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250 records (took 0.021 seconds)

    112.
    发明专利
    未知

    公开(公告)号：DE59208025D1

    公开(公告)日：1997-03-20

    申请号：DE59208025

    申请日：1992-11-19

    Applicant: BASF AG

    Inventor： STRUBE KARL-HERMANN ,  BIALOJAN SIEGFRIED ,  KROEGER BURKHARD ,  FRIEDRICH THOMAS

    IPC: A61K38/55 ,  A61K38/00 ,  A61P7/02 ,  C07K14/00 ,  C07K14/435 ,  C07K14/81 ,  C07K14/815 ,  C12N15/09 ,  C12N15/15 ,  C12P21/02 ,  C12R1/19

    Abstract: PCT No. PCT/EP92/02661 Sec. 371 Date May 18, 1994 Sec. 102(e) Date May 18, 1994 PCT Filed Nov. 19, 1992 PCT Pub. No. WO93/11239 PCT Pub. Date Oct. 6, 1993.Novel thrombin-inhibitory proteins from terrestrial leeches of the genus Haemadipsa with the amino-acid sequence Ile-Arg-Phe-Gly-Met-Gly-Lys-Val-Pro-Cys-Pro-Asp-Gly-Glu-Val-Gly-Tyr-Thr-Cys-Asp-Cys-Gly-Glu-Lys-Ile-Cys-Leu-Tyr-Gly-Gln-Ser-Cys-Asn-Asp-Gly-Gln-Cys-Ser-Gly-Asp-Pro-Lys-Pro-Ser-Ser-Glu-Phe-Glu-Glu-Phe-Glu-Ile-Asp-Glu-Glu-Glu-Lys, or an amino-acid sequence which is obtained by C-terminal truncation of this sequence by from one to twelve amino acids, are described. The proteins are suitable for controlling diseases. Also described are the nucleic acids coding for these proteins.

    Psod expression unit
    120.
    发明专利
    Psod expression unit 未知

    公开(公告)号：IN2599CH2006A

    公开(公告)日：2007-06-08

    申请号：IN2599CH2006

    申请日：2006-07-17

    Applicant: BASF AG

    Inventor： KROEGER BURKHARD ,  ZELDER OSKAR ,  KLOPPROGGE CORINNA ,  SCHROEDER HARTWIG ,  HAEFNER STEFAN

    IPC: C12N9/02 ,  C12N15/77

    Abstract: Use of a nucleic acid (I) with promoter activity for transcribing genes, where (I) is (a) a 173 nucleotide sequence (SEQ ID No.:1); (b) a variant of (SEQ ID No.:1) with at least 90% identity and derived by substitution, insertion or deletion of nucleotides; (c) a sequence that hybridizes to (SEQ ID No.:1) under stringent conditions; or (d) a functionally equivalent fragment of (a)-(c), is new. Independent claims are also included for: (1) use of an expression unit (EU), containing (I) and functionally linked to a sequence (X) that ensures translation of RNA, for expressing genes; (2) (I), other than sequence (SEQ ID No.:1), i.e. (Ia), as new compounds; (3) EU that contain (Ia) linked to (X); (4) altering (or producing) the transcription rate of genes in a microorganism, relative to the wild type; (5) expression cassette (EC) comprising at least one EU of (SEQ ID No.:1), at least one other nucleic acid sequence (to be expressed) and optionally additional gene control elements, where at least the first two are linked and the sequence being expressed is heterologous with respect to EU; (6) expression vector (EV) that contains EC; (7) genetically modified microorganisms (GMO) having, for at least one gene, an altered (or induced) transcription rate, relative to the wild type; (8) preparing biosynthetic products by culturing GMO of (7); (9) use of the sequence gaaagga (SEQ ID No.:44) as a ribosome-binding site in expression units that provide expression of genes in Corynebacterium or Brevibacterium; (10) use of the sequences tgcaat (SEQ ID No.:42) and tatcatt (SEQ ID No.:43) as -10 regionS for expression of genes in Corynebacterium or Brevibacterium; and (11) expression units that contain sequences (SEQ ID No.:42) - (SEQ ID No.:44).

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