公开(公告)号：US20180143134A1

公开(公告)日：2018-05-24

申请号：US15785829

申请日：2017-10-17

Applicant: Airware, Inc.

Inventor： Jacob Y. Wong ,  Thomas Campbell

IPC: G01N21/59 ,  G01N33/49

CPC classification number: G01N21/59 ,  G01J3/427 ,  G01N21/274 ,  G01N21/3577 ,  G01N33/49 ,  G01N2021/3148 ,  G01N2021/473 ,  G01N2201/0696 ,  G01N2201/127

Abstract: A glucose sensor measures glucose molecules in vivo through use of NDIR in which scattering noise is reduced and Absorption Interference Noise (AIN) is suppressed with a reflection technique. Electronics are used to provide an output of glucose concentration glucose in a liquid sampling matrix after it has been determined that a calibration curve is valid after signal processing is used to obtain average ratio values for reflected signal/reference channels and interference/reference channel obtained after a pulsed beam from signal, interference and reference sources is directed at an inclined angle to a normal of a spot of the liquid sampling matrix. The signal, interference and reference sources are each pulsed at a preselected frequency of at least N Hz which is sufficiently fast so that a given molecule of glucose or interfering molecule will not pass in and out of the liquid sampling matrix within the preselected frequency.

公开(公告)号：US20180120229A1

公开(公告)日：2018-05-03

申请号：US15845996

申请日：2017-12-18

Applicant: Quantum-Si Incorporated

Inventor： Jonathan M. Rothberg ,  Ali Kabiri ,  Jason W. Sickler ,  Brett J. Gyarfas ,  Jeremy Lackey ,  Gerard Schmid ,  Lawrence C. West ,  Keith G. Fife ,  Benjamin Cipriany ,  Farshid Ghasemi

IPC: G01N21/64

CPC classification number: G01N21/6408 ,  C12Q1/6869 ,  C12Q1/6874 ,  G01N21/6428 ,  G01N21/6454 ,  G01N21/648 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2021/6439 ,  G01N2021/6463 ,  G01N2201/0696 ,  G01N2201/08 ,  G01N2201/12

Abstract: System and methods for analyzing single molecules and performing nucleic acid sequencing. An integrated device includes multiple pixels with sample wells configured to receive a sample, which when excited, emits radiation. The integrated device includes at least one waveguide configured to propagate excitation energy to the sample wells from a region of the integrated device configured to couple with an excitation energy source. A pixel may also include at least one element for directing the emission energy towards a sensor within the pixel. The system also includes an instrument that interfaces with the integrated device. The instrument may include an excitation energy source for providing excitation energy to the integrated device by coupling to an excitation energy coupling region of the integrated device. One of multiple markers distinguishable by temporal parameters of the emission energy may label the sample and configuration of the sensor within a pixel may allow for detection of a temporal parameter associated with the marker labeling the sample.

公开(公告)号：US09863887B2

公开(公告)日：2018-01-09

申请号：US14441264

申请日：2012-11-15

Applicant: NEMOR TECHNOLOGIES OÜ

Inventor： Sergey Babichenko

IPC: G01N21/64 ,  G01N21/94

CPC classification number: G01N21/94 ,  G01N21/64 ,  G01N2021/6421 ,  G01N2021/945 ,  G01N2201/021 ,  G01N2201/061 ,  G01N2201/062 ,  G01N2201/0625 ,  G01N2201/0696

Abstract: The invention relates to a unit and method for detection of presence of oil on the water surface or in the water column. Unit comprises a sensor, whereby the sensor is connected to electronic compartment followed by microprocessor controller with embedded software for carrying out necessary analyses of reflected signals received by the sensor. The microprocessor controller is connected to communication means for transmitting an alarm signal through external communication line in case of oil pollution. All elements mentioned above are supplied by external power supply and are accommodated into a waterproof housing. The sensor comprises the probe light source formed by a pulsed UV LED, collimating optics and narrow band optical filter, at least one dichroic mirror, a projection-receiving lens, at least one optical filter, at least one photodetector and a reference photodetector.

