公开(公告)号：US20160003749A1

公开(公告)日：2016-01-07

申请号：US14855005

申请日：2015-09-15

Applicant: Bayer HealthCare LLC

Inventor： Hoi-Cheong Steve Sun ,  Paul M. Ripley

IPC: G01N21/78 ,  G01N21/47 ,  G01N25/20 ,  G01N21/25

CPC classification number: G01N21/78 ,  G01N21/251 ,  G01N21/4788 ,  G01N21/8483 ,  G01N25/20 ,  G01N33/521 ,  G01N2201/1211

Abstract: An assembly determines an analyte concentration in a sample of body fluid. The assembly includes a test sensor having a fluid-receiving area for receiving a sample of body fluid, where the fluid-receiving area contains a reagent that produces a measurable reaction with an analyte in the sample. The assembly also includes a meter having a port or opening configured to receive the test sensor; a measurement system configured to determine a measurement of the reaction between the reagent and the analyte; and a temperature-measuring system configured to determine a measurement of the test-sensor temperature when the test sensor is received into the opening. The meter determines a concentration of the analyte in the sample according to the measurement of the reaction and the measurement of the test-sensor temperature.

公开(公告)号：US20140295571A1

公开(公告)日：2014-10-02

申请号：US14227994

申请日：2014-03-27

Applicant: Bayer HealthCare LLC

Inventor： Hoi-Cheong Steve Sun ,  Paul M. Ripley

IPC: G01N33/52

CPC classification number: G01N21/78 ,  G01N21/251 ,  G01N21/4788 ,  G01N21/8483 ,  G01N25/20 ,  G01N33/521 ,  G01N2201/1211

Abstract: An assembly determines an analyte concentration in a sample of body fluid. The assembly includes a test sensor having a fluid-receiving area for receiving a sample of body fluid, where the fluid-receiving area contains a reagent that produces a measurable reaction with an analyte in the sample. The assembly also includes a meter having a port or opening configured to receive the test sensor; a measurement system configured to determine a measurement of the reaction between the reagent and the analyte; and a temperature-measuring system configured to determine a measurement of the test-sensor temperature when the test sensor is received into the opening. The meter determines a concentration of the analyte in the sample according to the measurement of the reaction and the measurement of the test-sensor temperature.

Abstract translation: 组件确定体液样品中的分析物浓度。 组件包括具有用于接收体液样本的流体接收区域的测试传感器，其中流体接收区域包含与样品中的分析物产生可测量反应的试剂。 组件还包括具有端口或开口的表，该端口或开口被配置为接收测试传感器; 测量系统，被配置为确定所述试剂和所述分析物之间的反应的测量; 以及温度测量系统，被配置为当测试传感器被接收到开口中时确定测试传感器温度的测量。 根据反应的测量和测试传感器温度的测量，仪表确定样品中分析物的浓度。

公开(公告)号：US20140067282A1

公开(公告)日：2014-03-06

申请号：US14013788

申请日：2013-08-29

Applicant: SICK AG

Inventor： Thomas BEYER ,  Julian EDLER

IPC: G01N21/25

CPC classification number: G01N21/255 ,  G01J3/28 ,  G01J3/433 ,  G01N21/274 ,  G01N21/3504 ,  G01N21/39 ,  G01N2021/399 ,  G01N2201/0691 ,  G01N2201/1211 ,  G01N2201/1215 ,  G01N2201/1218

Abstract: A method of determining a concentration of a gas in a sample and/or of the composition of a gas by means of a spectrometer includes measuring an absorption signal of the gas as a function of the wavelength. The wavelength substantially continuously runs through a wavelength range and is superimposed by a harmonic wavelength modulation, wherein the influence of the wavelength modulation on the absorption signal via the light source modulation properties and the detection properties of the spectrometer is dependent on the device properties of the respective spectrometer. The method includes converting the absorption signal into at least one first derivative signal; deriving a gas concentration measurement parameter from the first derivative signal; determining the concentration and/or composition of the gas from at least the gas concentration measurement parameter and from a calibration function compensating for influences of state variables of the gas and of the spectrometer properties.

