公开(公告)号：AU7997798A

公开(公告)日：1999-02-25

申请号：AU7997798

申请日：1998-08-13

Applicant: BASF AG

Inventor： HABECK THORSTEN ,  HAREMZA SYLKE ,  SCHEHLMANN VOLKER ,  WESTENFELDER HORST ,  WUNSCH THOMAS ,  DROGEMULLER MICHAEL ,  BOMM VOLKER

IPC: A61K8/00 ,  A61K8/35 ,  A61K8/37 ,  A61K8/40 ,  A61K8/41 ,  A61K8/42 ,  A61K31/12 ,  A61K31/122 ,  A61K31/216 ,  A61K31/277 ,  A61Q1/00 ,  A61Q1/04 ,  A61Q17/04 ,  C07C69/618 ,  C07C69/76 ,  C07C233/00 ,  C07C233/11 ,  C07C235/34 ,  A61K7/44 ,  A61K31/165 ,  A61K31/215 ,  C07C57/48 ,  C07C57/30

Abstract: Use of 4,4-diarylbutadienes (I) as photostable UV filters in cosmetics for protecting the skin and hair from the sun's rays. The use of 4,4-diarylbutadiene derivatives of formula (I) as a cosmetic preparation is new: Where the diene system is Z,Z; Z,E; E,Z or E,E; R1, R2 = H, 1-20C alkyl, 2-10C alkenyl, 3-10C cycloalkyl, 3-10C cycloalkenyl, 1-12C alkoxy, 1-20C alkoxycarbonyl, 1-12C alkylamino, 1-12C dialkylamino, aryl, heteroaryl (optionally substituted by carboxylate, sulfonate or ammonium residues); R3 = H, COOR5, COR5, CONR5,R6, CN, O=S(R5)=O, O=S(OR5)=O, R7OP(OR8)=O, 1-20C alkyl, 2-10C alkenyl, 3-10C cycloalkyl, 7-10C bicycloalkyl, 3-10C cycloalkenyl, 7-10C bicycloalkenyl, aryl or heteroaryl (optionally substituted); R4 = COOR6, COR6, CONR5,R6, CN, O=S(R6)=O, O=S(OR6)=O, R7OP(OR8)=O, 1-20C alkyl, 2-10C alkenyl, 3-10C cycloalkyl, 7-10C bicycloalkyl, 3-10C cycloalkenyl, 7-10C bicycloalkenyl, aryl or heteroaryl (optionally substituted); R5-R8 = H, 1-20C alkyl, 2-10C alkenyl, 3-10C cycloalkyl, 7-10C bicycloalkyl, 3-10C cycloalkenyl, 7-10C bicycloalkenyl, aryl or heteroaryl (optionally substituted); and n = 1-3; where R3-R8 may in each case together with the C atoms to which they are bonded, form a 5- or 6-membered ring which may be further fused.

公开(公告)号：DE19746654A1

公开(公告)日：1999-02-18

申请号：DE19746654

申请日：1997-10-22

Applicant: BASF AG

Inventor： HABECK THORSTEN DR ,  HAREMZA SYLKE DR ,  SCHEHLMANN VOLKER DR ,  WESTENFELDER HORST ,  WUENSCH THOMAS DR ,  DROEGEMUELLER MICHAEL DR ,  BOMM VOLKER DR

IPC: A61K8/35 ,  A61K8/37 ,  A61K8/40 ,  A61K8/42 ,  A61K31/12 ,  A61K31/122 ,  A61K31/216 ,  A61K31/277 ,  A61Q1/04 ,  A61Q17/04 ,  C07C69/618 ,  C07C233/11 ,  C07C235/34 ,  A61K7/44 ,  A61K31/215

Abstract: The use of 4,4-diaryl-butadiene derivatives of formula (I), in which the diene system has Z,Z-, Z,E-, E,Z- or Z,Z-configuration (or a mixture of these), is claimed as photostable ultraviolet (UV) stabilisers in cosmetic or pharmaceutical preparations for protecting human skin against sunlight, (I) optionally being used in combination with known UV absorbers. R1,R2 = H; 1-20C alkyl, 2-10C alkenyl, 3-10C cycloalkyl, 3-10C cycloalkenyl, 1-12C alkoxy, 1-20C alkoxycarbonyl, mono- or di-(1-12C alkyl)-amino, aryl or heteroaryl (all optionally substituted); or water-solubilising substituents selected from carboxylate, sulphonate and ammonium; R3 = H or (all optionally substituted) COOR5, COR5, CONR5R6, CN, SO2R5, SO2OR5, P(O)(OR7)(OR8), 1-20C alkyl, 2-10C alkenyl, 3-10C cycloalkyl, 7-10C bicycloalkyl, 3-10C cycloalkenyl, 7-10C bicycloalkenyl, aryl or heteroaryl; R4 = as R3 but not H; R5-R8 = H or (all optionally substituted) 1-20C alkyl, 2-10C alkenyl, 3-10C cycloalkyl, 7-10C bicycloalkyl, 3-10C cycloalkenyl, 7-10C bicycloalkenyl, aryl or heteroaryl; or groups R3-R8 can together complete a 5- or 6-membered ring (optionally further fused). Also claimed are : (i) the use of (I) as photostable UV-A filters; (ii) the use of (I) as UV stabilisers in cosmetic and pharmaceutical compositions; (iii) cosmetic or pharmaceutical compositions for protecting the human epidermis or hair against UV light in the 280-400 nm region, comprising (I) and optionally known UV absorbers in a suitable carrier; (iv) (I) for use as medicament; and (v) pharmaceutical preparations containing (I).

