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    Multiple Sample Attachment to Nano Manipulator for High Throughput Sample Preparation
    133.
    发明公开
    Multiple Sample Attachment to Nano Manipulator for High Throughput Sample Preparation 有权
    Mehrfachprobennahmebefestigung an Nanomanipulator zur Probenvorbereitung mit hohem Durchsatz

    公开(公告)号：EP2778652A3

    公开(公告)日：2016-05-25

    申请号：EP14159460.6

    申请日：2014-03-13

    Applicant: FEI COMPANY

    Inventor： Schmidt, Michael ,  Stone, Stacey ,  Senowitz, Corey

    IPC: G01N1/28 ,  H01J37/20 ,  H01J37/302

    CPC classification number: H01J37/3023 ,  G01N1/286 ,  H01J2237/201 ,  H01J2237/208 ,  H01J2237/31745

    Abstract: An improved method for extracting and handling multiple samples for S/TEM analysis is disclosed. Preferred embodiments of the present invention make use of a micromanipulator that attaches multiple samples at one time in a stacked formation and a method of placing each of the samples onto a TEM grid. By using a method that allows for the processing of multiple samples, the throughput of sample prep in increased significantly.

    Abstract translation: 公开了一种用于提取和处理多个样品进行S / TEM分析的改进方法。 本发明的优选实施例利用将叠层结构中的多个样品同时附着的显微操纵器和将每个样品放置在TEM网格上的方法。 通过使用允许多个样品处理的方法，样品制备的生产量显着增加。

    TEM-lamella, process for its manufacture, and apparatus for executing the process
    135.
    发明公开
    TEM-lamella, process for its manufacture, and apparatus for executing the process 有权
    TEM薄片，它们的制备方法以及用于执行该方法的装置中的处理

    公开(公告)号：EP2413126A3

    公开(公告)日：2012-02-29

    申请号：EP11006234.6

    申请日：2011-07-28

    Applicant: Universität Ulm ,  Carl Zeiss NTS GmbH

    Inventor： Lechner, Lorenz ,  Kaiser, Ute ,  Biskupek, Johannes

    IPC: G01N1/32 ,  H01J37/20

    CPC classification number: G01N1/28 ,  G01N1/32 ,  H01J37/20 ,  H01J37/3056 ,  H01J2237/201 ,  H01J2237/20207 ,  H01J2237/31745 ,  Y10T428/24479

    Abstract: A process for manufacturing a TEM-lamella includes mounting (51) a plate shaped substrate having a thickness in a support, manufacturing (53) a first strip-shaped recess on a first side of the substrate under a first angle to the support by means of a particle beam, and manufacturing (55) a second strip-shaped recess on a second side of the substrate under a second angle to the support by means of a particle beam, such that the first and the second strip-shaped recess mutually form an acute or right angle, and between them form an overlap region of lesser thickness. The lamella has a thicker rim region and a thinner central region, with a first strip-shaped recess on a first side of the lamella and a second strip-shaped recess on a second side of the lamella, wherein the first and the second strip-shaped recess mutually form an acute or right angle, and between them form an overlap region having a thickness of below 100 nm. An apparatus for executing the process or manufacturing the lamella includes a lamella support pivotable about a transverse axis and a longitudinal axis inclined to the vertical direction, a device for rotating about the longitudinal axis, and stop means for limiting a tilt of the lamella support about the transverse axis.

    Protein layers and their use in X-ray crystallography
    136.
    发明公开
    Protein layers and their use in X-ray crystallography 审中-公开
    Proteinschichten und deren Verwendungen in derRöntgen-Kristallographie

    公开(公告)号：EP2380902A1

    公开(公告)日：2011-10-26

    申请号：EP11166962.8

    申请日：2008-04-23

    Applicant: ISIS Innovation Limited

    Inventor： Sinclair, John Charles ,  Noble, Martin Edward Mäntylä

    IPC: C07K14/00 ,  C07K14/47 ,  C07K19/00 ,  G01N1/28 ,  H01J37/20

    CPC classification number: C07K14/001 ,  C07K14/24 ,  C07K14/47 ,  C07K19/00 ,  C07K2319/00 ,  H01J37/20 ,  H01J37/295 ,  H01J2237/201

    Abstract: Protein layers 1 repeating regularly in two dimensions comprise protein protomers 2 which each comprise at least two monomers 5, 6 genetically fused together. The monomers 5, 6 are monomers of respective oligomer assemblies 3, 4 into which the monomers are assembled to assembly of the protein layer. The first oligomer assembly 3 belongs to a dihedral point group of order O, where O equals 3, 4 or 6 and has a set of O rotational symmetry axes of order 2. The second oligomer assembly 4 has a rotational symmetry axis of order 2. Due to the symmetry of the oligomer assemblies 3, 4, the rotational symmetry axes of each second oligomer assembly 4 is aligned with one of said set of O rotational symmetry axes of a first oligomer assembly 3 with 2 protomers being arranged symmetrically therearound. Thus, an 2-fold fusion between the oligomer assemblies 3, 4 is produced and the arrangements of the rotational symmetry axes of the oligomer assemblies 3, 4 cause the protein layer to repeat regularly. The protein layer has many uses, for example to support molecular entities for biosensing, x-ray crystallography or electron microscopy.

    Abstract translation: 蛋白质层1在两个维度上规则地重复地包含蛋白质检测器2，每个包含至少两个基因上融合在一起的单体5,6。 单体5,6是各个低聚物组件3,4的单体，其中单体被组装成蛋白质层的组装。 第一低聚物组件3属于阶数为O的二面点组，其中O等于3,4或6，并且具有一组具有2级的O旋转对称轴。第二低聚物组件4具有2级的旋转对称轴。 由于低聚物组件3,4的对称性，每个第二低聚物组件4的旋转对称轴线与第一低聚物组件3的所述一组O旋转对称轴线中的一个对准，其中两个探测器对称地布置。 因此，产生低聚物组件3,4之间的2倍融合，并且低聚物组件3,4的旋转对称轴的布置导致蛋白质层定期重复。 蛋白质层具有许多用途，例如支持用于生物传感，X射线晶体学或电子显微镜的分子实体。

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