Patent search cpc:"G01N2201/10" Page 7

61.

发明授权
Method for reducing analyzer variability using a normalization target 有权

公开(公告)号：US11953428B2

公开(公告)日：2024-04-09

申请号：US17077810

申请日：2020-10-22

Applicant: Quidel Corporation

Inventor： David Dickson Booker , Jhobe Steadman

IPC: G01N21/27 , G01N21/64

CPC classification number: G01N21/274 , G01N21/278 , G01N21/645 , G01N2201/068 , G01N2201/10 , G01N2201/12746 , G01N2201/12753 , G01N2201/12761

Abstract: Disclosed herein is a method for improving the precision of a test result from an instrument with an optical system that detects a signal. The method comprises including in the instrument a normalization target disposed directly or indirectly in the optical path of the optical system. Also disclosed are instruments comprising a normalization target, and systems comprising such an instrument and a test device that receives a sample suspected of containing an analyte.

62.

发明公开
BIOLOGICAL SPECIMEN DETECTION SYSTEM, MICROSCOPE SYSTEM, FLUORESCENCE MICROSCOPE SYSTEM, BIOLOGICAL SPECIMEN DETECTION METHOD, AND PROGRAM 审中-公开

公开(公告)号：US20240085685A1

公开(公告)日：2024-03-14

申请号：US18246340

申请日：2021-10-05

Applicant: SONY GROUP CORPORATION

Inventor： TETSURO KUWAYAMA , HIROKAZU TATSUTA

IPC: G02B21/36 , G01N21/27 , G01N21/64 , G02B21/06

CPC classification number: G02B21/365 , G01N21/27 , G01N21/64 , G02B21/06 , G01N2201/10 , G01N2201/121 , G02B2207/113

Abstract: Suppressing deterioration in analysis accuracy on an image. A biological specimen detection system includes: a stage (20) capable of supporting a sample including a biological specimen; an observation system (40) that includes an objective lens (44) and observes the sample in a line-shaped visual field that is a part of a visual field through the objective lens; a signal acquisition unit (1) that acquires an image signal obtained from the sample by scanning the observation system in a first direction orthogonal to the line-shaped visual field; and a correction unit (24) that corrects distortion of a captured image based on the image signal on a basis of a positional relationship between an optical axis center of the objective lens and the line-shaped visual field.

63.

发明公开
METHOD AND SYSTEM FOR FLUORESCENCE LIFETIME BASED SEQUENCING 审中-公开

公开(公告)号：US20240060890A1

公开(公告)日：2024-02-22

申请号：US18500236

申请日：2023-11-02

Applicant: Illumina, Inc.

Inventor： Hod Finkelstein , Cheng Frank Zhong , Eliane H. Trepagnier

IPC: G01N21/64 , G01N21/77 , G01N21/05 , H01L31/107 , G01S7/4863 , H01L31/055 , G01S7/4865 , B01L3/00 , C12Q1/6869

CPC classification number: G01N21/6408 , G01N21/648 , G01N21/6452 , G01N21/7703 , G01N21/6454 , G01N21/05 , H01L31/107 , G01S7/4863 , H01L31/055 , G01S7/4865 , B01L3/502715 , C12Q1/6869 , G01N21/6428 , G01N2201/06113 , G01N2201/10

Abstract: An integrated detection, flow cell and photonics (DFP) device is provided that comprises a substrate having an array of pixel elements that sense photons during active periods. The substrate and pixel elements form an IC photon detection layer. At least one wave guide is formed on the IC photo detection layer as a photonics layer. An optical isolation layer is formed over at least a portion of the wave guide. A collection of photo resist (PR) walls patterned to define at least one flow cell channel that is configured to direct fluid along a fluid flow path. The wave guides align to extend along the fluid flow path. The flow cell channel is configured to receive samples at sample sites that align with the array of pixel elements.

64.

发明授权
Method and system for fluorescence lifetime based sequencing 有权

公开(公告)号：US11841322B2

公开(公告)日：2023-12-12

申请号：US17135595

申请日：2020-12-28

Applicant: ILLUMINA, INC.

