公开(公告)号：US20230073162A1

公开(公告)日：2023-03-09

申请号：US17868129

申请日：2022-07-19

Applicant: SHIMADZU CORPORATION

Inventor： Haruki OSA

IPC: H01J49/02 ,  H02M7/10 ,  H02M3/335

Abstract: Fluctuations of an output voltage at the time of a sudden change in a load current is suppressed while keeping an increase in size of a device. According to one aspect of the present invention, a high-voltage power supply device capable of outputting a high voltage of both positive and negative polarities in a switchable manner, includes: a first voltage generation unit (1A) configured to output a high voltage of a positive polarity; a second voltage generation unit (1B) configured to output a high voltage of a negative polarity; a first discharging diode (2A) connected to a voltage output end of the first voltage generation unit in a direction in which when a high voltage is outputted to the voltage output end of the first voltage generation unit, the high voltage is applied to the first discharging diode in a reverse biased state; a second discharging diode (2B) connected to a voltage output end of the second voltage generation unit in a direction in which when a high voltage is outputted to the voltage output end of the second generation unit, the high voltage is applied to the second discharge diode in a reverse biased state; a first output circuit connected between the voltage output end of the first voltage generation unit and a polarity switching voltage output end which is common to both the positive and negative polarities, the first output circuit being configured by a first switch (3A1) and a protective resistor (5A) connected in series to each other, the first switch being configured by a voltage-controlled semiconductor switch; a second output circuit connected between the voltage output end of the second voltage generation unit and the polarity switching voltage output end, the second output circuit being configured by a second switch (3B1) and a protective resistor (5A) connected in series to each other, the second switch being configured by a voltage-controlled semiconductor switch; an output capacitor (4) connected in parallel to a load (100) to be connected to the polarity switching voltage output end; a controller (7) configured to control operations of the first voltage generation unit and the second voltage generation unit and opening/closing operations of the first switch and the second switch such that both the first voltage generation unit and the second voltage generation unit are turned on once in a state in which both the operations of the first voltage generation unit and the second voltage generation unit are stopped when switching a polarity of a voltage outputted from the polarity switching voltage output end; a first limitation unit (3A2, 3A3) configured to limit a time rate of change of a voltage between both ends of the first switch when the controller turns on the first switch; and a second limitation unit (3B2, 3B3) configured to limit a time rate of change of a voltage between both ends of the second switch when the controller turns on the second switch.

公开(公告)号：US11594405B2

公开(公告)日：2023-02-28

申请号：US17468841

申请日：2021-09-08

Applicant: THE TRUSTEES OF INDIANA UNIVERSITY

Inventor： Martin F. Jarrold ,  Andrew W. Alexander ,  Aaron R. Todd

IPC: H01J49/02 ,  H01J49/42 ,  H01J49/00

Abstract: A CDMS may include an ELIT having a charge detection cylinder (CD), a charge generator for generating a high frequency charge (HFC), a charge sensitive preamplifier (CP) having an input coupled to the CD and an output configured to produce a charge detection signal (CHD) in response to a charge induced on the CD, and a processor configured to (a) control the charge generator to induce an HFC on the CD, (b) control operation of the ELIT to cause a trapped ion to oscillate back and forth through the CD each time inducing a charge thereon, and (c) process CHD to (i) determine a gain factor as a function of the HFC induced on the CD, and (ii) modify a magnitude of the portion of CHD resulting from the charge induced on the CD by the trapped ion passing therethrough as a function of the gain factor.

公开(公告)号：US20230059144A1

公开(公告)日：2023-02-23

申请号：US17839590

申请日：2022-06-14

Applicant: SHIMADZU CORPORATION

Inventor： Masaru NISHIGUCHI

IPC: H01J49/06 ,  H01J49/02

Abstract: An ion analyzer includes an ion optical element having four rod electrodes around an optical axis, for transferring ions from their surrounding space to the subsequent stage while converging the ions. To create an RF electric field within this space, a voltage supplier applies RF voltages of opposite polarities to two pairs of electrodes facing each other across the axis. The cross-sectional shape of each electrode in a plane orthogonal to the axis has a first side having width w facing the axis and is tangent to a circle of radius r0 around the axis, and two adjacent sides connected to the ends of the first side at an angle determined so that an RF field created by the adjacent sides exerts no influence within the space. The ratio w/r0 is determined so that the amount of dodecapole field component becomes a predetermined value or does not exceed it.

