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公开(公告)号：SK2312000A3
公开(公告)日：2001-02-12
申请号：SK2312000
申请日：1998-08-10
Applicant: ABBOTT LAB
Inventor： BLACK LAWRENCE A , BASHA ANWER , KOLASA TEODOZYJ , KORT MICHAEL E , LIU HUAQING , MCCARTY CATHERINE M , PATEL MEENA V , ROHDE JEFFREY J
IPC: C07D237/14 , A61K31/496 , A61K31/50 , A61K31/501 , A61K31/5377 , A61P5/00 , A61P19/02 , A61P29/00 , A61P35/00 , A61P43/00 , C07D20060101 , C07D237/10 , C07D237/16 , C07D237/18 , C07D237/20 , C07D237/22 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/04 , C07D403/06 , C07D403/10 , C07D403/12 , C07D405/04 , C07D405/06 , C07D405/12 , C07D409/04 , C07D409/06 , C07D409/12 , C07D413/06 , C07D413/12 , C07D417/06 , C07D417/12 , C07F9/547 , C07F9/6509 , C07F11/00
Abstract: In the present invention, there are described pyridazinone compounds, which are cyclooxygenase (COX) inhibitors, and in particular, are selective inhibitors of cyclooxygenase-2 (COX-2). COX-2 is the inducible isoform associated with inflammation, as opposed to the constitutive isoform, cyclooxygenase-1 (COX-1), which is an important "housekeeping" enzyme in many tissues, including the gastrointestinal (GI) tract and the kidneys. The selectivity of these compounds for COX-2 minimizes the unwanted GI and renal side effects seen with currently marketed non-steroidal anti-inflammatory drugs (NSAIDs).
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公开(公告)号：ZA9807555B
公开(公告)日：1999-02-23
申请号：ZA9807555
申请日：1998-08-20
Applicant: ABBOTT LAB
Inventor： BLACK LAWRENCE A , BASHA ANWER , KOLASA TEODOZYJ , KORT MICHAEL E , LIU HUAQING , MCCARTY CATHERINE M , PATEL MEENA V , ROHDE JEFFREY J
IPC: C07D237/14 , C07D237/18 , C07D401/06 , C07D401/12 , C07D403/06 , C07D403/12 , C07D405/06 , C07D409/06 , C07D409/12 , C07D417/06 , C07D , A61K , C07F
CPC classification number: C07D401/06 , C07D237/14 , C07D237/18 , C07D401/12 , C07D403/06 , C07D403/12 , C07D405/06 , C07D409/06 , C07D409/12 , C07D417/06
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公开(公告)号：PT98440B
公开(公告)日：1999-01-29
申请号：PT9844091
申请日：1991-07-24
Applicant: ABBOTT LAB
Inventor： BROOKS DEE W , KERKMAN DANIEL J , BASHA ANWER , STEWART ANDREW O , BHATIA PRAMILA A
IPC: A61K31/16 , A61K31/17 , A61K31/34 , A61K31/341 , A61K31/343 , A61K31/38 , A61K31/381 , A61K31/42 , A61K31/423 , A61K31/435 , A61K31/47 , A61K31/472 , A61K31/496 , A61K31/505 , A61P1/00 , A61P9/00 , A61P9/10 , A61P11/00 , A61P17/00 , A61P29/00 , A61P37/08 , C07C239/08 , C07C275/20 , C07C275/64 , C07C323/44 , C07C333/12 , C07D213/40 , C07D213/64 , C07D213/643 , C07D213/65 , C07D213/68 , C07D213/69 , C07D213/78 , C07D215/20 , C07D215/22 , C07D215/227 , C07D217/24 , C07D239/34 , C07D241/14 , C07D241/18 , C07D263/56 , C07D277/20 , C07D277/34 , C07D307/52 , C07D307/54 , C07D307/56 , C07D307/58 , C07D307/64 , C07D307/81 , C07D307/82 , C07D333/20 , C07D333/24 , C07D333/28 , C07D333/32 , C07D333/34 , C07D333/58 , C07D333/60 , C07D405/04 , C07D405/12 , C07D407/12 , C07D409/04 , C07D409/12 , C07C271/40 , C07D213/42 , C07D215/14 , C07D263/58
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公开(公告)号：DE69122759T2
