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公开(公告)号：IT1238072B
公开(公告)日：1993-07-03
申请号：IT1911290
申请日：1990-01-19
Applicant: SCLAVO SPA
Inventor： LATTANZI FILIPPO , VANNI RICCARDO
Abstract: New pharmaceutical compositions containing a calcitonin as active principle and suitable for oral administration in the form of perbuccal and sublingual tablets are described, in which the tive principle is homogenized with a mixture of solid excipients, said excipients consisting of a diluent, a lubricant, a disintegrating agent in the case of sublingual tablets, and a binder in the case of perbuccal tablets. Said compositions enable the same pattern of hematic levels to be obtained for the same unit dose as obtainable by conventional intramuscular administration.
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公开(公告)号：IT1238070B
公开(公告)日：1993-07-03
申请号：IT1911090
申请日：1990-01-19
Applicant: SCLAVO SPA
Inventor： PARENTE LUCA
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公开(公告)号：IT1238007B
公开(公告)日：1993-06-21
申请号：IT1928690
申请日：1990-02-07
Applicant: SCLAVO SPA
Inventor： PIZZA MARIAGRAZIA , COVACCI ANTONELLO , NENCIONI LUCIANO , RAPPUOLI RINO
IPC: C12K
Abstract: The toxin mutants (A) have at least one of the amino acid (AA) residues Glu129, Asp11, Trp26, Arg9, Phe50, Asp1, Arg13, Tyr130, Gly86, Ile88, Tyr89, Tyr8, Gly44, Thr53 and Gly80 of subunit S1 deleted and substd. by a natural AA. Also claimed are (a) Bordetella strains comprising (i) the gene encoding the wild type pertussin toxin; (ii) an expression and secretion regulation sequence; with the mutated subunit S1. E.g. Bordetella pertussis (W28)PT-9K/129G ATCC53894; B.parapertussis PT-129G ATCC 53892, PT-26l/129G ATCC 53893; B.bronchiseptica; (b) an immunogenic formulation. Details for obtg. (A) and Bordetella strains are given. Six specific examples of (A) are given, e.g. PT-13l/129G and PT-88E/89S have AA Glu129 + Arg13 and Ile88 + Tyr89 substd. by Gly+Ile and Glu+Ser respectively. (A), stable at 37 deg.C, have reduced or no mitogenicity of haemagglutinin activity and are obtd. by 0.035% and 0.42% formaldehyde treatment.
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公开(公告)号：DE3880625D1
公开(公告)日：1993-06-03
申请号：DE3880625
申请日：1988-10-31
Applicant: SCLAVO SPA
Inventor： GHIARA PAOLO , VILLA LUIGI , NENCIONI LUCIANO , TAGLIABUE ALDO , BORASCHI DIANA
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Patent Agency Ranking
公开(公告)号：DE3784799D1
公开(公告)日：1993-04-22
申请号：DE3784799
申请日：1987-06-29
Applicant: ENIRICERCHE SPA , SCLAVO SPA
Inventor： DI TRAPANI ROMANO , VERDINI ANTONIO SILVIO
IPC: C07C55/22 , C07C51/00 , C07C67/00 , C07C67/343 , C07C69/34 , C07C69/38 , C07C69/734 , C07C271/06 , C07C271/10 , C07C271/22 , C07C313/00 , C07C319/18 , C07C323/52 , C07C323/57 , C07K1/02 , C07K5/02
Abstract: The present invention refers to a new class of malonic acid derivatives of general formula I wherein R and R , each independently, represent hydrogen or a carboxyl protecting group, and the residue R corresponds to the side-chain of the amino acids lysine, ornithine, tyrosine, cysteine, aspartic acid and glutamic acid wherein the additional functionalities are suitably protected. The new compounds of the present invention are useful for preparing analogues of biologically active peptides wherein the direction of some amide bonds in which the amino acids lysine, ornithine, tyrosine, cysteine, aspartic acid or glutamic acid are involved, has been reversed.
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公开(公告)号：DE3783280D1
公开(公告)日：1993-02-11
申请号：DE3783280
申请日：1987-06-29
Applicant: ENIRICERCHE SPA , SCLAVO SPA
Inventor： VERDINI ANTONIO SILVIO , BONELLI FABIO , PESSI ANTONELLO , CARDINALI FRANCO , BORASCHI DIANA , CENSINI STEFANO , DI TRAPANI ROMANO
IPC: A61K39/39 , A61K38/00 , A61K38/43 , A61P31/04 , A61P35/00 , A61P37/04 , C07C271/22 , C07K1/06 , C07K1/113 , C07K5/02 , C07K5/06 , C07K5/078 , C07K5/10 , C07K1/00 , A61K37/02
Abstract: New partially retro-inverted tuftsin analogues of general formula I wherein R represents the side-chain of the amino acids threonine, methionine or leucine R represents the side-chain of the amino acids lysine or arginine R is hydrogen or a metabolically labile acyl group, all the asymmetric carbon atoms are either of the S- or R-configuration, or, alternatively, the first, third, and fourth asymmetric carbons, starting from the N-terminal residue, are of the S-configuration while the second one is of the R- or (R,S)-configuration, and the corresponding pharmacologically acceptable salts, esters and amides. The new compounds which share the same pharmacological properties of tuftsin, are much more stable toward the enzymatic degradation than the parent molecule.
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98.发明专利
公开(公告)号：GR3002765T3
公开(公告)日：1993-01-25
申请号：GR910401377
申请日：1991-09-19
Applicant: SCLAVO SPA
Inventor： LATTANZI FILIPPO , VANNI RICCARDO
Abstract: A new freeze-dried pharmaceutical composition for parenteral administration, which comprises a therapeutically effective amount of a calcitonin, as the active ingredient, and human albumin. The injectable solution which is obtained by dissolving the freeze-dried composition in a physiologically acceptable solvent is also described.
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公开(公告)号：CA2034618A1
公开(公告)日：1992-07-22
申请号：CA2034618
申请日：1991-01-21
Applicant: SCLAVO SPA
Inventor： PERRETTI MAURO , BECHERUCCI CRISTINA , MUGRIDGE KENNETH G , SOLITO EGLE , PRESENTINI RIVO , PARENTE LUCA
Abstract: SYNTHETIC PEPTIDE DERIVED FROM HUMAN LIPOCORTIN V AND USE THEREOF The synthetic peptide of formula (I) H-Ser-His-Leu-Arg-Lys-Val- Phe-Asp-Lys-OH and its physiologically acceptable organic or inorganic salts are novel. The synthetic peptide (I), whose amino acid sequence corresponds to that of the sequence 204-212 of human lipocortin V, shows in vitro the capability of inhibiting the prostaglandin E2 release and in vivo an antiinflammatory activity. Said peptide and its organic and inorganic salts are useful as therapeutic agents for the treatment of dermatological and collagen inflammatory infections.
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100.发明专利
公开(公告)号：ITMI910105A1
公开(公告)日：1992-07-19
申请号：ITMI910105
申请日：1991-01-18
Applicant: SCLAVO SPA
Inventor： LATTANZI FILIPPO
IPC: A61K9/48 , C08B20060101
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