公开(公告)号：US20170356848A1

公开(公告)日：2017-12-14

申请号：US15528123

申请日：2015-11-24

Applicant: GE HEALTHCARE BIO-SCIENCES AB

Inventor： Hanno Ehring

IPC: G01N21/64 ,  G01N21/05 ,  G01N21/33 ,  G01J3/42 ,  G01N21/17 ,  G01J3/44

CPC classification number: G01N21/645 ,  G01J3/42 ,  G01J3/4406 ,  G01J2003/421 ,  G01N21/05 ,  G01N21/33 ,  G01N2021/1736 ,  G01N2021/1738 ,  G01N2021/174 ,  G01N2021/6482 ,  G01N2021/6484 ,  G01N2021/6491 ,  G01N2201/0696

Abstract: Disclosed is apparatus (1) for measuring fluorescence and absorbance of a substance in a sample, said apparatus (1) comprising: a flow cell (2) for containing a sample, a first light source (3), a first conductor (5) for transmitting light from the first light source (3) to the flow cell (2) for irradiating a sample contained therein, a second conductor (7) for transmitting light from the flow cell (2) to a sample detector (9) arranged to detect an electromagnetic radiation that has passed through said cell (2), and a processing unit (16) arranged to receive a first signal (31) from a reference detector (15) and a second signal (32) from the sample detector (9) and to determine an absorbance based on said first and second signals (31,32), said apparatus (1) further comprising a second light source (4), a third conductor (6) for transmitting light from the second light source (4) to the cell (2) and wherein the sample detector (9) is further arranged to also detect fluorescence signals in the light that has passed through the flow cell (2). The invention also relates to a method for measuring the absorbance and the fluorescence of a substance in a sample.

公开(公告)号：US09835557B1

公开(公告)日：2017-12-05

申请号：US14598070

申请日：2015-01-15

Applicant: GENE CAPTURE, INC.

Inventor： Marc L Pusey

IPC: G01N1/00 ,  G01N21/64

CPC classification number: G01N21/6408 ,  G01N21/645 ,  G01N21/6458 ,  G01N2201/0621 ,  G01N2201/0696

Abstract: A device and system for measuring the multidimensional distribution of a sample tagged with a short life fluorescent label. The substance applied to a sample holder can be scanned with an optical point source excitation and read back optical stage. The sample can be excited at each of a plurality of points with a fast, e.g., nanosecond pulse of light. The resulting fluorescence can be detected after the excitation is extinguished. A detection gate window can be optimized to maximize the fluorescence signal detected for a predetermined amount of time.

公开(公告)号：US09801265B2

公开(公告)日：2017-10-24

申请号：US15045766

申请日：2016-02-17

Applicant: Verity Instruments, Inc.

Inventor： Larry Arlos Bullock ,  John D. Corless ,  Mark Anthony Meloni ,  Mike Whelan

IPC: G01J3/28 ,  H05B41/30 ,  G01J3/26 ,  G01J3/10 ,  G01J3/02 ,  G01N21/84 ,  G01J3/12

CPC classification number: H05B41/30 ,  G01J3/0205 ,  G01J3/027 ,  G01J3/10 ,  G01J3/26 ,  G01J2003/1278 ,  G01N21/84 ,  G01N2201/061 ,  G01N2201/0696

Abstract: A digital flashlamp controller, a flashlamp control system and a method of controlling a flashlamp bulb employing digital control electronics are provided herein. In one embodiment, the digital flashlamp controller includes: (1) a trigger interface configured to provide firing signals to control a trigger element for a flashlamp bulb and (2) digital electronics configured to generate the firing signals and control multiple pulsing of the flashlamp bulb.

公开(公告)号：US20170299516A1

公开(公告)日：2017-10-19

申请号：US15485803

申请日：2017-04-12

Applicant: Ezzat Hegazi ,  Vincent Cunningham ,  Christof Brunner ,  Christoph Stamm

Inventor： Ezzat Hegazi ,  Vincent Cunningham ,  Christof Brunner ,  Christoph Stamm

IPC: G01N21/64 ,  G01N33/28

CPC classification number: G01N21/645 ,  G01N21/85 ,  G01N33/28 ,  G01N2021/6463 ,  G01N2201/0621 ,  G01N2201/0696

Abstract: Methods and systems for determining contamination in a petroleum-based sample, including irradiating the petroleum-based sample with a light beam from a light source such that a fluorescence signal is generated, guiding, by a mirror, the fluorescence signal to a gear-less rotating diffraction grating, the gear-less rotating diffraction grating spatially separating a fluorescence wavelength from the florescence signal, detecting, by an optical detector, fluorescence wavelength, transforming the fluorescence wavelength into a spectral contour diagram, the spectral contour diagram comprising a fluorescence wavelength variation over time, and determining, the contamination in the petroleum-based sample using the spectral contour diagram.