公开(公告)号：US11587775B2

公开(公告)日：2023-02-21

申请号：US16878179

申请日：2020-05-19

Applicant: HAMAMATSU PHOTONICS K.K.

Inventor： Hiroshi Kobayashi ,  Sayaka Takatsuka ,  Yuuya Washiyama ,  Yuto Yanagihara

IPC: H01J49/02 ,  G01T1/29

Abstract: An ion detector according to this embodiment has a structure for reducing influences of signal reflection or the like on an output signal. The ion detector comprises an electron multiplier, a signal output unit, a signal output terminal, and an AC coupler. The AC coupler is disposed on a signal line between the signal output unit and the signal output terminal, including a resin sheet and a pair of conductive sections facing each other with the resin sheet interposed therebetween. One conductive section is electrically connected to an output terminal of the signal output unit, and the other conductive section is electrically connected to the signal output terminal.

公开(公告)号：US11581178B2

公开(公告)日：2023-02-14

申请号：US17453683

申请日：2021-11-05

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Robert Lang ,  Stefan Quint ,  Gabriele Punzmann

IPC: H01J49/00 ,  H01J49/04 ,  G01N30/72 ,  H01J49/02 ,  H01J49/16

Abstract: A mass spectrometry (MS) apparatus is provided. The MS apparatus includes a mass spectrometer, an ionization source coupled to the mass spectrometer, and a flow injection system (FIS) coupled to the ionization source. The ionization source is configured to provide an ionized gas flow of an analyte towards an entrance of the mass spectrometer. The ionization source is further configured to provide a second gas flow of a second gas. The MS apparatus is configured to measure a mass spectrometer (MS) signal of the analyte. The MS apparatus is further configured to analyze a dependency of the MS signal of the analyte versus a parameter of the second gas flow or a state of the second gas flow and to determine a condition of the apparatus based on the analyzed dependency.

公开(公告)号：US20230013173A1

公开(公告)日：2023-01-19

申请号：US17781483

申请日：2020-12-16

Applicant: THE TRUSTEES OF INDIANA UNIVERSITY

Inventor： Martin F. JARROLD ,  David E. CLEMMER

IPC: H01J49/02 ,  H01J49/42 ,  H01J49/40 ,  H01J49/16

Abstract: A mass spectrometer may have an ion source region including an ion generator configured to generate ions from a sample, an ion detector configured to detect ions and produce corresponding ion detection signals, an electric field-free drift region disposed between the ion source region and the ion detector through which the generated ions drift axially toward the ion detector, a plurality of spaced-apart charge detection cylinders disposed in the drift region and through which the ions drifting axially through the drift region pass, and a plurality of charge amplifiers each coupled to a different one of the plurality of charge detection cylinders and each configured to produce a charge detection signal corresponding to a magnitude of charge of one or more of the generated ions passing through a respective one of the plurality of charge detection cylinders.

公开(公告)号：US11532471B2

公开(公告)日：2022-12-20

申请号：US17468738

申请日：2021-09-08

Applicant: THE TRUSTEES OF INDIANA UNIVERSITY

Inventor： Martin F. Jarrold ,  Staci N. Anthony ,  Benjamin E. Draper

IPC: H01J49/06 ,  H01J49/02 ,  H01J49/24 ,  H01J49/42

Abstract: An instrument for separating ions may include an ion source in a first pressure environment at a first pressure and configured to generate ions from a sample, an ion separation instrument, controlled to an instrument pressure that is less than the first pressure, and configured to separate ions as a function of at least one molecular characteristic and an interface, controlled to a second pressure less than the first pressure and greater than the instrument pressure, for transporting the generated ions from the first pressure environment into the ion separation instrument operating at the instrument pressure. The interface may include a sealed ion funnel defining an axial passageway therethrough, and an ion carpet sealed to the first ion funnel. A portion of the axial passageway tapers from a first cross-sectional area to a reduced cross-sectional area such that the tapered axial passageway defining a virtual jet disrupter therein.

