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    WIDE-FIELD IMAGING OF BIREFRINGENT CRYSTALS AND OTHER MATERIALS USING LENS-FREE POLARIZED MICROSCOPE
    51.
    发明申请
    WIDE-FIELD IMAGING OF BIREFRINGENT CRYSTALS AND OTHER MATERIALS USING LENS-FREE POLARIZED MICROSCOPE 审中-公开

    公开(公告)号：US20190137932A1

    公开(公告)日：2019-05-09

    申请号：US16302087

    申请日：2017-05-24

    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

    Inventor： Aydogan Ozcan ,  Yibo Zhang ,  Seung Yoon Lee ,  John D. Fitzgerald

    IPC: G03H1/04 ,  G03H1/00 ,  G03H1/08 ,  H04N5/232 ,  G06T5/50

    Abstract: A method of imaging a sample having birefringent crystals (or other materials) using a lens-free polarized microscopy device includes illuminating the sample contained on a sample holder with circularly polarized partially coherent or coherent light and capturing lower resolution holographic images of the birefringent crystals with an image sensor. A polarization analyzer unit made from a λ/4 retarder and a linear polarizer is positioned between the sample holder and the image sensor. The lower resolution holographic images are obtained with the polarization analyzer unit in two different orientations (e.g. ˜90° orientations). Phase-retrieved, higher resolution images of the birefringent crystals at the different orientations are obtained using the lower resolution holographic images. A differential image is generated from the respective phase-retrieved, higher resolution images. An object support mask is applied to identify the birefringent crystals which can then be pseudo-colored.

    LABEL-FREE DIGITAL BRIGHTFIELD ANALYSIS OF NUCLEIC ACID AMPLIFICATION
    53.
    发明申请
    LABEL-FREE DIGITAL BRIGHTFIELD ANALYSIS OF NUCLEIC ACID AMPLIFICATION 审中-公开

    公开(公告)号：US20180373921A1

    公开(公告)日：2018-12-27

    申请号：US16019421

    申请日：2018-06-26

    Applicant: The Regents of the University of California

    Inventor： Dino Di Carlo ,  Aydogan Ozcan ,  Omai B. Garner ,  Hector E. Munoz ,  Carson Riche

    IPC: G06K9/00 ,  C12Q1/6806 ,  G06T7/155 ,  G06F15/18 ,  G06F17/27 ,  C12Q1/6844

    Abstract: An optical readout method for detecting a precipitate (e.g., a precipitate generated from the LAMP reaction) contained within a droplet includes generating a plurality of droplets, at least some which have a precipitate contained therein. The droplets are imaged using a brightfield imaging device. The image is subject to image processing using image processing software executed on a computing device. Image processing isolates individual droplets in the image and performs feature detection within the isolated droplets. Keypoints and information related thereto are extracted from the detected features within the isolated droplets. The keypoints are subject to a clustering operation to generate a plurality of visual “words.” The word frequency obtained for each droplet is input into a trained machine learning droplet classifier, wherein the trained machine learning droplet classifier classifies each droplet as positive for the precipitate or negative for the precipitate.

    METHOD AND DEVICE FOR SINGLE MOLECULE IMAGING
    56.
    发明申请
    METHOD AND DEVICE FOR SINGLE MOLECULE IMAGING 审中-公开

    公开(公告)号：US20170160197A1

    公开(公告)日：2017-06-08

    申请号：US15368420

    申请日：2016-12-02

    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

    Inventor： Aydogan Ozcan ,  Qingshan Wei ,  Wei Luo

    IPC: G01N21/64 ,  G06T5/00 ,  G06K9/00 ,  G06T7/00 ,  G06T3/60

    CPC classification number: G06K9/00134 ,  G01N21/6456 ,  G01N21/6458 ,  G06K9/0014 ,  G06T7/60 ,  G06T2207/10024 ,  G06T2207/10064 ,  G06T2207/30072

    Abstract: A device and method for imaging fluorescently labeled molecules (e.g., nucleic acids) includes securing a modular attachment device to the mobile phone with a sample containing stretched, fluorescently labeled nucleic acid molecules and illuminating the sample with excitation light to cause the fluorescently labeled nucleic acid molecules to emit fluorescent light. Images of the nucleic acids are captured using a camera of the mobile phone. The images from the mobile phone are transferred to a remote computer for image processing and analysis. The images are processed by the remote computer to generate analysis data of sample, wherein the analysis data includes the length of nucleic acid molecules contained in the sample or the length of molecular sub-region(s). The mobile phone or another computing device receives from the remote computer the analysis data and displays at least some of the analysis data thereon.