Inventor： Hod Finkelstein , Cheng Frank Zhong , Eliane H. Trepagnier

IPC: G01N21/64 , B01L3/00 , H01L31/107 , G01N21/77 , G01N21/05 , G01S7/4863 , H01L31/055 , G01S7/4865 , C12Q1/6869

CPC classification number: G01N21/6408 , B01L3/502715 , C12Q1/6869 , G01N21/05 , G01N21/648 , G01N21/6428 , G01N21/6452 , G01N21/6454 , G01N21/7703 , G01S7/4863 , G01S7/4865 , H01L31/055 , H01L31/107 , G01N2201/06113 , G01N2201/10

Abstract: An integrated detection, flow cell and photonics (DFP) device is provided that comprises a substrate having an array of pixel elements that sense photons during active periods. The substrate and pixel elements form an IC photon detection layer. At least one wave guide is formed on the IC photo detection layer as a photonics layer. An optical isolation layer is formed over at least a portion of the wave guide. A collection of photo resist (PR) walls patterned to define at least one flow cell channel that is configured to direct fluid along a fluid flow path. The wave guides align to extend along the fluid flow path. The flow cell channel is configured to receive samples at sample sites that align with the array of pixel elements.

65.

发明授权
Analysis method and analysis apparatus 有权

公开(公告)号：US11698336B2

公开(公告)日：2023-07-11

申请号：US17036825

申请日：2020-09-29

Applicant: JEOL Ltd. , National Institute of Advanced Industrial Science and Technology

Inventor： Kenichi Tsutsumi , Akihiro Tanaka , Kazushiro Yokouchi , Tatsuya Uchida , Noboru Taguchi , Shingo Tanaka

IPC: G01N21/17 , G01N21/25

CPC classification number: G01N21/25 , G01N2021/1765 , G01N2201/10 , G01N2201/127

Abstract: An analysis method includes: obtaining n×m pieces of map data by repeating, m times, a map measurement in which n pieces of map data are obtained by scanning a specimen with a primary probe to detect electrons emitted from the specimen with an electron spectrometer, while measurement energy ranges of an analyzer are varied; and generating a spectral map in which a position on the specimen is associated with a spectrum based on the n×m pieces of map data, the measurement energy ranges of m times of the map measurement not overlapping each other.

66.

发明申请
Method and Apparatus for Infrared Scattering Scanning Near-field Optical Microscopy with High Speed Point Spectroscopy 审中-公开

公开(公告)号：US20180203039A1

公开(公告)日：2018-07-19

申请号：US15693204

申请日：2017-08-31

Applicant: Anasys Instruments

Inventor： Honghua Yang , Kevin Kjoller , Sam Berweger , Craig Prater

IPC: G01Q60/18 , G01N21/35 , G01N21/47

CPC classification number: G01Q60/18 , G01N21/35 , G01N21/39 , G01N21/47 , G01N21/4738 , G01N2201/0612 , G01N2201/10 , G01Q30/02 , G01Q60/22

Abstract: This invention involves measurement of optical properties of materials with sub-micron spatial resolution through infrared scattering scanning near field optical microscopy (s-SNOM). Specifically, the current invention provides substantial improvements over the prior art by achieving high signal to noise, high measurement speed and high accuracy of optical amplitude and phase. Additionally, it some embodiments, it eliminates the need for an in situ reference to calculate wavelength dependent spectra of optical phase, or absorption spectra. These goals are achieved via improved asymmetric interferometry where the near-field scattered light is interfered with a reference beam in an interferometer. The invention achieves dramatic improvements in background rejection by arranging a reference beam that is much more intense than the background scattered radiation. Combined with frequency selective demodulation techniques, the near-field scattered light can be efficiently and accurately discriminated from background scattered light. These goals are achieved via a range of improvements including a large dynamic range detector, careful control of relative beam intensities, and high bandwidth demodulation techniques. In other embodiments, phase and amplitude stability are improved with a novel s-SNOM configuration. In other embodiments an absorption spectrum may be obtained directly by comparing properties from a known and unknown region of a sample as a function of illumination center wavelength.