公开(公告)号：US20090273782A1

公开(公告)日：2009-11-05

申请号：US12435970

申请日：2009-05-05

Applicant: Jong Hyun Yoo ,  Randolph S. Tribe ,  Chunyi Liu

Inventor： Jong Hyun Yoo ,  Randolph S. Tribe ,  Chunyi Liu

IPC: G01J3/30 ,  H01J49/00

CPC classification number: H01J49/0463 ,  B23K26/03 ,  B23K26/048 ,  B23K26/0861 ,  G01J3/443 ,  G01N21/718

Abstract: Provided is a laser ablation spectroscopy apparatus and method. A pulse laser is focused on the sample site to generate a plasma plume during a laser ablation process. The plasma plume is detected with a spectrometer and an intensified charge coupled device. A sample of material is coupled to a stage movable in the x, y and z directions using an array of x-y-z motors. A change in the height of the sample is detected using a triangulation sensor. The apparatus includes a system computer for synchronizing the movement of the stage in the x, y and z direction during the laser ablation process. The method includes a protocol of generating one or more laser ablations per sample site. The spectral data of the total number of laser ablations for each sample site are averaged together. The protocol includes laser ablating additional sample sites and averaging the spectral data of the total number of sample sites.

Abstract translation: 提供了一种激光烧蚀光谱仪和方法。 脉冲激光器聚焦在样品位置以在激光烧蚀过程中产生等离子体羽流。 用光谱仪和强化的电荷耦合器件检测等离子体羽流。 材料样品使用x-y-z电机的阵列耦合到在x，y和z方向上可移动的台。 使用三角测量传感器检测样品的高度变化。 该装置包括一个系统计算机，用于在激光烧蚀过程中使x，y和z方向上舞台的移动同步。 该方法包括每个样本位点产生一个或多个激光消融的协议。 将每个样品位点的激光烧蚀总数的光谱数据一起平均。 该协议包括激光烧蚀附加样品位点并平均样品总数的光谱数据。

公开(公告)号：US07609379B2

公开(公告)日：2009-10-27

申请号：US11664432

申请日：2005-09-30

Applicant: Lionel Canioni ,  Stéphane Santran ,  Bruno Bousquet

Inventor： Lionel Canioni ,  Stéphane Santran ,  Bruno Bousquet

IPC: G01J3/30

CPC classification number: G01J3/02 ,  G01J3/0218 ,  G01J3/18 ,  G01J3/4406 ,  G01N21/6402

Abstract: A system for detecting a chemical element within a material including at least one laser emission means for ionizing part of the material to generate fluorescence; at least one transmitting Bragg grating that filters the wavelength corresponding to the deexcitation wavelength of the element; and at least one photodiode that detects a line corresponding to the filtering wavelength, wherein the at least one Bragg grating is mobile to vary the filtering wavelength.

Abstract translation: 一种用于检测材料内的化学元素的系统，包括用于电离所述材料的一部分以产生荧光的至少一个激光发射装置; 至少一个发射布拉格光栅，其对与元件的去激励波长相对应的波长进行滤波; 以及至少一个光电二极管，其检测对应于所述滤波波长的线，其中所述至少一个布拉格光栅是移动的以改变所述滤波波长。

公开(公告)号：US20090242798A1

公开(公告)日：2009-10-01

申请号：US12060730

申请日：2008-04-01

Applicant: Joerg Bewersdorf ,  Manuel F. Juette ,  Travis Gould ,  Sam T. Hess

Inventor： Joerg Bewersdorf ,  Manuel F. Juette ,  Travis Gould ,  Sam T. Hess

IPC: G01J1/58 ,  G01J3/30 ,  H04N13/00

CPC classification number: G02B21/367 ,  G02B21/16 ,  G02B21/361 ,  G02B27/58 ,  H04N13/218 ,  H04N13/254 ,  H04N2013/0085

Abstract: A microscopy system is configured for creating 3D images from individually localized probe molecules. The microscopy system includes a sample stage, an activation light source, a readout light source, a beam splitting device, at least one camera, and a controller. The activation light source activates probes of at least one probe subset of photo-sensitive luminescent probes, and the readout light source causes luminescence light from the activated probes. The beam splitting device splits the luminescence light into at least two paths to create at least two detection planes that correspond to the same or different number of object planes of the sample. The camera detects simultaneously the at least two detection planes, the number of object planes being represented in the camera by the same number of recorded regions of interest. The controller is programmable to combine a signal from the regions of interest into a 3D data.

