公开(公告)号：JPH11228390A

公开(公告)日：1999-08-24

申请号：JP34003998

申请日：1998-11-30

Applicant: BASF AG

Inventor： KOTHRADE STEPHAN DR ,  ERNST ANDREAS ,  SANNER AXEL DR

IPC: A01N25/14 ,  A23K20/10 ,  A23K40/10 ,  A23K40/20 ,  A23L27/00 ,  A23L33/10 ,  A61K9/20 ,  A61K31/167 ,  A61K31/277 ,  A61K47/32

Abstract: PROBLEM TO BE SOLVED: To obtain a solid pharmaceutical formulated form, especially a medicine form simply at a low cost, by using a specific oxazoline homopolymer or copolymer as a polymer binder. SOLUTION: A homopolymer and/or a copolymer composed of an oxazoline substituted at the 2-position, preferably a monomer of the formula (R is an alkyl, an aryl or a heterocyclic group which is optionally interrupted by O or the like) as a binder is formulated with optionally at least one action substance and optionally an additive while forming a plastic mixture and formed.

公开(公告)号：JPH11228392A

公开(公告)日：1999-08-24

申请号：JP34168698

申请日：1998-12-01

Applicant: BASF AG

Inventor： KOTHRADE STEPHAN DR ,  BERNDL GUNTHER ,  ERNST ANDREAS ,  SANNER AXEL DR

IPC: A61K9/14 ,  A61K9/16 ,  A61K9/20 ,  A61K47/32

Abstract: PROBLEM TO BE SOLVED: To obtain an administration form producible by melt extrusion, capable of rapidly releasing an action substance, by using a homopolymer and copolymer of N-vinylcaprolactam as a polymer binder. SOLUTION: A homopolymer of N-vinyl caprolactam or a copolymer containing preferably at least 10 wt.% of N-vinylcaprolactam unit by copolymerization as a polymer binder is formulated with at least one action substance and optionally an common additive. A plastic mixture is formed and molded to give the objective solid administration form.

公开(公告)号：JP2001158733A

公开(公告)日：2001-06-12

申请号：JP2000273706

申请日：2000-09-08

Applicant: BASF AG

Inventor： ERNST ANDREAS ,  KESSLER THOMAS ,  BERNDL GUNTHER

IPC: A01N25/10 ,  A01N25/12 ,  A23K40/10 ,  A23K40/20 ,  A23L33/15 ,  A23L33/155 ,  A23P1/02 ,  A61J3/00 ,  A61K9/16 ,  A61K9/19 ,  A61K47/32 ,  B01J2/20 ,  B29B9/06 ,  C08J3/205 ,  A23L1/302

Abstract: PROBLEM TO BE SOLVED: To develop a method for inexpensively and simply preparing a functional substance-containing preparation which is dissolved or itself dispersed in water or in gastrointestinal tracts, such as medicines or food additives. SOLUTION: This method for preparing granules which contain a biologically active substance and in which the biologically active substance is homogeneously dispersed in a matrix based on at least one thermoplastic polymer having a solubility dependent to pH values in an aqueous medium, by homogeneously mixing the charged substance in the state of the melt and then extruding and shaping the mixture, characterized by forming the granules in an insoluble or nondispersible cooling medium.

公开(公告)号：WO9927916A3

公开(公告)日：1999-08-12

申请号：PCT/EP9807716

申请日：1998-11-30

Applicant: BASF AG ,  KOTHRADE STEPHAN ,  MEFFERT HELMUT ,  BERNDL GUNTHER ,  ERNST ANDREAS ,  SANNER AXEL

Inventor： KOTHRADE STEPHAN ,  MEFFERT HELMUT ,  BERNDL GUNTHER ,  ERNST ANDREAS ,  SANNER AXEL

IPC: A61K47/32 ,  A23K20/10 ,  A23K40/10 ,  A23K40/20 ,  A23L27/00 ,  A23L33/10 ,  A61K9/16 ,  A61K9/20 ,  A61K9/22 ,  A61K31/277 ,  A61K31/421

CPC classification number: A61K31/421 ,  A23K20/10 ,  A23K40/10 ,  A23K40/20 ,  A23K40/25 ,  A23L27/74 ,  A23L33/10 ,  A23V2002/00 ,  A61K9/2027 ,  A61K9/2095 ,  A61K31/277 ,  A23V2200/21 ,  A23V2250/30 ,  A23V2250/51088 ,  A23V2250/5118

Abstract: The invention relates to a method for producing solid dosing forms by mixing at least one polymeric binding agent, at least one active substance, and optional common additives while producing a plastic mixture and during shaping, whereby a copolymer from a N-vinyl lactam and from an copolymerizable monomer with a hydrophobic radical is used as a polymeric binding agent. Dosing forms which slowly release the active substance are obtained in a simple and economical manner.

