公开(公告)号：US20150160131A1

公开(公告)日：2015-06-11

申请号：US14558984

申请日：2014-12-03

Applicant: AZBIL CORPORATION

Inventor： Seiichiro KINUGASA

IPC: G01N21/64 ,  G01N15/10

CPC classification number: G01N21/64 ,  G01N15/1012 ,  G01N21/274 ,  G01N2015/0046 ,  G01N2021/6421 ,  G01N2201/127

Abstract: A particle detecting device includes: a light source that illuminates a fluid with an excitation beam; a fluorescent intensity measuring instrument that measures an optical intensity of a fluorescent band, generated in a region that is illuminated by the excitation beam, at two or more wavelengths; an evaluating portion that compares a measured value for the optical intensity and a boundary range, which is a range of optical intensities at two or more wavelengths for discriminating between a fluorescent particle that is a subject to be detected and a particle that is not a subject to be detected, and evaluates whether or not a fluid includes a fluorescent particle that is a subject to be detected; and a correcting portion that corrects the boundary range in accordance with the status of at least one of the light source and the fluorescent intensity measuring instrument.

Abstract translation: 粒子检测装置包括：用激发光照射流体的光源; 荧光强度测量仪器，其在两个或更多个波长处测量在由激发光束照射的区域中产生的荧光波段的光强度; 比较光强度的测量值和边界范围的评估部分，所述边界范围是两个或更多个波长处的光强度范围，用于区分待检测对象的荧光颗粒和不是被检体的颗粒 并且评价流体是否包括作为被检测体的荧光体粒子; 以及根据光源和荧光强度测量仪器中的至少一个的状态校正边界范围的校正部分。

公开(公告)号：US20150099309A1

公开(公告)日：2015-04-09

申请号：US14396639

申请日：2013-04-19

Applicant: SIEMENS HEALTHCARE DIAGNOSTICS INC.

Inventor： Frank Krufka

IPC: G01N21/31 ,  G01N21/76 ,  G01N21/64

CPC classification number: G01N21/31 ,  G01J1/44 ,  G01J3/0264 ,  G01J3/2803 ,  G01J3/36 ,  G01J2003/2806 ,  G01N21/64 ,  G01N21/76 ,  G01N2201/061 ,  G01N2201/127

Abstract: Disclosed is a multi-channel light measurement system adapted to illuminate and measure a test sample in a vessel. The multi-channel light measurement system has at least one photodetector per channel and a variable integrate and hold circuit coupled to each photodetector, the variable integrate and hold circuit allows adjustment of a sampling factor selected from a group of an integration time, a value of capacitance, an area of a discrete photodetector array, or any combination thereof. The system may readily equilibrate reference intensity output for multiple channels. Methods and apparatus are disclosed, as are other aspects.

Abstract translation: 公开了一种多通道光测量系统，其适于照亮和测量容器中的测试样品。 多通道光测量系统每个通道具有至少一个光电检测器和耦合到每个光电检测器的可变积分和保持电路，可变积分和保持电路允许调整从积分时间组中选出的采样因子， 电容，分立光电检测器阵列的面积，或其任何组合。 系统可以容易地平衡多个通道的参考强度输出。 公开了方法和装置，以及其他方面。

公开(公告)号：US20150085279A1

公开(公告)日：2015-03-26

申请号：US14490648

申请日：2014-09-18

Applicant: L'Oréal ,  Spectral Sensors Inc.

Inventor： Guive Balooch ,  Chloe A. Legendre ,  Wayne D. Jung ,  Russell W. Jung ,  Walter W. Sloan ,  Paresh Patel ,  Alan R. Loudermilk

IPC: A45D44/00 ,  G01N21/25

CPC classification number: A45D44/005 ,  A61B5/0022 ,  A61B5/0075 ,  A61B5/1032 ,  A61B5/7264 ,  G01J3/0254 ,  G01J3/0272 ,  G01J3/463 ,  G01J3/465 ,  G01J3/524 ,  G01J2003/466 ,  G01N21/255 ,  G01N2201/062 ,  G01N2201/08 ,  G01N2201/125 ,  G01N2201/127 ,  G06F19/00 ,  G16H40/67

Abstract: Systems and methods for measuring spectra and other optical characteristics such as colors, translucence, gloss, and other characteristics of objects and materials such as skin. Instruments and methods for measuring spectra and other optical characteristics of skin or other translucent or opaque objects utilize an abridged spectrophotometer and improved calibration/normalization methods. Improved linearization methods also are provided, as are improved classifier-based algorithms. User control is provided via a graphical user interface. Product or product formulations to match the measured skin or other object or to transform the skin or other object are provided to lighten, darken, make more uniform and the like.

