公开(公告)号：CZ302038B6

公开(公告)日：2010-09-15

申请号：CZ2009553

申请日：2001-04-27

Applicant: ABBOTT LAB

Inventor： SCHRIMPF MICHAEL R ,  TIETJE KARIN R ,  TOUPENCE RICHARD B ,  JI JIANGUO ,  BASHA ANWER ,  BUNNELLE WILLIAM H ,  DAANEN JEROME F ,  PACE JENNIFER M ,  SIPPY KEVIN B

IPC: C07D231/54 ,  C07D471/04 ,  A61K31/397 ,  A61K31/407 ,  A61K31/4353 ,  A61K31/4427 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/4709 ,  A61P1/00 ,  A61P13/00 ,  A61P15/10 ,  A61P25/00 ,  A61P25/04 ,  A61P25/14 ,  A61P25/16 ,  A61P25/18 ,  A61P25/24 ,  A61P25/28 ,  A61P25/34 ,  C07D487/04

Abstract: Diazabicyklické slouceniny obecného vzorce II, nebo jejich farmaceuticky prijatelné soli, kde Y je vybráno ze skupiny sestávající se z kovalentní vazby, CH.sub.2 .n.a CH.sub.2.n.CH.sub.2.n.; Z je vybráno ze skupiny sestávající se z kovalentní vazby, CH.sub.2 .n.a CH.sub.2.n.CH.sub.2.n., za predpokladu, že pokud Y je CH.sub.2.n.CH.sub.2.n., pak Z je kovalentní vazba, a dále za predpokladu, že pokud Z je CH.sub.2.n.CH.sub.2.n., pak Y je kovalentní vazba; a substituenty R.sub.1.n., R.sub.9 .n.mají specifický význam; které jsou aktivní vuci centrálnímu nervovému systému.

公开(公告)号：AU2010202299A1

公开(公告)日：2010-06-24

申请号：AU2010202299

申请日：2010-06-02

Applicant: ABBOTT LAB

Inventor： BASHA ANWER ,  BUNNELLE WILLIAM H ,  DART MICHAEL J ,  GALLAGHER MEGAN E ,  JI JIANGUO ,  MORTELL KATHLEEN H ,  NERSESIAN DIANA L ,  PACE JENNIFER M ,  RYTHER KEITH B ,  SCHRIMPF MICHAEL R ,  TIETJE KARIN R

IPC: C07D471/04 ,  A61K31/435 ,  A61P25/00 ,  C07D471/08 ,  C07D487/04 ,  C07D487/08

Abstract: Compounds of formula (I) Z-Ar 1 -Ar 2 wherein Z is a diazabicyclic amine, Ar 1 is a 5- or 6-membered aromatic ring, and Ar 2 is selected from the group consisting of an unsubstituted or substituted 5-or 6-membered heteroaryl ring; unsubstituted or substituted bicyclic heteroaryl ring; 3,4-(methylenedioxy)phenyl; carbazolyl; tetrahydrocarbazoyl; naphthyl; and phenyl; wherein the phenyl is substituted with 0, 1, 2, or 3 substituents in the meta- or para-positions. The compounds are useful in treating conditions or disorders prevented by or ameliorated by ±7 nAChR ligands. Also disclosed are pharmaceutical compositions comprising compounds of formula (I) and methods for using such compounds and compositions.

公开(公告)号：NO324250B1

公开(公告)日：2007-09-17

申请号：NO20025107

申请日：2002-10-24

Applicant: ABBOTT LAB

Inventor： BASHA ANWER ,  BUNNELLE WILLIAM H ,  DAANEN JEROME F ,  SCHRIMPF MICHAEL R ,  SIPPY KEVIN B ,  JI JIANGUO ,  TIETJE KARIN R ,  TOUPENCE RICHARD B ,  PACE JENNIFER M

IPC: C07D231/54 ,  C07D487/04 ,  A61K31/454 ,  A61K31/4545 ,  A61P25/00 ,  A61P25/04 ,  A61P25/14 ,  A61P25/16 ,  A61P25/18 ,  A61P25/24 ,  A61P25/28 ,  A61P25/34 ,  C07D471/04

Abstract: Compounds of formula (I), pharmaceutical compositions of these compounds, and use of said compositions to control synaptic transmission in mammals

公开(公告)号：CA2299300C

公开(公告)日：2007-04-17

申请号：CA2299300

申请日：1998-08-10

Applicant: ABBOTT LAB

Inventor： KORT MICHAEL E ,  ROHDE JEFFREY J ,  LIU HUAQING ,  KOLASA TEODOZYJ ,  PATEL MEENA V ,  MCCARTY CATHERINE M ,  BLACK LAWRENCE A ,  BASHA ANWER

IPC: C07D237/14 ,  A61K31/50 ,  C07D237/18 ,  C07D401/06 ,  C07D401/12 ,  C07D403/06 ,  C07D403/12 ,  C07D405/06 ,  C07D409/06 ,  C07D409/12 ,  C07D413/06 ,  C07D417/06 ,  C07F11/00

Abstract: The present invention describes pyridazinone compounds of formula III, which are cyclooxygenase (COX) inhibitors, and in particular, are selective inhibitors of cyclooxygenase-2 (COX/2), COX-2 us the inducible isoform associated with inflammation, as opposed to the constitutive isoform, cyclooxygenase-1 (COX- 1) which is an important "housekeeping" enzyme in many tissues, including the gastrointestinal (GI) tract and the kidneys. The selectivity of these compounds for COX-2 minimizes the unwanted GI and renal side-effects seen with current ly marked non-steroidal anti-inflammatory drugs (NSAIDs).