Abstract translation: 本发明涉及一种用于通过将至少一种聚合物粘合剂，至少一种活性成分，并在适当的常规添加剂，以形成塑料混合物制备固体剂型，和成形，使用如聚合物粘合剂的N-乙烯基内酰胺的共聚物和可共聚的单体 与疏水性残留物一起使用。 以简单和廉价的方式，获得缓慢释放活性成分的剂型。

公开(公告)号：WO2004012696A8

公开(公告)日：2005-01-20

申请号：PCT/EP0307700

申请日：2003-07-16

Applicant: BASF AG ,  JENTZSCH AXEL ,  HABICH ANDREAS ,  KOEPSEL CHRISTIAN ,  ERNST ANDREAS

Inventor： JENTZSCH AXEL ,  HABICH ANDREAS ,  KOEPSEL CHRISTIAN ,  ERNST ANDREAS

IPC: A23L33/15 ,  A23L33/155 ,  A61K8/67 ,  A61Q1/02 ,  A61Q17/04 ,  A61Q19/00 ,  A61K7/48 ,  A61K7/02 ,  A61K7/42

CPC classification number: A61Q19/00 ,  A61K8/671 ,  A61K8/676 ,  A61K8/678 ,  A61K2800/522 ,  A61K2800/59 ,  A61Q1/02 ,  A61Q17/04

Abstract: Disclosed are preparations containing at least one retinoid, at least one water-soluble antioxidant, and at least one oil-soluble antioxidant. The invention is characterized by the fact that the preparations contain at least 1 part by weight of one or several water-soluble antioxidants and 0.1 to 100 parts by weight of one or several oil-soluble antioxidants per part by weight of retinoid, the content of one or several water-soluble antioxidants ranging between 0.05 and 0.8 percent by weight relative to the total quantity of the preparations.

Abstract translation: 含有至少一种类维生素A，至少一种水溶性抗氧化剂和至少一种油溶性的抗氧化剂，按重量计的一种或多种油溶性抗氧化剂，其中的特征在于，在每部分中的制剂重量的类视黄醇存在至少1重量份的一种或多种水溶性的抗氧化剂和0.1〜100份的制剂 在0.05的范围内的一种或多种水溶性的抗氧化剂的含量以0.8重量％，基于所述制剂的总量。

公开(公告)号：WO0167896A3

公开(公告)日：2002-10-31

申请号：PCT/EP0102939

申请日：2001-03-15

Applicant: BASF AG ,  BETZ ROLAND ,  BEWERT WOLFGANG ,  ERNST ANDREAS ,  KAESLER BRUNO ,  PFEIFFER ANGELIKA-MARIA ,  RUNGE FRANK ,  SCHNEIDER JOACHIM U ,  STANG MICHAEL

Inventor： BETZ ROLAND ,  BEWERT WOLFGANG ,  ERNST ANDREAS ,  KAESLER BRUNO ,  PFEIFFER ANGELIKA-MARIA ,  RUNGE FRANK ,  SCHNEIDER JOACHIM U ,  STANG MICHAEL

IPC: A23K1/00 ,  A23K1/16 ,  A23K1/165 ,  A23K1/17 ,  A23K1/20 ,  A23L1/302 ,  A61K8/04 ,  A61K8/06 ,  A61K8/67 ,  A61K8/92 ,  A61K9/10 ,  A61K31/197 ,  A61K31/375 ,  A61K31/4188 ,  A61K31/4415 ,  A61K31/455 ,  A61K31/51 ,  A61K31/525 ,  A61K31/593 ,  A61K31/714 ,  A61K47/12 ,  A61K47/22 ,  A61P3/02 ,  A61Q1/00 ,  A61Q1/04 ,  A61Q19/00 ,  B02C23/24

CPC classification number: A61K31/525 ,  A23K20/174 ,  A23K40/00 ,  A23K40/30 ,  A23L33/15 ,  A23V2002/00 ,  A61K8/044 ,  A61K8/67 ,  A61K9/10 ,  A61K31/375 ,  A61K31/4415 ,  A61K31/593 ,  A61K31/714 ,  A61K2800/412 ,  A61Q19/00 ,  A61K2300/00 ,  A23V2250/18 ,  A23V2250/211 ,  A23V2250/708 ,  A23V2250/712 ,  A23V2250/7042 ,  A23V2250/7146 ,  A23V2250/702 ,  A23V2250/70 ,  A23V2250/705 ,  A23V2250/1944 ,  A23V2250/704 ,  A23V2250/714 ,  A23V2250/71

Abstract: The invention relates to a method of producing oily suspensions of water-soluble vitamins. The inventive method is characterized by a) grinding at least one water-soluble vitamin in an oil to an average particle size of from 0.1 to 100 mu m, or b) grinding at least one water-soluble vitamin to an average particle size of from 0.1 to 100 mu m without using a continuous phase, and then suspending the ground particles in an oil.

