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公开(公告)号：FI964446A
公开(公告)日：1997-01-03
申请号：FI964446
申请日：1996-11-05
Applicant: BASF AG
Inventor： AMBERG WILHELM , BERNARD HARALD , BUSCHMANN ERNST , HAUPT ANDREAS , JANITSCHKE LOTHAR , JANSSEN BERND , KARL ULRICH , KLING ANDREAS , MUELLER STEFAN , DE POTZOLLI BERND , RITTER KURT , THYES MARCO , ZIERKE THOMAS
Abstract: Compounds of the formulawhere R1, R2, R3 and R4 have the meaning stated in the description, and a process for preparing them are described. The compounds are suitable as starting material for synthesizing substances which are active against tumors.
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公开(公告)号：FI964448A0
公开(公告)日：1996-11-05
申请号：FI964448
申请日：1996-11-05
Applicant: BASF AG
Inventor： AMBERG WILHELM , BERNARD HARALD , BUSCHMANN ERNST , HAUPT ANDREAS , JANITSCHKE LOTHAR , JANSSEN BERND , KARL ULRICH , KLING ANDREAS , MUELLER STEFAN , DE POTZOLLI BERND , RITTER KURT , THYES MARCO , ZIERKE THOMAS
IPC: A61K38/08 , A61K38/00 , A61P35/00 , C07K1/08 , C07K5/10 , C07K5/103 , C07K7/06 , C07K14/52 , C07K
Abstract: PCT No. PCT/EP95/01577 Sec. 371 Date Nov. 4, 1996 Sec. 102(e) Date Nov. 4, 1996 PCT Filed Apr. 26, 1995 PCT Pub. No. WO95/30691 PCT Pub. Date Nov. 16, 1995The compound Me2Val-Val-MeVal-Pro-Pro-NHBzlxHCl is described. It is prepared from Z-Val-Val-MeVal-Pro-OR1 where Z and R1 have the meanings stated in the description. The compound shows antineoplastic activity.
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公开(公告)号：ZA953584B
公开(公告)日：1996-11-04
申请号：ZA953584
申请日：1995-05-04
Applicant: BASF AG
Inventor： BUSCHMANN ERNST , AMBERG WILHELM , BERNARD HARALD , HAUPT ANDREAS , JANSSEN BERND , KARL ULRICH , KLING ANDREAS , MUELLER STEFAN , JANITSCHKE LOTHAR , RITTER KURT , THYES MARCO , ZIERKE THOMAS , POTZOLLI BERND DE
IPC: A61K38/08 , A61P35/00 , A61K38/00 , C07K1/08 , C07K5/10 , C07K5/103 , C07K7/06 , C07K14/52 , C07K , A61K
Abstract: PCT No. PCT/EP95/01577 Sec. 371 Date Nov. 4, 1996 Sec. 102(e) Date Nov. 4, 1996 PCT Filed Apr. 26, 1995 PCT Pub. No. WO95/30691 PCT Pub. Date Nov. 16, 1995The compound Me2Val-Val-MeVal-Pro-Pro-NHBzlxHCl is described. It is prepared from Z-Val-Val-MeVal-Pro-OR1 where Z and R1 have the meanings stated in the description. The compound shows antineoplastic activity.
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公开(公告)号：CA2201785A1
公开(公告)日：1996-04-25
申请号：CA2201785
申请日：1995-10-07
Applicant: BASF AG
Inventor： AMBERG WILHELM , KLING ANDREAS , RIECHERS HARTMUT , KLINGE DAGMAR , WERNET WOLFGANG , UNGER LILIANE , RASCHACK MANFRED , MUELLER STEFAN , BAUMANN ERNST , RHEINHEIMER JOACHIM , VOGELBACHER UWE JOSEF
IPC: C07D251/30 , A61K31/505 , A61P9/00 , A61P9/08 , A61P9/10 , A61P9/12 , A61P11/08 , A61P13/02 , A61P15/00 , A61P25/04 , C07D239/00 , C07D239/26 , C07D239/28 , C07D239/34 , C07D239/38 , C07D239/60 , C07D239/70 , C07D239/96 , C07D251/12 , C07D251/52 , C07D257/02 , C07D309/00 , C07D403/06 , C07D403/12 , C07D405/12 , C07D417/12 , C07D487/04 , C07D491/04 , C07D491/044 , C07D491/048
Abstract: Carboxylic acid derivatives have the formula (I), in which R to R6, X, Y, and Z have the meanings given in the description. Also disclosed is their preparation. These new compounds are useful for controlling diseases.
