公开(公告)号：ES2169073T3

公开(公告)日：2002-07-01

申请号：ES94917601

申请日：1994-05-09

Applicant: BASF AG

Inventor： GRABOWSKI SVEN ,  MUELLER WINFRIED ,  ROSENBERG JOERG ,  BINDER RUDOLF ,  SANNER AXEL

IPC: A61K47/32 ,  A61K9/14 ,  A61K31/37 ,  A61K31/41 ,  A61K31/425 ,  A61K31/433 ,  A61K47/30 ,  A61K47/38

Abstract: PCT No. PCT/EP94/01489 Sec. 371 Date Nov. 7, 1995 Sec. 102(e) Date Nov. 7, 1995 PCT Filed May 9, 1994 PCT Pub. No. WO94/26267 PCT Pub. Date Nov. 24, 1994Compositions in the form of solid solutions containing a) 1-90% by weight of a coumarin derivative A from the group of alkoxycoumarins with a heterocyclic substituent or of hydroxycoumarins esterified with a sulfonic acid as active substance and b) 10-99% by weight of at least one water-soluble polymer B as carrier substance.

公开(公告)号：DE59609104D1

公开(公告)日：2002-05-23

申请号：DE59609104

申请日：1996-10-23

Applicant: BASF AG

Inventor： BREITENBACH JOERG ,  HAERTL PAUL ,  HOFMANN JUERGEN ,  ROSENBERG JOERG ,  SCHIESSL MICHAEL ,  ZETTLER DIETER

IPC: A61J3/10 ,  A61K9/20 ,  A61K9/24 ,  A61K9/28 ,  A61K31/07 ,  A61K31/167 ,  A61K31/192 ,  A61K31/277 ,  A61K31/355 ,  A61K31/375 ,  A61K31/401 ,  A61K31/4422 ,  A61K31/52 ,  A61K31/522 ,  A61K31/60

Abstract: PCT No. PCT/EP96/04601 Sec. 371 Date Apr. 15, 1998 Sec. 102(e) Date Apr. 15, 1998 PCT Filed Oct. 23, 1996 PCT Pub. No. WO97/15293 PCT Pub. Date May 1, 1997The present invention relates to a process for producing multilayer, solid drug forms for oral or rectal administration, which comprises coextrusion of at least two compositions which in each case comprise a thermoplastic, pharmacologically acceptable polymeric binder which is soluble or swellable in a physiological environment, and at least one of which contains a pharmaceutical active ingredient, and shaping the coextruded multilayer material to the required drug form.

公开(公告)号：ES2163008T3

公开(公告)日：2002-01-16

申请号：ES96907439

申请日：1996-03-12

Applicant: BASF AG

Inventor： ROSENBERG JOERG ,  BREITENBACH JORG

IPC: A61K9/14 ,  A61K9/20 ,  B01J2/20

Abstract: PCT No. PCT/EP96/01047 Sec. 371 Date Nov. 21, 1996 Sec. 102(e) Date Nov. 21, 1996 PCT Filed Mar. 12, 1996 PCT Pub. No. WO96/29061 PCT Pub. Date Sep. 26, 1996A process for producing active substance compositions in the form of a solid solution of the active substance in a polymer matrix, which comprises melt extrusion of the active substance in nonionic form together with a polymer and a salt.

公开(公告)号：DE10026698A1

公开(公告)日：2001-12-06

申请号：DE10026698

申请日：2000-05-30

Applicant: BASF AG

Inventor： BERNDL GUNTHER ,  BREITENBACH JOERG ,  HEGER ROBERT ,  STADLER MICHAEL ,  WILKE PETER ,  ROSENBERG JOERG

IPC: A61F13/53 ,  A23P1/02 ,  A23P1/08 ,  A61F13/49 ,  A61K9/107 ,  A61K9/16 ,  A61K47/00 ,  A61K47/10 ,  A61K47/12 ,  A61K47/14 ,  A61K47/26 ,  A61K47/32 ,  A61K47/34 ,  A61K47/38 ,  A61K9/10

Abstract: The invention relates to self-emulsifying formulations based on an active substance constituent and on a formulation base with a lipid constituent and with a binding agent constituent. The invention also relates to the use of this formulation as a dosed form in the area of life science. The invention also relates to a method for producing self-emulsifying formulations by mixing the formulation constituents while forming a plastic mixture and optionally while preparing the formulations as a dosed form, advantageously while using melt extrusion. The formulations spontaneously form emulsions in water or in aqueous fluids.

