자소엽 추출물을 포함하는 뇌신경질환 예방 또는 치료용 의약 조성물
    12.
    发明公开
    자소엽 추출물을 포함하는 뇌신경질환 예방 또는 치료용 의약 조성물 有权
    包含PERILLA FRUTESCENS提取物用于预防或治疗脑神经疾病的医学成分

    公开(公告)号:KR1020130051142A

    公开(公告)日:2013-05-20

    申请号:KR1020110116324

    申请日:2011-11-09

    CPC classification number: A61K36/535 A23V2200/322 A61K2236/331 A61K2236/333

    Abstract: PURPOSE: A pharmaceutical composition containing a Perilla frutescens extract or benzo[b]naphtha[2,3-d]thiophene isolated from the extract for preventing or treating neuronal diseases is provided to suppress acetylcholine esterase(AChE), and to effectively prevent, treat, or relieve Alzheimer's disease, dementia, and neurodegenerative diseases. CONSTITUTION: A pharmaceutical composition for preventing or treating neuronal diseases contains a Perilla frutescens extract as an active ingredient. The extract is prepared by using an organic solvent, water, or a mixture thereof. The extract is an ethanol extract. The extract is also an ethyl acetate fraction which is prepared by extracting with ethanol and sequentially fractioning a residue of the Perilla frutescens extract with hexane, chloroform, and ethyl acetate. The extract is a fraction which is prepared by performing silicagel column chromatography using chloroform and ethanol in a ratio of 100:0-80:20. The extract also contains benzo[b]naphtha[2,3-d]thiophene.

    Abstract translation: 目的:提供从用于预防或治疗神经元疾病的提取物中分离出的紫苏提取物或苯并[b]石脑油[2,3-d]噻吩的药物组合物,以抑制乙酰胆碱酯酶(AChE),并有效预防,治疗 ,或缓解阿尔茨海默病,痴呆和神经变性疾病。 构成:用于预防或治疗神经元疾病的药物组合物含有紫苏提取物作为活性成分。 提取物通过使用有机溶剂,水或其混合物制备。 提取物是乙醇提取物。 提取物也是乙酸乙酯级分,其通过用乙醇萃取并用己烷,氯仿和乙酸乙酯依次分馏紫苏提取物的残余物制备。 提取物是通过使用氯仿和乙醇以100:0-80:20的比例进行硅胶柱色谱法制备的级分。 提取物还含有苯并[b]石脑油[2,3-d]噻吩。

    곰취 추출물을 포함하는 뇌신경세포 보호용 조성물
    14.
    发明公开
    곰취 추출물을 포함하는 뇌신경세포 보호용 조성물 有权
    包含LIGULARIA FISCHERI提取物的组合物,用于保护神经细胞

    公开(公告)号:KR1020120025826A

    公开(公告)日:2012-03-16

    申请号:KR1020100087968

    申请日:2010-09-08

    Abstract: PURPOSE: A composition containing Ligularia fischeri extract or 2,5,8,11,14,17,20-heptaoxaheneicosane is provided to prevent or treat cerebral diseases, Alzheimer's disease, and Parkinson's disease. CONSTITUTION: A composition for protecting neural cells contains Ligularia fischeri extract as an active ingredient. The extract is prepared using organic solvent, water, or mixture thereof. The extract is a chloroform fraction prepared by extracting Ligularia fischeri with ethanol, fractioning the residue with hexane, chloforom, and ethyl acetate in order, and performing silicagel column chromatography.

    Abstract translation: 目的:提供含有igigiaia fischeri提取物或2,5,8,11,14,17,20-七氧杂二十烷并用于预防或治疗脑疾病,阿尔茨海默病和帕金森病的组合物。 构成:用于保护神经细胞的组合物含有茯苓提取物作为活性成分。 使用有机溶剂,水或其混合物制备提取物。 提取物是通过用乙醇萃取茯苓提取物制备的氯仿级分,用己烷,氯仿和乙酸乙酯分级残余物,并进行硅胶柱色谱。

    뇌 신경 세포 보호물질을 포함하는 질경이 추출물을포함하는 조성물

    公开(公告)号:KR101060909B1

    公开(公告)日:2011-08-30

    申请号:KR1020080062877

    申请日:2008-06-30

    Abstract: 본 발명은 뇌 신경 세포 보호물질을 포함하는 질경이 추출물을 포함하는 퇴행성 신경 질환의 예방 또는 치료용 조성물에 관한 것이다. 보다 구체적으로, 뇌 신경 세포 보호물질로서 4-비닐-2-메톡시페놀을 포함하고, 산화적 스트레스(oxidative stress) 유발을 감소시키며 세포 활성(cell viability)을 증대시킬 뿐만 아니라 치매 모델 동물실험의 대안행동(alternative behavior) 및 스텝쓰루 레턴시(step through latency) 수동회피검사에서 기억 학습 능력을 유지시키는 질경이 추출물이 포함된 인체에 무해한 퇴행성 신경 질환의 예방 또는 치료용 조성물에 관한 것이다.
    질경이 추출물, 아밀로이드 베타 펩타이드-유도 산화적 스트레스, 퇴행성 신경 질환

    세포외 다당질의 생산 방법
    16.
    发明公开
    세포외 다당질의 생산 방법 有权
    生产挥发油的方法

    公开(公告)号:KR1020100078999A

    公开(公告)日:2010-07-08

    申请号:KR1020080137396

    申请日:2008-12-30

    CPC classification number: C12P19/04 C12N1/20

    Abstract: PURPOSE: A method for producing extracellular polysaccharide is provided to efficiently produce a large amount of extracellular polysaccharide through culture condition of the strain. CONSTITUTION: A method for producing extracellular polysaccharide comprises: a step of culturing lactobacillus rhamnosus at pH 5-6; and a step of collecting extracellular polysaccharide. The culture is performed at 35-39°C and together with EPS-low producing strain.