Abstract translation: 通过光谱仪测定样品和/或气体组成中的气体的浓度的方法包括测量作为波长的函数的气体的吸收信号。 波长基本上连续地穿过波长范围并通过谐波波长调制叠加，其中波长调制对吸收信号的影响经由光源调制性质和光谱仪的检测特性取决于器件的性质 各自的光谱仪。 该方法包括将吸收信号转换成至少一个一阶导数信号; 从一阶导数信号导出气体浓度测量参数; 从至少气体浓度测量参数和补偿气体的状态变量和光谱仪性质的影响的校准函数确定气体的浓度和/或组成。

公开(公告)号：US20130301052A1

公开(公告)日：2013-11-14

申请号：US13882902

申请日：2011-10-28

Applicant: Calum John MacGregor ,  Desmond Robert Gibson

Inventor： Calum John MacGregor ,  Desmond Robert Gibson

IPC: G01N21/27

CPC classification number: G01N21/27 ,  G01N21/274 ,  G01N21/3504 ,  G01N33/0006 ,  G01N2201/1211 ,  G01N2201/12723 ,  G01N2201/12753 ,  G01N2201/12792

Abstract: An optical absorption gas sensor has an LED light source and a photodiode light detector, a temperature measuring device for measuring the LED temperature and a temperature measuring device for measuring the photodiode temperature. The sensor is calibrated by measuring the response of photodiode current at zero analyte gas concentration and at a reference analyte gas concentration. From these measurement, calibration data taking into account the effect of photodiode temperature on the sensitivity of the photodiode and, independently, the effect of changes in the spectrum of light output by the LED on the light detected by the photodiode with LED temperature can be obtained. Calibration data is written to memory in the gas sensor and in operation of the gas sensor, the output is compensated for both LED and photodiode temperature. The LED and photodiode can therefore be relatively far apart and operate at significantly different temperatures allowing greater freedom of optical pathway design.

Abstract translation: 光吸收气体传感器具有LED光源和光电二极管光检测器，用于测量LED温度的温度测量装置和用于测量光电二极管温度的温度测量装置。 通过测量零分析气体浓度和参考分析物气体浓度下的光电二极管电流的响应来校准传感器。 从这些测量中，考虑到光电二极管温度对光敏二极管的影响的校准数据，并且独立地，可以获得LED输出的光谱的变化对由LED温度由光电二极管检测的光的影响 。 校准数据被写入气体传感器中的存储器，并且在气体传感器的操作中，输出被补偿LED和光电二极管的温度。 因此，LED和光电二极管可以相对较远并且在显着不同的温度下操作，从而允许更大的光路设计自由度。

公开(公告)号：US20130271751A1

公开(公告)日：2013-10-17

申请号：US13882585

申请日：2011-10-28

Applicant: Calum John Macgegor ,  Desmond Robert Gibson

Inventor： Calum John Macgegor ,  Desmond Robert Gibson

IPC: G01N21/61

CPC classification number: G01N21/61 ,  G01J11/00 ,  G01N21/274 ,  G01N21/3504 ,  G01N2201/0696 ,  G01N2201/1211 ,  G01N2201/127

Abstract: An optical absorption gas sensor for detecting an analyte gas comprises a gas sample receiving chamber, at least one light emitting diode (LED) and a photodiode or other photosensor. A plurality of light pulses are generated by passing pulses of current through the at least one LED. The current through the at least one LED is measured a plurality of times during each pulse and taken into account when generating a compensated output signal. The transfer ratio between LED current and photodiode output signal is calculated a plurality of times during each pulse. An ADC measures the LED and photodiode currents alternately. The LED pulses are generated by inductor discharge flyback and the period of time for which current is supplied to the inductor prior to each pulse is selected so that the photodiode output current is at an optimal region within the input range of the ADC. At least the temperature of the at least one LED is measured and taken into account when generating the compensated output signal. Thus, rather than providing especially careful control of the LED pulses, the pulses are measured, enabling a simpler, lower power circuit which is tolerant of variations in temperature to be provided.