Abstract translation: 用于测量光谱和其他光学特性的系统和方法，如物体和材料（如皮肤）的颜色，半透明度，光泽度和其他特性。 用于测量皮肤或其他半透明或不透明物体的光谱和其他光学特性的仪器和方法利用了一种简化的分光光度计和改进的校准/归一化方法。 还提供了改进的线性化方法，以及改进的基于分类器的算法。 用户控制是通过图形用户界面提供的。 提供与所测量的皮肤或其他物体匹配或改变皮肤或其它物体的产品或产品配方以减轻，变暗，变得更均匀等。

公开(公告)号：US20140370509A1

公开(公告)日：2014-12-18

申请号：US14352031

申请日：2012-10-16

Applicant: Eppendorf AG

Inventor： Michael Wild ,  Christoph Jolie

IPC: G01N21/64

CPC classification number: G01N21/6486 ,  G01N21/274 ,  G01N21/64 ,  G01N21/6428 ,  G01N21/6452 ,  G01N2201/062 ,  G01N2201/124 ,  G01N2201/127

Abstract: The invention is related to a method for the quantitative optical measurement of a characteristic property of at least one analyte in at least one laboratory sample, in particular for the fluorescence measurement of at least one biochemical or biological sample, has the method using a laboratory apparatus, which h at least one light source and at least one detector device, the apparatus utilizing at least sensitivity parameter S, which controls the capability of the laboratory apparatus to detect a signal by means of the at least one detector device, the method using source light for causing the at least one sample to emit a sample light, and the at least one detector device for detecting sample light and utilizing the at least one sensitivity parameter S to detect the corresponding at least one intensity I of the sample light, the method comprising the steps: —determining at least one reference point (S_ref; I ref); —using at least one first sensitivity parameter S_m1, which is not the same as S_ref, for measuring at least one first intensity I_m1 of sample light as-signed to a first analyte; —determining a quantity Q1, which is a measure for the slope of a line, which is determined by utilizing the at least one reference point (S_ref; 1_ref) and the at least one measurement point (S_m1; I_m1); using the quantity Q1 for calculating a first analyte value C_m1, which is dependent on Q1 and which is characteristic for a property of the first analyte, in particular for a concentration of the first analyte in the at least one sample, in particular according to the formula Q1=(I_m1−1_ref)/(S_m1−S_ref). The method, further, is related to a laboratory apparatus, which is configured to apply the method according to the invention.

Abstract translation: 本发明涉及一种用于定量光学测量至少一个实验室样品中至少一种分析物的特征性质的方法，特别是用于至少一种生化或生物样品的荧光测量的方法，具有使用实验室装置的方法 ，其至少一个光源和至少一个检测器装置，所述装置至少使用灵敏度参数S，其控制实验室装置通过至少一个检测器装置检测信号的能力，所述方法使用源 用于使所述至少一个样品发射样品光的光，以及所述至少一个检测器装置，用于检测样品光并利用所述至少一个灵敏度参数S来检测所述样品光的相应的至少一个强度I，所述方法 包括以下步骤： - 确定至少一个参考点（S_ref; I ref）; - 使用与S_ref不同的至少一个第一灵敏度参数S_m1来测量与第一分析物相符合的样本光的至少一个第一强度I_m1; - 确定通过利用所述至少一个参考点（S_ref; 1_ref）和所述至少一个测量点（S_m1; I_m1）确定的线的斜率的度量的量Q1; 使用数量Q1来计算取决于Q1的第一分析物值C_m1，其特征在于至少一个样品中的第一分析物的浓度，特别是对于至少一个样品中的第一分析物的浓度，其特征在于第一分析物的性质， 公式Q1 =（I_m1-1_ref）/（S_m1-S_ref）。 该方法还涉及实验室设备，其被配置为应用根据本发明的方法。

公开(公告)号：US08830469B2

公开(公告)日：2014-09-09

申请号：US13003464

申请日：2009-07-01

Applicant: Jia Chen ,  Andreas Hangauer ,  Rainer Strzoda

Inventor： Jia Chen ,  Andreas Hangauer ,  Rainer Strzoda

IPC: G01N21/00 ,  G01N21/39 ,  G01N21/27 ,  G01N21/35

CPC classification number: G01N21/39 ,  G01N21/274 ,  G01N21/3504 ,  G01N2021/399 ,  G01N2201/127

Abstract: A method and a sensor for detecting a target gas by laser spectroscopy using a laser or a laser diode having a monochrome emission wavelength that can be modulated by varying the operating temperature or the operating current. The wavelength range of the target gas comprises a first modulation of the laser or the laser diode over a first large modulation width, in addition to at least two absorption lines of a reference gas and at least one absorption line of the target gas. The absorption lines are used to calibrate the wavelength scale of the laser or the laser diode in relation to the varied operating temperature or operating current, a second modulation of the laser or the laser diode being performed over a second small modulation width, with the at least one absorption line of the target gas, for detecting the target gas.