公开(公告)日：1997-05-15
申请号：DE69122759
申请日：1991-07-11
Applicant: ABBOTT LAB
Inventor： BROOKS DEE , STEWART ANDREW , KERKMAN DANIEL , BHATIA PRAMILA , BASHA ANWER , MARTIN JONATHAN
IPC: A61K31/16 , A61K31/17 , A61K31/34 , A61K31/341 , A61K31/343 , A61K31/38 , A61K31/381 , A61K31/42 , A61K31/423 , A61K31/435 , A61K31/47 , A61K31/472 , A61K31/496 , A61K31/505 , A61P1/00 , A61P9/00 , A61P9/10 , A61P11/00 , A61P17/00 , A61P29/00 , A61P37/08 , C07C239/08 , C07C275/20 , C07C275/64 , C07C323/44 , C07C333/12 , C07D213/40 , C07D213/64 , C07D213/643 , C07D213/65 , C07D213/68 , C07D213/69 , C07D213/78 , C07D215/20 , C07D215/22 , C07D215/227 , C07D217/24 , C07D239/34 , C07D241/14 , C07D241/18 , C07D263/56 , C07D277/20 , C07D277/34 , C07D307/52 , C07D307/54 , C07D307/56 , C07D307/58 , C07D307/64 , C07D307/81 , C07D307/82 , C07D333/20 , C07D333/24 , C07D333/28 , C07D333/32 , C07D333/34 , C07D333/58 , C07D333/60 , C07D405/04 , C07D405/12 , C07D407/12 , C07D409/04 , C07D409/12
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公开(公告)号：ZA948250B
公开(公告)日：1995-08-02
申请号：ZA948250
申请日：1994-10-20
Applicant: ABBOTT LAB
Inventor： LEE WENDY , DELLARIA JOSEPH F , BLACK LAWRENCE A , BASHA ANWER , CHERNESKY LINDA J
IPC: C07D309/10 , C07D405/12 , A01N , A61K
Abstract: Compounds of the structure where W is selected from where Q is oxygen or sulfur, R6 and R7 are hydrogen or alkyl, or R6 and R7, together with the nitrogen atoms to which they are attached, define a radical of formula Z is -CH2-, oxygen, sulfur, or -NR9, L1 and L2 are selected from a valence bond, alkylene, propenylene, and propynylene; R1 and R2 are independently selected from alkyl, alkoxy, haloalkyl, halogen, cyano, amino, alkoxycarbonyl, and dialkylaminocarbonyl; Y is selected from oxygen, >NR10, and three carbon atoms, propenylene, propynylene, and R3, R4, and R5 are hydrogen or alkyl of one to four carbon atoms inhibit the synthesis of leukotrienes. These compounds are useful in the treatment or amelioration of allergic and inflammatory disease states.
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Patent Agency Ranking
公开(公告)号：ZA946331B
公开(公告)日：1995-05-08
申请号：ZA946331
申请日：1994-08-19
Applicant: ABBOTT LAB
Inventor： DELLARIA JOSEPH F , BASHA ANWER , BLACK LAWRENCE A , CHERNESKY LINDA J , LEE WENDY E
IPC: C07D309/04 , C07D309/06 , C07D405/12 , A61K , C07D
Abstract: Compounds of structure where W is selected from where Q is oxygen or sulfur, R5 and R6 are independently selected from hydrogen and alkyl, or R5 and R6, together with the nitrogen atoms to which they are attached, define a radical of formula L1 and L2 are independently selected from a valence bond, alkylene, propenylene, and propynylene, R1, R2, R3, and R4 are independently selected from alkyl, alkoxy, haloalkyl, halogen, cyano, amino, alkoxycarbonyl, and dialkylaminocarbonyl, Y is oxygen, >NR9 where R9 is hydrogen or alkyl, or where n=0, 1, or 2, and A is selected from inhibit the biosynthesis of leukotrienes. These compounds are useful in the treatment or amelioration of allergic and inflammatory disease states.
