公开(公告)号：US20190013189A1

公开(公告)日：2019-01-10

申请号：US15764129

申请日：2015-09-29

Applicant: SHIMADZU CORPORATION

Inventor： Daisuke OKUMURA ,  Yusuke SAKAGOSHI

IPC: H01J49/04 ,  G01N27/62 ,  H01J49/40

Abstract: A liquid sample introduction system for an ion source which ionizes a liquid sample by supplying the liquid sample to an ionization probe 30 in an ion source and making an atomization-promoting gas blow at the liquid sample exiting from the tip of the ionization probe 30, the liquid sample introduction system including: a liquid sample container 70a-70f which is a hermetically closable container for holding a liquid sample; a liquid-supply-gas passage 50 having one end connected to a point in a passage 41 for supplying an atomization-promoting gas to the ion source, and the other end connected to a space above a liquid level in the liquid sample container 70a-70f; and a sample supply passage 60 having one end connected to a space below the liquid level in the liquid sample container 70a-70f and the other end connected to the ionization probe 30.

公开(公告)号：US20180315588A1

公开(公告)日：2018-11-01

申请号：US15750362

申请日：2015-08-06

Applicant: SHIMADZU CORPORATION

Inventor： Masaru NISHIGUCHI ,  Daisuke OKUMURA

IPC: H01J49/06 ,  H01J49/24 ,  H01J49/14 ,  H01J49/40

CPC classification number: H01J49/067 ,  H01J49/004 ,  H01J49/14 ,  H01J49/24 ,  H01J49/40

Abstract: A mass spectrometer includes a collision cell (16) converging electrode (18), accelerating electrode (19) and front-side ion lens system (20) which is an electrostatic lens, which are all located within a medium-vacuum region, and a partition wall (22) for separating the medium-vacuum region from a high-vacuum region and an ion transport optical system (23) located within the high-vacuum region. Ions which have been extracted and accelerated by an accelerating electric field created between an exit electrode (16a) and the accelerating electrode (19) are focused into a micro-sized ion-passage opening (19a) by the converging electrode (18). The accelerating electrode (19) blocks a stream of gas, thereby decreasing the chance of contact of ions with gas particles behind the electrode. Additionally, the accelerating electric field imparts a considerable amount of kinetic energy to the ions, thereby preventing the ions from being dispersed even when they come in contact with the gas particles.

公开(公告)号：US20140239170A1

公开(公告)日：2014-08-28

申请号：US14188247

申请日：2014-02-24

Applicant: SHIMADZU CORPORATION

Inventor： Daisuke OKUMURA

IPC: H01J49/00

CPC classification number: H01J49/005 ,  H01J49/0031 ,  H01J49/04

Abstract: An ion trap is provided between a collision cell and a time-of-flight mass separator. During a time period in which precursor ions derived from the same compound are selected with a quadrupole mass filter, a collision energy is changed from one to another. Various product ions that are produced by dissociation respectively under collision energies of the plurality of stages and precursor ions that are not dissociated are temporarily trapped in the ion trap, and are ejected in a packet form in the state where these ions are mixed, and are introduced into the time-of-flight mass separator 6 to be subjected to a mass spectrometry. Thereby, in a data processing unit, one MS/MS spectrum in which product ions produced in various dissociation modes under various CID conditions appear is created.

Abstract translation: 在碰撞池和飞行时间质量分离器之间设置离子阱。 在用四极质量过滤器选择来自相同化合物的前体离子的时间段内，碰撞能量从一个变化到另一个。 分别在不分解的多级和前体离子的碰撞能量下分解产生的各种产物离子暂时被捕获在离子阱中，并且在这些离子混合的状态下以包状排出，并且 引入飞行时质量分离器6进行质谱分析。 因此，在数据处理单元中，产生在各种CID条件下出现以各种解离模式产生的产物离子的一个MS / MS谱。

公开(公告)号：US20200075305A1

公开(公告)日：2020-03-05

申请号：US16118643

申请日：2018-08-31

Applicant: SHIMADZU CORPORATION

Inventor： Tomoya KUDO ,  Daisuke OKUMURA

IPC: H01J49/40 ,  H01J49/06

Abstract: Even if vibration is applied to an electrode, a connector section is not separated due to urge of a spring section by using a mass spectrometer that includes an electrode (plate-like electrode); a power source section that supplies electric power to the electrode with a predetermined voltage and/or current; a connection line formed of a conductive wire rod having elasticity for electrically connecting the electrode and the power source section; a connector section provided at one end of the connection line; a seat provided in the electrode to be contacted with the connector section; a fixation section provided in the connection line to be fixed to the power source section; and a spring section formed between the connector section and the fixation section of the connection line or in the connector section and for urging the connector section to the seat.

