公开(公告)号：EP2936222A4

公开(公告)日：2016-09-07

申请号：EP13863794

申请日：2013-12-16

Applicant: PACIFIC BIOSCIENCES CALIFORNIA

Inventor： GROT ANNETTE ,  WANG SHANG ,  CALLEBAUT HANS ,  LUNDQUIST PAUL ,  TURNER STEPHEN

IPC: G01N21/64 ,  B82Y5/00 ,  B82Y15/00 ,  B82Y20/00 ,  G01N21/77 ,  G01N33/543 ,  G01N33/553 ,  G02B6/10

CPC classification number: G02B6/0016 ,  B82Y15/00 ,  B82Y20/00 ,  G01N21/6452 ,  G01N21/648 ,  G01N21/6486 ,  G01N21/7703 ,  G02B6/024 ,  G02B6/10 ,  G02B6/12004 ,  G02B6/122 ,  G02B23/2461

Abstract: Optical analytical devices and their methods of use are provided. The devices are useful in the analysis of highly multiplexed optical reactions in large numbers at high densities, including biochemical reactions, such as nucleic acid sequencing reactions. The devices include optical waveguides for illumination of the optical reactions. The devices further provide for the efficient coupling of optical excitation energy from the waveguides to the optical reactions. Optical signals emitted from the reactions can thus be measured with high sensitivity and discrimination using features such as spectra, amplitude, and time resolution, or combinations thereof. The devices of the invention are well suited for miniaturization and high throughput.

公开(公告)号：EP2959283A4

公开(公告)日：2016-08-03

申请号：EP14754479

申请日：2014-02-21

Applicant: PACIFIC BIOSCIENCES CALIFORNIA

Inventor： LUNDQUIST PAUL ,  TURNER STEPHEN

IPC: G01N21/17 ,  C12Q1/68 ,  G01N21/63 ,  G01N21/64

CPC classification number: C12Q1/6874 ,  G01N21/6428 ,  G01N21/6454 ,  G01N21/648 ,  G01N21/7746 ,  G01N2021/7789 ,  G01N2201/08 ,  G02B6/0229 ,  G02B2006/12147

Abstract: Optical analytical devices and their methods of use are provided. The devices are useful in the analysis of highly multiplexed optical reactions in large numbers at high densities, including biochemical reactions, such as nucleic acid sequencing reactions. The devices include integrated illumination elements and optical waveguides for illumination of the optical reactions. The devices further provide for the efficient coupling of optical excitation energy from the waveguides to the optical reactions. Optical signals emitted from the reactions can thus be measured with high sensitivity and discrimination using features such as spectra, amplitude, and time resolution, or combinations thereof. The devices of the invention are well suited for miniaturization and high throughput.

公开(公告)号：EP2064488A4

公开(公告)日：2016-01-06

申请号：EP07814642

申请日：2007-08-31

Applicant: PACIFIC BIOSCIENCES CALIFORNIA

Inventor： LUNDQUIST PAUL ,  TURNER STEPHEN

IPC: F21V9/16 ,  G01N21/64 ,  G01N21/77 ,  G02B6/43

CPC classification number: G01N21/648 ,  G01N21/6428 ,  G01N21/6452 ,  G01N21/7703 ,  G01N2021/7786 ,  G02B6/43

公开(公告)号：EP1984670A4

公开(公告)日：2013-03-06

申请号：EP07750409

申请日：2007-02-09

Applicant: PACIFIC BIOSCIENCES CALIFORNIA

Inventor： LUNDQUIST PAUL ,  ZACCARIN DENIS ,  LACROIX YVES ,  MAXHAM MARK ,  FOQUET MATHIEU ,  TURNER STEPHEN

IPC: G01N21/64 ,  G01J3/44

CPC classification number: G01N21/6452 ,  G01J3/02 ,  G01J3/0224 ,  G01J3/10 ,  G01J3/14 ,  G01J3/2803 ,  G01N21/6445 ,  G01N21/6456 ,  G01N21/648 ,  G01N2021/6417 ,  G01N2021/6441