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公开(公告)号：AU647177B2
公开(公告)日：1994-03-17
申请号：AU8414291
申请日：1991-07-11
Applicant: ABBOTT LAB
Inventor： BROOKS DEE W , STEWART ANDREW O , KERKMAN DANIEL J , BHATIA PRAMILA A , BASHA ANWER , MARTIN JONATHAN G
IPC: A61K31/16 , A61K31/17 , A61K31/34 , A61K31/341 , A61K31/343 , A61K31/38 , A61K31/381 , A61K31/42 , A61K31/423 , A61K31/435 , A61K31/47 , A61K31/472 , A61K31/496 , A61K31/505 , A61P1/00 , A61P9/00 , A61P9/10 , A61P11/00 , A61P17/00 , A61P29/00 , A61P37/08 , C07C239/08 , C07C275/20 , C07C275/64 , C07C323/44 , C07C333/12 , C07D213/40 , C07D213/64 , C07D213/643 , C07D213/65 , C07D213/68 , C07D213/69 , C07D213/78 , C07D215/20 , C07D215/22 , C07D215/227 , C07D217/24 , C07D239/34 , C07D241/14 , C07D241/18 , C07D263/56 , C07D277/20 , C07D277/34 , C07D307/52 , C07D307/54 , C07D307/56 , C07D307/58 , C07D307/64 , C07D307/81 , C07D307/82 , C07D333/20 , C07D333/24 , C07D333/28 , C07D333/32 , C07D333/34 , C07D333/58 , C07D333/60 , C07D405/04 , C07D405/12 , C07D407/12 , C07D409/04 , C07D409/12 , A61K31/425 , A61K31/44 , C07C271/08 , C07C271/40 , C07D213/42 , C07D215/14 , C07D263/58 , C07D307/86
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公开(公告)号：PT98440A
公开(公告)日：1992-05-29
申请号：PT9844091
申请日：1991-07-24
Applicant: ABBOTT LAB
Inventor： BROOKS DEE W , KERKMAN DANIEL J , BASHA ANWER , STEWART ANDREW O , BHATIA PRAMILA A
IPC: A61K31/16 , A61K31/17 , A61K31/34 , A61K31/341 , A61K31/343 , A61K31/38 , A61K31/381 , A61K31/42 , A61K31/423 , A61K31/435 , A61K31/47 , A61K31/472 , A61K31/496 , A61K31/505 , A61P1/00 , A61P9/00 , A61P9/10 , A61P11/00 , A61P17/00 , A61P29/00 , A61P37/08 , C07C239/08 , C07C275/20 , C07C275/64 , C07C323/44 , C07C333/12 , C07D213/40 , C07D213/64 , C07D213/643 , C07D213/65 , C07D213/68 , C07D213/69 , C07D213/78 , C07D215/20 , C07D215/22 , C07D215/227 , C07D217/24 , C07D239/34 , C07D241/14 , C07D241/18 , C07D263/56 , C07D277/20 , C07D277/34 , C07D307/52 , C07D307/54 , C07D307/56 , C07D307/58 , C07D307/64 , C07D307/81 , C07D307/82 , C07D333/20 , C07D333/24 , C07D333/28 , C07D333/32 , C07D333/34 , C07D333/58 , C07D333/60 , C07D405/04 , C07D405/12 , C07D407/12 , C07D409/04 , C07D409/12 , C07C , A61K , C07D
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公开(公告)号：CZ302795B6
公开(公告)日：2011-11-16
申请号：CZ2010538
申请日：2001-04-27
Applicant: ABBOTT LAB
Inventor： SCHRIMPF MICHAEL R , TIETJE KARIN R , TOUPENCE RICHARD B , JI JIANGUO , BASHA ANWER , BUNNELLE WILLIAM H , DAANEN JEROME F , PACE JENNIFER M , SIPPY KEVIN B
IPC: C07D231/54 , C07D471/04 , A61K31/4427 , A61K31/454 , A61K31/4545 , A61K31/4709 , A61P25/00 , A61P25/04 , A61P25/14 , A61P25/16 , A61P25/18 , A61P25/24 , A61P25/28 , A61P25/34 , C07D487/04
Abstract: N-substituovaný diazabicyklický derivát obecného vzorce VII, kde obecné symboly mají specifický význam, farmaceutická kompozice zahrnující terapeuticky úcinné množství diazabicyklického derivátu v kombinaci s farmaceuticky prijatelným nosicem techto sloucenin. Farmaceutické kompozice jsou vhodné k regulaci synaptické transmise u savcu.
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100.发明专利
公开(公告)号：SK287658B6
公开(公告)日：2011-05-06
申请号：SK102010
申请日：2001-04-27
Applicant: ABBOTT LAB
Inventor： SCHRIMPF MICHAEL R , TIETJE KARIN R , TOUPENCE RICHARD B , JI JIANGUO , BASHA ANWER , BUNNELLE WILLIAM H , DAANEN JEROME F , SIPPY KEVIN B
IPC: C07D231/54 , C07D487/00 , A61K31/454 , A61K31/4545 , A61P25/00 , A61P25/04 , A61P25/14 , A61P25/16 , A61P25/18 , A61P25/24 , A61P25/28 , A61P25/34 , C07D471/00 , C07D471/04 , C07D487/04
Abstract: Described are compounds of the general formula (I), wherein particular substituents have the meaning defined in claims, pharmaceutical compositions containing the compounds and use of pharmaceutical formulations for controlling synaptic transmission in mammals.
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