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11.发明公开호스트셀의 알코올 내성을 증대시키는 단리된 폴리뉴클레오티드, 이를 포함하는 벡터, 호스트셀 및 이를 이용한 알코올의 생산방법 无效分离多元醇增加酒精耐受性，载体和含有它的宿主细胞，以及使用其制造酒精的方法
公开(公告)号：KR1020100117465A
公开(公告)日：2010-11-03
申请号：KR1020090036253
申请日：2009-04-24
Applicant: 삼성전자주식회사 , 성균관대학교산학협력단
CPC classification number: C07K14/395
Abstract: PURPOSE: A method for producing bio alcohol using a polynucleotide which enhances alcohol resistance of host cells is provided to enhance productivity in alcohol fermentation. CONSTITUTION: An isolated polynucleotide comprises: a polynucleotide comprising nucleotide having 90% or more identity with a nucleotide selected from sequence numbers 1-8; a polynucleotide encoding a polypeptide comprising amino acids having 90% or more identity with amino acids selected from sequence numbers 14-20; a polynucleotide comprising nucleotide sequence hybridizing with the selected nucleotide sequence under severe condition; and a polypeptide encoding polypeptide.
Abstract translation: 目的：提供使用增强宿主细胞的耐酒精性的多核苷酸生产生物醇的方法，以提高酒精发酵的生产率。 构成：分离的多核苷酸包含：包含与选自序列号1-8的核苷酸具有90％或更高同一性的核苷酸的多核苷酸; 编码多肽的多核苷酸，其包含与选自序列号14-20的氨基酸具有90％以上同一性的氨基酸; 包含在恶劣条件下与选择的核苷酸序列杂交的核苷酸序列的多核苷酸; 和编码多肽的多肽。
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公开(公告)号：KR1020100096038A
公开(公告)日：2010-09-01
申请号：KR1020100016400
申请日：2010-02-23
Applicant: 성균관대학교산학협력단 , (주)에이피테크놀로지
IPC: A61K9/127 , A61K31/122 , A61K31/575 , A61K47/48
CPC classification number: A61K9/1275 , A61K9/127 , A61K31/122 , A61K31/575 , A61K47/50
Abstract: PURPOSE: A method for preparing an insoluble drug nanocomplex is provided to enhance manufacture yield of the insoluble drug nanocomplex. CONSTITUTION: A method for preparing an insoluble drug nanocomplex comprises: a step of dissolving insoluble drug in a solvent containing surfactant; a step of adding apolipoprotein in the solution; a step of heating the solution; and a step of removing surfactant and solvent from the solution. The insoluble drug is dissolved with phospholipid. The phospholipid is phosphatidylcholine. The insoluble drug is coenzyme Q10, ursodeoxycholic acid, ilaprazole, paclitaxel or imatinib mesylate. The surfactant is cholic acid or salt thereof. The apolipoprotein is apolipotprotein A-I.
Abstract translation: 目的：提供一种制备不溶性药物纳米复合物的方法，以提高不溶性药物纳米复合物的制造成品率。 构成：制备不溶性药物纳米复合物的方法包括：将不溶性药物溶解在含有溶剂的表面活性剂中的步骤; 在溶液中加入载脂蛋白的步骤; 加热溶液的步骤; 以及从溶液中除去表面活性剂和溶剂的步骤。 不溶性药物用磷脂溶解。 磷脂是磷脂酰胆碱。 不溶性药物是辅酶Q10，熊去氧胆酸，伊拉唑，紫杉醇或甲磺酸伊马替尼。 表面活性剂是胆酸或其盐。 载脂蛋白是载脂蛋白A-I。
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13.发明公开
公开(公告)号：KR1020100039722A
公开(公告)日：2010-04-16
申请号：KR1020080098801
申请日：2008-10-08
Applicant: 성균관대학교산학협력단
Abstract: PURPOSE: A method for fixing membrane protein on a solid surface is provided to widely screen membrane protein in chip-based array. CONSTITUTION: A method for fixing membrane protein on a solid surface comprises a step of collecting the membrane protein inside a membrane structure and a step of fixing the membrane protein on the solid surface. The membrane structure is formed by surrounding phospholipid by apolipoprotein A-1 which is elongated at N-terminal or C-terminal or both terminals. The solid is Ni-NTA and amino acid sequence is histidine sequence. The solid contains glutathione and the sequence of the amino acid is glutathione-S-transferase(GST). The amino acid sequence is bound to the apolipoprotein A-I by mediating peptide linker.
