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公开(公告)号：US11251889B2
公开(公告)日：2022-02-15
申请号：US16569565
申请日：2019-09-12
Inventor： Kurt W. Derr , Samuel Ramirez , Sneha K. Kasera , Christopher D. Becker , Aniqua Z. Baset
IPC: H04B17/345 , H04B17/391 , G06N20/10
Abstract: Wireless signal classifiers and systems that incorporate the same may include an energy-based detector configured to analyze an entire set of measurements and generate a first signal classification result, a cyclostationary-based detector configured to analyze less than the entire set of measurements and generate a second signal classification result; and a classification merger configured to merge the first signal classification result and the second signal classification result. Ensemble wireless signal classification and systems and devices the incorporate the same are disclosed. Some ensemble wireless signal classification may include energy-based classification processes and machine learning-based classification processes. In some embodiments, incremental machine learning techniques may be incorporated to add new machine learning-based classifiers to a system or update existing machine learning-based classifiers.
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公开(公告)号：US11233503B2
公开(公告)日：2022-01-25
申请号：US16825128
申请日：2020-03-20
Applicant: UNIVERSITY OF UTAH RESEARCH FOUNDATION
Inventor： Ali Azam , Jeffrey Walling
Abstract: Embodiments of the disclosure are drawn to a low-voltage temperature sensor. The temperature sensor may include a waveform generator, a complementary-to-absolute-temperature (CTAT) voltage generator, a voltage reference, two comparators, and digital logic. A waveform of the waveform generator may be compared to both the CTAT voltage and the voltage reference. The output of the comparison of the CTAT and the waveform may be a pulse-width modulated signal that is temperature-dependent. The output of the comparison of the voltage reference and the waveform may be a signal with constant pulse width. The digital logic may receive the pulsed signals and take a ratio of the two signals to determine a temperature.
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公开(公告)号：US20210386790A1
公开(公告)日：2021-12-16
申请号：US17422646
申请日：2020-01-15
Applicant: University of Utah Research Foundation
Inventor： Goro Kuramoto , Teruo Okano , Robert Silver , David Grainger
Abstract: The disclosure provides a method of reducing formation of fibrotic tissue in a uterus of a subject in need thereof, comprising applying a mesenchymal stem cell (MSC) sheet to the uterus of the subject, wherein the MSC sheet comprises one or more layers of aggregated confluent mesenchymal stem cells (MSCs), and wherein applying the MSC sheet to the uterus reduces the formation of fibrotic tissue in the uterus relative to a uterus in which the MSC sheet is not applied. The disclosure also provides a method of increasing myometrial regeneration in a uterus of a subject in need thereof, comprising applying a mesenchymal stem cell (MSC) sheet to the uterus of the subject, wherein the MSC sheet comprises one or more layers of aggregated confluent mesenchymal stem cells (MSCs), and wherein applying the MSC sheet to the uterus increases myometrial regeneration relative to a uterus in which the MSC sheet is not applied.
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公开(公告)号：US11162781B2
公开(公告)日：2021-11-02
申请号：US16691932
申请日：2019-11-22
Applicant: University of Utah Research Foundation
Inventor： Clayton C. Williams
Abstract: An interferometry system includes a plurality of coherent light sources that each generate a beam of coherent light. Separate waveguide pathways are optically associated with each coherent light source. Each separate waveguide pathway has an endpoint configured to emit at least a portion of the beam of coherent light from the associated light source. A plurality of photodetectors is optically associated with waveguide pathways. In some cases, a retroreflector receives the light emitted from the endpoints, modulates the received light, and directs the modulated light back to the endpoints. The modulated light and a portion of the coherent light reflected from the endpoint of the waveguide pathway receiving the modulated light is directed a photodetector.
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公开(公告)号：US20210322559A1
公开(公告)日：2021-10-21
申请号：US17184289
申请日：2021-02-24
Applicant: University of Utah Research Foundation
Inventor： Julian Kessler , Michael S. Yu , Yang Li
Abstract: Disclosed are peptide conjugates comprising an active agent, a spacer moiety, and a dimeric collagen hybridizing peptide comprising a first and second collagen hybridizing peptide, a linker; and a branch point, wherein the first and second collagen hybridizing peptides comprise the sequence of at least (GXY)n, wherein G is glycine, wherein X and Y are any amino acid, and wherein n is any number between 3 and 12. Also disclosed are methods of detecting denatured collagen in a sample comprising contacting a composition comprising any one of the disclosed peptide conjugates to a sample, wherein the active agent comprises a therapeutic agent, and detecting the presence or absence of binding of the peptide conjugate to denatured collagen, the presence of binding indicating the presence of denatured collagen in the sample. Also disclosed are methods of treating a disease or injury involving collagen damage comprising administering to a subject having a disease or injury involving collagen damage any one of the disclosed peptide conjugates.
