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    USER INTERFACE FOR ION MOBILITY SEPARATION DEVICE
    1.
    发明申请
    USER INTERFACE FOR ION MOBILITY SEPARATION DEVICE 审中-公开

    公开(公告)号：US20200035472A1

    公开(公告)日：2020-01-30

    申请号：US16522366

    申请日：2019-07-25

    Applicant: Micromass UK Limited

    Inventor： Sandra Richardson ,  Keith George Richardson ,  Kevin Giles ,  Jakub Ujma

    IPC: H01J49/00 ,  G01N27/62 ,  G06F3/0484 ,  G06F3/0482

    Abstract: A method of controlling the operation of an ion mobility separation device is disclosed. The method comprises displaying to a user via a user interface a pool of modes of operation of the ion mobility separation device, wherein each one of the modes is selectable by the user for inclusion in an experiment, and the modes are displayed in a first area 202 of the user interface. The method comprises receiving, via the user interface, an indication from the user of a selection of one or more instance of each one of a plurality of the modes from the pool to be included in an experiment, and an indication from the user of a set of one or more parameters for controlling the ion mobility separation device in respect of one or more selected instances of a mode. The selected instances of modes are displayed in a sequence in a second area 204 of the user interface. The operation of the ion mobility separation device is controlled in accordance with the received indications.

    USER INTERFACE FOR ION MOBILITY SEPARATION DEVICE
    3.
    发明申请
    USER INTERFACE FOR ION MOBILITY SEPARATION DEVICE 有权

    公开(公告)号：US20220392755A1

    公开(公告)日：2022-12-08

    申请号：US17843402

    申请日：2022-06-17

    Applicant: Micromass UK Limited

    Inventor： Sandra Richardson ,  Keith George Richardson ,  Kevin Giles ,  Jakub Ujma

    IPC: H01J49/00 ,  G06F3/0482 ,  G06F3/0484 ,  G01N27/623

    Abstract: A method of controlling the operation of an ion mobility separation device is disclosed. The method comprises displaying to a user via a user interface a pool of modes of operation of the ion mobility separation device, wherein each one of the modes is selectable by the user for inclusion in an experiment, and the modes are displayed in a first area 202 of the user interface. The method comprises receiving, via the user interface, an indication from the user of a selection of one or more instance of each one of a plurality of the modes from the pool to be included in an experiment, and an indication from the user of a set of one or more parameters for controlling the ion mobility separation device in respect of one or more selected instances of a mode. The selected instances of modes are displayed in a sequence in a second area 204 of the user interface. The operation of the ion mobility separation device is controlled in accordance with the received indications.

    METHOD OF CHARACTERISING MOLECULES BY ION-MOBILITY SPECTROMETRY
    4.
    发明申请
    METHOD OF CHARACTERISING MOLECULES BY ION-MOBILITY SPECTROMETRY 有权

    公开(公告)号：US20220074892A1

    公开(公告)日：2022-03-10

    申请号：US17298159

    申请日：2019-11-29

    Applicant: Micromass UK Limited

    Inventor： Jakub Ujma ,  Kevin Giles ,  Nick Tomczyk

    IPC: G01N27/624 ,  H01J49/00 ,  H01J49/40

    Abstract: A method of identifying and/or characterizing ions comprises separating analyte ions according to a first physico-chemical property (ion-mobility), selecting first ions of the analyte ions, and activating, fragmenting or reacting the first ions to produce first product ions, separating the first product ions according to the first physico- chemical property, and determining a pattern of the first product ions. The first ions are identified and/or characterized using the pattern of the first product ions.