公开(公告)号：ES2123811T3

公开(公告)日：1999-01-16

申请号：ES94924232

申请日：1994-07-05

Applicant: BASF AG

Inventor： SCHADE CHRISTIAN ,  WESTENFELDER HORST ,  SPERLING-VIETMEIER KARIN ,  SANNER AXEL ,  WEKEL HANS-ULRICH

IPC: A61K8/06 ,  A61K8/72 ,  A61K8/81 ,  A61K47/30 ,  A61K9/113 ,  A61K47/32 ,  C08F2/08 ,  C08F20/04 ,  C08F20/06 ,  C08F220/00 ,  C08F220/06 ,  C08F220/08 ,  C08F222/00 ,  C08K3/20 ,  C09K23/00 ,  C09K23/52 ,  A61K7/48

Abstract: The use of crosslinked copolymers obtainable by precipitation polymerization of monomer mixtures comprising(a) monoethylenically unsaturated C3-C8-carboxylic acids, their anhydrides or mixtures of said carboxylic acids and anhydrides,(b) compounds with at least 2 non-conjugated ethylenic double bonds in the molecule as crosslinkers and, where appropriate,(c) other monoethylenically unsaturated monomers which are copolymerizable with monomers (a) and (b),in the presence of free-radical polymerization initiators and from 0.1 to 20% by weight, based on the monomers used, of saturated, nonionic surface-active compounds, as stabilizer in oil-in-water emulsions in amounts of from 0.01 to 5% of the weight of the emulsions, and cosmetic and pharmaceutical formulations based on oil-in-water emulsions which contain said precipitation polymers.

公开(公告)号：DE19719006A1

公开(公告)日：1998-11-12

申请号：DE19719006

申请日：1997-05-06

Applicant: BASF AG

Inventor： WEKEL HANS-ULRICH DR ,  BUSSCHE-HUENNEFELD LINDA JOAN ,  STREICHER HARALD DR ,  WESTENFELDER HORST

IPC: A61K8/30 ,  A61K8/36 ,  A61K8/365 ,  A61K8/40 ,  A61K8/42 ,  A61K8/60 ,  A61Q17/04 ,  A61Q19/00 ,  C07C273/02 ,  C07C273/18 ,  C07C275/50 ,  C07H13/12 ,  A61K7/48

公开(公告)号：ES2120892A1

公开(公告)日：1998-11-01

申请号：ES9601577

申请日：1996-07-15

Applicant: BASF AG

Inventor： KANDZIA CHRISTOF ,  WESTENFELDER HORST

IPC: C09K3/00 ,  A61K8/37 ,  A61K8/67 ,  A61Q17/04 ,  C09K15/08 ,  A61K7/42

Abstract: AGENTES PROTECTORES CONTRA LA LUZ QUE CONTIENEN ESTERES DEL ACIDO P-METOXICINAMICO, ESTABILIZADOS, CONTRA LA OXIDACION, CONSTITUIDOS POR (A) ESTERES DEL ACIDO P-METOXICINAMICO DE ACCION FILTRANTE DE LOS W Y (B) CANTIDADES SUBORDINADOS DE TOCOFEROL O BIEN DE SU ACETATO COMO ANTIOXIDANTE.

公开(公告)号：DE19712033A1

公开(公告)日：1998-09-24

申请号：DE19712033

申请日：1997-03-21

Applicant: BASF AG

Inventor： HABECK THORSTEN DR ,  AUMUELLER ALEXANDER DR ,  SCHEHLMANN VOLKER DR ,  WESTENFELDER HORST ,  WUENSCH THOMAS DR ,  HAREMZA SYLKE DR

IPC: A61K8/41 ,  A61K8/42 ,  A61K8/46 ,  A61K8/49 ,  A61Q1/04 ,  A61Q17/04 ,  C07C229/56 ,  C07C229/60 ,  C07C255/30 ,  C07C255/58 ,  C07D275/02 ,  C07D275/03 ,  C07D319/06 ,  A61K7/42 ,  A61K31/235 ,  A61K31/275 ,  A61K31/425