    FLUORESCENT IMAGING USING A FLATBED SCANNER
    57.
    发明申请
    FLUORESCENT IMAGING USING A FLATBED SCANNER 有权
    使用平面扫描仪进行荧光成像

    公开(公告)号：US20160161409A1

    公开(公告)日：2016-06-09

    申请号：US14906789

    申请日：2014-06-20

    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

    Inventor： Aydogan Ozcan ,  Zoltan Gorocs ,  Yuye Ling ,  Meng Dai Yu

    IPC: G01N21/64 ,  G01N33/58

    CPC classification number: G01N21/6458 ,  G01N15/1434 ,  G01N15/1456 ,  G01N21/6456 ,  G01N33/50 ,  G01N33/582 ,  G01N2201/0612 ,  G01N2201/062 ,  G01N2201/068 ,  G01N2201/101

    Abstract: A scanning system for fluorescent imaging includes a sample holder configured to hold a sample therein, the sample holder defining a sample holding region. A scanner head spans the sample holding region and is movable relative to the sample holder. An array of light sources is disposed on an opposing side of the sample holder and is angled relative thereto. Respective controller are operably coupled to the scanner head and the array of light sources, wherein one controller selectively actuates a one or more rows of the array of light sources and another controller controls movement of the scanner head to capture fluorescent light emitted from within the sample holder in response to illumination from the actuated light sources. A filter designed to filter out scattered light from the sample may be interposed between the sample holder and the scanner head.

    Abstract translation: 用于荧光成像的扫描系统包括被配置为将样本保持在其中的样本保持器，所述样本保持器限定样本保持区域。 扫描器头跨越样品保持区域并且可相对于样品保持器移动。 光源阵列设置在样品保持器的相对侧并且相对于其倾斜。 相应的控制器可操作地耦合到扫描仪头部和光源阵列，其中一个控制器选择性地致动光源阵列的一行或多行，另一个控制器控制扫描器头部的移动以捕获从样品内发射的荧光 响应于来自致动光源的照明。 用于过滤来自样品的散射光的滤光器可以插入在样品架和扫描仪头之间。

    METHOD AND DEVICE FOR FLUORESCENT IMAGING OF SINGLE NANO-PARTICLES AND VIRUSES
    58.
    发明申请
    METHOD AND DEVICE FOR FLUORESCENT IMAGING OF SINGLE NANO-PARTICLES AND VIRUSES 审中-公开
    用于单一纳米颗粒和病毒的荧光成像的方法和装置

    公开(公告)号：US20160070092A1

    公开(公告)日：2016-03-10

    申请号：US14845142

    申请日：2015-09-03

    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

    Inventor： Aydogan Ozcan ,  Qingshan Wei

    IPC: G02B21/36 ,  G02B21/34 ,  H04N7/18 ,  G02B7/00 ,  G02B21/00 ,  H04N5/225 ,  G02B21/26 ,  G02B21/16

    CPC classification number: G02B21/362 ,  G02B21/0008 ,  G02B21/16 ,  G02B21/26 ,  G02B21/361 ,  H04N5/2256

    Abstract: A field-portable fluorescence imaging platform is disclosed that is installed on mobile communications device for imaging of individual nanoparticles or microparticles such as viruses, bacterial, and the like using a light-weight and compact opto-mechanical attachment or housing configured to be removably secured to the mobile communication device. The housing includes a sample holder configured to hold a sample along with a light source and a lens or lens system that is positioned generally opposite the lens in the mobile communication device. An optical filter is disposed in the housing and is interposed between the lens of the housing and the lens of the mobile communication device. A z-adjust stage is disposed in the housing and coupled to the sample holder, the z-adjust stage is configured to adjust the position of the sample holder in a z direction along an optical path passing through the lenses and onto an image sensor contained in the mobile communication device.