Abstract translation: 目的：提供一种将膜蛋白固定在固体表面上的方法，以广泛筛选基于芯片的阵列中的膜蛋白。 构成：将膜蛋白固定在固体表面上的方法包括在膜结构内收集膜蛋白的步骤和将膜蛋白固定在固体表面上的步骤。 膜结构由在N末端或C末端或两个末端延伸的载脂蛋白A-1包围磷脂形成。 固体为Ni-NTA，氨基酸序列为组氨酸序列。 固体含有谷胱甘肽，氨基酸序列为谷胱甘肽-S-转移酶（GST）。 氨基酸序列通过介导肽接头与载脂蛋白A-1结合。
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公开(公告)号：KR101882740B1
公开(公告)日：2018-07-27
申请号：KR1020120061819
申请日：2012-06-08
Applicant: 삼성전자주식회사 , 성균관대학교산학협력단
Abstract: 젖산의고효율생산을위한변형미생물, 상기변형미생물을제작하기위한발현벡터, 및상기변형미생물을이용한젖산의생산방법이개시된다. 상기변형미생물은산성조건하에서도고효율로젖산을생산할수 있다.
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Patent Agency Ranking
公开(公告)号：KR1020170064622A
公开(公告)日：2017-06-12
申请号：KR1020150170057
申请日：2015-12-01
Applicant: 성균관대학교산학협력단
Abstract: 본발명은플라즈마멸균기및 플라즈마멸균기의과산화수소기체발생장치에관한것으로서, 본발명에따른플라즈마멸균기는멸균챔버를 100torr 이상의상압(준상압)으로형성한다음, 비활성기체를이용하여플라즈마를발생시키고, 발생된플라즈마에의해과산화수소기체로부터 OH 라디컬을생성시킴으로써멸균대상을멸균시키며, 이때비활성기체를이용하여과산화수소기체를생성하는것을특징으로한다.
Abstract translation: 本发明涉及在等离子体灭菌器和等离子体灭菌装置中产生气体的过氧化氢，根据本发明的等离子体灭菌器生成在常压下灭菌室至100托或更多的形成（标准大气压），然后，产生的等离子体使用惰性气体， 通过生成OH由等离子体从过氧化氢的气体基团sikimyeo灭菌灭菌目标，此时使用的惰性气体的特征在于，以产生过氧化氢的气体。
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公开(公告)号：KR101374409B1
公开(公告)日：2014-03-18
申请号：KR1020110105985
申请日：2011-10-17
Applicant: 성균관대학교산학협력단
IPC: A61K31/497 , A61K31/495 , A61P31/00
CPC classification number: A61K31/495 , A61K31/345 , A61K31/496 , Y02A50/475 , Y02A50/483
Abstract: 본 발명은 비유전성 항생제 내성을 가지는 미생물에게 항생제에 대한 감수성을 부여할 수 있는 화합물을 항생제와 함께 처리하여 비유전성 항생제 내성을 가지는 미생물을 사멸시키는 방법, 상기 화합물을 포함하는 항생제 내성 억제용 조성물 및 항생제와 상기 화합물을 유효성분으로 포함하는 미생물감염성 질환의 예방 또는 치료용 약학 조성물에 관한 것이다. 본 발명의 화합물은 다양한 항생제에 투여시 나타나는 비유전적 항생제 내성을 억제하여 이에 의한 2차 감염을 방지할 수 있으므로, 항생제를 이용하여 미생물감염증을 효과적으로 예방 또는 치료하는데 널리 활용될 수 있을 것이다.
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公开(公告)号：KR101373997B1
公开(公告)日：2014-03-12
申请号：KR1020120088641
申请日：2012-08-13
Applicant: 성균관대학교산학협력단
Abstract: 본 발명은 비만세포의 탈과립에 관여하는 SNARE(soluble NSF attachment protein receptor) 복합체 형성 저해능을 확인함으로써, 항알러지 물질을 스크리닝하는 방법에 관한 것이다. 본 발명의 방법을 이용하면, 항알러지 물질을 효과적으로 스크리닝하여 알러지 질환 개선 및 치료 물질의 개발에 이용할 수 있으며, 본 발명에서 확인한 결과를 바탕으로 알러지의 메커니즘을 보다 효과적으로 연구할 수 있는 장점이 있다.