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Patent Agency Ranking
公开(公告)号：US11135231B2
公开(公告)日：2021-10-05
申请号：US16467320
申请日：2017-12-07
Applicant: Tufts Medical Center, Inc. , Washington State University , University of Utah Research Foundation
Inventor： Roberta O'Connor , Eric W. Schmidt
IPC: A61K31/365 , A61K31/69 , A61P33/06 , A61K45/06
Abstract: Methods and compositions for preventing and/or treating diseases and conditions caused by certain apicomplexan infections are provided. The methods involve administering/providing to a subject one or more of tartrolon D and E, including isomers thereof. Exemplary apicomplexan infections that are prevented/treated by the compounds of the invention include those caused by Cryptosporidium, Babesia, Cyclospora, Isospora, Plasmodium, Sarcocystis, Besnoitia, Hammondia, Neospora, Theileria and Toxoplasma.
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公开(公告)号：US11130679B2
公开(公告)日：2021-09-28
申请号：US16294872
申请日：2019-03-06
Applicant: University of Utah Research Foundation
Inventor： Seyyed Pouya Hadipour Moghaddam , Hamidreza Ghandehari
Abstract: The disclosure extends to biodegradable hollow nanoparticles, and systems, methods, devices, and processes for producing the same. The disclosure includes a method of preparing a hollow mesoporous nanoparticle by providing a plurality of silica core particles. Each of the plurality of silica core particles comprises a diameter within a range of about 600 nanometers to about 30 nanometers. The method further includes synthesizing a mesoporous silica shell around the plurality of silica core particles forming a plurality of mesoporous coated silica core particles. Further, the method provides for etching the plurality of mesoporous coated silica core particles with an aqueous solution of sodium carbonate and water to remove the silica core particle from the plurality of mesoporous coated silica core particles forming a plurality of hollow mesoporous particles. The method also includes diffusing a payload into the plurality of hollow mesoporous particles in an aqueous solution.
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公开(公告)号：US20210267573A1
公开(公告)日：2021-09-02
申请号：US17315039
申请日：2021-05-07
Applicant: UNIVERSITY OF UTAH RESEARCH FOUNDATION
Inventor： Christopher F. Reiche , Florian Solzbacher , Navid Farhoudi , Steven M. Blair , Jules J. Magda , Lars B. Laurentius , Prattay Deepta Kairy
Abstract: Systems and methods for measuring changes in smart hydrogel microresonator structures positioned in an in vivo or other environment, having an acoustic resonance frequency in an ultrasound range. The system includes a smart hydrogel microresonator structure positioned within the environment configured to exhibit a change in resonance frequency in response to interaction with one or more predefined analytes in the environment. The system includes an ultrasound transducer for querying the smart hydrogel microresonator structure at or near its resonance frequency. The system also includes a computer system configured to receive ultrasound data as provided by query of the smart hydrogel microresonator structure and to determine changes in resonance frequency, amplitude or intensity of the ultrasound query wave, or mean grayscale value (MGV) associated with the ultrasound data of the smart hydrogel microresonator structure due to the change in resonance frequency. Such change can be correlated to concentration of the analyte.
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89.发明授权公开(公告)号：US11091800B2
公开(公告)日：2021-08-17
申请号：US16137432
申请日：2018-09-20
Applicant: University of Utah Research Foundation
Inventor： Hunter R. Underhill
IPC: C12Q1/6848 , C12Q1/6855 , C12Q1/6874 , C12Q1/6806
Abstract: A method of increasing detection of low-abundant fragments of cell-free DNA (ccfDNA) in a biological sample is disclosed and discussed. Such a method can include isolating an initial fraction of ccfDNA fragments from a biological sample, ligating a unique molecular identifier (UMI) to each of the ccfDNA fragments in the initial fraction, amplifying the plurality of ccfDNA fragments to generate a ccfDNA library, isolating a short fraction of ccfDNA fragments from the ccfDNA library, where the ccfDNA fragments in the short fraction are limited to a size of less than or equal to 160 base pairs (bp), amplifying the ccfDNA fragments in the short fraction, and sequencing the ccfDNA fragments in the short fraction to generate sequenced ccfDNA fragments.
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公开(公告)号：US20210222245A1
公开(公告)日：2021-07-22
申请号：US17099195
申请日：2020-11-16
Applicant: LineaGen, Inc. , University of Utah Research Foundation
Inventor： Mark Leppert , William McMahon , Nori Matsunami , Michael S. Paul , Alex S. Lindell
IPC: C12Q1/6883
Abstract: The present disclosure relates to the identification of a subject that is affected with, or predisposed to, autism or to one or more autism spectrum disorders (ASD). The present disclosure includes methods related to the association of certain genetic markers with autism and/or ASD. More particularly, the present disclosure is related to methods and diagnostic tests for diagnosing or predicting ASD in an individual.
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