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公开(公告)号：DE59208025D1
公开(公告)日：1997-03-20
申请号：DE59208025
申请日：1992-11-19
Applicant: BASF AG
Inventor： STRUBE KARL-HERMANN , BIALOJAN SIEGFRIED , KROEGER BURKHARD , FRIEDRICH THOMAS
IPC: A61K38/55 , A61K38/00 , A61P7/02 , C07K14/00 , C07K14/435 , C07K14/81 , C07K14/815 , C12N15/09 , C12N15/15 , C12P21/02 , C12R1/19
Abstract: PCT No. PCT/EP92/02661 Sec. 371 Date May 18, 1994 Sec. 102(e) Date May 18, 1994 PCT Filed Nov. 19, 1992 PCT Pub. No. WO93/11239 PCT Pub. Date Oct. 6, 1993.Novel thrombin-inhibitory proteins from terrestrial leeches of the genus Haemadipsa with the amino-acid sequence Ile-Arg-Phe-Gly-Met-Gly-Lys-Val-Pro-Cys-Pro-Asp-Gly-Glu-Val-Gly-Tyr-Thr-Cys-Asp-Cys-Gly-Glu-Lys-Ile-Cys-Leu-Tyr-Gly-Gln-Ser-Cys-Asn-Asp-Gly-Gln-Cys-Ser-Gly-Asp-Pro-Lys-Pro-Ser-Ser-Glu-Phe-Glu-Glu-Phe-Glu-Ile-Asp-Glu-Glu-Glu-Lys, or an amino-acid sequence which is obtained by C-terminal truncation of this sequence by from one to twelve amino acids, are described. The proteins are suitable for controlling diseases. Also described are the nucleic acids coding for these proteins.
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公开(公告)号：AT146526T
公开(公告)日：1997-01-15
申请号：AT92919916
申请日：1992-09-21
Applicant: BASF AG
Inventor： FRIEDRICH THOMAS , BIALOJAN SIEGFRIED , BOLLSCHWEILER CLAUS , KUENAST CHRISTOPH
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公开(公告)号：CA2121352A1
公开(公告)日：1993-05-13
申请号：CA2121352
申请日：1992-10-27
Applicant: BASF AG
Inventor： FRIEDRICH THOMAS , BIALOJAN SIEGFRIED , KROEGER BURKHARD , KUENAST CHRISTOPH
IPC: A61K35/64 , A61K38/00 , A61K38/55 , A61P7/02 , C07K14/00 , C07K14/245 , C07K14/435 , C07K14/81 , C12N15/15 , C12P21/02 , C12R1/19 , A61K38/57
Abstract: 2121352 9309232 PCTABS00022 The description relates to a novel thrombin inhibiting protein from reduvii with a molecular weight of some 12000 Dalton and the N-terminus Glu-Gly-Gly-Glu-Pro-Cys-Ala-Cys-Pro-His-Ala-Leu-His-Arg-Val-Cys-Gly-Ser-Asp. The protein is useful in combatting diseases.
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公开(公告)号：CA2121246A1
公开(公告)日：1993-05-13
申请号：CA2121246
申请日：1992-09-23
Applicant: BASF AG
Inventor： FRIEDRICH THOMAS , KOERWER WOLFGANG , KROEGER BURKHARD , BIALOJAN SIEGFRIED
IPC: A61K35/64 , A61K38/00 , A61K38/55 , A61P7/02 , C07K1/14 , C07K14/435 , C07K14/81 , C12N15/09 , C12N15/15 , C12P21/02 , A61K38/57
Abstract: 2121246 9309231 PCTABS00022 The invention relates to a novel thrombin-inhibiting protein from ticks with a molecular weight of some 26000 Dalton and which has the amino acid partial sequences Val-Ala-Lys-Phe-Ala-X-Asn-Ser-Gly-Ser-Glu-Thr-Gly, His-Ala-Y-Phe-Glu, Arg-Val-Ser-Asp-Phe-Glu and Phe-Val-Tyr-Thr-Ile-Glu, in which X and Y may be the same or different and stand for a naturally occurring amino acid. The protein is suitable for combatting diseases.