    Abstract translation: 目的:提供细胞外多糖的制备方法,通过菌株的培养条件有效地产生大量的细胞外多糖。 构成:细胞外多糖的制造方法,其特征在于,包括在pH 5-6下培养鼠李糖乳杆菌的工序; 和收集细胞外多糖的步骤。 培养在35-39℃和EPS低产菌株一起进行。

    공액리놀레인산의 제조방법
    17.
    发明公开
    공액리놀레인산의 제조방법 有权
    预处理联合亚油酸的方法

    公开(公告)号:KR1020090091890A

    公开(公告)日:2009-08-31

    申请号:KR1020080017095

    申请日:2008-02-26

    CPC classification number: C12P7/6409 C12N1/20

    Abstract: A method for manufacturing a conjugated linoleic acid is provided to preculture in linoleic acid and maximize the productivity of the conjugated linoleic acid. A method for manufacturing a conjugated linoleic acid comprises: a step of producing culture media from bovine ruminant stomach liquid; and a step of inoculating culture media in basic media contaiing linoleic acid which is emulsified with bovine fetal serum.

    Abstract translation: 提供共轭亚油酸的制备方法用于在亚油酸中进行预培养,并使共轭亚油酸的生产率最大化。 共轭亚油酸的制造方法包括:从牛反刍动物胃液制造培养基的工序; 以及将培养基接种在含有牛胎儿血清乳化的亚油酸的基础培养基中的步骤。

    팔미트산을 포함하는 알츠하이머병의 예방 또는 치료용조성물
    18.
    发明授权
    팔미트산을 포함하는 알츠하이머병의 예방 또는 치료용조성물 有权
    包含用于预防或治疗阿尔茨海默病的乳酸的组合物

    公开(公告)号:KR100787765B1

    公开(公告)日:2007-12-24

    申请号:KR1020060109547

    申请日:2006-11-07

    Abstract: A composition comprising palmitic acid is provided to inhibit the oxidative stress induced by amyloid beta peptide excellently and secure excellent cell survival rate, thereby being usefully used for preventing or treating Alzheimer's disease. A pharmaceutical composition for preventing or treating Alzheimer's disease comprises palmitic acid which is obtained by extracting Gardenia jasminoides with water, alcohol or a mixture of water and alcohol, filtering the extract, concentrating the filtrate under reduced pressure and then freeze-drying the concentrate. A food composition useful for preventing Alzheimer's disease comprises palmitic acid extracted and isolated from Gardenia jasminoides.

    Abstract translation: 提供了包含棕榈酸的组合物以极好地抑制淀粉样蛋白β肽诱导的氧化应激,并确保优异的细胞存活率,从而有效地用于预防或治疗阿尔茨海默氏病。 用于预防或治疗阿尔茨海默氏病的药物组合物包括通过用水,醇或水和醇的混合物提取栀子花获得的棕榈酸,过滤提取物,在减压下浓缩滤液,然后冷冻干燥浓缩物。 用于预防阿尔茨海默病的食物组合物包括从栀子栀子提取并分离的棕榈酸。

    인삼씨 추출물을 포함하는 뇌신경세포 보호 및 우울증의 예방, 개선 및 치료용 조성물
    20.
    发明公开
    인삼씨 추출물을 포함하는 뇌신경세포 보호 및 우울증의 예방, 개선 및 치료용 조성물 无效
    一种包含用于保护大脑细胞的金山提取物的组合物,预防,改善和治疗呕吐

    公开(公告)号:KR1020150113434A

    公开(公告)日:2015-10-08

    申请号:KR1020140036964

    申请日:2014-03-28

    Abstract: 본발명은인삼씨추출물의뇌신경세포보호및 우울증의예방, 개선및 치료를위한신규용도를제공한다. 본발명의인삼씨추출물을유효성분으로포함하는조성물은우울증유발과관련있는코르티코스테론에의한독성에대한신경세포보호효과및 신경영양인자의발현개선효과를나타내므로우울증발생및 진행을예방또는개선하거나, 우울증을치료하는데효과적으로사용될수 있다.

    Abstract translation: 提供人参种子提取物用于保护脑细胞和预防,治疗或缓解抑郁症的新用途。 含有人参种子提取物作为活性成分的组合物表现出与由抑郁诱导相关的皮质酮引起的毒性的神经元保护作用,以及对神经营养因子表达的改善作用,从而有效地用于预防或缓解发育和进展 抑郁症或治疗抑郁症。

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