum interface. Sample is introduced into the ionization chamber from an electrospray assembly at approximately ground potential. Two electrodes are provided within the chamber such that three electric fields are generated, a first field extending from the electrospray assembly to the first electrode, a second field extending from the second electrode to the first electrode, and a third field extending from the second electrode to the vacuum interface. Ions are forced to travel through the fields in order before entering the vacuum chamber. In addition, the invention provides a method of delivering ions to a vacuum chamber.