Abstract translation: 配置显微镜系统以从单独定位的探针分子创建3D图像。 显微镜系统包括样品台，激活光源，读出光源，分束装置，至少一个照相机和控制器。 活化光源激活光敏发光探针的至少一个探针子集的探针，并且读出的光源引起来自激活的探针的发光。 分束装置将发光分成至少两条路径，以产生对应于样品的相同或不同数目的物平面的至少两个检测平面。 相机同时检测至少两个检测平面，相机中相同数量的记录感兴趣区域的对象平面数目被表示在相机中。 控制器是可编程的，以将来自感兴趣区域的信号组合成3D数据。

公开(公告)号：US20090225311A1

公开(公告)日：2009-09-10

申请号：US12368839

申请日：2009-02-10

Applicant: Tomoyuki Umetsu

Inventor： Tomoyuki Umetsu

IPC: G01J3/30

CPC classification number: G01J3/42 ,  G01J3/0208 ,  G01J3/0218 ,  G01J3/10 ,  G01N21/3563 ,  G01N21/3581

Abstract: A probe apparatus includes a first focusing lens and a second focusing lens. The first focusing lens is arranged on a surface of a base to which a terahertz excitation beam is applied, the surface being opposite to the surface to which terahertz excitation beam is applied, with the lens axis deviated from the center of a point at which the terahertz excitation beam is applied. The second focusing lens is arranged on a surface of a base to which a terahertz detected beam is applied from a source of the terahertz excitation beam, the surface being opposite to the surface to which the terahertz detected beam is applied, with the lens axis deviated from the center of a point at which the terahertz detected beam is applied, in a direction opposite to the direction in which the lens axis of the first focusing lens is deviated.

Abstract translation: 探针装置包括第一聚焦透镜和第二聚焦透镜。 第一聚焦透镜布置在施加有太赫兹激发光束的基底的表面上，该表面与施加太赫兹激发光束的表面相对，透镜轴偏离了该点的中心 施加太赫兹激发光束。 第二聚焦透镜布置在从太赫兹激发束的源施加有太赫兹检测光束的基底的表面上，该表面与施加太赫兹检测的光束的表面相反，透镜轴偏离 从与第一聚焦透镜的透镜轴偏离的方向相反的方向从被施加太赫兹检测光束的点的中心开始。

公开(公告)号：US20090201500A1

公开(公告)日：2009-08-13

申请号：US12069971

申请日：2008-02-13

Applicant: Yixiang Duan ,  Quanxi Jia ,  Wenqing Cao

Inventor： Yixiang Duan ,  Quanxi Jia ,  Wenqing Cao

IPC: G01J3/30 ,  G01N7/00

CPC classification number: G01N21/67 ,  G01J3/30 ,  G01N2201/0221

Abstract: A hydrogen sensor for detecting/quantitating hydrogen and hydrogen isotopes includes a sampling line and a microplasma generator that excites hydrogen from a gas sample and produces light emission from excited hydrogen. A power supply provides power to the microplasma generator, and a spectrometer generates an emission spectrum from the light emission. A programmable computer is adapted for determining whether or not the gas sample includes hydrogen, and for quantitating the amount of hydrogen and/or hydrogen isotopes are present in the gas sample.

