公开(公告)号：LT2489659T

公开(公告)日：2018-03-26

申请号：LT12152224

申请日：2005-06-24

Applicant: VERTEX PHARMA

Inventor： HADIDA RUAH SARAH S ,  HAZLEWOOD ANNA R ,  GROOTENHUIS PETER D J ,  VAN GOOR FREDRICK F ,  SINGH ASHVANI K ,  ZHOU JINGLAN ,  MCCARTNEY JASON

IPC: C07D215/56 ,  A61K31/47 ,  A61P11/08 ,  A61P29/00 ,  A61P31/00

公开(公告)号：HRP20171901T1

公开(公告)日：2018-02-23

申请号：HRP20171901

申请日：2017-12-07

Applicant: VERTEX PHARMA

Inventor： DEMATTEI JOHN ,  LOOKER ADAM R ,  NEUBERT LANGILLE BOBBIANA ,  TRUDEAU MARTIN ,  ROPER STEFANIE ,  RYAN MICHAEL ,  YAP DAHRIKA MILFRED LAO ,  KRUEGER BRIAN R ,  GROOTENHUIS PETER D J ,  VAN GROOR FREDERICK F ,  BOTFIELD MARTYN C ,  ZLOKARNIK GREGOR

IPC: C07D215/233

公开(公告)号：DK2821400T3

公开(公告)日：2018-01-02

申请号：DK14182117

申请日：2010-03-19

Applicant: VERTEX PHARMA

Inventor： DEMATTEI JOHN ,  NEUBERT-LANGILLE BOBBIANA ,  TRUDEAU MARTIN ,  RYAN MICHAEL ,  YAP DAHRIKA MILFRED LAO ,  KRUEGER BRIAN R ,  GROOTENHUIS PETER D J ,  VAN GROOR FREDERICK F ,  BOTFIELD MARTYN C ,  LOOKER ADAM R ,  ROPER STEFANIE ,  ZLOKARNIK GREGOR

IPC: C07D215/233

公开(公告)号：PL2502911T3

公开(公告)日：2017-09-29

申请号：PL12152225

申请日：2005-06-24

Applicant: VERTEX PHARMA

Inventor： HADIDA RUAH SARAH S ,  HAZLEWOOD ANNA R ,  GROOTENHUIS PETER D J ,  VAN GOOR FREDRICK F ,  SINGH ASHVANI K ,  ZHOU JINGLAN ,  MCCARTNEY JASON

IPC: C07D401/12 ,  A61K31/47 ,  A61K31/4709 ,  A61P25/00 ,  A61P31/00 ,  A61P35/00 ,  C07C215/76 ,  C07D209/08 ,  C07D209/12 ,  C07D209/14 ,  C07D209/18 ,  C07D215/56 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12

公开(公告)号：LT2502911T

公开(公告)日：2017-09-11

申请号：LT12152225

申请日：2005-06-24

Applicant: VERTEX PHARMA

Inventor： HADIDA RUAH SARAH S ,  HAZLEWOOD ANNA R ,  GROOTENHUIS PETER D J ,  VAN GOOR FREDRICK F ,  SINGH ASHVANI K ,  ZHOU JINGLAN ,  MCCARTNEY JASON

IPC: C07D401/12 ,  A61K31/47 ,  A61K31/4709 ,  A61P25/00 ,  A61P31/00 ,  A61P35/00 ,  C07C215/76 ,  C07D209/08 ,  C07D209/12 ,  C07D209/14 ,  C07D209/18 ,  C07D215/56 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12

公开(公告)号：CA2733908C

公开(公告)日：2017-05-30

申请号：CA2733908

申请日：2009-08-13

Applicant: VERTEX PHARMA

Inventor： ROWE WILLIAM ,  HURTER PATRICIA ,  YOUNG CHRISTOPHER ,  DINEHART KIRK ,  VERWIJS MARINUS JACOBUS ,  OVERHOFF KIRK ,  GROOTENHUIS PETER D J ,  BOTFIELD MARTYN ,  GROSSI ALFREDO

IPC: A61K47/32

Abstract: The present invention relates to pharmaceutical compositions comprising a solid dispersion of N- [2,4-Bis( 1, 1-dimethylethyl)-5 -hydroxyphenyl]- 1,4-dihydro-4-oxoquinoline-3-carboxamide, and a polymer, wherein Compound 1 is present in an amount of about 80% by weight of the solid dispersion.