公开(公告)号：US20220384170A1

公开(公告)日：2022-12-01

申请号：US17762247

申请日：2020-09-24

Applicant: DH Technologies Development PTE. LTD.

Inventor： Manuel FAUR ,  Ernesto GRADIN

IPC: H01J49/02 ,  H02M1/14

Abstract: A high-voltage power supply system for a mass spectrometer comprises a ground-referenced power supply with a first transformer having a primary winding and a secondary winding, the primary winding is electrically coupled to a first source of AC power, and a floated bias voltage power supply with a second transformer having a primary winding and a secondary winding, the primary winding of the second transformer is electrically coupled to a second source of AC power. A return electrical path of the floated bias voltage power supply is electrically coupled to the ground-referenced power supply to bias an output voltage of the ground-referenced power supply. A floating shield is around the floating bias voltage power supply, and at least one resistive element is in the return electrical path of the floated bias voltage power supply to reduce noise coupled from the floated bias voltage power supply to the ground-referenced power supply.

公开(公告)号：US20220344144A1

公开(公告)日：2022-10-27

申请号：US17723501

申请日：2022-04-19

Applicant: FASMATECH SCIENCE AND TECHNOLOGY SA

Inventor： DIMITRIS PAPANASTASIOU

IPC: H01J49/42 ,  H01J49/02

Abstract: An apparatus (100, 300, 700) is described, comprising: a linear ion trap (102) comprising two pairs of pole electrodes and a radiofrequency, RF, electrical potential supply (117) configured to apply respective RF waveforms to the pairs of pole electrodes, thereby forming a RF trapping field component to trap analyte ions (116) radially in a trapping region (115) of the linear ion trap for processing of the analyte ions (116) therein; a charged particle source (101) comprising a pulse valve (103), a conduit (106, 107), having an entrance in fluid communication therewith and an exit, wherein the conduit (106, 107) extends in the direction of the trapping region (115), and a discharge device (108) electrically coupled to an electrical potential supply (109) and disposed between the entrance and the exit of the conduit (106, 107), wherein the pulse valve (103) is configured to release a gas pulse from a gas supply into the entrance of the conduit (106, 107) and wherein the electrical potential supply (109) is configured to apply a high voltage to the discharge device (108) to generate a discharge (110) in the gas pulse in the conduit (106, 107), thereby generating charged particles (114) from the gas and accelerating the generated charged particles in the direction of the trapping region (115). A method is also described.

公开(公告)号：US20220301841A1

公开(公告)日：2022-09-22

申请号：US17837773

申请日：2022-06-10

Applicant: Thermo Fisher Scientific (Bremen) GmbH

Inventor： Alexander KHOLOMEEV ,  Gregor QUIRING ,  Frank CZEMPER

IPC: H01J49/00 ,  H01J49/42 ,  H01J49/02 ,  H01J49/28

Abstract: A signal processing unit comprises: at least one data signal input line adapted to receive a measured data signal generated by an image current, the measured data signal comprising an added crosstalk signal induced by a source of electromagnetic disturbance; at least one disturbance signal input line adapted to receive a decoupled disturbance signal, extracted from the source of electromagnetic disturbance; an output line adapted to supply a compensated data signal; a conditioning module, to which the decoupled disturbance signal is supplied via the disturbance signal input line and which provides a compensation signal; and an adding module, to which the measured data signal and the compensation signal are provided and in which the measured data signal and the compensation signal are superposed, whereby the decoupled disturbance signal is conditioned by the conditioning module such that the compensation signal essentially corresponds to an inverted added crosstalk signal.