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公开(公告)号：KR1020130139820A
公开(公告)日：2013-12-23
申请号：KR1020130148792
申请日：2013-12-02
Applicant: 성균관대학교산학협력단
IPC: A61K31/497 , A61K31/496 , A61K31/495 , A61K31/34 , A61P31/00
CPC classification number: Y02A50/475 , Y02A50/483 , A61K31/496 , A61K31/341 , A61K31/495
Abstract: The present invention relates to a method for killing microorganisms having non-inherited antibiotic resistance by processing an antibiotic with a compound which can add sensitivity for the antibiotic to the microorganism having the non-inherited antibiotic resistance; to a compound for suppressing antibiotic resistance which includes the compound; and to a pharmaceutical composition for preventing or treating microorganism infectious diseases which includes the compound as an active ingredient. The compound of the present invention suppresses the non-inherited antibiotic resistance which is shown when administered to various antibiotics in order to prevent secondary infections caused thereby and to effectively prevent or treat the microorganism infectious diseases using the antibiotic.
Abstract translation: 本发明涉及通过用具有抗生素对具有非遗传抗生素抗性的微生物增加敏感性的化合物处理抗生素来杀死具有非遗传抗生素抗性的微生物的方法; 涉及包含该化合物的抗生素抗性抑制化合物; 涉及包含该化合物作为有效成分的微生物感染性疾病的预防或治疗用药物组合物。 本发明的化合物抑制了当施用于各种抗生素时显示的非遗传性抗生素抗性，以防止由此引起的继发性感染并有效地预防或治疗使用抗生素的微生物感染性疾病。
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公开(公告)号：KR1020130041613A
公开(公告)日：2013-04-25
申请号：KR1020110105985
申请日：2011-10-17
Applicant: 성균관대학교산학협력단
IPC: A61K31/497 , A61K31/495 , A61P31/00
CPC classification number: A61K31/495 , A61K31/345 , A61K31/496 , Y02A50/475 , Y02A50/483
Abstract: PURPOSE: A non-inherited antibiotic resistance inhibitor and a use thereof are provided to induce apoptosis of a microbe with non-inherited antibiotic resistance. CONSTITUTION: A method for inducing apoptosis of a microbe with non-inherited antibiotic resistance comprises a step of treating the microbe with non-inherited antibiotic resistance using antibiotics and a compound with antibiotic sensitivity, which is selected from the group consisting of 4-(4-(3-chlorophenyl)piperazin-1-yl)piperidin-3-yl 2-naphthoate, 3-(4-(4-methoxyphenyl)piperazin-1-yl)piperidin-4-yl biphenyl-4-carboxylate, (E)-2-nitro-5-styrylfuran, 1-(3-(bis(4-fluorophenyl)methoxy)phenyl)piperazine, a derivative thereof, and a combination thereof. The antibiotic is selected from the group consisting of beta-lactam antibiotics, tetracycline antibiotics, quinolone antibiotics, amino glycoside antibiotics, glycopeptides antibiotics, sulfonamide antibiotics, and a combination thereof.
Abstract translation: 目的：提供非遗传性抗生素抗性抑制剂及其用途，以诱导具有非遗传抗生素抗性的微生物细胞凋亡。 构成：用非导电抗生素抗性诱导微生物细胞凋亡的方法包括使用抗生素和具有抗生素敏感性的化合物治疗具有非遗传抗生素抗性的微生物的步骤，其选自4-（4 - （3-氯苯基）哌嗪-1-基）哌啶-3-基2-萘甲酸酯，3-（4-（4-甲氧基苯基）哌嗪-1-基）哌啶-4-基联苯-4-羧酸乙酯（E ）-2-硝基-5-苯乙烯基呋喃，1-（3-（双（4-氟苯基）甲氧基）苯基）哌嗪及其衍生物及其组合。 抗生素选自β-内酰胺抗生素，四环素抗生素，喹诺酮抗生素，氨基糖苷抗生素，糖肽抗生素，磺胺类抗生素及其组合。
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