Abstract translation: 本发明涉及一种生产在油米研磨至少一种水溶性维生素的水溶性维生素，其特征在于，为0.1至100微米的平均粒度的油状悬浮液）或b）至少一种水溶性维生素，而无需使用 连续相为0.1〜100微米的研磨，然后悬浮在油研磨颗粒的平均颗粒尺寸。

公开(公告)号：AU2003250967B2

公开(公告)日：2009-05-28

申请号：AU2003250967

申请日：2003-07-16

Applicant: BASF AG

Inventor： HABICH ANDREAS ,  JENTZSCH AXEL ,  KOPSEL CHRISTIAN ,  ERNST ANDREAS

IPC: A61K8/04 ,  A23K1/00 ,  A23K1/16 ,  A23K3/00 ,  A23L1/275 ,  A23L1/30 ,  A23L3/3508 ,  A23L5/41 ,  A23L33/15 ,  A23L33/155 ,  A61K8/67 ,  A61K9/107 ,  A61K9/14 ,  A61K31/07 ,  A61K31/201 ,  A61K31/202 ,  A61K31/203 ,  A61K31/355 ,  A61K31/375 ,  A61K31/59 ,  A61Q19/00 ,  C09K15/34

Abstract: Suspensions comprising A) at least one oxidation-sensitive substance selected from the group consisting of carotenoids, retinoids and unsaturated fatty acids and B) solid particles of one or more salts of ascorbic acid in a dispersant in which the salts of ascorbic acid are insoluble.

公开(公告)号：PT1083790E

公开(公告)日：2004-09-30

申请号：PT99920733

申请日：1999-04-22

Applicant: BASF AG

Inventor： BRATZ MATTHIAS ,  SCHNEIDER KARL-HEINRICH ,  SCHELBERGER KLAUS ,  KESSLER THOMAS ,  LANGE ARMIN ,  ERNST ANDREAS ,  STRATHMANN SIEGFRIED

IPC: A01N25/10 ,  A01N20060101 ,  A01N3/02 ,  A01N25/18 ,  A01N37/34 ,  A01N37/36 ,  A01N37/50 ,  A01N37/52 ,  A01N63/00 ,  A01P3/00 ,  A01P5/00 ,  A01P7/00 ,  A01P21/00 ,  A61K20060101

Abstract: Solid formulation of a crop protection product can be obtained by melt extrusion and shaping of a mixture consisting of:0.1-80% by wt. of an active ingredient which can be used in crop protection, or of a combination of such active ingredients,10-80% by wt. of at least one mineral filler,0-20% by wt. of inorganic or organic additives, andto 100% by wt. of at least one thermoplastic water-insoluble polymer

公开(公告)号：AU2003246705A1

公开(公告)日：2004-02-23

申请号：AU2003246705

申请日：2003-07-16

Applicant: BASF AG

Inventor： JENTZSCH AXEL ,  HABICH ANDREAS ,  KOPSEL CHRISTIAN ,  ERNST ANDREAS

IPC: A23L33/15 ,  A23L33/155 ,  A61K8/67 ,  A61Q1/02 ,  A61Q17/04 ,  A61Q19/00 ,  A61K7/48 ,  A61K7/42 ,  A61K7/02

Abstract: Preparations comprising at least one retinoid, at least one water-soluble antioxidant and at least one oil-soluble antioxidant, where, per part by weight of retinoid, at least 1 part by weight of one or more water-soluble antioxidants and 0.1 to 100 parts by weight of one or more oil-soluble antioxidants are present in the preparations, where the content of one or more water-soluble antioxidants is in the range from 0.05 to 0.8% by weight, based on the total amount of the preparations.

公开(公告)号：DK1035841T3

公开(公告)日：2002-09-02

申请号：DK98965716

申请日：1998-11-30

Applicant: BASF AG

Inventor： KOTHRADE STEPHAN ,  MEFFERT HELMUT ,  BERNDL GUNTHER ,  ERNST ANDREAS ,  SANNER AXEL

IPC: A61K47/32 ,  A23K20/10 ,  A23K40/10 ,  A23K40/20 ,  A23L27/00 ,  A23L33/10 ,  A61K9/16 ,  A61K9/20 ,  A61K9/22 ,  A61K31/277 ,  A61K31/421

Abstract: Solid dosage forms are obtained by mixing at least one polymeric binder, at least one active ingredient, and, where appropriate, conventional additives to form a plastic mixture, and shaping, using as polymeric binder a copolymer of an N-vinyllactam and a copolymerizable monomer having a hydrophobic radical. Dosage forms which show slow release of the active ingredient are obtained in a simple and low-cost manner.