公开(公告)号：CA2714630A1

公开(公告)日：2009-08-13

申请号：CA2714630

申请日：2009-02-06

Applicant: PACIFIC BIOSCIENCES CALIFORNIA

Inventor： OTTO GEOFFREY ,  SHEN GENE ,  KONG XIANGXU ,  EMIG ROBIN

IPC: C07H19/10 ,  C07H19/20 ,  C07H21/00 ,  C07K1/13 ,  C12M1/34 ,  C12Q1/68

Abstract: The present invention provides methods and compositions for performing illuminated reactions, particularly sequencing reactions, while mitigating and/or preventing photodamage to reactants that can result from prolonged illumination. In particular, the invention provides methods and compositions for incorporating photoprotective agents into conjugates comprising reporter molecules and nucleoside polyphosphates.

公开(公告)号：AU2006320414B2

公开(公告)日：2012-10-04

申请号：AU2006320414

申请日：2006-12-01

Applicant: PACIFIC BIOSCIENCES CALIFORNIA INC

Inventor： OTTO GEOFFREY ,  EID JOHN ,  TURNER STEPHEN ,  MURPHY DEVON

IPC: G01N33/53 ,  C12N11/02

Abstract: Compositions, devices, systems and methods for reducing and/or preventing photodamage of one or more reactants in illuminated analytical reactions by one or more of incorporating photodamage mitigating agents within the reaction mixture and/or interrogating different observation regions of the reaction mixture for a period that is less than a photodamage threshold period.

公开(公告)号：AU2006331512B2

公开(公告)日：2012-02-23

申请号：AU2006331512

申请日：2006-12-21

Applicant: PACIFIC BIOSCIENCES CALIFORNIA INC

Inventor： KORLACH JONAS ,  OTTO GEOFFREY ,  HANZEL DAVID ,  PELUSO PAUL ,  TURNER STEPHEN ,  RANK DAVID ,  PHAM THANG

IPC: C12Q1/68 ,  C12N11/14

Abstract: Active surface coupled polymerases, surfaces that include such polymerases, and methods of making and using surface-attached polymerases are provided.

公开(公告)号：WO2007064905A2

公开(公告)日：2007-06-07

申请号：PCT/US2006046025

申请日：2006-12-01

Applicant: PACIFIC BIOSCIENCES CALIFORNIA ,  EID JOHN ,  MURPHY DEVON ,  OTTO GEOFFREY ,  TURNER STEPHEN

Inventor： EID JOHN ,  MURPHY DEVON ,  OTTO GEOFFREY ,  TURNER STEPHEN

IPC: A61K38/43 ,  A61K38/44

CPC classification number: A61K38/446 ,  A61K38/063 ,  A61K38/443 ,  G01N33/582

Abstract: Compositions, devices, systems and methods for reducing and/or preventing photodamage of one or more reactants in illuminated analytical reactions by one or more of incorporating photodamage mitigating agents within the reaction mixture and/or interrogating different observation regions of the reaction mixture for a period that is less than a photodamage threshold period.

Abstract translation: 用于通过一种或多种在反应混合物内掺入光损伤缓和剂和/或询问反应混合物的不同观​​察区域一段时间来减少和/或防止一种或多种反应物在照明分析反应中的光损伤的组合物，装置，系统和方法 这小于光损伤阈值期。

公开(公告)号：AU2007261114B2

公开(公告)日：2012-07-12

申请号：AU2007261114

申请日：2007-06-11

Applicant: PACIFIC BIOSCIENCES CALIFORNIA INC

Inventor： FOQUET MATHIEU ,  ROITMAN DANIEL BERNARDO ,  TURNER STEPHEN ,  PELUSO PAUL ,  OTTO GEOFFREY

IPC: C12M3/00 ,  G02B6/10

Abstract: Substrates, including zero mode waveguide substrates that have been fabricated to provide additional fυ&pgr;clionai elements and/or components including increased volumes for positioning of active surfaces and or components for the mitigation of negative electrochemical properties of the underlying substrates.

公开(公告)号：AT518010T

公开(公告)日：2011-08-15

申请号：AT06848008

申请日：2006-12-21

Applicant: PACIFIC BIOSCIENCES CALIFORNIA

Inventor： HANZEL DAVID ,  KORLACH JONAS ,  PELUSO PAUL ,  OTTO GEOFFREY ,  PHAM THANG ,  RANK DAVID ,  TURNER STEPHEN

IPC: C12Q1/68 ,  C12N11/14

Abstract: Active surface coupled polymerases, surfaces that include such polymerases, and methods of making and using surface-attached polymerases are provided.

公开(公告)号：AU2007261114A1

公开(公告)日：2007-12-27

申请号：AU2007261114

申请日：2007-06-11

Applicant: PACIFIC BIOSCIENCES CALIFORNIA

Inventor： FOQUET MATHIEU ,  PELUSO PAUL ,  ROITMAN DANIEL BERNARDO ,  TURNER STEPHEN ,  OTTO GEOFFREY

IPC: C12M3/00 ,  G02B6/10

Abstract: Zero mode waveguide substrate (300) comprising an opaque cladding layer (304), a core (302) and a recess (308) forming an extension of the core volume into a transparent substrate (306) to provide increased volumes for positioning of active surfaces. The substrate (300) can be used in chemical and biochemical analysis.

公开(公告)号：CA2633476A1

公开(公告)日：2007-07-05

申请号：CA2633476

申请日：2006-12-21

Applicant: PACIFIC BIOSCIENCES CALIFORNIA INC

Inventor： KORLACH JONAS ,  HANZEL DAVID ,  RANK DAVID ,  PHAM THANG ,  TURNER STEPHEN ,  PELUSO PAUL ,  OTTO GEOFFREY

IPC: C12Q1/68 ,  C12M3/00

Abstract: Active surface coupled polymerases, surfaces that include such polymerases, and methods of making and using surface-attached polymerases are provided.

公开(公告)号：CA2633476C

公开(公告)日：2015-04-21

申请号：CA2633476

申请日：2006-12-21

Applicant: PACIFIC BIOSCIENCES CALIFORNIA

Inventor： HANZEL DAVID ,  KORLACH JONAS ,  PELUSO PAUL ,  OTTO GEOFFREY ,  PHAM THANG ,  RANK DAVID ,  TURNER STEPHEN

IPC: C12N9/12 ,  C12N9/22 ,  C12N11/00 ,  C12P19/34 ,  C12Q1/68

Abstract: Active surface coupled polymerases, surfaces that include such polymerases, and methods of making and using surface-attached polymerases are provided.

公开(公告)号：CA2654470A1

公开(公告)日：2007-12-27

申请号：CA2654470

申请日：2007-06-11

Applicant: PACIFIC BIOSCIENCES CALIFORNIA

Inventor： FOQUET MATHIEU ,  ROITMAN DANIEL BERNARDO ,  TURNER STEPHEN ,  OTTO GEOFFREY ,  PELUSO PAUL

IPC: G02B6/10

Abstract: Substrates, including zero mode waveguide substrates that have been fabri cated to provide additional f.upsilon..pi.clionai elements and/or components including increased volumes for positioning of active surfaces and or compo nents for the mitigation of negative electrochemical properties of the under lying substrates.