    Abstract translation: 公开了一种现场便携式荧光成像平台，其安装在移动通信设备上，用于使用重量轻且紧凑的光机械附件或壳体对单个纳米颗粒或微粒例如病毒，细菌等进行成像，该外壳被构造成可移除地固定 到移动通信设备。 壳体包括样本保持器，其被配置为沿着光源保持样本，以及在移动通信设备中与透镜大致相对定位的透镜或透镜系统。 光学滤光器设置在壳体中并且插入在壳体的透镜和移动通信装置的透镜之间。 z调整台设置在壳体中并且耦合到样品保持器，z调整台被配置为沿着沿着穿过透镜的光路在氮方向上调整样品保持器的位置，并且包括在 移动通信设备。

    Compact wide-field fluorescent imaging on a mobile device
    59.
    发明授权
    Compact wide-field fluorescent imaging on a mobile device 有权
    在移动设备上的紧凑型宽场荧光成像

    公开(公告)号：US09057702B2

    公开(公告)日：2015-06-16

    申请号：US13769043

    申请日：2013-02-15

    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

    Inventor： Aydogan Ozcan ,  Hongying Zhu

    IPC: G01N21/64 ,  G01N21/00 ,  G02B23/24 ,  G02B7/00 ,  G02B7/02 ,  G02B13/00 ,  H04M1/02 ,  H04N5/225 ,  G01N21/76 ,  H04M1/21

    CPC classification number: G01N21/6486 ,  G01N21/6458 ,  G01N21/648 ,  G01N2201/0221 ,  G02B7/006 ,  G02B7/02 ,  G02B13/0025 ,  G02B23/243 ,  H04M1/0254 ,  H04M1/21 ,  H04M2250/52 ,  H04N5/2254

    Abstract: Wide-field fluorescent imaging on a mobile device having a camera is accomplished with a compact, light-weight and inexpensive optical components that are mechanically secured to the mobile device in a removable housing. Battery powered light-emitting diodes (LEDs) contained in the housing pump the sample of interest from the side using butt-coupling, where the pump light is guided within the sample holder to uniformly excite the specimen. The fluorescent emission from the sample is then imaged using an additional lens that is positioned adjacent to the existing lens of the mobile device. A color filter is sufficient to create the dark-field background required for fluorescent imaging, without the need for expensive thin-film interference filters.

    Abstract translation: 具有照相机的移动设备上的宽场荧光成像通过紧凑，重量轻且廉价的光学部件来实现，该组件机械地固定到可拆卸外壳中的移动装置。 包含在壳体中的电池供电的发光二极管（LED）使用对接耦合从侧面泵送感兴趣的样品，其中泵浦光在样品保持器内引导以均匀地激发样品。 然后使用与移动装置的现有透镜相邻定位的附加透镜来成像来自样品的荧光发射。 滤色器足以产生荧光成像所需的暗场背景，而不需要昂贵的薄膜干涉滤光片。

    ALLERGEN TESTING PLATFORM FOR USE WITH MOBILE ELECTRONIC DEVICES
    60.
    发明申请
    ALLERGEN TESTING PLATFORM FOR USE WITH MOBILE ELECTRONIC DEVICES 审中-公开
    过敏测试平台与移动电子设备一起使用

    公开(公告)号：US20140120563A1

    公开(公告)日：2014-05-01

    申请号：US14053475

    申请日：2013-10-14

    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

    Inventor： Aydogan Ozcan ,  Ahmet F. Coskun ,  Justin Wong

    IPC: G01N21/78

    CPC classification number: G01N21/78 ,  G01N21/274

    Abstract: An allergy testing system for use with a mobile electronic device having a camera includes a housing that can be attached to the mobile electronic device. First and second light sources within the housing are configured to illuminate, respectively, a test sample and a control sample. A colorimetric assay is performed on the test sample and the control sample. The first light source and the second light source are activated and the camera of the mobile electronic device captures images of transmitted light. The relative intensity of transmitted light is then used by software loaded on the mobile electronic device to determine a relative absorbance value. The relative absorbance value is used, together with a calibration curve, to measure the concentration of a particular allergen within the test sample. Based on the concentration of the allergen the test sample can be labeled as either “positive” or “negative.”

    Abstract translation: 与具有相机的移动电子设备一起使用的过敏测试系统包括可附接到移动电子设备的外壳。 壳体内的第一和第二光源被分别配置成照射测试样品和对照样品。 对测试样品和对照样品进行比色测定。 第一光源和第二光源被激活，并且移动电子设备的照相机捕获透射光的图像。 透射光的相对强度然后由装载在移动电子设备上的软件使用以确定相对吸光度值。 使用相对吸光度值以及校准曲线来测量测试样品中特定变应原的浓度。 基于过敏原的浓度，测试样品可以标记为“阳性”或“阴性”。

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