Abstract translation: 用于检测分析气体的光吸收气体传感器包括气体样品接收室，至少一个发光二极管（LED）和光电二极管或其它光电传感器。 通过使电流的脉冲通过至少一个LED来产生多个光脉冲。 通过至少一个LED的电流在每个脉冲期间被测量多次，并且在产生补偿的输出信号时被考虑。 在每个脉冲期间多次计算LED电流和光电二极管输出信号之间的传输比。 ADC交替测量LED和光电二极管电流。 LED脉冲由电感放电回扫产生，并且选择在每个脉冲之前向电感器提供电流的时间段，使得光电二极管输出电流处于ADC的输入范围内的最佳区域。 当产生补偿的输出信号时，至少测量并考虑至少一个LED的温度。 因此，不是特别仔细地控制LED脉冲，而是测量脉冲，使得能够提供容忍温度变化的更简单的较低功率电路。

公开(公告)号：US20130250301A1

公开(公告)日：2013-09-26

申请号：US13428591

申请日：2012-03-23

Applicant: Alfred Feitisch ,  Xiang Liu ,  Hsu-Hung Huang ,  Wenhai Ji ,  Richard Cline

Inventor： Alfred Feitisch ,  Xiang Liu ,  Hsu-Hung Huang ,  Wenhai Ji ,  Richard Cline

IPC: G06F19/00 ,  G01J3/42

CPC classification number: G01J3/0297 ,  G01J3/42 ,  G01N21/05 ,  G01N21/274 ,  G01N21/3504 ,  G01N21/39 ,  G01N2021/0314 ,  G01N2021/399 ,  G01N2201/1211 ,  G01N2201/1218 ,  G01N2201/127

Abstract: Validation verification data quantifying an intensity of light reaching a detector of a spectrometer from a light source of the spectrometer after the light passes through a validation gas across a known path length can be collected or received. The validation gas can include an amount of an analyte compound and an undisturbed background composition that is representative of a sample gas background composition of a sample gas to be analyzed using a spectrometer. The sample gas background composition can include one or more background components. The validation verification data can be compared with stored calibration data for the spectrometer to calculate a concentration adjustment factor, and sample measurement data collected with the spectrometer can be modified using this adjustment factor to compensate for collisional broadening of a spectral peak of the analyte compound by the background components. Related methods, articles of manufacture, systems, and the like are described.

Abstract translation: 验证验证数据可以收集或接收在光通过已知路径长度的验证气体之后，量化从光谱仪的光源到达光谱仪的检测器的光强度。 验证气体可以包括一定量的分析物化合物和未受干扰的背景组合物，其代表使用光谱仪分析的样品气体的样品气体背景组成。 样品气体背景组合物可以包括一种或多种背景组分。 可以将验证验证数据与存储的光谱仪校准数据进行比较，以计算浓度调节因子，并且可以使用该调整因子修改用光谱仪收集的样品测量数据，以补偿分析物化合物的光谱峰的碰撞展宽 背景组件。 描述了相关方法，制品，系统等。

公开(公告)号：US20130234045A1

公开(公告)日：2013-09-12

申请号：US13869066

申请日：2013-04-24

Applicant: OLYMPUS CORPORATION ,  TERUMO KABUSHIKI KAISHA

Inventor： Kazuya MAEDA ,  Hiromasa KOHNO

IPC: G01N21/64

CPC classification number: G01N21/64 ,  G01N21/6428 ,  G01N21/6454 ,  G01N2201/1211

Abstract: A correction method of a fluorescence sensor includes a first detection signal acquiring step for acquiring, at a first temperature, a first detection signal using a fluorescence sensor having a temperature detecting function and a temperature adjusting function, a second detection signal acquiring step for acquiring, at a second temperature, a second detection signal when an analyte amount is the same as an analyte amount in the first detection signal acquiring step, a correction coefficient calculating step for calculating, on the basis of the first detection signal and the second detection signal, a correction coefficient for correcting the fluorescent light detection signal, and a correcting step for correcting subsequent detection signals using the correction coefficient and a temperature detection signal.