公开(公告)号：NZ719598A

公开(公告)日：2017-03-31

申请号：NZ71959808

申请日：2008-11-12

Applicant: VERTEX PHARMA

Inventor： RUAH SARA HADIDA S ,  MILLER MARK T ,  NUMA MEHDI MICHEL DJAMEL ,  ZHOU JINGLAN ,  VAN GOOR FREDRICK ,  GROOTENHUIS PETER D J ,  MCCARTNEY JASON ,  BEAR BRIAN

IPC: C07D405/12 ,  A61K31/404 ,  A61P3/00 ,  A61P25/00

Abstract: Disclosed herein is a use of an indol-cyclopropanecarboxamide derivative represented by structural formula shown herein in the manufacture of a medicament for treating a condition, disease, or disorder in a patient implicated by ABC transporter activity. Said compound is a modulator of ATP-Binding Cassette (’ABC’) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) and is also suitable for treating a condition, disease, or disorder selected from cystic fibrosis, hereditary emphysema, hereditary hemochromatosis, coagulation-fibrinolysis deficiencies, lipid processing deficiencies, lysosomal storage diseases, neurodegenerative diseases, polyglutamine neurological disorders, spongiform encephalopathies, chronic obstructive pulmonary disease (COPD), dry-eye disease, and Sjögren’s disease.

公开(公告)号：CA2856037C

公开(公告)日：2017-03-07

申请号：CA2856037

申请日：2006-12-28

Applicant: VERTEX PHARMA

Inventor： RUAH SARA S HADIDA ,  MILLER MARK T ,  BEAR BRIAN ,  MCCARTNEY JASON ,  GROOTENHUIS PETER D J

IPC: C07C237/24 ,  A61K31/00 ,  C07C311/46 ,  C07D207/12 ,  C07D307/79 ,  C07D317/60 ,  C07D319/18 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D498/04

Abstract: A compound of formula (I): (see formula I) or a pharmaceutically acceptable salt thereof, a pharmaceutical composition comprising a compound according to formula (I) and a pharmaceutically acceptable carrier, a kit for use in measuring the activity of an ABC transporter or a fragment thereof in a biological sample in vitro or in vivo, comprising a composition comprising the compound of formula (I) and instructions for a) contacting the composition with the biological sample and b) measuring activity of said ABC transporter or a fragment thereof, and use of an effective amount of the compound of formula (I) or the pharmaceutically acceptable salt thereof for treating or lessening the severity of a disease in a patient need thereof.

公开(公告)号：AU2016244296A1

公开(公告)日：2016-11-03

申请号：AU2016244296

申请日：2016-10-13

Applicant: VERTEX PHARMA

Inventor： DEMATTEI JOHN ,  LOOKER ADAM R ,  NEUBERT-LANGILLE BOBBIANNA J ,  TRUDEAU MARTIN ,  ROEPER STEFANIE ,  RYAN MICHAEL P ,  GUERETTE DAHRIKA MILFRED LAO YAP ,  KRUEGER BRIAN R ,  GROOTENHUIS PETER D J ,  VAN GOOR FREDRICK F ,  BOTFIELD MARTYN C ,  ZLOKARNIK GREGOR

IPC: C07D215/233

Abstract: The invention provides a process for the preparation of a compound of Formula 1, N H (Rx-X H R2 Formula 1 comprising coupling a carboxylic acid of Formula 2 (Rx-X OH Formula 2 with an aniline of Formula 3 Formula 3 in the presence of a coupling agent.

公开(公告)号：BRPI1012549A8

公开(公告)日：2016-10-04

申请号：BRPI1012549

申请日：2010-03-19

Applicant: VERTEX PHARMA

Inventor： GOOR FREDRICK F VAN ,  ZLOKARNIK GREGOR ,  BOTFIELD MARTYN C ,  GROOTENHUIS PETER D J ,  RUAH SARA S HADIDA ,  YANG XIAOQING

IPC: A61K31/47 ,  A61P3/00 ,  C07D215/233