公开(公告)号：US20170236701A1

公开(公告)日：2017-08-17

申请号：US15504541

申请日：2014-08-19

Applicant: SHIMADZU CORPORATION

Inventor： Daisuke OKUMURA

IPC: H01J49/40 ,  H01J49/06

CPC classification number: H01J49/401 ,  H01J49/0045 ,  H01J49/062 ,  H01J49/24 ,  H01J49/40

Abstract: An ion transport optical system is disposed between a collision cell and an orthogonal acceleration unit. When releasing ions that are held in the collision cell, an accelerating electric field in which a large potential difference exists is created between an exit-side end of an ion guide and a first stage of the ion transport optical system, and a decelerating electric field in which a relatively small potential difference exists is created between a final stage of the ion transport optical system and an entrance end of the orthogonal acceleration unit. In the accelerating electric field, the velocity of ions is increased overall by imparting a large amount of energy to the ions, and spreading of ions in the ion travel direction that is caused by differences between the mass-to-charge ratios of the ions is reduced.

公开(公告)号：US20230022148A1

公开(公告)日：2023-01-26

申请号：US17740991

申请日：2022-05-10

Applicant: SHIMADZU CORPORATION

Inventor： Takuya SUZUMURA ,  Daisuke OKUMURA ,  Tomoya KUDO

IPC: H01J49/40

Abstract: An orthogonal acceleration time-of-flight mass spectrometer (1) includes: an ion ejector (123) which ejects measurement-target ions in a predetermined direction; an orthogonal accelerator (132) which accelerates ions in a direction orthogonal to the direction in which the ions are ejected; a ring electrode (131) located between the ion ejector and the orthogonal accelerator, the ring electrode having an opening for allowing ions to pass through and arranged so that the central axis (C2) of the opening is shifted from the central axis (C1) of the ion ejector in a direction along the axis of the acceleration of the ions by the orthogonal accelerator; a reflectron electrode (134) which creates a repelling electric field for reversing the direction of the ions accelerated by the orthogonal accelerator; and an ion detector (135) which detects ions after the direction of flight of the ions is reversed by the reflectron electrode.

公开(公告)号：US20220199386A1

公开(公告)日：2022-06-23

申请号：US17692386

申请日：2022-03-11

Applicant: SHIMADZU CORPORATION

Inventor： Daisuke OKUMURA ,  Shingo Fujioka ,  Kazuma Maeda

IPC: H01J49/04 ,  G01N27/623 ,  G01N1/00

Abstract: The other end of an individual sample supply channel one end of which is connected to a gas buffer container the inside of which is empty is connected to one sub-port of a valve that selects one of standard samples to be supplied to an ESI probe. During analysis, the standard sample stored in one of liquid sample containers is selected by switching a connection state of the valve. The standard sample supplied by being pushed by a gas sent to the liquid sample containers through liquid supply gas branch channels is sent to the ESI probe through a sample supply main channel. At the time of finishing analysis, when the valve is switched such that the sub-port and a main port are communicatively connected, a nitrogen gas is sent to the sample supply main channel, and the remaining liquid is discharged.

