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公开(公告)号：WO2007076057A3
公开(公告)日：2008-06-26
申请号：PCT/US2006049122
申请日：2006-12-21
Applicant: PACIFIC BIOSCIENCES CALIFORNIA , HANZEL DAVID K , OTTO GEOFF , MURPHY DEVON , PELUSO PAUL , PHAM THANG , RANK DAVID R , MITSIS PAUL , CHRISTIANS FRED C , BIBILLO AREK , PARK INSIL , CLARK SONYA , LYLE JOHN
Inventor： HANZEL DAVID K , OTTO GEOFF , MURPHY DEVON , PELUSO PAUL , PHAM THANG , RANK DAVID R , MITSIS PAUL , CHRISTIANS FRED C , BIBILLO AREK , PARK INSIL , CLARK SONYA , LYLE JOHN
IPC: C12Q1/68
CPC classification number: C12N9/1252 , C07K2319/20 , C12P19/34 , C12Q1/6827 , C12Q1/6869 , C12Y207/07007 , Y02P20/52
Abstract: Compositions that include polymerases with features for improving entry of nucleotide analogues into active site regions and for coordinating with the nucleotide analogues in the active site region are provided. Methods of making the polymerases and of using the polymerases in sequencing and DNA replication and amplification as well as kinetic models of polymerase activity and computer-implemented methods of using the models are also provided.
Abstract translation: 提供了包含具有改善核苷酸类似物进入活性位点区域并与活性位点区域中的核苷酸类似物配位的特征的聚合酶的组合物。 还提供了制备聚合酶和在测序和DNA复制和扩增中使用聚合酶的方法以及聚合酶活性的动力学模型和使用该模型的计算机实现的方法。
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2.发明申请PROTEIN ENGINEERING STRATEGIES TO OPTIMIZE ACTIVITY OF SURFACE ATTACHED PROTEINS 审中-公开蛋白质工程策略优化表面附着蛋白的活性
公开(公告)号：WO2007075873A3
公开(公告)日：2007-11-29
申请号：PCT/US2006048764
申请日：2006-12-21
Applicant: PACIFIC BIOSCIENCES CALIFORNIA , HANZEL DAVID , KORLACH JONAS , PELUSO PAUL , OTTO GEOFF , PHAM THANG , RANK DAVID , TURNER STEPHEN
Inventor： HANZEL DAVID , KORLACH JONAS , PELUSO PAUL , OTTO GEOFF , PHAM THANG , RANK DAVID , TURNER STEPHEN
CPC classification number: C12N9/22 , C07K2319/21 , Y10T428/2991 , Y10T428/2993 , Y10T428/2996 , Y10T428/31663 , Y10T428/31768
Abstract: Isolated and/or recombinant enzymes that include surface binding domains, surfaces with active enzymes bound to them and methods of coupling enzymes to surfaces are provided. Enzymes can include large and/or multiple surface coupling domains for surface coupling.
Abstract translation: 提供了包括表面结合结构域，具有与其结合的活性酶的表面和将酶偶联到表面的方法的分离和/或重组酶。 酶可以包括用于表面偶联的大和/或多个表面偶联域。
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公开(公告)号：AT518010T
公开(公告)日：2011-08-15
申请号：AT06848008
申请日：2006-12-21
Applicant: PACIFIC BIOSCIENCES CALIFORNIA
Inventor： HANZEL DAVID , KORLACH JONAS , PELUSO PAUL , OTTO GEOFFREY , PHAM THANG , RANK DAVID , TURNER STEPHEN
Abstract: Active surface coupled polymerases, surfaces that include such polymerases, and methods of making and using surface-attached polymerases are provided.
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公开(公告)号：CA2633476A1
公开(公告)日：2007-07-05
申请号：CA2633476
申请日：2006-12-21
Applicant: PACIFIC BIOSCIENCES CALIFORNIA INC
Inventor： KORLACH JONAS , HANZEL DAVID , RANK DAVID , PHAM THANG , TURNER STEPHEN , PELUSO PAUL , OTTO GEOFFREY
Abstract: Active surface coupled polymerases, surfaces that include such polymerases, and methods of making and using surface-attached polymerases are provided.