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公开(公告)号：MX9203293A
公开(公告)日：1992-12-01
申请号：MX9203293
申请日：1992-06-24
Applicant: BASF AG
Inventor： BOCKSTIEGEL BERNHARD , EMLING FRANZ , KLING ANDREAS , JESSEL BARBARA , JANSSEN BERND
IPC: C07C219/06 , C07C229/06
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Patent Agency Ranking
公开(公告)号：CA2189691C
公开(公告)日：2011-02-15
申请号：CA2189691
申请日：1995-04-26
Applicant: BASF AG
Inventor： AMBERG WILHELM , BERNARD HARALD , BUSCHMANN ERNST , HAUPT ANDREAS , JANITSCHKE LOTHAR , JANSSEN BERND , KARL ULRICH , KLING ANDREAS , MULLER STEFAN , DE POTZOLLI BERND , RITTER KURT , THYES MARCO , ZIERKE THOMAS
Abstract: Compounds of formula (I) are disclosed, wherein R1, R2, R3, and R4 have the meanings indicated in the description, as well as a process for the production of these compounds. The compounds are suitable for use as starting material for the synthesis of substances which have anti-tumour properties.
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公开(公告)号：DE19533023B4
公开(公告)日：2007-05-16
申请号：DE19533023
申请日：1995-09-07
Applicant: BASF AG
Inventor： RIECHERS HARTMUT , KLINGE DAGMAR , AMBERG WILHELM , KLING ANDREAS , MUELLER STEFAN , BAUMANN ERNST , RHEINHEIMER JOACHIM , VOGELBACHER UWE JOSEF , WERNET WOLFGANG , UNGER LILIANE , RASCHACK MANFRED
IPC: C07D239/60 , C07D251/30 , A61K31/41 , A61K31/505 , A61P9/00 , A61P9/08 , A61P9/10 , A61P9/12 , A61P11/08 , A61P13/02 , A61P15/00 , A61P25/04 , C07D239/00 , C07D239/26 , C07D239/28 , C07D239/34 , C07D239/38 , C07D239/70 , C07D239/96 , C07D251/12 , C07D251/52 , C07D257/02 , C07D309/00 , C07D403/06 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D487/04 , C07D491/04 , C07D491/044 , C07D491/048 , C07D495/04
Abstract: Heterocyclyl-substd. propanoic acids and their derivs., of formula (I), are new. R = formyl, tetrazolyl, nitrile, COOH or a gp. that can be hydrolysed to COOH; X = N or CR14; R2 = H, OH, NH2, alkylamino, dialkylamino, halo, alkyl, haloalkyl, alkoxy, haloalkoxy or alkylthio; R14 = H or 1-5 C alkyl; R3 = R2 or alkoxyimino; or CR3 + CR14 = 5 or 6 membered alkylene or alkenyl ring (opt. substd. by 1-2 alkyl) in which a methylene can be replaced by O, S, NH or alkylamino; R4, R5 = phenyl or naphthyl (both opt. substd. by one or more halo, NO2, CN, OH, alkyl, haloalkyl, alkoxy, haloalkyloxy, phenoxy, alkylthio, NH2, alkylamine or dialkylamino) or 3-7 C cycloalkyl; or the phenyl or naphthyl gps. are opt. bonded at the O- position (by a bond, CH2, O, S, SO2, ethylene, ethenylene or opt. alkylated amino); R6 = H, 1-8 C alkyl, 2-6 C alkenyl, 3-6 C alkynyl, 3-8 C cycloalkyl (all opt. substd. by 1 or more halo, NO2, CN, alkoxy 3-6 C alkenyloxy, 3-6 C alkynyloxy, alkylthio, haloalkoxy, alkylcarbonyl, alkoxycarbonyl, 3-8 C alkylcarbonylalkyl, alkylamino, dialkylamino, phenyl, Ph or OPh), Ar or Het; Y = S, O or bond; Q = S, O, SO, SO2 or bond; Ph = substd. phenyl, where substits. are halo, NO2, CN, alkyl, haloalkyl, alkoxy, haloalkoxy or alkylthio; Ar = phenyl or naphthyl (both opt. substd. by 1 or more halo, NO2, CN, OH, NH2, alkylamino, dialkylamino or OCH2CH2O); Het = 5 or 6 membered heteroaromatic with 1-3 N atoms and/or one S or O (opt. substd. by 1-4 halo and/or 1 or 2 alkyl, haloalkyl, alkoxy, haloalkoxy, alkylthio, phenyl, phenoxy or phenyl carbonyl (where the phenyl is opt. substd. by 1-5 halo and/or 1-3 alkyl, haloalkyl, alkoxy, haloalkoxy and/or alkylthio)); alkyl and alkoxy have 1-4 C unless otherwise stated; provided that R6 is not H when Q = bond.