公开(公告)号：US20190162697A1

公开(公告)日：2019-05-30

申请号：US16320673

申请日：2016-07-27

Applicant: SHIMADZU CORPORATION

Inventor： Daisuke OKUMURA

IPC: G01N27/62 ,  H01J49/40 ,  H01J49/42

Abstract: When a normal mass spectrometry is performed without dissociating an ion, the m/z range limitation voltage setting unit applies a radio-frequency voltage to each rod electrode of the quadrupole mass filter and controls the quadrupole voltage generator so as to apply a direct current voltage smaller than that at the time of ion selection for MS/MS spectrometry. When a small direct current voltage is applied, a mass scanning line is set so as to pass through a stability region on a Mathieu diagram over a long range, hence large m/z ions that do not fall within the stability region are blocked in the quadrupole mass filter. By adjusting a cut-off point on larger m/z side blocked in accordance with the measurement period of OA-TOFMS including the orthogonal accelerator, heavy ions that cause period delay are prevented from being introduced into the orthogonal accelerator.

公开(公告)号：US20160163527A1

公开(公告)日：2016-06-09

申请号：US14909256

申请日：2013-08-02

Applicant: SHIMADZU CORPORATION ,  PUBLIC UNIVERSITY CORPORATION YOKOHAMA CITY UNIVERSITY

Inventor： Kanako SEKIMOTO ,  Mitsuo TAKAYAMA ,  Daisuke OKUMURA

IPC: H01J49/16 ,  H01J49/26 ,  H01J49/14

CPC classification number: H01J49/167 ,  H01J49/142 ,  H01J49/145 ,  H01J49/168 ,  H01J49/26

Abstract: In the ionizer of the present invention, a stream of gas spouted from a nozzle (18) of a DART ionization unit (10) vaporizes and ionizes the components in a sample (25). Gaseous sample-component molecules which have not been ionized by that process are subsequently ionized by a reaction with a reactant ion produced by a corona discharge generated from a needle electrode (20). Such a two-stage ionization of the sample-component molecules improves the ionization efficiency. A needle-electrode support mechanism (21) adjusts the position and/or angle of the needle electrode (20) and thereby controls a potential gradient. Therefore, a specific sample-derived ion species can be efficiently introduced into an ion introduction tube (31) and be detected with a high level of sensitivity.

Abstract translation: 在本发明的电离器中，从DART离子化单元（10）的喷嘴（18）喷出的气体气流使样品（25）中的组分汽化并电离。 随后通过与由针状电极（20）产生的电晕放电产生的反应物离子的反应使被该方法未被离子化的气态样品成分分子电离。 样品组分分子的这种两阶段电离提高了电离效率。 针状电极支撑机构（21）调整针状电极（20）的位置和/或角度，由此控制电位梯度。 因此，可以将特定的取样离子种类有效地引入离子导入管（31），并以高灵敏度检测。

公开(公告)号：US20140361163A1

公开(公告)日：2014-12-11

申请号：US14467293

申请日：2014-08-25

Applicant: SHIMADZU CORPORATION

Inventor： Junichi TANIGUCHI ,  Daisuke OKUMURA ,  Hiroto ITOI

IPC: H01J49/06 ,  H01J49/02 ,  H01J49/40

CPC classification number: H01J49/063 ,  H01J49/022

Abstract: A method of operating an electrode changeover switch which switches the connection state of electrodes, the electrode changeover switch is provided in the wiring path between eight electrodes through, arranged rotation-symmetrically about ion optical axis, and voltage generation switch which generates square wave high voltage ±V. When switch is switched as shown in the drawing, two circumferentially adjacent rod electrodes are connected to form one set, a square wave voltage of opposite phase is applied to circumferentially adjacent sets, and an effectively quadrupole electric field is formed. When switch is switched, a square wave voltage of opposite phase is applied to circumferentially adjacent rod electrodes and an octupole electric field is formed. In this way, by switching the switch according to the mass range, etc., it becomes possible to rapidly switch the number of poles of a multipole electric field and to suitably transport ions.

Abstract translation: 一种操作电极切换开关的方法，其切换电极的连接状态，电极切换开关设置在通过围绕离子光轴旋转对称布置的八个电极之间的布线路径中，以及产生方波高电压的电压产生开关 ±V。 当如图所示切换开关时，两个周向相邻的杆电极连接形成一组，相反相位的方波电压施加到周向相邻的组，并且形成有效的四极电场。 当开关切换时，将相反相位的方波电压施加到周向相邻的棒电极，并形成八极电场。 以这种方式，通过根据质量范围等切换开关，可以快速切换多极电场的极数并适当地输送离子。