公开(公告)号：CA2904641A1

公开(公告)日：2014-10-02

申请号：CA2904641

申请日：2014-03-12

Applicant: VERTEX PHARMA

Inventor： MAXWELL JOHN PATRICK ,  CHARIFSON PAUL S ,  TANG QING ,  RONKIN STEVEN M ,  JACKSON KATRINA LEE ,  PIERCE ALBERT CHARLES ,  LAUFFER DAVID J ,  LI PAN ,  GIROUX SIMON ,  WAAL NATHAN D ,  XU JINWANG ,  GU WENXIN ,  MORRIS MARK A ,  COTTRELL KEVIN M ,  COURT JOHN J ,  DENG HONGBO

IPC: C07D403/12 ,  A61K31/517 ,  A61P35/00 ,  C07D405/12 ,  C07D413/04 ,  C07D417/12 ,  C07D491/052

Abstract: The present invention relates to compounds (I) useful as inhibitors of DNA-PK. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.

公开(公告)号：SG191945A1

公开(公告)日：2013-08-30

申请号：SG2013053418

申请日：2012-01-13

Applicant: VERTEX PHARMA

Inventor： SHANNON DEAN ,  WANG TIANSHENG ,  GIROUX SIMON

Abstract: The present application is directed to compounds, intermediates and methods for preparing compounds of formula (I), or a pharmaceutically acceptable salts thereof, wherein R is H or F, and each of R3, R4, and R5 are as defined herein. The compounds of formula (I) and pharmaceutical compositions comprising said compounds and salts inhibit bacterial gyrase and/or Topo IV and are useful in treating bacterial infections.

公开(公告)号：AU2011232331A1

公开(公告)日：2012-10-11

申请号：AU2011232331

申请日：2011-03-24

Applicant: VERTEX PHARMA

Inventor： DAS SANJOY KUMAR ,  BENNANI YOUSSEF L ,  KONG LAVAL CHAN CHUN ,  MAXWELL JOHN ,  REDDY JAGADEESWAR ,  YANNOPOULOS CONSTANTIN ,  LIU BINGCAN ,  CADILHAC CAROLINE ,  GIROUX SIMON ,  HENDERSON JAMES ,  DENIS REAL ,  VAILLANCOURT LOUIS ,  PEREIRA OSWY ,  POISSON CARL ,  FALARDEAU GUY ,  MORRIS MARK

IPC: C07D403/14 ,  A61K31/4184 ,  A61P31/14 ,  C07D401/14 ,  C07D405/14 ,  C07D409/14 ,  C07D471/14 ,  C07D495/04

Abstract: Compounds represented by formula I as described herein or pharmaceutically acceptable salts thereof, wherein A, B, B', X, Y, R, R, R', R, R', R, R', R, R', m, n, or p are as defined herein, are useful for treating flaviviridae viral infections.

公开(公告)号：CA2794181A1

公开(公告)日：2011-09-29

申请号：CA2794181

申请日：2011-03-24

Applicant: VERTEX PHARMA

Inventor： KONG LAVAL CHAN CHUN ,  DAS SANJOY KUMAR ,  BENNANI YOUSSEF L ,  REDDY T JAGADEESWAR ,  GIROUX SIMON ,  YANNOPOULOS CONSTANTIN ,  COTTRELL KEVIN M ,  XU JINGWANG ,  MORRIS MARK A ,  SANJOY KUMAR DAS ,  LIU BINGCAN

IPC: C07D495/04

Abstract: Compounds represented by formula (I) : or pharmaceutically acceptable salts thereof, wherein A, B, B', X, Y, R1, R2, R2', R3, R3', R4, R4', R5, R5'm, n, or p are as defined herein, are useful for treating flaviviridae viral infections.