公开(公告)号：EP2370598A4

公开(公告)日：2012-06-13

申请号：EP09832251

申请日：2009-12-10

Applicant: PACIFIC BIOSCIENCES CALIFORNIA

Inventor： FLUSBERG BENJAMIN ,  TURNER STEPHEN ,  LEE JESSICA ,  JIA LEI ,  KORLACH JONAS ,  SORENSON JON ,  WEBSTER DALE ,  LYLE JOHN ,  TRAVERS KEVIN ,  HANES JEREMIAH

IPC: C12Q1/68 ,  C12N15/10

CPC classification number: C12Q1/6869 ,  C12Q1/6837 ,  C12Q1/6858 ,  C12Q2561/113 ,  C12Q2537/164 ,  C12Q2527/113 ,  C12Q2521/101 ,  C12Q2525/307 ,  C12Q2525/117

公开(公告)号：EP2203566A4

公开(公告)日：2011-02-09

申请号：EP08836415

申请日：2008-09-26

Applicant: PACIFIC BIOSCIENCES CALIFORNIA

Inventor： HEINER CHERYL ,  TURNER STEPHEN ,  TRAVERS KEVIN

IPC: C12Q1/68 ,  C07H21/04

CPC classification number: C12Q1/6806 ,  C12Q1/6869 ,  C12Q2563/179 ,  C12Q2563/155 ,  C12Q2525/307

公开(公告)号：EP3332032A1

公开(公告)日：2018-06-13

申请号：EP16833794

申请日：2016-08-03

Applicant: PACIFIC BIOSCIENCES CALIFORNIA INC

Inventor： TURNER STEPHEN ,  KORLACH JONAS ,  WARREN STEVEN

IPC: C12Q1/68 ,  B01L3/00 ,  C12M1/34 ,  G01N27/22 ,  H01L31/109

CPC classification number: C12Q1/6869 ,  B82Y10/00 ,  B82Y15/00 ,  G01N27/4145 ,  G01N27/4146 ,  G01N27/4148 ,  G11C19/28 ,  H01L29/0669 ,  H01L29/0673 ,  H01L29/1606

Abstract: A circuit comprising a substrate with sectors on the substrate is provided, each sector comprising clock and data lines, a controller in electrical communication with the clock and data lines, a counter bias line, an amplifier input line and nano-electronic measurement devices on the substrate. A source of each device is coupled to the counter bias line and a drain of each device is coupled to the amplifier input line to obtain an electrical signal on the drain, the identity of which is determined by electrical interaction between the device and a charge label. Each device drain is gated by a corresponding switch between an on state, in which the drain is connected to the amplifier input line, and an off state, in which the drain is isolated from the amplifier input line. The controller controls switch states responsive to clock signal line pulses and data input line data.

公开(公告)号：EP2831283A4

公开(公告)日：2015-11-04

申请号：EP13769322

申请日：2013-03-18

Applicant: PACIFIC BIOSCIENCES CALIFORNIA

Inventor： KORLACH JONAS ,  TURNER STEPHEN ,  CLARK TYSON A

IPC: C12Q1/68 ,  G01N33/48

CPC classification number: C12Q1/6869 ,  C12Q1/6827 ,  C12Q2535/122 ,  C12Q2537/164 ,  C12Q2521/514