公开(公告)号：DK0756480T3

公开(公告)日：2001-10-08

申请号：DK95915844

申请日：1995-04-05

Applicant: BASF AG

Inventor： GRABOWSKI SVEN ,  ROSENBERG JOERG ,  SANNER AXEL

IPC: A61K9/16 ,  A61K9/22

Abstract: Slow-release matrix pellets with a spherical or lenticular shape and uniform maximum diameters in the range from 0.5 to 4 mm, composed ofa) 0.1-87% by weight of at least one biologically active compound,b) 5-50% by weight of at least one water-insoluble polymer,c) 5-45% by weight of at least one lipophilic component as plasticizer for polymer b),d) 3-40% by weight of a natural or semisynthetic gel former,e) 0-50% by weight of one or more conventional formulation aids.

公开(公告)号：GR3034441T3

公开(公告)日：2000-12-29

申请号：GR20000402133

申请日：2000-09-20

Applicant: BASF AG

Inventor： BREITENBACH JOERG ,  SANNER AXEL ,  ROSENBERG JOERG

IPC: A61K9/00 ,  A61K9/20 ,  A61K31/19 ,  A61K31/192 ,  A61K47/30

Abstract: PCT No. PCT/EP96/01021 Sec. 371 Date Sep. 16, 1997 Sec. 102(e) Date Sep. 16, 1997 PCT Filed Mar. 9, 1996 PCT Pub. No. WO96/29053 PCT Pub. Date Sep. 26, 1996Transparent rapid release active substance compositions obtainable by extrusion of melts, containing non-steroidal analgesics, homopolymers of N-vinylpyrrolidone, saccharides or sugar alcohols and sodium or potassium salts.

公开(公告)号：BR9810851A

公开(公告)日：2000-07-25

申请号：BR9810851

申请日：1998-07-21

Applicant: BASF AG

Inventor： ZEIDLER JUERGEN ,  NEUMANN JOERG ,  LIEPOLD BERND ,  ROSENBERG JOERG ,  BERNDL GUNTHER ,  BREITENBACH JOERG ,  VOLLGRAF CHRISTIANE

IPC: A61K9/20 ,  A61K31/192 ,  A61K47/02 ,  A61K47/32 ,  A61P29/00 ,  A61K31/19

Abstract: A fast-acting analgesic comprises as analgesic substance ibuprofen in an adjuvant matrix with a porous structure and a density of greater than 1 and up to 2.5 g/cm3.

公开(公告)号：NO307811B1

公开(公告)日：2000-06-05

申请号：NO932875

申请日：1993-08-12

Applicant: BASF AG

Inventor： GRABOWSKI SVEN ,  SANNER AXEL ,  ROSENBERG JOERG

IPC: A01N25/12 ,  A61K9/14 ,  A01N25/10 ,  A61K9/20 ,  A61K9/22 ,  A61K9/26 ,  A61K47/30

Abstract: Preparations in solid particle form containing active compounds, obtainable by intimate mixing of the active compound with a water-soluble melt of a) 10 to 90% by weight of a water-soluble polymer A of a viscosity Va of 1,000 to 120,000 cps and b) 10 to 90% by weight of a water-soluble polymer B of a viscosity Vb of 1 to 500 cps as a carrier substance, the viscosities Va and Vb being those of a 2% strength by weight aqueous solution at 20@C, measured by the capillary method ASTM D 2363-72 (European Pharmacopoeia, Vol. III, p. 37), and processing of the melt with shaping to give the particles.

公开(公告)号：DK0799012T3

公开(公告)日：2000-06-05

申请号：DK95942731

申请日：1995-12-22

Applicant: BASF AG

Inventor： ROSENBERG JOERG ,  MAIER WERNER ,  GRABOWSKI SVEN ,  BREITENBACH JOERG

IPC: A61J1/03 ,  A61J3/00 ,  A61J3/10 ,  A61K9/20 ,  A61K9/28 ,  B30B11/16 ,  B65B9/04

公开(公告)号：DE19853985A1

公开(公告)日：2000-05-25

申请号：DE19853985

申请日：1998-11-23

Applicant: BASF AG

Inventor： ROSENBERG JOERG ,  MAIER WERNER

IPC: A61J3/10 ,  A61K9/20 ,  A61K47/32 ,  A61K47/36 ,  A61K47/38 ,  B30B11/16 ,  A61K9/16

Abstract: Production of solid dosage form(A) from a plastic mixture of at least one active ingredient(I) and at least one polymeric binder(II) using a molding calender with two molding cylinders(MC) that rotate in opposite directions. One MC has at least one ringnut along its edge while the other has at least one rim along its edge with teeth that extend radially outwards and interlock with the ringnut. An Independent claim is also included for (A) produced this way.