Abstract translation: 用于检测/定量氢和氢同位素的氢传感器包括从气体样品中激发氢气并从激发的氢气产生光发射的采样管线和微质发生器。 电源为微量发生器提供电力，光谱仪从发光中产生发射光谱。 可编程计算机适于确定气体样品是否包括氢，并且用于定量气体样品中存在氢和/或氢同位素的量。

公开(公告)号：US20090161104A1

公开(公告)日：2009-06-25

申请号：US12398180

申请日：2009-03-05

Applicant: Sheldon Schultz ,  David A. Schultz ,  David R. Smith ,  Jack J. Mock ,  Thomas J. Silva

Inventor： Sheldon Schultz ,  David A. Schultz ,  David R. Smith ,  Jack J. Mock ,  Thomas J. Silva

IPC: G01J3/30 ,  G01N33/566

CPC classification number: G06K19/06084 ,  B01J2219/0054 ,  B01J2219/00648 ,  B01J2219/00659 ,  B01J2219/00707 ,  B82Y30/00 ,  C12Q1/6816 ,  C12Q1/6825 ,  C40B70/00 ,  G01N21/554 ,  G01N21/648 ,  G01N21/658 ,  G06K7/1408 ,  Y10S436/805

Abstract: A method and apparatus for interrogating a target having a plurality of plasmon resonant particles (PREs) distributed in the target are disclosed. In the method, a field containing the target is illuminated, and one or more spectral emission characteristics of the light-scattering particles in the field are detected. From this data, an image of positions and spectral characteristic values in the field is constructed, allowing PREs with a selected spectral signature to be discriminated from other light-scattering entities, to provide information about the field. Also disclosed are a novel PRE composition for use in practicing the method, and a variety of diagnostic applications of the method.

Abstract translation: 公开了一种用于询问具有分布在靶中的多个等离子体共振粒子（PRE）的靶的方法和装置。 在该方法中，照射包含靶的场，并且检测场中的光散射粒子的一个或多个光谱发射特性。 从该数据中，构建场中的位置和频谱特征值的图像，使得具有所选频谱特征的PRE能够与其他光散射实体区分开来，以提供关于该场的信息。 还公开了一种用于实施该方法的新型PRE组合物，以及该方法的各种诊断应用。

公开(公告)号：US20090161103A1

公开(公告)日：2009-06-25

申请号：US12390784

申请日：2009-02-23

Applicant: Daphna Palti-Wasserman ,  Yaron Kober ,  Erez Kelly

Inventor： Daphna Palti-Wasserman ,  Yaron Kober ,  Erez Kelly

IPC: G01J3/30

CPC classification number: G01N21/6428 ,  G01N21/3504 ,  G01N21/6458

Abstract: A system for imaging a fluorescently labeled sample is presented, The system comprises a capsule, which is a closable structure made of a material isolating the inside of the capsule from its surrounding environment, and which has a support stage for receiving the sample and carrying it thereinside during the imaging; and an optical device at least partly accommodated inside the capsule and operable to illuminate the sample with incident radiation to excite a fluorescent response of the sample, detect the fluorescent response, and generate data indicative thereof.

Abstract translation: 提出了一种用于荧光标记样品成像的系统，该系统包括一个胶囊，该胶囊是由将胶囊内部与其周围环境隔离的材料制成的封闭结构，并且具有用于接收样品并携带它的支撑台 在成像期间; 以及光学装置，其至少部分地容纳在所述胶囊内部并且可操作以用入射辐射照射所述样品，以激发所述样品的荧光响应，检测所述荧光响应并产生指示其的数据。

公开(公告)号：US07545495B2

公开(公告)日：2009-06-09

申请号：US11321993

申请日：2005-12-29

Applicant: Kerry M. Swift ,  Edmund D. Matayoshi

Inventor： Kerry M. Swift ,  Edmund D. Matayoshi

IPC: G01J3/30 ,  G01J3/44

CPC classification number: G01N21/6486 ,  G01J3/10 ,  G01J3/36 ,  G01J3/42 ,  G01N21/6458 ,  G01N21/65

Abstract: The present invention relates to optical methods of observing, distinguishing and/or visualizing grown or nascent crystals of biological material within a biological sample.