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Patent Agency Ranking
公开(公告)号：MX9206339A
公开(公告)日：1993-05-01
申请号：MX9206339
申请日：1992-11-04
Applicant: BASF AG
Inventor： FRIEDRICH THOMAS , BIALOJAN SIEGFRIED , KROEGER BURKHARD , KUENAST CHRISTIPH
IPC: A61K35/64 , A61K38/00 , A61K38/55 , A61P7/02 , C07K14/00 , C07K14/245 , C07K14/435 , C07K14/81 , C12N15/15 , C12P21/02 , C12R1/19
Abstract: PCT No. PCT/EP92/02450 Sec. 371 Date Apr. 26, 1994 Sec. 102(e) Date Apr. 26, 1994 PCT Filed Oct. 27, 1992 PCT Pub. No. WO93/09232 PCT Pub. Date May 13, 1993.A novel thrombin-inhibitory protein from assassin bugs with a molecular weight of about 12,000 dalton and the N terminus Glu-Gly-Gly-Glu-Pro-Cys-Ala-Cys-Pro-His-Ala-Leu-His-Arg-Val-Cys-Gly-Ser-Asp is described. The protein is suitable for controlling diseases.
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公开(公告)号：CA2110497A1
公开(公告)日：1993-01-21
申请号：CA2110497
申请日：1992-06-23
Applicant: BASF AG
Inventor： BRAATZ REINHARD , KURTH ROLAND , MENKEL-CONEN ELKE , RETTENMAIER HANSJOERG , FRIEDRICH THOMAS , SUBKOWSKI THOMAS
Abstract: 2110497 9300924 PCTABS00019 Described is the use of a bacterial lipase which shows a positive immunological cross-reaction to antibodies of the lipase to produce drugs for use in the therapy of digestive disorders. The lipase is formed from the species Psedomonas spec. DSM 6483 and/or Pseudomonas cepacia IAM 1057.
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公开(公告)号：NO332356B1
公开(公告)日：2012-09-03
申请号：NO20031213
申请日：2003-03-17
Applicant: BASF AG
Inventor： FRIEDRICH THOMAS
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公开(公告)号：EE05498B1
公开(公告)日：2011-12-15
申请号：EEP200300086
申请日：2001-08-30
Applicant: BASF AG
Inventor： HAUER BERNHARD , FRIEDRICH THOMAS , NUEBLING CHRISTOPH , STUERMER RAINER , LADNER WOLFGANG
IPC: C12N1/20 , C12N15/09 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/16 , C12N9/18 , C12N15/55 , C12N15/63 , C12P7/00 , C12P7/62 , C12P41/00 , C12R1/38
Abstract: The invention relates to novel proteins from Pseudomonas glumae, having esterase activity, in particular butynol I esterase activity, to nucleic acid sequences coding therefore, to expression cassettes, vectors and recombinant microorganisms; to methods for preparing said proteins and to the use thereof for enzymic, in particular enantioselective enzymic, ester hydrolysis or transesterification of organic esters.
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公开(公告)号：ES2280125T3
公开(公告)日：2007-09-01
申请号：ES99952558
申请日：1999-10-13
Applicant: BASF AG
Inventor： RESS-LOSCHKE MARION , FRIEDRICH THOMAS , HAUER BERNHARD , MATTES RALF , ENGELS DIRK
IPC: C12N9/78 , C12N15/09 , C07H21/00 , C12N1/21 , C12N15/55 , C12N15/63 , C12P7/40 , C12P7/42 , C12P41/00 , C12R1/05
Abstract: Una secuencia aislada de ácido nucleico que codifica para un polipéptido que tiene una actividad de nitrilasa, seleccionada del grupo de a) una secuencia de ácido nucleico que tiene representada en la SEQ ID NO: 1, b) secuencias de ácido nucleico que se derivan de la secuencia de ácido representada en la SEQ ID NO: 1 como un resultado de la degeneración del código genético. c) homólogos de la secuencia de ácido nucleico representada en la SEQ ID NO: 1, que codifican para polipéptidos que tienen al menos 98% de homología, por el rango entero de secuencia, a SEQ ID NO: 2, sin reducción en la acción enzimática de los polipéptidos.
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