公开(公告)号：EP2537019A4

公开(公告)日：2014-03-12

申请号：EP11745384

申请日：2011-02-18

Applicant: PACIFIC BIOSCIENCES CALIFORNIA

Inventor： MCCAFFREY NATHANIEL JOSEPH ,  TURNER STEPHEN ,  SAXENA RAVI ,  HELGESEN SCOTT EDWARD

IPC: G01N21/64 ,  B82Y20/00 ,  G01N21/03 ,  G01N21/05

CPC classification number: C12Q1/6874 ,  B01L3/502707 ,  B01L3/502715 ,  B01L2300/0654 ,  B01L2300/0663 ,  B01L2300/0816 ,  B01L2300/168 ,  B82Y20/00 ,  C12Q1/6825 ,  C12Q1/6869 ,  G01N21/03 ,  G01N21/0303 ,  G01N21/05 ,  G01N21/64 ,  G01N21/6428 ,  G01N21/645 ,  G01N21/6452 ,  G01N21/6454 ,  G01N21/6456 ,  G01N21/648 ,  G01N21/75 ,  G01N21/77 ,  G01N33/54373 ,  G01N2021/0346 ,  G01N2021/6434 ,  G01N2021/6439 ,  G01N2021/6441 ,  G01N2021/6463 ,  G01N2021/757 ,  G01N2021/7786 ,  G01N2201/067 ,  G01N2201/068 ,  G01N2201/08 ,  G02B6/1226 ,  Y10T436/143333

Abstract: A system for measuring analytical reactions comprising a socket (51, 57) which is suitable for holding an optode array chip (40).The socket comprises electrical contacts that mate with electrical contacts on a chip when such a chip is inserted into the socket. The socket furthermore permits fluid from a fluidics system (33) and illumination from an illumination system (53) to be for delivered to a chip when such a chip is inserted into the socket. The socket may be of the clam shell type.

Abstract translation: 一种用于测量分析反应的系统，包括适于保持光栅阵列芯片（40）的插座（51,57）。当这种芯片插入插座时，该插座包括与芯片上的电触点相配合的电触点。 插座还允许来自流体系统（33）的流体和来自照明系统（53）的照明在将芯片插入插座时被输送到芯片。 插座可以是蛤壳型。

公开(公告)号：EP2537010A4

公开(公告)日：2013-12-25

申请号：EP11745387

申请日：2011-02-18

Applicant: PACIFIC BIOSCIENCES CALIFORNIA ,  FEHR ADRIAN ,  MCCAFFREY NATHANIEL JOSEPH ,  TURNER STEPHEN

Inventor： FEHR ADRIAN ,  MCCAFFREY NATHANIEL JOSEPH ,  TURNER STEPHEN

IPC: G01N21/64 ,  G01J3/02 ,  G01N33/543

CPC classification number: C12Q1/6874 ,  B01L3/502707 ,  B01L3/502715 ,  B01L2300/0654 ,  B01L2300/0663 ,  B01L2300/0816 ,  B01L2300/168 ,  B82Y20/00 ,  C12Q1/6825 ,  C12Q1/6869 ,  G01N21/03 ,  G01N21/0303 ,  G01N21/05 ,  G01N21/64 ,  G01N21/6428 ,  G01N21/645 ,  G01N21/6452 ,  G01N21/6454 ,  G01N21/6456 ,  G01N21/648 ,  G01N21/75 ,  G01N21/77 ,  G01N33/54373 ,  G01N2021/0346 ,  G01N2021/6434 ,  G01N2021/6439 ,  G01N2021/6441 ,  G01N2021/6463 ,  G01N2021/757 ,  G01N2021/7786 ,  G01N2201/067 ,  G01N2201/068 ,  G01N2201/08 ,  G02B6/1226 ,  Y10T436/143333

Abstract: A system for measuring analytical reactions comprising a socket (51, 57) which is suitable for holding an optode array chip (40).The socket comprises electrical contacts that mate with electrical contacts on a chip when such a chip is inserted into the socket. The socket furthermore permits fluid from a fluidics system (33) and illumination from an illumination system (53) to be for delivered to a chip when such a chip is inserted into the socket. The socket may be of the clam shell type.

Abstract translation: 一种用于测量分析反应的系统，包括适于保持光栅阵列芯片（40）的插座（51,57）。当这种芯片插入插座时，该插座包括与芯片上的电触点相配合的电触点。 插座还允许来自流体系统（33）的流体和来自照明系统（53）的照明在将芯片插入插座时被输送到芯片。 插座可以是蛤壳型。