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公开(公告)号：AU2006330947A1
公开(公告)日：2007-07-05
申请号：AU2006330947
申请日：2006-12-21
Applicant: PACIFIC BIOSCIENCES CALIFORNIA
Inventor： BIBILLO AREK , MITSIS PAUL , PHAM THANG , CHRISTIANS FRED C , MURPHY DEVON , PARK INSIL , HANZEL DAVID K , LYLE JOHN , RANK DAVID R , CLARK SONYA , PELUSO PAUL , OTTO GEOFF
IPC: C12Q1/68
Abstract: Compositions that include polymerases with features for improving entry of nucleotide analogues into active site regions and for coordinating with the nucleotide analogues in the active site region are provided. Methods of making the polymerases and of using the polymerases in sequencing and DNA replication and amplification as well as kinetic models of polymerase activity and computer-implemented methods of using the models are also provided.
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Patent Agency Ranking
公开(公告)号：WO2007075987A3
公开(公告)日：2009-01-29
申请号：PCT/US2006048973
申请日：2006-12-21
Applicant: PACIFIC BIOSCIENCES CALIFORNIA , HANZEL DAVID , KORLACH JONAS , PELUSO PAUL , OTTO GEOFFREY , PHAM THANG , RANK DAVID , TURNER STEPHEN
Inventor： HANZEL DAVID , KORLACH JONAS , PELUSO PAUL , OTTO GEOFFREY , PHAM THANG , RANK DAVID , TURNER STEPHEN
CPC classification number: C12Q1/6837 , C07K2319/23 , C12N9/1252 , C12Q1/6844 , C12Q2521/101 , C12Q2565/531
Abstract: Active surface coupled polymerases, surfaces that include such polymerases, and methods of making and using surface-attached polymerases are provided.
Abstract translation: 提供活性表面偶联的聚合酶，包括这种聚合酶的表面，以及制备和使用表面连接的聚合酶的方法。
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公开(公告)号：AU2006331677A1
公开(公告)日：2007-07-05
申请号：AU2006331677
申请日：2006-12-21
Applicant: PACIFIC BIOSCIENCES CALIFORNIA INC
Inventor： RANK DAVID , KORLACH JONAS , HANZEL DAVID , PHAM THANG , OTTO GEOFF , TURNER STEPHEN , PELUSO PAUL
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公开(公告)号：AU2006331512A1
公开(公告)日：2007-07-05
申请号：AU2006331512
申请日：2006-12-21
Applicant: PACIFIC BIOSCIENCES CALIFORNIA
Inventor： KORLACH JONAS , OTTO GEOFFREY , HANZEL DAVID , PELUSO PAUL , TURNER STEPHEN , RANK DAVID , PHAM THANG
Abstract: Active surface coupled polymerases, surfaces that include such polymerases, and methods of making and using surface-attached polymerases are provided.
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公开(公告)号：CA2633476C
公开(公告)日：2015-04-21
申请号：CA2633476
申请日：2006-12-21
Applicant: PACIFIC BIOSCIENCES CALIFORNIA
Inventor： HANZEL DAVID , KORLACH JONAS , PELUSO PAUL , OTTO GEOFFREY , PHAM THANG , RANK DAVID , TURNER STEPHEN
Abstract: Active surface coupled polymerases, surfaces that include such polymerases, and methods of making and using surface-attached polymerases are provided.
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公开(公告)号：AU2006330947B2
公开(公告)日：2012-04-12
申请号：AU2006330947
申请日：2006-12-21
Applicant: PACIFIC BIOSCIENCES CALIFORNIA INC
Inventor： BIBILLO AREK , MITSIS PAUL , PHAM THANG , CHRISTIANS FRED C , MURPHY DEVON , PARK INSIL , HANZEL DAVID K , LYLE JOHN , RANK DAVID R , CLARK SONYA , PELUSO PAUL , OTTO GEOFF
IPC: C12Q1/68
Abstract: Compositions that include polymerases with features for improving entry of nucleotide analogues into active site regions and for coordinating with the nucleotide analogues in the active site region are provided. Methods of making the polymerases and of using the polymerases in sequencing and DNA replication and amplification as well as kinetic models of polymerase activity and computer-implemented methods of using the models are also provided.
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