Abstract translation: 荧光传感器的校正方法包括：第一检测信号获取步骤，用于在第一温度下使用具有温度检测功能和温度调节功能的荧光传感器获取第一检测信号;第二检测信号获取步骤， 在第二温度下，当分析物量与第一检测信号获取步骤中的分析物量相同时的第二检测信号;校正系数计算步骤，用于根据第一检测信号和第二检测信号， 用于校正荧光检测信号的校正系数，以及校正步骤，用于使用校正系数和温度检测信号校正后续检测信号。

公开(公告)号：US20130034859A1

公开(公告)日：2013-02-07

申请号：US13619679

申请日：2012-09-14

Applicant: Steven J. BOEGE ,  Mark F. OLDHAM ,  Eugene F. YOUNG

Inventor： Steven J. BOEGE ,  Mark F. OLDHAM ,  Eugene F. YOUNG

IPC: C12M1/40 ,  G01N21/64

CPC classification number: G01N21/64 ,  F21K9/00 ,  F21K9/64 ,  F21V29/54 ,  F21V29/677 ,  F21V29/74 ,  F21Y2115/10 ,  G01J3/0286 ,  G01J3/10 ,  G01N21/645 ,  G01N21/6452 ,  G01N2021/6439 ,  G01N2201/06113 ,  G01N2201/062 ,  G01N2201/0638 ,  G01N2201/1211 ,  G05D23/1919 ,  G05D23/20

Abstract: An optical instrument is provided for simultaneously illuminating two or more spaced-apart reaction regions with an excitation beam generated by a light source. A collimating lens can be disposed along a beam path between the light source and the reaction regions to form bundles of collimated excitation beams, wherein each bundle corresponds to a respective reaction region. Methods of analysis using the optical instrument are also provided.

Abstract translation: 提供了一种光学仪器，用于同时用由光源产生的激发光束照射两个或更多间隔开的反应区域。 准直透镜可以沿着光源和反应区域之间的光束路径设置，以形成准直激励束的束，其中每个束对应于相应的反应区域。 还提供了使用光学仪器的分析方法。

公开(公告)号：US20120055232A1

公开(公告)日：2012-03-08

申请号：US12876501

申请日：2010-09-07

Applicant: Walter R. Thorson

Inventor： Walter R. Thorson

IPC: G01N21/17

CPC classification number: G01N21/1702 ,  G01N2201/1211 ,  G01N2201/1214 ,  G01N2201/1218 ,  G01N2201/123

Abstract: A flexible gas sensor includes a housing with a predetermined form factor, a photoacoustic gas sensing chamber, and at least one of acoustic, temperature, relative humidity or pressure sensors in combination with processing circuitry which can emulate the characteristic gas response output of a catalytic bead pellistor-type gas sensor in response to a selected gas. The processing circuitry can include a programmable processor and a storage unit. The storage unit can be loaded with data and executable instructions to specify, at least in part, how the signals from the photoacoustic sensor are to be processed by the processing circuitry.

Abstract translation: 柔性气体传感器包括具有预定形状因数的壳体，光声气体检测室以及与处理电路组合的声学，温度，相对湿度或压力传感器中的至少一个，其可以模拟催化珠粒的特征气体响应输出 响应于所选气体的电阻型气体传感器。 处理电路可以包括可编程处理器和存储单元。 存储单元可以被加载数据和可执行指令，以至少部分地指定来自光声传感器的信号将如何由处理电路来处理。

公开(公告)号：US20120027044A1

公开(公告)日：2012-02-02

申请号：US13146290

申请日：2009-10-13

Applicant: Jyrki Laitinen ,  Markku Ojala

Inventor： Jyrki Laitinen ,  Markku Ojala

IPC: G01K15/00 ,  G06F19/00

CPC classification number: G01N21/253 ,  G01N21/6452 ,  G01N2201/1211

Abstract: An optical measurement instrument includes one or more temperature sensors (122) arranged to measure sample well specific temperatures from sample wells (111-117) arranged to store samples (103-109) to be optically measured. A processing device (121) of the optical measurement instrument is arranged to correct, using a pre-determined mathematical rule, measurement results obtained by the optical measurements on the basis of the measured sample well specific temperatures. Hence, the adverse effect caused by temperature differences between different samples on the accuracy of the temperature correction of the measurement results is mitigated.

Abstract translation: 一种光学测量仪器包括一个或多个温度传感器（122），其设置成测量样品阱特定的温度，该样品井被布置成存储待光学测量的样品（103-109）的样品孔（111-117）。 光学测量仪器的处理设备（121）被布置成使用预定的数学规则来校正通过基于测量的样品阱特定温度的光学测量获得的测量结果。 因此，不同样品之间的温度差异对测量结果的温度校正精度的不利影响得到了缓解。