    ION GUIDE
    7.
    发明申请
    ION GUIDE 有权

    公开(公告)号：US20220216045A1

    公开(公告)日：2022-07-07

    申请号：US17613796

    申请日：2020-05-29

    Applicant: Micromass UK Limited

    Inventor： Kevin Giles ,  Jakub Ujma ,  James Harrison ,  Bharat Chande ,  Graham Scambler

    IPC: H01J49/06 ,  H01J49/02 ,  G01N27/622

    Abstract: An ion guide or ion trap that comprises a plurality of electrodes (102) is disclosed. The ion guide or ion trap includes a detector (205) that can detect light or particles (114) emitted from the ion guide or ion trap due to electrical breakdown, and a control circuit (111) that can control the ion guide or ion trap in response to the detector (205) detecting light or particles (114) emitted from the ion guide or ion trap.

    MEASURING IONS WITH CHARGE REDUCTION
    8.
    发明申请
    MEASURING IONS WITH CHARGE REDUCTION 有权

    公开(公告)号：US20250164443A1

    公开(公告)日：2025-05-22

    申请号：US18841235

    申请日：2023-02-24

    Applicant: Micromass UK Limited

    Inventor： Jakub Ujma ,  Kevin Giles

    IPC: G01N27/623 ,  H01J49/00

    Abstract: Disclosed are methods of mass spectrometry that use charge reduction techniques to reduce the average charge of the ions to increase the mass to charge ratio spacings between different charge states for the ion species prior to mass analysis. In embodiments there is disclosed a method for determining a collision cross section for an ion species, wherein an ion mobility is determined for an ion species in a first state without charge reduction and the mass to charge ratios for the ion species are then measured in a second, charge-reduced state. The average charge determined for the ion species in the first state is then used together with the average mass determined from the ion species in the second state and the ion mobility determined for the ion species in the first state to determine a collision cross section for the ion species in the first state.

    CHARACTERISATION OF HIGH MASS PARTICLES
    9.
    发明公开
    CHARACTERISATION OF HIGH MASS PARTICLES 审中-公开

    公开(公告)号：US20240044841A1

    公开(公告)日：2024-02-08

    申请号：US18259012

    申请日：2021-12-23

    Applicant: Micromass UK Limited

    Inventor： Jakub Ujma ,  David Langridge ,  Jason Wildgoose ,  Keith Richardson ,  Kevin Giles

    IPC: G01N27/623

    CPC classification number: G01N27/623

    Abstract: A method of analysing high-mass (>1 MDa) particles comprises ionising particles to as to produce ions, separating the ions according to mass to charge ratio by passing the ions through an ion separation device in which one or more time-varying electric fields is used to urge ions through a gas such that ions are separated according to mass to charge ratio, measuring the transit time of the ions through the ion separation device, and determining a drift time or mass to charge ratio distribution of the ions therefrom. The method further comprises identifying one or more charge envelopes in the drift time or mass to charge ratio distribution, and using the one or more charge envelopes to characterise the particles.

    DE-CLUSTERING ION GUIDE
    10.
    发明公开
    DE-CLUSTERING ION GUIDE 审中-公开

    公开(公告)号：US20230152277A1

    公开(公告)日：2023-05-18

    申请号：US17916930

    申请日：2021-03-31

    Applicant: Micromass UK Limited

    Inventor： Kevin Giles ,  Jakub Ujma

    IPC: G01N27/623 ,  H01J49/06 ,  H01J49/24

    CPC classification number: G01N27/623 ,  H01J49/062 ,  H01J49/24

    Abstract: A method of mass and/or ion mobility spectrometry comprising: providing an ion guide comprising a plurality of electrodes and having a background gas therein; applying an RF voltage to electrodes of the ion guide for radially confining ions therein; transmitting clusters of analyte ions and adduct species into the ion guide; applying, in a first mode, one or more AC voltage to the ion guide so as to oscillate the clusters such that they collide with molecules of the background gas and cause adduct species in the clusters to detach from the analyte ions, wherein the one or more AC voltage has a different amplitude and/or frequency to that of said RF voltage; and (i) varying the speed with which the clusters are urged along the ion guide during the first mode; and/or (ii) varying he amplitude and/or frequency of the one or more AC voltage as the clusters travel along the ion guide.

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