公开(公告)号：US09759651B2

公开(公告)日：2017-09-12

申请号：US14978292

申请日：2015-12-22

Applicant: Magellan Diagnostics, Inc.

Inventor： Norman F. Sheppard, Jr. ,  Gary Conrad Jensen

IPC: G01N27/416 ,  G01N21/31 ,  G01N33/49 ,  G01N21/47

CPC classification number: G01N21/31 ,  G01N21/474 ,  G01N33/49 ,  G01N2201/062 ,  G01N2201/0625 ,  G01N2201/0696

Abstract: A sensor and analyzer for measuring an analyte in a liquid sample are disclosed. The sensor includes a substrate with a reservoir disposed therein. The reservoir may include a top surface and a bottom surface, at least one transparent portion forming at least a part of the bottom surface of the reservoir, and a reflector disposed on the upper surface of the reservoir at a location opposite the at least one transparent portion. The analyzer may include a support surface, an aperture extending through the support surface, a light source disposed below the support surface and oriented so that at least a portion of the light emitted from the light source passes through the aperture, and a detector configured to measure an intensity of light received at the detector.

公开(公告)号：US09678000B1

公开(公告)日：2017-06-13

申请号：US15444136

申请日：2017-02-27

Applicant: Airware, Inc.

Inventor： Jacob Y Wong ,  Thomas Campbell

IPC: G01N33/49 ,  G01N21/3504

CPC classification number: G01N21/3504 ,  G01J3/10 ,  G01J3/42 ,  G01J3/427 ,  G01N21/3151 ,  G01N21/3577 ,  G01N21/61 ,  G01N33/49 ,  G01N2021/3159 ,  G01N2201/0696

Abstract: A concentration of glucose in a blood sample is determined through use of a signal channel output/reference channel ratio obtained by use of an NDIR absorption technique in which scattering noise attributable to the liquid phase is reduced by alternately and successively pulsing infrared radiation from signal and reference sources which are multiplexed and collimated into a pulsed beam directed through the sample space containing the liquid phase and the pulse frequency is sufficiently fast so that a given molecule of glucose will not pass in and out of the sample space within the pulse frequency.

公开(公告)号：US20170102320A1

公开(公告)日：2017-04-13

申请号：US15385482

申请日：2016-12-20

Applicant: Halliburton Energy Services, Inc.

Inventor： Michael Pelletier ,  William Soltmann ,  David L. Perkins ,  Christopher M. Jones

IPC: G01N21/25 ,  G01J3/10 ,  H05B37/02 ,  G01J3/433 ,  G01J5/52 ,  G01N21/31 ,  G01J3/02 ,  G01J3/427

CPC classification number: G01N21/255 ,  E21B47/102 ,  E21B49/08 ,  G01J3/0205 ,  G01J3/027 ,  G01J3/10 ,  G01J3/108 ,  G01J3/427 ,  G01J3/433 ,  G01J5/522 ,  G01N21/31 ,  G01N21/47 ,  G01N2201/061 ,  G01N2201/06186 ,  G01N2201/0696 ,  G01N2201/12 ,  G01V8/10 ,  H03K7/08 ,  H05B37/0209

Abstract: A light source and a method for its use in an optical sensor are provided, the light source including a resistively heated element. The light source includes a power circuit configured to provide a pulse width modulated voltage to the resistively heated element, the pulse width modulated voltage including: a duty cycle with a first voltage; and a pulse period including a period with a second voltage, wherein: the duty cycle, the first voltage, and the pulse period are selected so that the resistively heated element is heated to a first temperature; and the first temperature is selected to emit black body radiation in a continuum spectral range. Also provided is an optical sensor for determining a chemical composition including a light source as above.