Abstract translation: 一种通过激光光谱法使用具有可通过改变工作温度或工作电流进行调制的具有单色发射波长的激光或激光二极管来检测目标气体的方法和传感器。 目标气体的波长范围除了基准气体的至少两条吸收线和目标气体的至少一条吸收线之外，包括在第一大调制宽度上的激光或激光二极管的第一调制。 吸收线用于相对于变化的工作温度或工作电流来校准激光器或激光二极管的波长标度，激光器或激光二极管的第二调制在第二小调制宽度上执行，其中at 目标气体的至少一个吸收线，用于检测目标气体。

公开(公告)号：US20140088876A1

公开(公告)日：2014-03-27

申请号：US14038622

申请日：2013-09-26

Applicant: Daniel A. Shiley ,  Brian Curtiss

Inventor： Daniel A. Shiley ,  Brian Curtiss

IPC: G01V13/00

CPC classification number: G01V13/00 ,  G01N21/3563 ,  G01N21/359 ,  G01N21/65 ,  G01N21/718 ,  G01N23/223 ,  G01N33/24 ,  G01N2021/1734 ,  G01N2021/1736 ,  G01N2021/3595 ,  G01N2201/127 ,  G01N2201/129 ,  G01N2223/3037 ,  G01N2223/616

Abstract: Systems and methods for analyzing an unknown geological sample are disclosed. The system may include at least two analytical subsystems, and each of the at least two analytical subsystems provides different information about the geological sample. The data sets from various analytic subsystems are combined for further analysis, and the system includes a chemometric calibration model that relates geological attributes from analytical data previously obtained from at least two analytical techniques. A prediction engine applies the chemometric calibration model to the combined analytical information from the geological sample to predict specific geological attributes in the unknown geological sample.

Abstract translation: 公开了用于分析未知地质样品的系统和方法。 系统可以包括至少两个分析子系统，并且至少两个分析子系统中的每一个提供关于地质样品的不同信息。 来自各种分析子系统的数据集合进行进一步分析，并且该系统包括化学计量校准模型，该模型将来自先前从至少两种分析技术获得的分析数据的地质属性相关联。 预测引擎将化学计量校准模型应用于地质样品的综合分析信息，以预测未知地质样品中的具体地质属性。

公开(公告)号：US20120148450A1

公开(公告)日：2012-06-14

申请号：US13401047

申请日：2012-02-21

Applicant: Kanako IWAMURA ,  Shoichi Kanayama

Inventor： Kanako IWAMURA ,  Shoichi Kanayama

IPC: G01N21/59

CPC classification number: G01N21/253 ,  G01N35/025 ,  G01N35/04 ,  G01N2035/0455 ,  G01N2201/0415 ,  G01N2201/124 ,  G01N2201/1245 ,  G01N2201/127

Abstract: According to one embodiment, an automatic analyzer comprises a light source, a spectroscope, a photo detection unit, a storage unit, a selection unit, and a calculation unit. The storage unit stores photo detector identifiers related to photo detectors and wavelength band identifiers in association with each other. The selection unit selects a specific photo detector from photo detectors. The specific photo detector corresponds to a specific photo detector identifier associated with a wavelength band identifier of a wavelength band according to a measurement item of a sample. The calculation unit calculates an absorbance related to the measurement item based on a signal from the selected specific photo detector.

Abstract translation: 根据一个实施例，自动分析仪包括光源，分光镜，光检测单元，存储单元，选择单元和计算单元。 存储单元相关联地存储与光检测器和波长带标识符相关的光检测器标识符。 选择单元从光电检测器中选择特定的光电检测器。 特定的光检测器对应于根据样品的测量项目与波长带的波长带标识符相关联的特定光检测器标识符。 计算单元基于来自所选择的特定光检测器的信号计算与测量项目相关的吸光度。