Abstract translation: 本发明涉及在生物样品中观察，区分和/或可视化生物材料的生长或新生晶体的光学方法。

公开(公告)号：US07532325B2

公开(公告)日：2009-05-12

申请号：US10573056

申请日：2004-09-23

Applicant: Samir A. Ahmed ,  Fereidun Moshary ,  Barry Michael Gross

Inventor： Samir A. Ahmed ,  Fereidun Moshary ,  Barry Michael Gross

IPC: G01J3/447 ,  G01J3/30

CPC classification number: G01J3/44 ,  A61B5/0059 ,  G01J3/02 ,  G01J3/0224 ,  G01J3/4406 ,  G01N21/21 ,  G01N21/274 ,  G01N21/64 ,  G01N21/6402 ,  G01N21/6445 ,  G01N21/65 ,  G01N2021/1793 ,  G01N2021/6417 ,  G01N2201/129

Abstract: An apparatus for separating fluorescent light from light elastically scattered/reflected from a material illuminated with a broadband illumination source includes a polarization discriminator, which separates the substantially polarized elastically scattered/reflected light from the unpolarized fluorescent light, and a spectrometer to analyze the full and separated reflectance spectra. A linear polarizer may be provided to polarize the illumination source. A method for separating fluorescence light induced in a material by broadband light from an elastic scattering/reflection component includes providing polarization discrimination to separate the components, the fluorescence light being substantially unpolarized, and spectrally analyzing the reflectance components. The method may include linearly polarizing the light source. A fluorescence spectra may be extracted from a minimum reflectance spectra or from a residual polarization reflectance spectra.

Abstract translation: 用于将荧光与从宽带照明源照射的材料弹性散射/反射的光分离的装置包括：偏振鉴别器，其将基本上偏振的弹性散射/反射光与非偏振荧光分开;以及光谱仪， 分离的反射光谱。 可以提供线性偏振器以使照明源极化。 通过宽带光从弹性散射/反射分量中分离在材料中诱导的荧光的方法包括提供偏振鉴别以分离成分，荧光基本上是非偏振的，并对光谱分析反射分量。 该方法可以包括使光源线性偏振。 可以从最小反射光谱或残余极化反射光谱中提取荧光光谱。

公开(公告)号：US20090103084A1

公开(公告)日：2009-04-23

申请号：US12259819

申请日：2008-10-28

Applicant: Omowunmi A. SADIK ,  Hongwu XU

Inventor： Omowunmi A. SADIK ,  Hongwu XU

IPC: G01J3/30

CPC classification number: G01N21/8507 ,  G01N21/643 ,  G01N21/7703 ,  G01N2021/6432 ,  G01N2021/6434 ,  G01N2021/6439 ,  G01N2021/6484 ,  G01N2021/7786

Abstract: An oxygen sensor usable and accurate in solutions of up to pH 14 is featured. The sensor is fabricated by immobilizing a layer of polystyrene mixed with a fluorophore (e.g., Ruthenium tris(4,7-diphenyl-1,10-phenanthroline) dichloride) in a solvent such as dichloromethane. The mixture may be coated onto a structure such as a stainless steel sensor probe. In typical use, the inventive sensor probe is inserted into a flow cell through which the solution to be monitored flows. A blue LED light source having a wavelength of approximately 470 nm, and a spectrophotometer detector complete the sensor system. In operation, the fluorophore layer of the probe is illuminated by a blue LED light and the fluorescence is reflected back to the spectrophotometer. The monitored solution, typically an electroless gold plating bath, is pumped from the process equipment through the flow cell, and then back to the solution's origin.

Abstract translation: 具有高达pH 14的溶液中可用和精确的氧传感器。 通过将固定有与荧光团（例如三（4,7-二苯基-1,10-菲咯啉）钌的钌）的聚苯乙烯层固定在溶剂如二氯甲烷中来制造传感器。 混合物可以涂覆到诸如不锈钢传感器探针的结构上。 在典型的使用中，将本发明的传感器探针插入待监测的溶液流过的流动池中。 具有约470nm波长的蓝色LED光源和分光光度计检测器完成传感器系统。 在操作中，探针的荧光团层被蓝色LED光照射，荧光反射回分光光度计。 监控的解决方案，通常是无电镀金浴，从工艺设备通过流动池泵送，然后回到溶液的起源。