公开(公告)号：DE69926903T2

公开(公告)日：2006-07-13

申请号：DE69926903

申请日：1999-10-27

Applicant: ABBOTT LAB

Inventor： BLACK A ,  BASHA ANWER ,  KOLASA TEODOZYJ ,  KORT E ,  LIU HUAQING ,  MCCARTY M ,  PATEL V ,  ROHDE J ,  COGHLAN J ,  STEWART O

IPC: C07D237/14 ,  A61K31/50 ,  A61K31/501 ,  A61P19/02 ,  A61P25/04 ,  A61P29/00 ,  A61P35/00 ,  C07D237/16 ,  C07D237/18 ,  C07D237/22 ,  C07D401/04 ,  C07D401/06 ,  C07D401/12 ,  C07D403/04 ,  C07D403/10 ,  C07D403/12 ,  C07D405/04 ,  C07D405/12 ,  C07D409/04 ,  C07D409/06 ,  C07D409/12 ,  C07D413/04 ,  C07D413/12 ,  C07D417/06

Abstract: The present invention describes pyridazinone compounds of formula (I) which are cyclooxygenase (COX) inhibitors, and in particular, are selective inhibitors of cyclooxygenase-2 (COX-2). COX-2 is the inducible isoform associated with inflammation, as opposed to the constitutive isoform, cyclooxygenase-1 (COX-1) which is an important "housekeeping" enzyme in many tissues, including the gastrointestinal (GI) tract and the kidneys. The selectively of these compounds for COX-2 minimizes the unwanted GI and renal side-effects seen with currently marketed non-steroidal anti-inflammatory drugs (NSAIDs).

公开(公告)号：HK1041876B

公开(公告)日：2006-06-23

申请号：HK02101207

申请日：2002-02-19

Applicant: ABBOTT LAB

Inventor： BLACK LAWRENCE A ,  BASHA ANWER ,  KOLASA TEODOZYJ ,  KORT MICHAEL E ,  LIU HUAQING ,  MCCARTY CATHERINE M ,  PATEL MEENA V ,  ROHDE JEFFREY J ,  COGHLAN MICHAEL J ,  STEWART ANDREW O

IPC: C07D20060101 ,  A61K20060101 ,  A61K31/50 ,  A61K31/501 ,  A61P19/02 ,  A61P25/04 ,  A61P29/00 ,  A61P35/00 ,  C07D237/14 ,  C07D237/16 ,  C07D237/18 ,  C07D237/22 ,  C07D401/04 ,  C07D401/06 ,  C07D401/12 ,  C07D403/04 ,  C07D403/10 ,  C07D403/12 ,  C07D405/04 ,  C07D405/12 ,  C07D409/04 ,  C07D409/06 ,  C07D409/12 ,  C07D413/04 ,  C07D413/12 ,  C07D417/06

公开(公告)号：AU2004274492A1

公开(公告)日：2005-03-31

申请号：AU2004274492

申请日：2004-09-17

Applicant: ABBOTT LAB

Inventor： BUNNELLE WILLIAM H ,  DART MICHAEL J ,  TIETJE KARIN R ,  SCHRIMPF MICHAEL R ,  RYTHER KEITH B ,  GALLAGHER MEGAN E ,  NERSESIAN DIANA L ,  MORTELL KATHLEEN H ,  PACE JENNIFER M ,  BASHA ANWER ,  JI JIANGUO

IPC: C07D471/04 ,  A61K31/435 ,  A61P25/00 ,  C07D471/08 ,  C07D487/04 ,  C07D487/08

Abstract: Compounds of formula (I) Z-Ar 1 -Ar 2 wherein Z is a diazabicyclic amine, Ar 1 is a 5- or 6-membered aromatic ring, and Ar 2 is selected from the group consisting of an unsubstituted or substituted 5-or 6-membered heteroaryl ring; unsubstituted or substituted bicyclic heteroaryl ring; 3,4-(methylenedioxy)phenyl; carbazolyl; tetrahydrocarbazoyl; naphthyl; and phenyl; wherein the phenyl is substituted with 0, 1, 2, or 3 substituents in the meta- or para-positions. The compounds are useful in treating conditions or disorders prevented by or ameliorated by ±7 nAChR ligands. Also disclosed are pharmaceutical compositions comprising compounds of formula (I) and methods for using such compounds and compositions.