Abstract: Use of enamine derivatives of formula (R )(R NH)C=C(R )(R ) (I) as UV filters in cosmetic and pharmaceutical preparations for protection of hair or skin against sun-radiation, alone or in combination with UV absorbers is new: R = COOR , COR , CONR R , CN, SO2R , SO2OR or P(=O)OR OR ; R = COOR , COR , CONR R , CN, SO2R , SO2OR or P(=O)OR OR ; R = H, or optionally substituted aliphatic, cycloaliphatic, arylaliphatic or aromatic residue with up to 18C; R = optionally substituted 5-12C aromatic or heteroaromatic residue; and R , R = H or aliphatic, arylaliphatic, cycloaliphatic, or optionally substituted aromatic with up to 18C; or R -R together with their bonded carbon atoms may form a 5-6 membered ring which may be further annelated.

公开(公告)号：ITMI961443A3

公开(公告)日：1998-01-12

申请号：ITMI961443

申请日：1996-07-12

Applicant: BASF AG

Inventor： KANDZIA CHRISTOF ,  WESTENFELDER HORST

IPC: C09K3/00 ,  A61K8/37 ,  A61K8/67 ,  A61Q17/04 ,  C09K15/08

公开(公告)号：ITMI961443A1

公开(公告)日：1998-01-12

申请号：ITMI961443

申请日：1996-07-12

Applicant: BASF AG

Inventor： KANDZIA CHRISTOF ,  WESTENFELDER HORST

IPC: C09K3/00 ,  A61K20060101 ,  A61K8/37 ,  A61K8/67 ,  A61Q17/04 ,  C09K15/08

公开(公告)号：DE19609900A1

公开(公告)日：1997-09-18

申请号：DE19609900

申请日：1996-03-13

Applicant: BASF AG

Inventor： KANDZIA CHRISTOF DR ,  WESTENFELDER HORST

IPC: A61K8/35 ,  A61Q17/04 ,  C07C45/51 ,  C07C45/74 ,  C07C49/683 ,  C07C49/697 ,  C07C49/753 ,  C07C225/22 ,  C09K15/06 ,  C07C49/437 ,  A61K7/42 ,  A61K7/48 ,  A61K31/125

Abstract: Cinnamylidene camphor derivatives of formula (I) and where the diene system has the E,E; E,Z; Z,E or Z,Z configuration, are new. - R1 = H or Me; - R2 = 1-6C alkyl, 1-6C alkoxy, halo, NHR3 or N(R3)2; - R3 = 1-4C alkyl; - R4 = H or 1-6C alkyl; - n = 1 or 2.

公开(公告)号：DE59306889D1

公开(公告)日：1997-08-14

申请号：DE59306889

申请日：1993-04-14

Applicant: BASF AG

Inventor： SCHADE CHRISTIAN ,  SANNER AXEL ,  WEKEL HANS-ULRICH ,  FROSCH FRANZ ,  WESTENFELDER HORST

IPC: A61K47/30 ,  A61K8/06 ,  A61K8/72 ,  A61K8/81 ,  A61K9/10 ,  A61K47/32 ,  A61Q19/00 ,  C08F20/02 ,  C08F20/10 ,  C08F20/26 ,  C08F220/02 ,  C08F220/04 ,  C08F220/06 ,  C08F220/20 ,  C08F220/28 ,  C08F222/00 ,  C08F222/02 ,  C08F222/04 ,  C08L33/02 ,  C09K23/52 ,  A61K7/48

Abstract: The use of copolymers obtainable by the radically initiated polymerization of A) 50 to 99.9 wt % of an olefinically unsaturated C3 to C5 monocarboxylic acid, an olefinically unsaturated C4 to C8 dicarboxylic acid or its anhydride, or a mixture of such carboxylic acids or carboxylic acid anhydrides with B) 0.1 to 50 wt % of one or more long-chained compounds with isolated multiple C-C bonds from the group (1) mono or polyunsaturated C8 to C30 monocarboxylic acids which may have additional hydroxyl groups and their alkaline metal and earth alkaline metal salts, alkyl esters, amides, sorbitane esters, glycerin esters and polyglycerin esters, (2) mono or polyunsaturated aliphatic Ca to C30 amines, (3) mono or polyunsaturated C8 to C30 alcohols and esters thereof with saturated Cl to C4 monocarboxylic acids, (4) to (C8 to C30 alkyl) vinyl ether which may incorporate up to 25 alkylene oxide units, and (5) final and medium-position Ci3 to C30 alkenes; C) 0 to 49.9 wt % of other copolymerizable monomers, and D) 0 to 10 wt % of one or more compounds with at least two olefinically unsaturated groups in the molecule as cross-linking agents, as thickening or dispersing agents, especially in cosmetic and pharmaceutical preparations.