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公开(公告)号：AT296102T
公开(公告)日：2005-06-15
申请号：AT01945258
申请日：2001-06-06
Applicant: BASF AG
Inventor： GENESTE HERVE , KLING ANDREAS , LANGE UDO , SEITZ WERNER , GRAEF CLAUDIA ISABELLA , SUBKOWSKI THOMAS , HORNBERGER WILFRIED , LAUTERBACH ARNULF
IPC: C07D223/10 , A61K31/55 , A61K31/5513 , A61K45/00 , A61K45/06 , A61P3/10 , A61P5/18 , A61P7/00 , A61P7/02 , A61P9/00 , A61P9/10 , A61P9/12 , A61P13/12 , A61P17/00 , A61P17/02 , A61P17/06 , A61P19/00 , A61P19/02 , A61P29/00 , A61P31/00 , A61P31/12 , A61P33/00 , A61P35/00 , A61P43/00 , C07D263/48 , C07D277/08 , C07D307/68 , C07D333/38 , C07D401/12 , C07D401/14 , C07D403/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D417/14 , C07D471/04 , C07D495/04 , C07K5/023
Abstract: The invention relates to the use of cyclic compounds as ligands of integrin receptors, in particular as ligands of the alpha V beta 3 integrin receptor, the novel compounds themselves, their use, and pharmaceutical preparations comprising these compounds.
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公开(公告)号：AR030699A1
公开(公告)日：2003-09-03
申请号：ARP010102837
申请日：2001-06-14
Applicant: BASF AG
Inventor： GENESTE HERVE , KLING ANDREAS , LANGE ARNO , LAUTERBACH ARNULF , SEITZ A , GRAEF CLAUDIA ISABELLA , SUBKOWSKI THOMAS , HORNBERGER W
IPC: A61K45/06 , A61P9/00 , C07D223/16 , C07D403/12 , A61K31/55
Abstract: Un compuesto ligando de integrina de la formula (1): B-G-L donde B, G y L tienen los siguientes significados: L es un elemento estructural de la formula: -U-T donde T es un grupo COOH, un radical hidrolizable en COOH o un radical bioisotérico en COOH y ûU- es (XL)a-(CRL1RL2)b-, -CRL1=CRL2- etinileno o =CRL1 donde a es 0 o 1, b es 0, 1 o 2; XL es CRL3RL4, NRL5, oxígeno o azufre; RL1, RL2, RL3, RL4, RL5, RL6, RL7, son como se definen en la memoria; G es un elemento estructural de la formula (2) donde la incorporacion del elemento estructural G puede tener lugar en ambas orientaciones, y YG, RG5, RG6 y WG son como se definen en la memoria; y B es un elemento estructural que contiene al menos un átomo que, en condiciones fisiologicas, como un aceptor de hidrogeno puede formar puentes de hidrogeno, donde al menos un átomo aceptor de hidrogeno tiene una distancia de 4 a 15 enlaces de átomos de elemento estructura G a lo largo de la ruta más corta posible a lo largo del esqueleto del elemento estructural, las sales de tolerancia fisiologica, sales, prodrogas y las formas enantioméricamente puras o diastereoméricamente puras y las formas tautoméricas. Uso del elemento estructural de la formula: -G-L para preparar compuestos que se unen con receptores de la integrina y droga que lo contiene. Una composicion farmacéutica que comprende al menos un compuesto de formula (1) además de los excipientes farmacéuticos usuales. Dichos compuestos son utiles como ligando de los receptores de la integrina, preferentemente como ligandos del receptor de integrina avb3.
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公开(公告)号：PL351441A1
公开(公告)日：2003-04-22
申请号：PL35144100
申请日：2000-03-28
Applicant: BASF AG
Inventor： HILLEN HEINZ , SCHMIDT MARTIN , MACK HELMUT , SEITZ WERNER , HAUPT ANDREAS , ZECHEL JOHANN-CHRISTIAN , KLING ANDREAS
IPC: A61K38/00 , A61K38/55 , A61P1/04 , A61P1/18 , A61P5/14 , A61P7/02 , A61P9/00 , A61P9/10 , C12N9/99 , A61P11/00 , A61P11/06 , A61P13/12 , A61P15/00 , A61P17/02 , A61P19/02 , A61P21/04 , A61P25/00 , A61P25/28 , A61P29/00 , A61P37/02 , C07B43/00 , C07D401/12 , C07D409/12 , C07K5/06 , C07K5/062 , C07K5/065 , C07K5/068 , C07K5/072 , C07K5/078 , A61K38/05
Abstract: Peptide substances, their preparation and their use as complement inhibitors are described. These are in particular substances having a guanidine or amidine radical as a terminal group. In particular, inhibitors of the complement proteases C1s and C1r are described.
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