公开(公告)号：US20120021455A1

公开(公告)日：2012-01-26

申请号：US13185898

申请日：2011-07-19

Applicant: Bradford G. Clay

Inventor： Bradford G. Clay

IPC: C12Q1/04 ,  C12M1/34

CPC classification number: G01N33/84 ,  C12M41/26 ,  C12M41/34 ,  C12M41/36 ,  G01N21/3151 ,  G01N21/78 ,  G01N21/783 ,  G01N21/80 ,  G01N2021/3181 ,  G01N2201/127

Abstract: A detector arrangement for a blood culture bottle incorporating a colorimetric sensor which is subject to change of color due to change in pH or CO2 of a sample medium within the blood culture bottle. The detector arrangement includes a sensor LED illuminating the colorimetric sensor, a reference LED illuminating the colorimetric sensor, a control circuit for selectively and alternately activating the sensor LED and the reference LED, and a photodetector. The photodetector measures reflectance from the colorimetric sensor during the selective and alternating illumination of the colorimetric sensor with the sensor LED and the reference LED and generates intensity signals. The reference LED is selected to have a peak wavelength of illumination such that the intensity signals of the photodetector from illumination by the reference LED are not substantially affected by changes in the color of the colorimetric sensor.

Abstract translation: 一种用于血液培养瓶的检测器装置，其包含由于血培养瓶内的样品介质的pH或CO 2的变化而使颜色变化的比色传感器。 检测器装置包括照亮比色传感器的传感器LED，照亮比色传感器的参考LED，用于选择性地和交替地激活传感器LED和参考LED的控制电路和光电检测器。 光电检测器在比色传感器与传感器LED和参考LED的选择性和交替照明期间测量来自比色传感器的反射率，并产生强度信号。 参考LED被选择为具有照明的峰值波长，使得来自参考LED的照明的光电检测器的强度信号基本上不受比色传感器的颜色的变化的影响。

公开(公告)号：US20110293476A1

公开(公告)日：2011-12-01

申请号：US13147809

申请日：2010-03-01

Applicant: Sakuichiro Adachi ,  Akihisa Makino

Inventor： Sakuichiro Adachi ,  Akihisa Makino

IPC: G01N21/75

CPC classification number: G01N35/025 ,  G01N21/253 ,  G01N21/272 ,  G01N21/274 ,  G01N2201/127 ,  Y10T436/113332 ,  Y10T436/114998

Abstract: To reduce measurement time, it may be considered to quicken reaction or speed up analytic determination. In existing analyzing devices, photometry is performed, typically, about every 15 seconds, so that it has not been possible to secure satisfactory reproducibility. Namely, reducing the measurement time and securing reproducibility have not been compatible. It has therefore been desired to increase the number of times of measurements performed in a short period of time. A cell disk is controlled to stop at a position for photometry during the time after a sample and a reagent are mixed and before measurement is finished and, while the cell disk is stopped, photometry is performed once or plural times thereby increasing the total number of times of measurements.

Abstract translation: 为了减少测量时间，可以考虑加快反应或加速分析测定。 在现有的分析装置中，通常每隔15秒进行测光，因此不可能确保令人满意的再现性。 也就是说，减少测量时间和确保再现性不兼容。 因此，期望在短时间内增加测量次数。 控制细胞盘在样品和试剂混合之后并在测量结束之前的时间点停止在测光位置，并且在细胞盘停止时，测光一次或多次，从而增加总数 测量次数。

公开(公告)号：US08021613B2

公开(公告)日：2011-09-20

申请号：US11900263

申请日：2007-09-11

Applicant: Norman H. Fontaine ,  Prantik Mazumder ,  Mark A. Quesada ,  Eric J. Mozdy ,  Po Ki Yuen

Inventor： Norman H. Fontaine ,  Prantik Mazumder ,  Mark A. Quesada ,  Eric J. Mozdy ,  Po Ki Yuen

IPC: G01N15/06 ,  G01N21/00 ,  G01N21/76

CPC classification number: G01N21/7743 ,  G01N21/05 ,  G01N21/276 ,  G01N21/553 ,  G01N2021/0346 ,  G01N2021/058 ,  G01N2201/108 ,  G01N2201/1211 ,  G01N2201/1217 ,  G01N2201/127 ,  G01N2201/12723 ,  G01N2201/128 ,  Y10T436/117497 ,  Y10T436/2575

Abstract: A system and method are described herein for self-referencing a sensor that is used to detect a biomolecular binding event and/or kinetics which occur in a sample solution flowing along side a reference solution in a micron-sized deep flow channel.

Abstract translation: 本文描述了一种系统和方法，用于自我参考用于检测在微米尺寸深流动通道中沿着参考溶液侧流动的样品溶液中发生的生物分子结合事件和/或动力学的传感器。