公开(公告)号：PL358340A1

公开(公告)日：2004-08-09

申请号：PL35834001

申请日：2001-04-27

Applicant: ABBOTT LAB

Inventor： SCHRIMPF MICHAEL R ,  TIETJE KARIN R ,  TOUPENCE RICHARD B ,  JI JIANGUO ,  BASHA ANWER ,  BUNNELLE WILLIAM H ,  DAANEN JEROME F ,  PACE JENNIFER M ,  SIPPY KEVIN B

IPC: C07D231/54 ,  A61K31/454 ,  A61K31/4545 ,  A61P25/00 ,  A61P25/04 ,  A61P25/14 ,  A61P25/16 ,  A61P25/18 ,  A61P25/24 ,  A61P25/28 ,  A61P25/34 ,  C07D471/04 ,  C07D487/04 ,  C07D487/08 ,  C07D471/08 ,  C07D519/00 ,  A61K31/395

Abstract: Compounds of formula (I), pharmaceutical compositions of these compounds, and use of said compositions to control synaptic transmission in mammals

公开(公告)号：ZA200208274B

公开(公告)日：2004-02-11

申请号：ZA200208274

申请日：2002-10-14

Applicant: ABBOTT LAB

Inventor： SCHRIMPF MICHAEL R ,  TOUPENCE RICHARD B ,  BASHA ANWER ,  DAANEN JEROME F ,  SIPPY KEVIN B ,  TIETJE KARIN R ,  JI JIANGUO ,  BUNNELLE WILLIAM H ,  PACE JENNIFER M

IPC: A61K20060101 ,  A61P20060101 ,  C07D20060101 ,  C07D ,  A61K ,  A61P

公开(公告)号：AR030421A1

公开(公告)日：2003-08-20

申请号：ARP010101990

申请日：2001-04-27

Applicant: ABBOTT LAB

Inventor： TIETJE KARIN ,  TOUPENCE RICHARD ,  COURT JIANGUO ,  BASHA ANWER ,  BUNELLE WILLIAM ,  DAANEN JEROME ,  PACE JENNIFER ,  SIPPY KEVIN ,  SCHRIMPF MICHAEL

IPC: C07D231/54 ,  A61K31/454 ,  A61K31/4545 ,  A61P25/00 ,  A61P25/04 ,  A61P25/14 ,  A61P25/16 ,  A61P25/18 ,  A61P25/24 ,  A61P25/28 ,  A61P25/34 ,  C07D471/04 ,  C07D487/04 ,  C07D519/00 ,  A61K31/41 ,  A61K31/437

Abstract: Un compuesto diazabicíclico N-sustituido y sales aceptables para uso farmacéutico y prodrogas de los mismos de formula (1) en donde A se selecciona entre el grupo que consiste en un enlace covalente, CH2, CH2CH2, y CH2CH2CH2; B se selecciona entre el grupo que consiste en CH2 y CH2CH2, siempre y cuando si A es CH2CH2CH2, luego B es CH2; Y se selecciona entre el grupo que consiste en un enlace covalente CH2, y CH2CH2; Z se selecciona entre el grupo que consiste en un enlace covalente, CH2 y CH2CH2, siempre y cuando si Y es CH2CH2, luego Z es un enlace covalente siempre y cuando si Z es CH2CH2, luego Y es un enlace covalente; R1 se describe en la memoria descriptiva; R3 se selecciona entre el grupo que consiste en hidrogeno, alquilo y halogeno; R4 se selecciona entre el grupo que consiste en hidrogeno, alcoxilo, alquilo, amino, halogeno y nitro; R5 se selecciona entre el grupo que consiste en hidrogeno, alquenilo, alcoxilo, alcoxialcoxilo, alcoxialquilo, alcoxicarbonilo, alcoxicarbonilalquilo, alquilo, alquilocarbonilo, alquilocarboniloxilo, alquilotio, alquinilo, amino, aminoalquilo, aminocarbonilo, aminocarbonilalquilo, aminosulfonilo, carboxilo, carboxialquilo, ciano, cianoalquilo, formilo, formilalquilo, haloalcoxilo, haloalquilo, halogeno, hidroxilo, hidroxialquilo, mercapto, mercaptoalquilo, nitro, 5-tetrazolilo, -NR6S(O)2R7, -C(NR6)NR7R8, -CH2C(NR6)NR7R8, -C(NOR6)R7, -C(NCN)R6, -C(NNR6R7)R8, -S(O)2OR6, y -S(O)2R6; R6, R7 y R8 son independientemente seleccionados entre el grupo que consiste en hidrogeno y alquilo; y R9 se selecciona entre el grupo que consiste en hidrogeno, alcoxicarbonilo, alquilo, amino, amioalquilo, aminocarbonilalquilo, sernziloxicarbonilo, cianoalquilo, dihidro-3-piridinilcarbonilo, hidroxilo, hidroxialquilo, y fenoxicarbonilo.